PANTHER Gene Information

Gene Symbol(s):

KEX2

Organism:

Saccharomyces cerevisiae

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Gene Name:

Kexin

Gene ID:

S000005182

Protein ID:

P13134

Persistent Id:

PTN000083063

Alternate Ids:

D6W0V5(AltAccession)	NP_014161(refSeq)
47168726(GI)	KEX2_YEAST(UniProtKB-ID)
M22870(EMBL)	AAA34718(EMBL-CDS)
KEX2(Symbol)	YNL238W_mRNA(Ensembl_TRS)
YNL238W(Ensembl_PRO)	KEX2(Synonym)
YNL238W(Ensembl)	855483(GeneID)
3.4.21.61(EC)	S000005182(SGD)
YEAST:YNL238W-MON(BioCyc)
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PANTHER Classification

PANTHER Family:	PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED (PTHR42884)
PANTHER Subfamily:	NEUROENDOCRINE CONVERTASE 1 (PTHR42884:SF14)
PANTHER GO-slim Molecular Function:	serine-type endopeptidase activity
PANTHER GO-slim Biological Process:	protein processing
PANTHER GO-slim Cellular Component:	membrane
PANTHER protein class:	serine protease

Pathway Categories:

Alzheimer disease-amyloid secretase pathway

Furin

Alzheimer disease-presenilin pathway

Furin

Endothelin signaling pathway

Furin

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	metal ion binding, serine-type endopeptidase activity, serine-type peptidase activity
GO BP Complete:	proteolysis, peptide pheromone maturation, protein processing
GO CC Complete:	trans-Golgi network, cytoplasm, intracellular membrane-bounded organelle, membrane, endomembrane system, Golgi membrane, Golgi apparatus, fungal-type vacuole

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Signaling by TGF-beta Receptor Complex, Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer, RNA Polymerase II Transcription, Gene expression (Transcription), SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription, Signaling by TGFB family members, Generic Transcription Pathway, Signal Transduction

Orthologs

ID	Organism	Type
HUMAN\|HGNC=8743\|UniProtKB=P29120	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000017091.5\|UniProtKB=H2QR92	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000006986.3\|UniProtKB=G3QVR2	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000005134.4\|UniProtKB=H9FVB9	Macaca mulatta	LDO
MOUSE\|MGI=MGI=97511\|UniProtKB=P63239	Mus musculus	LDO
RAT\|RGD=3272\|UniProtKB=P28840	Rattus norvegicus	LDO
BOVIN\|Gene=PCSK1\|UniProtKB=Q9GLR1	Bos taurus	O
BOVIN\|Ensembl=ENSBTAG00000020843.6\|UniProtKB=F1MFR6	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00005014097.1\|UniProtKB=A0A4X1VFF1	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000020422.3\|UniProtKB=F6TCF0	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000006327.6\|UniProtKB=M3W5Q0	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845003112.1\|UniProtKB=A0A8I3RR59	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000020079.4\|UniProtKB=F7GI61	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000001210.3\|UniProtKB=F6Z764	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010012232.1\|UniProtKB=A0A8V0YDL8	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000012731.3\|UniProtKB=G1KMV9	Anolis carolinensis	LDO
XENLA\|Gene=pcsk1.S\|UniProtKB=A0A1L8HR72	Xenopus laevis	O
XENLA\|Gene=LOC108717363\|UniProtKB=A0A8J1L617	Xenopus laevis	LDO
XENTR\|Gene=pcsk1\|UniProtKB=A0A8J0QWV0	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000008605.2\|UniProtKB=H2LXE5	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-071009-1\|UniProtKB=B6VCA1	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000001386.1\|UniProtKB=W5LZN5	lepisosteus oculatus	LDO
BRAFL\|Gene=LOC118409753\|UniProtKB=A0A9J7KMU7	Branchiostoma floridae	LDO
TRICA\|EnsemblGenome=TC004402\|UniProtKB=D6X568	Tribolium castaneum	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_59868\|UniProtKB=E9H9G1	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_43136\|UniProtKB=E9FZ50	Daphnia pulex	LDO
IXOSC\|EnsemblGenome=ISCW010275\|UniProtKB=B7PYT9	Ixodes scapularis	LDO
HELRO\|EnsemblGenome=HelroG184031\|UniProtKB=T1FKG6	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG193616\|UniProtKB=T1FV66	helobdella robusta	LDO
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g160244\|UniProtKB=A7RLT1	Nematostella vectensis	LDO
TRIAD\|EnsemblGenome=TriadG22925\|UniProtKB=B3RSJ2	Trichoplax adhaerens	LDO
HUMAN\|HGNC=8748\|UniProtKB=Q16549	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000004321.6\|UniProtKB=A0A2I3SSR3	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000014344.3\|UniProtKB=G3REL1	Gorilla gorilla gorilla	O
MACMU\|Ensembl=ENSMMUG00000002061.4\|UniProtKB=F6WWR1	Macaca mulatta	O
MOUSE\|MGI=MGI=107421\|UniProtKB=Q61139	Mus musculus	O
RAT\|RGD=3275\|UniProtKB=Q62849	Rattus norvegicus	O
BOVIN\|Ensembl=ENSBTAG00000003052.6\|UniProtKB=E1BEJ2	Bos taurus	O
PIG\|Ensembl=ENSSSCG00000015072.4\|UniProtKB=A0A4X1SX84	Sus scrofa	O
HORSE\|Ensembl=ENSECAG00000017980.4\|UniProtKB=A0A5F5Q0X5	Equus caballus	O
FELCA\|Ensembl=ENSFCAG00000013582.6\|UniProtKB=M3WJ40	Felis catus	O
CANLF\|Ensembl=ENSCAFG00845004009.1\|UniProtKB=A0A8I3MUZ4	Canis lupus familiaris	O
MONDO\|Ensembl=ENSMODG00000013739.4\|UniProtKB=F6X8A8	Monodelphis domestica	O
ORNAN\|Ensembl=ENSOANG00000047725.1\|UniProtKB=A0A6I8N7G4	Ornithorhynchus anatinus	O
CHICK\|Ensembl=ENSGALG00010023086.1\|UniProtKB=A0A8V0ZRB7	Gallus gallus	O
XENLA\|Gene=pcsk7.L\|UniProtKB=Q52KX3	Xenopus laevis	O
XENLA\|Gene=pcsk7.S\|UniProtKB=A0A1L8FFU7	Xenopus laevis	O
XENTR\|Xenbase=XB-GENE-950061\|UniProtKB=F7AB14	Xenopus tropicalis	O
ORYLA\|Ensembl=ENSORLG00000015722.2\|UniProtKB=H2MLV3	Oryzias latipes	O
DANRE\|ZFIN=ZDB-GENE-030131-7293\|UniProtKB=A0A8M1P8P5	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000006279.1\|UniProtKB=W5MGS7	lepisosteus oculatus	O
CIOIN\|Ensembl=ENSCING00000006411.3\|UniProtKB=F6QWQ4	Ciona intestinalis	O
BRAFL\|Gene=LOC118417315\|UniProtKB=A0A9J7MTV3	Branchiostoma floridae	O
STRPU\|EnsemblGenome=LOC585040\|UniProtKB=A0A7M7NAB2	Strongylocentrotus purpuratus	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g161314\|UniProtKB=A7RPN3	Nematostella vectensis	O
TRIAD\|EnsemblGenome=TriadG60295\|UniProtKB=B3S7U3	Trichoplax adhaerens	O
ORYLA\|Ensembl=ENSORLG00000002233.2\|UniProtKB=A0A3B3HDJ8	Oryzias latipes	O
LEPOC\|Ensembl=ENSLOCG00000017102.1\|UniProtKB=W5NKH4	lepisosteus oculatus	O
STRPU\|EnsemblGenome=LOC581070\|UniProtKB=A0A7M7PGF8	Strongylocentrotus purpuratus	O
CAEEL\|WormBase=WBGene00000088\|UniProtKB=P91863	Caenorhabditis elegans	O
CAEBR\|WormBase=WBGene00038888\|UniProtKB=A8XWH5	Caenorhabditis briggsae	O
CAEEL\|WormBase=WBGene00000254\|UniProtKB=P51559	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG12593\|UniProtKB=A8XG44	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00098129\|UniProtKB=A0A2A6BMV1	Pristionchus pacificus	O
DROME\|FlyBase=FBgn0004598\|UniProtKB=P30432	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP002915\|UniProtKB=A0A1S4GGJ0	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC031960\|UniProtKB=A0A139WNE9	Tribolium castaneum	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_306585\|UniProtKB=E9FZ52	Daphnia pulex	O
IXOSC\|EnsemblGenome=ISCW018863\|UniProtKB=B7PMP4	Ixodes scapularis	O
HELRO\|EnsemblGenome=HelroG72480\|UniProtKB=T1G106	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG74170\|UniProtKB=T1G1M9	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG82977\|UniProtKB=T1G4Y7	helobdella robusta	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g348\|UniProtKB=A7S624	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g168742\|UniProtKB=A7SBU0	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g129977\|UniProtKB=A7SSI6	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g112522\|UniProtKB=A7SBU1	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g221467\|UniProtKB=A7T2M8	Nematostella vectensis	O
HUMAN\|HGNC=8744\|UniProtKB=P16519	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000013273.4\|UniProtKB=H2QJZ8	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000007255.3\|UniProtKB=G3QWE4	Gorilla gorilla gorilla	O
MACMU\|Ensembl=ENSMMUG00000014626.4\|UniProtKB=F7GNE5	Macaca mulatta	O
MOUSE\|MGI=MGI=97512\|UniProtKB=P21661	Mus musculus	O
RAT\|RGD=3273\|UniProtKB=P28841	Rattus norvegicus	O
BOVIN\|Gene=PCSK2\|UniProtKB=Q9GLR0	Bos taurus	O
BOVIN\|Ensembl=ENSBTAG00000008687.6\|UniProtKB=F6Q5F4	Bos taurus	O
PIG\|Gene=PCSK2\|UniProtKB=Q03333	Sus scrofa	O
PIG\|Ensembl=ENSSSCG00005030759.1\|UniProtKB=A0A480EG12	Sus scrofa	O
HORSE\|Ensembl=ENSECAG00000001142.4\|UniProtKB=F6W2D5	Equus caballus	O
FELCA\|Ensembl=ENSFCAG00000011356.6\|UniProtKB=A0A5F5XCX7	Felis catus	O
CANLF\|Ensembl=ENSCAFG00845019218.1\|UniProtKB=A0A8I3P927	Canis lupus familiaris	O
MONDO\|Ensembl=ENSMODG00000005404.3\|UniProtKB=F7G632	Monodelphis domestica	O
ORNAN\|Ensembl=ENSOANG00000001239.3\|UniProtKB=F6YDT9	Ornithorhynchus anatinus	O
CHICK\|Ensembl=ENSGALG00010017927.1\|UniProtKB=A0A8V0ZB97	Gallus gallus	O
ANOCA\|Ensembl=ENSACAG00000000663.4\|UniProtKB=G1K8P0	Anolis carolinensis	O
XENLA\|Gene=pcsk2.S\|UniProtKB=Q6GM20	Xenopus laevis	O
XENLA\|Gene=pcsk2.L\|UniProtKB=Q6GLS0	Xenopus laevis	O
XENTR\|Xenbase=XB-GENE-960013\|UniProtKB=A0JP87	Xenopus tropicalis	O
ORYLA\|Ensembl=ENSORLG00000006472.2\|UniProtKB=H2LPZ0	Oryzias latipes	O
DANRE\|ZFIN=ZDB-GENE-090608-1\|UniProtKB=B6VCA2	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000015998.1\|UniProtKB=W5NGE3	lepisosteus oculatus	O
CIOIN\|Ensembl=ENSCING00000005712.3\|UniProtKB=F6WPG2	Ciona intestinalis	O
BRAFL\|Gene=LOC118418937\|UniProtKB=A0A9J7MV19	Branchiostoma floridae	O
STRPU\|EnsemblGenome=LOC579017\|UniProtKB=A0A7M7REC6	Strongylocentrotus purpuratus	O
CAEEL\|WormBase=WBGene00001172\|UniProtKB=G5ECN9	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG09536\|UniProtKB=A8X8V5	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00103503\|UniProtKB=A0A2A6CRK7	Pristionchus pacificus	O
DROME\|FlyBase=FBgn0023179\|UniProtKB=Q9VBC7	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP002176\|UniProtKB=Q7QK68	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC009181\|UniProtKB=D6WTB9	Tribolium castaneum	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_193075\|UniProtKB=E9G2S6	Daphnia pulex	O
IXOSC\|EnsemblGenome=ISCW020499\|UniProtKB=B7Q266	Ixodes scapularis	O
HELRO\|EnsemblGenome=HelroG96355\|UniProtKB=T1G9B6	helobdella robusta	O
HUMAN\|HGNC=8569\|UniProtKB=P29122	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000007514.6\|UniProtKB=H2R439	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000008971.3\|UniProtKB=A0A2I2YLR1	Gorilla gorilla gorilla	O
MACMU\|Ensembl=ENSMMUG00000011829.4\|UniProtKB=F7H767	Macaca mulatta	O
MOUSE\|MGI=MGI=102897\|UniProtKB=F6XJP7	Mus musculus	O
RAT\|RGD=3246\|UniProtKB=Q63415	Rattus norvegicus	O
BOVIN\|Ensembl=ENSBTAG00000006675.5\|UniProtKB=F1MCT1	Bos taurus	O
PIG\|Ensembl=ENSSSCG00000005785.5\|UniProtKB=F1RZ92	Sus scrofa	O
HORSE\|Ensembl=ENSECAG00000001688.4\|UniProtKB=F6QW48	Equus caballus	O
FELCA\|Ensembl=ENSFCAG00000013386.6\|UniProtKB=A0A337SA17	Felis catus	O
CANLF\|Ensembl=ENSCAFG00845000759.1\|UniProtKB=A0A8I3MGG5	Canis lupus familiaris	O
MONDO\|Ensembl=ENSMODG00000012001.4\|UniProtKB=F7B8Z0	Monodelphis domestica	O
ORNAN\|Ensembl=ENSOANG00000002267.4\|UniProtKB=F6RXC2	Ornithorhynchus anatinus	O
CHICK\|Ensembl=ENSGALG00010019081.1\|UniProtKB=A0A8V0ZA56	Gallus gallus	O
XENLA\|Gene=LOC108712815\|UniProtKB=A0A1L8GSH2	Xenopus laevis	O
XENLA\|Gene=pcsk6.L\|UniProtKB=Q68KF9	Xenopus laevis	O
XENTR\|Xenbase=XB-GENE-979058\|UniProtKB=A0A8J0SZJ1	Xenopus tropicalis	O
ORYLA\|Ensembl=ENSORLG00000020313.2\|UniProtKB=H2N190	Oryzias latipes	O
DANRE\|Gene=pcsk6\|UniProtKB=A0A8M9QIA8	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000014091.1\|UniProtKB=W5N9Q8	lepisosteus oculatus	O
HUMAN\|HGNC=8747\|UniProtKB=Q92824	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000021033.5\|UniProtKB=H2QXD2	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000015095.3\|UniProtKB=G3RGI9	Gorilla gorilla gorilla	O
MACMU\|Ensembl=ENSMMUG00000022023.4\|UniProtKB=A0A1D5R646	Macaca mulatta	O
MOUSE\|MGI=MGI=97515\|UniProtKB=Q04592	Mus musculus	O
RAT\|RGD=620326\|UniProtKB=P41413	Rattus norvegicus	O
BOVIN\|Ensembl=ENSBTAG00000008101.6\|UniProtKB=A0A3Q1MCD7	Bos taurus	O
PIG\|Ensembl=ENSSSCG00000023520.4\|UniProtKB=A0A8D1ZHZ0	Sus scrofa	O
HORSE\|Ensembl=ENSECAG00000006788.4\|UniProtKB=F6VT99	Equus caballus	O
FELCA\|Ensembl=ENSFCAG00000027896.4\|UniProtKB=A0A337SGR1	Felis catus	O
CANLF\|Ensembl=ENSCAFG00845010995.1\|UniProtKB=A0A8I3N6N9	Canis lupus familiaris	O
MONDO\|Ensembl=ENSMODG00000001932.4\|UniProtKB=A0A5F8GFP3	Monodelphis domestica	O
ORNAN\|Ensembl=ENSOANG00000040724.1\|UniProtKB=A0A6I8P5U9	Ornithorhynchus anatinus	O
CHICK\|Ensembl=ENSGALG00010015038.1\|UniProtKB=A0A8V0YXI1	Gallus gallus	O
ANOCA\|Ensembl=ENSACAG00000005525.4\|UniProtKB=R4GDB1	Anolis carolinensis	O
XENLA\|Gene=pcsk5.S\|UniProtKB=Q5EE48	Xenopus laevis	O
XENLA\|Gene=pcsk5.L\|UniProtKB=A0A1L8HYP2	Xenopus laevis	O
XENTR\|Gene=fur2\|UniProtKB=Q0P4Q8	Xenopus tropicalis	O
XENTR\|Xenbase=XB-GENE-959596\|UniProtKB=A0A6I8RXE3	Xenopus tropicalis	O
ORYLA\|Ensembl=ENSORLG00000004853.2\|UniProtKB=H2LJC9	Oryzias latipes	O
DANRE\|Gene=pcsk5a\|UniProtKB=A0A8M1RIN1	Danio rerio	O
ORYLA\|Ensembl=ENSORLG00000005789.2\|UniProtKB=A0A3B3HF70	Oryzias latipes	O
DANRE\|ZFIN=ZDB-GENE-070822-7\|UniProtKB=Q069L0	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000009798.1\|UniProtKB=W5MUD3	lepisosteus oculatus	O
CIOIN\|Ensembl=ENSCING00000005033.3\|UniProtKB=F6SM76	Ciona intestinalis	O
BRAFL\|Gene=LOC118430324\|UniProtKB=A0A9J7M9W2	Branchiostoma floridae	O
BRAFL\|Gene=LOC118432114\|UniProtKB=A0A9J7NDI2	Branchiostoma floridae	O
BRAFL\|Gene=LOC118431777\|UniProtKB=A0A9J7MDV2	Branchiostoma floridae	O
HUMAN\|HGNC=8746\|UniProtKB=Q6UW60	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000010204.5\|UniProtKB=H2R6J0	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000007307.3\|UniProtKB=G3QWJ5	Gorilla gorilla gorilla	O
MACMU\|Ensembl=ENSMMUG00000003056.4\|UniProtKB=A0A5F8A473	Macaca mulatta	O
MOUSE\|MGI=MGI=97514\|UniProtKB=P29121	Mus musculus	O
RAT\|RGD=620325\|UniProtKB=Q78EH2	Rattus norvegicus	O
BOVIN\|Ensembl=ENSBTAG00000002305.6\|UniProtKB=G5E527	Bos taurus	O
PIG\|Ensembl=ENSSSCG00000024379.4\|UniProtKB=I3LT46	Sus scrofa	O
HORSE\|Ensembl=ENSECAG00000036064.3\|UniProtKB=A0A5F5Q0E6	Equus caballus	O
FELCA\|Ensembl=ENSFCAG00000042231.2\|UniProtKB=A0A337SNQ6	Felis catus	O
CANLF\|Ensembl=ENSCAFG00845012009.1\|UniProtKB=A0A8I3NX00	Canis lupus familiaris	O
MONDO\|Ensembl=ENSMODG00000005062.5\|UniProtKB=F7ASZ3	Monodelphis domestica	O
ORNAN\|Ensembl=ENSOANG00000004488.3\|UniProtKB=A0A6I8PGU8	Ornithorhynchus anatinus	O
ANOCA\|Ensembl=ENSACAG00000000486.4\|UniProtKB=H9G3W0	Anolis carolinensis	O
XENLA\|Gene=pcsk4.L\|UniProtKB=Q5EE50	Xenopus laevis	O
XENTR\|Xenbase=XB-GENE-969614\|UniProtKB=A0A6I8Q8M5	Xenopus tropicalis	O
HUMAN\|HGNC=8568\|UniProtKB=P09958	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000007461.3\|UniProtKB=H2QA34	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000008162.3\|UniProtKB=G3QYP4	Gorilla gorilla gorilla	O
MACMU\|Ensembl=ENSMMUG00000004657.4\|UniProtKB=G7MVY8	Macaca mulatta	O
MOUSE\|MGI=MGI=97513\|UniProtKB=P23188	Mus musculus	O
RAT\|RGD=3274\|UniProtKB=P23377	Rattus norvegicus	O
BOVIN\|Gene=FURIN\|UniProtKB=Q28193	Bos taurus	O
BOVIN\|Ensembl=ENSBTAG00000002939.4\|UniProtKB=B0JYR0	Bos taurus	O
PIG\|Ensembl=ENSSSCG00000001817.4\|UniProtKB=F1RMJ1	Sus scrofa	O
HORSE\|Ensembl=ENSECAG00000019913.3\|UniProtKB=F7DHR9	Equus caballus	O
FELCA\|Ensembl=ENSFCAG00000006091.6\|UniProtKB=M3W594	Felis catus	O
CANLF\|Ensembl=ENSCAFG00845002348.1\|UniProtKB=A0A8I3N1T9	Canis lupus familiaris	O
MONDO\|Ensembl=ENSMODG00000019452.3\|UniProtKB=F6RXE5	Monodelphis domestica	O
ORNAN\|Ensembl=ENSOANG00000047447.1\|UniProtKB=A0A6I8P5R3	Ornithorhynchus anatinus	O
CHICK\|Ensembl=ENSGALG00010000058.1\|UniProtKB=A0A8V0X4D8	Gallus gallus	O
ANOCA\|Ensembl=ENSACAG00000004561.4\|UniProtKB=H9G9G0	Anolis carolinensis	O
XENLA\|Gene=furin.L\|UniProtKB=Q5XHG7	Xenopus laevis	O
XENLA\|Gene=furin\|UniProtKB=P29119	Xenopus laevis	O
XENLA\|Gene=furin.S\|UniProtKB=Q6DE77	Xenopus laevis	O
XENTR\|Xenbase=XB-GENE-999035\|UniProtKB=F7CEB1	Xenopus tropicalis	O
ORYLA\|Ensembl=ENSORLG00000011931.2\|UniProtKB=A0A3B3H4Y1	Oryzias latipes	O
DANRE\|ZFIN=ZDB-GENE-040901-2\|UniProtKB=F1QKU2	Danio rerio	O
ORYLA\|Ensembl=ENSORLG00000009133.2\|UniProtKB=H2LZ89	Oryzias latipes	O
DANRE\|ZFIN=ZDB-GENE-040901-1\|UniProtKB=F1QQ43	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000002313.1\|UniProtKB=W5M2W2	lepisosteus oculatus	O
LEPOC\|Ensembl=ENSLOCG00000015082.1\|UniProtKB=W5ND58	lepisosteus oculatus	O
CIOIN\|Ensembl=ENSCING00000006088.3\|UniProtKB=F6YWW9	Ciona intestinalis	O
CIOIN\|Ensembl=ENSCING00000016470.2\|UniProtKB=F6WDF7	Ciona intestinalis	O
BRAFL\|Gene=LOC118413720\|UniProtKB=A0A9J7MN03	Branchiostoma floridae	O
BRAFL\|Gene=LOC118423134\|UniProtKB=A0A9J7MZ93	Branchiostoma floridae	O
BRAFL\|Gene=LOC118410573\|UniProtKB=A0A9J7KQG0	Branchiostoma floridae	O
STRPU\|EnsemblGenome=LOC578721\|UniProtKB=A0A7M7N8B9	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC574878\|UniProtKB=A0A7M7RBS1	Strongylocentrotus purpuratus	O
CAEEL\|WormBase=WBGene00002232\|UniProtKB=O17798	Caenorhabditis elegans	O
CAEBR\|WormBase=WBGene00035938\|UniProtKB=A8XMZ6	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00098806\|UniProtKB=A0A8R1U734	Pristionchus pacificus	O
DROME\|FlyBase=FBgn0004509\|UniProtKB=P26016	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP001330\|UniProtKB=F5HMT2	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC010869\|UniProtKB=A0A139WP98	Tribolium castaneum	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_306271\|UniProtKB=E9GW88	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_126713\|UniProtKB=E9FSP9	Daphnia pulex	O
IXOSC\|EnsemblGenome=ISCW006048\|UniProtKB=B7PPF6	Ixodes scapularis	O
HELRO\|EnsemblGenome=HelroG105284\|UniProtKB=T1EDT0	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG107946\|UniProtKB=T1EEE2	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG170307\|UniProtKB=T1F2W7	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG190143\|UniProtKB=T1FRQ4	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG82350\|UniProtKB=T1G4R0	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG84740\|UniProtKB=T1G5N0	helobdella robusta	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g234208\|UniProtKB=A7RME4	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g134107\|UniProtKB=A7SVH1	Nematostella vectensis	O
TRIAD\|EnsemblGenome=TriadG54612\|UniProtKB=B3RSI8	Trichoplax adhaerens	O
MONBE\|EnsemblGenome=MONBRDRAFT_30798\|UniProtKB=A9UPB2	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_14515\|UniProtKB=A9US94	Monosiga brevicollis	LDO
EREGS\|EnsemblGenome=AGOS_ABL203W\|UniProtKB=Q75E73	Eremothecium gossypii	LDO
CANAL\|CGD=CAL0000186377\|UniProtKB=A0A1D8PEG3	Candida albicans	LDO
YARLI\|EnsemblGenome=YALI0_F13189g\|UniProtKB=P42781	Yarrowia lipolytica	LDO
EMENI\|EnsemblGenome=ANIA_03583\|UniProtKB=G5EB75	Emericella nidulans	LDO
ASPFU\|EnsemblGenome=AFUA_4G12970\|UniProtKB=Q4WQI8	Neosartorya fumigata	LDO
NEUCR\|EnsemblGenome=NCU03219\|UniProtKB=V5IPW5	Neurospora crassa	LDO
SCLS1\|EnsemblGenome=SS1G_06027\|UniProtKB=A7EL30	Sclerotinia sclerotiorum	LDO
PHANO\|EnsemblGenome=SNOG_04420\|UniProtKB=Q0UUZ4	Phaeosphaeria nodorum	LDO
SCHPO\|PomBase=SPAC22E12.09c\|UniProtKB=Q09175	Schizosaccharomyces pombe	LDO
SCHJY\|EnsemblGenome=SJAG_04398\|UniProtKB=B6K6Q9	Schizosaccharomyces japonicus	LDO
CRYNJ\|EnsemblGenome=CNA01380\|UniProtKB=Q5KPV9	Cryptococcus neoformans	O
CRYNJ\|EnsemblGenome=CNH01120\|UniProtKB=Q5KCI3	Cryptococcus neoformans	LDO
USTMA\|EnsemblGenome=UMAG_02843\|UniProtKB=A0A0D1DXD6	Ustilago maydis	LDO
PUCGT\|EnsemblGenome=PGTG_08683\|UniProtKB=E3KGS2	Puccinia graminis	LDO
BATDJ\|Gene_ORFName=BATDEDRAFT_11523\|UniProtKB=F4P3C2	Batrachochytrium dendrobatidis	LDO
LEIMA\|EnsemblGenome=LMJF_13_1040\|UniProtKB=Q4QG50	Leishmania major	LDO
GIAIC\|Gene_ORFName=GL50803_0060596\|UniProtKB=A0A644F4P2	Giardia intestinalis	LDO
GIAIC\|EnsemblGenome=GL50803_2897\|UniProtKB=E2RTR3	Giardia intestinalis	O
GIAIC\|EnsemblGenome=GL50803_9948\|UniProtKB=A8BA31	Giardia intestinalis	LDO
TRIV3\|Gene_ORFName=TVAG_456780\|UniProtKB=A2DC02	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_187410\|UniProtKB=A2GMZ5	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_444370\|UniProtKB=A2E2H8	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_083790\|UniProtKB=A2DMA3	Trichomonas vaginalis	LDO
TRIV3\|Gene_ORFName=TVAG_042330\|UniProtKB=A2EUX2	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_270490\|UniProtKB=A2FFZ9	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_184220\|UniProtKB=A2E9V8	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_365540\|UniProtKB=A2DHJ8	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_444380\|UniProtKB=A2E2H9	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_109130\|UniProtKB=A2G1N4	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_103310\|UniProtKB=A2EKP2	Trichomonas vaginalis	LDO
TRIV3\|Gene_ORFName=TVAG_210920\|UniProtKB=A2F878	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_420190\|UniProtKB=A2ED42	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_444360\|UniProtKB=A2E2H7	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_465250\|UniProtKB=A2DTZ0	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_019800\|UniProtKB=A2DX52	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_276930\|UniProtKB=A2FUF3	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_028690\|UniProtKB=A2E0B6	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_162950\|UniProtKB=A2DFX3	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_444400\|UniProtKB=A2E2I1	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_369830\|UniProtKB=A2FS93	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_142720\|UniProtKB=A2GAP8	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_282560\|UniProtKB=A2DEF9	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_325090\|UniProtKB=A2F144	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_321410\|UniProtKB=A2FK64	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_161600\|UniProtKB=A2EUN3	Trichomonas vaginalis	O
PLAF7\|EnsemblGenome=PF3D7_1136900\|UniProtKB=Q8IHZ5	Plasmodium falciparum	LDO
PLAF7\|EnsemblGenome=PF3D7_0507500\|UniProtKB=Q8I0V0	Plasmodium falciparum	O
WHEAT\|EnsemblGenome=TraesCS3A02G380300\|UniProtKB=A0A3B6ELI2	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS3A02G380200\|UniProtKB=A0A3B6EMU2	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS3B02G412900\|UniProtKB=A0A077RWL0	Triticum aestivum	LDO
WHEAT\|EnsemblGenome=TraesCS3D02G373400\|UniProtKB=A0A3B6GYR9	Triticum aestivum	LDO
WHEAT\|EnsemblGenome=TraesCS3A02G420500\|UniProtKB=A0A3B6EMZ2	Triticum aestivum	O
PYRAE\|EnsemblGenome=PAE0712\|UniProtKB=Q8ZYM3	Pyrobaculum aerophilum	LDO
CHLAA\|EnsemblGenome=Caur_0716\|UniProtKB=A9WFL7	Chloroflexus aurantiacus	LDO
STRCO\|Gene_OrderedLocusName=SCO5731\|UniProtKB=O86650	Streptomyces coelicolor	O
STRCO\|Gene_OrderedLocusName=SCO0432\|UniProtKB=Q9RL54	Streptomyces coelicolor	O
STRCO\|Gene_OrderedLocusName=SCO5722\|UniProtKB=O86642	Streptomyces coelicolor	LDO
MYCTU\|Gene_OrderedLocusName=Rv3449\|UniProtKB=I6YC58	Mycobacterium tuberculosis	O
MYCTU\|Gene_OrderedLocusName=Rv1796\|UniProtKB=O53945	Mycobacterium tuberculosis	LDO
MYCTU\|Gene_OrderedLocusName=Rv3886c\|UniProtKB=O05458	Mycobacterium tuberculosis	O
GLOVI\|Gene=Q7NC92_GLOVI\|UniProtKB=Q7NC92	Gloeobacter violaceus	LDO
NEIMB\|EnsemblGenome=NMB1969\|UniProtKB=Q9JXM7	Neisseria meningitidis serogroup b	LDO
GEOSL\|EnsemblGenome=GSU3219\|UniProtKB=Q747P6	Geobacter sulfurreducens	LDO
XANCP\|EnsemblGenome=XCC2025\|UniProtKB=Q8P941	Xanthomonas campestris	LDO