PANTHER Gene Information

Gene Symbol(s):

PCSK2

Organism:

Equus caballus

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Gene Name:

Proprotein convertase subtilisin_kexin type 2

Gene ID:

ENSECAG00000001142.4

Protein ID:

F6W2D5

Persistent Id:

PTN001325144

Alternate Ids:

ENSECAT00000002741(Ensembl_TRS)	XM_001491591(refSeq)
100050755(GeneID)	ENSECAP00000001963(Ensembl_PRO)
194224135(GI)	F6W2D5_HORSE(UniProtKB-ID)
F6W2D5(Synonym)	ENSECAG00000001142(Ensembl)
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PANTHER Classification

PANTHER Family:	PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED (PTHR42884)
PANTHER Subfamily:	NEUROENDOCRINE CONVERTASE 2 (PTHR42884:SF13)
PANTHER GO-slim Molecular Function:	serine-type endopeptidase activity
PANTHER GO-slim Biological Process:	peptide metabolic process protein processing hormone metabolic process
PANTHER GO-slim Cellular Component:	extracellular space trans-Golgi network Golgi membrane neuron projection
PANTHER protein class:	serine protease

Pathway Categories:

Alzheimer disease-amyloid secretase pathway

Furin

Alzheimer disease-presenilin pathway

Furin

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	endopeptidase activity, serine-type endopeptidase activity, serine-type peptidase activity
GO BP Complete:	insulin processing, proteolysis, enkephalin processing, nervous system development, protein processing, protein autoprocessing, peptide hormone processing
GO CC Complete:	extracellular space, secretory granule, intracellular membrane-bounded organelle, membrane, neuron projection, nucleoplasm

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Orthologs

ID	Organism	Type
HUMAN\|HGNC=8744\|UniProtKB=P16519	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000013273.4\|UniProtKB=H2QJZ8	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000007255.3\|UniProtKB=G3QWE4	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000014626.4\|UniProtKB=F7GNE5	Macaca mulatta	LDO
MOUSE\|MGI=MGI=97512\|UniProtKB=P21661	Mus musculus	LDO
RAT\|RGD=3273\|UniProtKB=P28841	Rattus norvegicus	LDO
BOVIN\|Gene=PCSK2\|UniProtKB=Q9GLR0	Bos taurus	O
BOVIN\|Ensembl=ENSBTAG00000008687.6\|UniProtKB=F6Q5F4	Bos taurus	LDO
PIG\|Gene=PCSK2\|UniProtKB=Q03333	Sus scrofa	O
PIG\|Ensembl=ENSSSCG00005030759.1\|UniProtKB=A0A480EG12	Sus scrofa	LDO
FELCA\|Ensembl=ENSFCAG00000011356.6\|UniProtKB=A0A5F5XCX7	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845019218.1\|UniProtKB=A0A8I3P927	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000005404.3\|UniProtKB=F7G632	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000001239.3\|UniProtKB=F6YDT9	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010017927.1\|UniProtKB=A0A8V0ZB97	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000000663.4\|UniProtKB=G1K8P0	Anolis carolinensis	LDO
XENLA\|Gene=pcsk2.S\|UniProtKB=Q6GM20	Xenopus laevis	O
XENLA\|Gene=pcsk2.L\|UniProtKB=Q6GLS0	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-960013\|UniProtKB=A0JP87	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000006472.2\|UniProtKB=H2LPZ0	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-090608-1\|UniProtKB=B6VCA2	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000015998.1\|UniProtKB=W5NGE3	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000005712.3\|UniProtKB=F6WPG2	Ciona intestinalis	LDO
BRAFL\|Gene=LOC118418937\|UniProtKB=A0A9J7MV19	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=LOC579017\|UniProtKB=A0A7M7REC6	Strongylocentrotus purpuratus	LDO
CAEEL\|WormBase=WBGene00001172\|UniProtKB=G5ECN9	Caenorhabditis elegans	LDO
CAEBR\|Gene_ORFName=CBG09536\|UniProtKB=A8X8V5	Caenorhabditis briggsae	LDO
PRIPA\|EnsemblGenome=WBGene00103503\|UniProtKB=A0A2A6CRK7	Pristionchus pacificus	LDO
DROME\|FlyBase=FBgn0023179\|UniProtKB=Q9VBC7	Drosophila melanogaster	LDO
ANOGA\|EnsemblGenome=AGAP002176\|UniProtKB=Q7QK68	Anopheles gambiae	LDO
TRICA\|EnsemblGenome=TC009181\|UniProtKB=D6WTB9	Tribolium castaneum	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_193075\|UniProtKB=E9G2S6	Daphnia pulex	LDO
IXOSC\|EnsemblGenome=ISCW020499\|UniProtKB=B7Q266	Ixodes scapularis	LDO
HELRO\|EnsemblGenome=HelroG96355\|UniProtKB=T1G9B6	helobdella robusta	LDO
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g234208\|UniProtKB=A7RME4	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g134107\|UniProtKB=A7SVH1	Nematostella vectensis	O
TRIAD\|EnsemblGenome=TriadG54612\|UniProtKB=B3RSI8	Trichoplax adhaerens	O
MONBE\|EnsemblGenome=MONBRDRAFT_30798\|UniProtKB=A9UPB2	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_14515\|UniProtKB=A9US94	Monosiga brevicollis	O
YEAST\|SGD=S000005182\|UniProtKB=P13134	Saccharomyces cerevisiae	O
EREGS\|EnsemblGenome=AGOS_ABL203W\|UniProtKB=Q75E73	Eremothecium gossypii	O
CANAL\|CGD=CAL0000186377\|UniProtKB=A0A1D8PEG3	Candida albicans	O
YARLI\|EnsemblGenome=YALI0_F13189g\|UniProtKB=P42781	Yarrowia lipolytica	O
EMENI\|EnsemblGenome=ANIA_03583\|UniProtKB=G5EB75	Emericella nidulans	O
ASPFU\|EnsemblGenome=AFUA_4G12970\|UniProtKB=Q4WQI8	Neosartorya fumigata	O
NEUCR\|EnsemblGenome=NCU03219\|UniProtKB=V5IPW5	Neurospora crassa	O
SCLS1\|EnsemblGenome=SS1G_06027\|UniProtKB=A7EL30	Sclerotinia sclerotiorum	O
PHANO\|EnsemblGenome=SNOG_04420\|UniProtKB=Q0UUZ4	Phaeosphaeria nodorum	O
SCHPO\|PomBase=SPAC22E12.09c\|UniProtKB=Q09175	Schizosaccharomyces pombe	O
SCHJY\|EnsemblGenome=SJAG_04398\|UniProtKB=B6K6Q9	Schizosaccharomyces japonicus	O
CRYNJ\|EnsemblGenome=CNA01380\|UniProtKB=Q5KPV9	Cryptococcus neoformans	O
CRYNJ\|EnsemblGenome=CNH01120\|UniProtKB=Q5KCI3	Cryptococcus neoformans	O
USTMA\|EnsemblGenome=UMAG_02843\|UniProtKB=A0A0D1DXD6	Ustilago maydis	O
PUCGT\|EnsemblGenome=PGTG_08683\|UniProtKB=E3KGS2	Puccinia graminis	O
BATDJ\|Gene_ORFName=BATDEDRAFT_11523\|UniProtKB=F4P3C2	Batrachochytrium dendrobatidis	O
LEIMA\|EnsemblGenome=LMJF_13_1040\|UniProtKB=Q4QG50	Leishmania major	O
GIAIC\|Gene_ORFName=GL50803_0060596\|UniProtKB=A0A644F4P2	Giardia intestinalis	O
GIAIC\|EnsemblGenome=GL50803_2897\|UniProtKB=E2RTR3	Giardia intestinalis	O
GIAIC\|EnsemblGenome=GL50803_9948\|UniProtKB=A8BA31	Giardia intestinalis	O
TRIV3\|Gene_ORFName=TVAG_456780\|UniProtKB=A2DC02	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_187410\|UniProtKB=A2GMZ5	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_444370\|UniProtKB=A2E2H8	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_083790\|UniProtKB=A2DMA3	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_042330\|UniProtKB=A2EUX2	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_270490\|UniProtKB=A2FFZ9	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_184220\|UniProtKB=A2E9V8	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_365540\|UniProtKB=A2DHJ8	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_444380\|UniProtKB=A2E2H9	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_109130\|UniProtKB=A2G1N4	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_103310\|UniProtKB=A2EKP2	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_210920\|UniProtKB=A2F878	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_420190\|UniProtKB=A2ED42	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_444360\|UniProtKB=A2E2H7	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_465250\|UniProtKB=A2DTZ0	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_019800\|UniProtKB=A2DX52	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_276930\|UniProtKB=A2FUF3	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_028690\|UniProtKB=A2E0B6	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_162950\|UniProtKB=A2DFX3	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_444400\|UniProtKB=A2E2I1	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_369830\|UniProtKB=A2FS93	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_142720\|UniProtKB=A2GAP8	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_282560\|UniProtKB=A2DEF9	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_325090\|UniProtKB=A2F144	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_321410\|UniProtKB=A2FK64	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_161600\|UniProtKB=A2EUN3	Trichomonas vaginalis	O
PLAF7\|EnsemblGenome=PF3D7_1136900\|UniProtKB=Q8IHZ5	Plasmodium falciparum	O
PLAF7\|EnsemblGenome=PF3D7_0507500\|UniProtKB=Q8I0V0	Plasmodium falciparum	O
WHEAT\|EnsemblGenome=TraesCS3A02G380300\|UniProtKB=A0A3B6ELI2	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS3A02G380200\|UniProtKB=A0A3B6EMU2	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS3B02G412900\|UniProtKB=A0A077RWL0	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS3D02G373400\|UniProtKB=A0A3B6GYR9	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS3A02G420500\|UniProtKB=A0A3B6EMZ2	Triticum aestivum	O
PYRAE\|EnsemblGenome=PAE0712\|UniProtKB=Q8ZYM3	Pyrobaculum aerophilum	O
CHLAA\|EnsemblGenome=Caur_0716\|UniProtKB=A9WFL7	Chloroflexus aurantiacus	O
STRCO\|Gene_OrderedLocusName=SCO5731\|UniProtKB=O86650	Streptomyces coelicolor	O
STRCO\|Gene_OrderedLocusName=SCO0432\|UniProtKB=Q9RL54	Streptomyces coelicolor	O
STRCO\|Gene_OrderedLocusName=SCO5722\|UniProtKB=O86642	Streptomyces coelicolor	O
MYCTU\|Gene_OrderedLocusName=Rv3449\|UniProtKB=I6YC58	Mycobacterium tuberculosis	O
MYCTU\|Gene_OrderedLocusName=Rv1796\|UniProtKB=O53945	Mycobacterium tuberculosis	O
MYCTU\|Gene_OrderedLocusName=Rv3886c\|UniProtKB=O05458	Mycobacterium tuberculosis	O
GLOVI\|Gene=Q7NC92_GLOVI\|UniProtKB=Q7NC92	Gloeobacter violaceus	O
NEIMB\|EnsemblGenome=NMB1969\|UniProtKB=Q9JXM7	Neisseria meningitidis serogroup b	O
GEOSL\|EnsemblGenome=GSU3219\|UniProtKB=Q747P6	Geobacter sulfurreducens	O
XANCP\|EnsemblGenome=XCC2025\|UniProtKB=Q8P941	Xanthomonas campestris	O