PANTHER Gene Information

Gene Symbol(s):

FURIN

Organism:

Macaca mulatta

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Gene Name:

Furin preproprotein

Gene ID:

ENSMMUG00000004657.4

Protein ID:

G7MVY8

Persistent Id:

PTN000082943

Alternate Ids:

715813(GeneID)	383418727(GI)
ENSMMUP00000006194(Ensembl_PRO)	JV047209(EMBL)
ENSMMUG00000004657(Ensembl)	AFE78480(EMBL-CDS)
NM_001257742(refSeq)	ENSMMUT00000006585(Ensembl_TRS)
G7MVY8(Synonym)	G7MVY8_MACMU(UniProtKB-ID)
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PANTHER Classification

PANTHER Family:	PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED (PTHR42884)
PANTHER Subfamily:	FURIN (PTHR42884:SF1)
PANTHER GO-slim Molecular Function:	serine-type endopeptidase activity
PANTHER GO-slim Biological Process:	peptide metabolic process protein processing hormone metabolic process
PANTHER GO-slim Cellular Component:	trans-Golgi network Golgi membrane
PANTHER protein class:	serine protease

Pathway Categories:

Alzheimer disease-amyloid secretase pathway

Furin

Alzheimer disease-presenilin pathway

Furin

Endothelin signaling pathway

Furin

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	serine-type endopeptidase inhibitor activity, heparan sulfate binding, endopeptidase activity, serine-type endopeptidase activity, serine-type peptidase activity, protease binding, heparin binding, peptide binding, peptidase activity, nerve growth factor binding
GO BP Complete:	regulation of cholesterol transport, regulation of protein catabolic process, dibasic protein processing, signal peptide processing, positive regulation of viral entry into host cell, regulation of signal transduction, nerve growth factor production, zymogen activation, negative regulation of low-density lipoprotein particle receptor catabolic process, negative regulation of transforming growth factor beta1 production, cytokine precursor processing, proteolysis, peptide biosynthetic process, blastocyst formation, viral life cycle, protein processing, protein maturation, peptide hormone processing, secretion by cell
GO CC Complete:	trans-Golgi network, endosome, trans-Golgi network transport vesicle, membrane raft, Golgi membrane, endoplasmic reticulum, Golgi apparatus, endosome membrane, extracellular region, plasma membrane, cell surface

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Orthologs

ID	Organism	Type
HUMAN\|HGNC=8568\|UniProtKB=P09958	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000007461.3\|UniProtKB=H2QA34	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000008162.3\|UniProtKB=G3QYP4	Gorilla gorilla gorilla	LDO
MOUSE\|MGI=MGI=97513\|UniProtKB=P23188	Mus musculus	LDO
RAT\|RGD=3274\|UniProtKB=P23377	Rattus norvegicus	LDO
BOVIN\|Gene=FURIN\|UniProtKB=Q28193	Bos taurus	O
BOVIN\|Ensembl=ENSBTAG00000002939.4\|UniProtKB=B0JYR0	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000001817.4\|UniProtKB=F1RMJ1	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000019913.3\|UniProtKB=F7DHR9	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000006091.6\|UniProtKB=M3W594	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845002348.1\|UniProtKB=A0A8I3N1T9	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000019452.3\|UniProtKB=F6RXE5	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000047447.1\|UniProtKB=A0A6I8P5R3	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010000058.1\|UniProtKB=A0A8V0X4D8	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000004561.4\|UniProtKB=H9G9G0	Anolis carolinensis	LDO
XENLA\|Gene=furin.L\|UniProtKB=Q5XHG7	Xenopus laevis	O
XENLA\|Gene=furin\|UniProtKB=P29119	Xenopus laevis	O
XENLA\|Gene=furin.S\|UniProtKB=Q6DE77	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-999035\|UniProtKB=F7CEB1	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000011931.2\|UniProtKB=A0A3B3H4Y1	Oryzias latipes	O
DANRE\|ZFIN=ZDB-GENE-040901-2\|UniProtKB=F1QKU2	Danio rerio	O
ORYLA\|Ensembl=ENSORLG00000009133.2\|UniProtKB=H2LZ89	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-040901-1\|UniProtKB=F1QQ43	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000002313.1\|UniProtKB=W5M2W2	lepisosteus oculatus	O
LEPOC\|Ensembl=ENSLOCG00000015082.1\|UniProtKB=W5ND58	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000006088.3\|UniProtKB=F6YWW9	Ciona intestinalis	LDO
CIOIN\|Ensembl=ENSCING00000016470.2\|UniProtKB=F6WDF7	Ciona intestinalis	O
BRAFL\|Gene=LOC118413720\|UniProtKB=A0A9J7MN03	Branchiostoma floridae	O
BRAFL\|Gene=LOC118423134\|UniProtKB=A0A9J7MZ93	Branchiostoma floridae	O
BRAFL\|Gene=LOC118410573\|UniProtKB=A0A9J7KQG0	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=LOC578721\|UniProtKB=A0A7M7N8B9	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC574878\|UniProtKB=A0A7M7RBS1	Strongylocentrotus purpuratus	LDO
CAEEL\|WormBase=WBGene00002232\|UniProtKB=O17798	Caenorhabditis elegans	LDO
CAEBR\|WormBase=WBGene00035938\|UniProtKB=A8XMZ6	Caenorhabditis briggsae	LDO
PRIPA\|EnsemblGenome=WBGene00098806\|UniProtKB=A0A8R1U734	Pristionchus pacificus	LDO
DROME\|FlyBase=FBgn0004509\|UniProtKB=P26016	Drosophila melanogaster	LDO
ANOGA\|EnsemblGenome=AGAP001330\|UniProtKB=F5HMT2	Anopheles gambiae	LDO
TRICA\|EnsemblGenome=TC010869\|UniProtKB=A0A139WP98	Tribolium castaneum	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_306271\|UniProtKB=E9GW88	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_126713\|UniProtKB=E9FSP9	Daphnia pulex	LDO
IXOSC\|EnsemblGenome=ISCW006048\|UniProtKB=B7PPF6	Ixodes scapularis	LDO
HELRO\|EnsemblGenome=HelroG105284\|UniProtKB=T1EDT0	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG107946\|UniProtKB=T1EEE2	helobdella robusta	LDO
HELRO\|EnsemblGenome=HelroG170307\|UniProtKB=T1F2W7	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG190143\|UniProtKB=T1FRQ4	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG82350\|UniProtKB=T1G4R0	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG84740\|UniProtKB=T1G5N0	helobdella robusta	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g234208\|UniProtKB=A7RME4	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g134107\|UniProtKB=A7SVH1	Nematostella vectensis	LDO
TRIAD\|EnsemblGenome=TriadG54612\|UniProtKB=B3RSI8	Trichoplax adhaerens	LDO
MONBE\|EnsemblGenome=MONBRDRAFT_30798\|UniProtKB=A9UPB2	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_14515\|UniProtKB=A9US94	Monosiga brevicollis	O
YEAST\|SGD=S000005182\|UniProtKB=P13134	Saccharomyces cerevisiae	O
EREGS\|EnsemblGenome=AGOS_ABL203W\|UniProtKB=Q75E73	Eremothecium gossypii	O
CANAL\|CGD=CAL0000186377\|UniProtKB=A0A1D8PEG3	Candida albicans	O
YARLI\|EnsemblGenome=YALI0_F13189g\|UniProtKB=P42781	Yarrowia lipolytica	O
EMENI\|EnsemblGenome=ANIA_03583\|UniProtKB=G5EB75	Emericella nidulans	O
ASPFU\|EnsemblGenome=AFUA_4G12970\|UniProtKB=Q4WQI8	Neosartorya fumigata	O
NEUCR\|EnsemblGenome=NCU03219\|UniProtKB=V5IPW5	Neurospora crassa	O
SCLS1\|EnsemblGenome=SS1G_06027\|UniProtKB=A7EL30	Sclerotinia sclerotiorum	O
PHANO\|EnsemblGenome=SNOG_04420\|UniProtKB=Q0UUZ4	Phaeosphaeria nodorum	O
SCHPO\|PomBase=SPAC22E12.09c\|UniProtKB=Q09175	Schizosaccharomyces pombe	O
SCHJY\|EnsemblGenome=SJAG_04398\|UniProtKB=B6K6Q9	Schizosaccharomyces japonicus	O
CRYNJ\|EnsemblGenome=CNA01380\|UniProtKB=Q5KPV9	Cryptococcus neoformans	O
CRYNJ\|EnsemblGenome=CNH01120\|UniProtKB=Q5KCI3	Cryptococcus neoformans	O
USTMA\|EnsemblGenome=UMAG_02843\|UniProtKB=A0A0D1DXD6	Ustilago maydis	O
PUCGT\|EnsemblGenome=PGTG_08683\|UniProtKB=E3KGS2	Puccinia graminis	O
BATDJ\|Gene_ORFName=BATDEDRAFT_11523\|UniProtKB=F4P3C2	Batrachochytrium dendrobatidis	O
LEIMA\|EnsemblGenome=LMJF_13_1040\|UniProtKB=Q4QG50	Leishmania major	O
GIAIC\|Gene_ORFName=GL50803_0060596\|UniProtKB=A0A644F4P2	Giardia intestinalis	O
GIAIC\|EnsemblGenome=GL50803_2897\|UniProtKB=E2RTR3	Giardia intestinalis	O
GIAIC\|EnsemblGenome=GL50803_9948\|UniProtKB=A8BA31	Giardia intestinalis	O
TRIV3\|Gene_ORFName=TVAG_456780\|UniProtKB=A2DC02	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_187410\|UniProtKB=A2GMZ5	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_444370\|UniProtKB=A2E2H8	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_083790\|UniProtKB=A2DMA3	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_042330\|UniProtKB=A2EUX2	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_270490\|UniProtKB=A2FFZ9	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_184220\|UniProtKB=A2E9V8	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_365540\|UniProtKB=A2DHJ8	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_444380\|UniProtKB=A2E2H9	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_109130\|UniProtKB=A2G1N4	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_103310\|UniProtKB=A2EKP2	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_210920\|UniProtKB=A2F878	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_420190\|UniProtKB=A2ED42	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_444360\|UniProtKB=A2E2H7	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_465250\|UniProtKB=A2DTZ0	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_019800\|UniProtKB=A2DX52	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_276930\|UniProtKB=A2FUF3	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_028690\|UniProtKB=A2E0B6	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_162950\|UniProtKB=A2DFX3	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_444400\|UniProtKB=A2E2I1	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_369830\|UniProtKB=A2FS93	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_142720\|UniProtKB=A2GAP8	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_282560\|UniProtKB=A2DEF9	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_325090\|UniProtKB=A2F144	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_321410\|UniProtKB=A2FK64	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_161600\|UniProtKB=A2EUN3	Trichomonas vaginalis	O
PLAF7\|EnsemblGenome=PF3D7_1136900\|UniProtKB=Q8IHZ5	Plasmodium falciparum	O
PLAF7\|EnsemblGenome=PF3D7_0507500\|UniProtKB=Q8I0V0	Plasmodium falciparum	O
WHEAT\|EnsemblGenome=TraesCS3A02G380300\|UniProtKB=A0A3B6ELI2	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS3A02G380200\|UniProtKB=A0A3B6EMU2	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS3B02G412900\|UniProtKB=A0A077RWL0	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS3D02G373400\|UniProtKB=A0A3B6GYR9	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS3A02G420500\|UniProtKB=A0A3B6EMZ2	Triticum aestivum	O
PYRAE\|EnsemblGenome=PAE0712\|UniProtKB=Q8ZYM3	Pyrobaculum aerophilum	O
CHLAA\|EnsemblGenome=Caur_0716\|UniProtKB=A9WFL7	Chloroflexus aurantiacus	O
STRCO\|Gene_OrderedLocusName=SCO5731\|UniProtKB=O86650	Streptomyces coelicolor	O
STRCO\|Gene_OrderedLocusName=SCO0432\|UniProtKB=Q9RL54	Streptomyces coelicolor	O
STRCO\|Gene_OrderedLocusName=SCO5722\|UniProtKB=O86642	Streptomyces coelicolor	O
MYCTU\|Gene_OrderedLocusName=Rv3449\|UniProtKB=I6YC58	Mycobacterium tuberculosis	O
MYCTU\|Gene_OrderedLocusName=Rv1796\|UniProtKB=O53945	Mycobacterium tuberculosis	O
MYCTU\|Gene_OrderedLocusName=Rv3886c\|UniProtKB=O05458	Mycobacterium tuberculosis	O
GLOVI\|Gene=Q7NC92_GLOVI\|UniProtKB=Q7NC92	Gloeobacter violaceus	O
NEIMB\|EnsemblGenome=NMB1969\|UniProtKB=Q9JXM7	Neisseria meningitidis serogroup b	O
GEOSL\|EnsemblGenome=GSU3219\|UniProtKB=Q747P6	Geobacter sulfurreducens	O
XANCP\|EnsemblGenome=XCC2025\|UniProtKB=Q8P941	Xanthomonas campestris	O