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comprehensive information about the evolution of protein-coding gene families, particularly
protein phylogeny, function and genetic variation impacting that function. Learn more

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Current Release: PANTHER 19.0 | 15,683 family phylogenetic trees | 144 species | News
Whole genome function views

PANTHER Gene Information

Gene Symbol(s):

20194732

Organism:

helobdella robusta

View Gene in Tree

Tree

Gene Name:

P_Homo B domain-containing protein

Gene ID:

HelroG105284

Protein ID:

T1EDT0

Persistent Id:

PTN002872345

Alternate Ids:

HelroT105284(Ensembl_TRS)	T1EDT0(Synonym)
20194732(GeneID)	HelroP105284(Ensembl_PRO)
ESO12333(EMBL-CDS)	KB095811(EMBL)
555709100(GI)	HelroG105284(Ensembl)
T1EDT0_HELRO(UniProtKB-ID)	XM_009010805(refSeq)
Show All

PANTHER Classification

PANTHER Family:	PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED (PTHR42884)
PANTHER Subfamily:	FURIN-LIKE PROTEASE 1, ISOFORMS 1_1-X_2 (PTHR42884:SF3)
PANTHER GO-slim Molecular Function:	serine-type endopeptidase activity
PANTHER GO-slim Biological Process:	protein processing
PANTHER GO-slim Cellular Component:	trans-Golgi network Golgi membrane
PANTHER protein class:	serine protease

Pathway Categories:

DPP signaling pathway

furin 1

DPP-SCW signaling pathway

furin 1

Activin beta signaling pathway

furin 1

Endothelin signaling pathway

Furin

SCW signaling pathway

furin 1

MYO signaling pathway

furin 1

BMP/activin signaling pathway-drosophila

furin 1

GBB signaling pathway

furin 1

Alzheimer disease-amyloid secretase pathway

Furin

ALP23B signaling pathway

furin 1

Alzheimer disease-presenilin pathway

Furin

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	serine-type endopeptidase activity, serine-type peptidase activity
GO BP Complete:	proteolysis, peptide hormone processing
GO CC Complete:	trans-Golgi network, membrane, Golgi membrane

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

-

Orthologs

ID	Organism	Type
HUMAN\|HGNC=8569\|UniProtKB=P29122	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000007514.6\|UniProtKB=H2R439	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000008971.3\|UniProtKB=A0A2I2YLR1	Gorilla gorilla gorilla	O
MACMU\|Ensembl=ENSMMUG00000011829.4\|UniProtKB=F7H767	Macaca mulatta	O
MOUSE\|MGI=MGI=102897\|UniProtKB=F6XJP7	Mus musculus	O
RAT\|RGD=3246\|UniProtKB=Q63415	Rattus norvegicus	O
BOVIN\|Ensembl=ENSBTAG00000006675.5\|UniProtKB=F1MCT1	Bos taurus	O
PIG\|Ensembl=ENSSSCG00000005785.5\|UniProtKB=F1RZ92	Sus scrofa	O
HORSE\|Ensembl=ENSECAG00000001688.4\|UniProtKB=F6QW48	Equus caballus	O
FELCA\|Ensembl=ENSFCAG00000013386.6\|UniProtKB=A0A337SA17	Felis catus	O
CANLF\|Ensembl=ENSCAFG00845000759.1\|UniProtKB=A0A8I3MGG5	Canis lupus familiaris	O
MONDO\|Ensembl=ENSMODG00000012001.4\|UniProtKB=F7B8Z0	Monodelphis domestica	O
ORNAN\|Ensembl=ENSOANG00000002267.4\|UniProtKB=F6RXC2	Ornithorhynchus anatinus	O
CHICK\|Ensembl=ENSGALG00010019081.1\|UniProtKB=A0A8V0ZA56	Gallus gallus	O
XENLA\|Gene=LOC108712815\|UniProtKB=A0A1L8GSH2	Xenopus laevis	O
XENLA\|Gene=pcsk6.L\|UniProtKB=Q68KF9	Xenopus laevis	O
XENTR\|Xenbase=XB-GENE-979058\|UniProtKB=A0A8J0SZJ1	Xenopus tropicalis	O
ORYLA\|Ensembl=ENSORLG00000020313.2\|UniProtKB=H2N190	Oryzias latipes	O
DANRE\|Gene=pcsk6\|UniProtKB=A0A8M9QIA8	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000014091.1\|UniProtKB=W5N9Q8	lepisosteus oculatus	O
HUMAN\|HGNC=8747\|UniProtKB=Q92824	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000021033.5\|UniProtKB=H2QXD2	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000015095.3\|UniProtKB=G3RGI9	Gorilla gorilla gorilla	O
MACMU\|Ensembl=ENSMMUG00000022023.4\|UniProtKB=A0A1D5R646	Macaca mulatta	O
MOUSE\|MGI=MGI=97515\|UniProtKB=Q04592	Mus musculus	O
RAT\|RGD=620326\|UniProtKB=P41413	Rattus norvegicus	O
BOVIN\|Ensembl=ENSBTAG00000008101.6\|UniProtKB=A0A3Q1MCD7	Bos taurus	O
PIG\|Ensembl=ENSSSCG00000023520.4\|UniProtKB=A0A8D1ZHZ0	Sus scrofa	O
HORSE\|Ensembl=ENSECAG00000006788.4\|UniProtKB=F6VT99	Equus caballus	O
FELCA\|Ensembl=ENSFCAG00000027896.4\|UniProtKB=A0A337SGR1	Felis catus	O
CANLF\|Ensembl=ENSCAFG00845010995.1\|UniProtKB=A0A8I3N6N9	Canis lupus familiaris	O
MONDO\|Ensembl=ENSMODG00000001932.4\|UniProtKB=A0A5F8GFP3	Monodelphis domestica	O
ORNAN\|Ensembl=ENSOANG00000040724.1\|UniProtKB=A0A6I8P5U9	Ornithorhynchus anatinus	O
CHICK\|Ensembl=ENSGALG00010015038.1\|UniProtKB=A0A8V0YXI1	Gallus gallus	O
ANOCA\|Ensembl=ENSACAG00000005525.4\|UniProtKB=R4GDB1	Anolis carolinensis	O
XENLA\|Gene=pcsk5.S\|UniProtKB=Q5EE48	Xenopus laevis	O
XENLA\|Gene=pcsk5.L\|UniProtKB=A0A1L8HYP2	Xenopus laevis	O
XENTR\|Gene=fur2\|UniProtKB=Q0P4Q8	Xenopus tropicalis	O
XENTR\|Xenbase=XB-GENE-959596\|UniProtKB=A0A6I8RXE3	Xenopus tropicalis	O
ORYLA\|Ensembl=ENSORLG00000004853.2\|UniProtKB=H2LJC9	Oryzias latipes	O
DANRE\|Gene=pcsk5a\|UniProtKB=A0A8M1RIN1	Danio rerio	O
ORYLA\|Ensembl=ENSORLG00000005789.2\|UniProtKB=A0A3B3HF70	Oryzias latipes	O
DANRE\|ZFIN=ZDB-GENE-070822-7\|UniProtKB=Q069L0	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000009798.1\|UniProtKB=W5MUD3	lepisosteus oculatus	O
CIOIN\|Ensembl=ENSCING00000005033.3\|UniProtKB=F6SM76	Ciona intestinalis	O
BRAFL\|Gene=LOC118430324\|UniProtKB=A0A9J7M9W2	Branchiostoma floridae	O
BRAFL\|Gene=LOC118432114\|UniProtKB=A0A9J7NDI2	Branchiostoma floridae	O
BRAFL\|Gene=LOC118431777\|UniProtKB=A0A9J7MDV2	Branchiostoma floridae	O
HUMAN\|HGNC=8746\|UniProtKB=Q6UW60	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000010204.5\|UniProtKB=H2R6J0	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000007307.3\|UniProtKB=G3QWJ5	Gorilla gorilla gorilla	O
MACMU\|Ensembl=ENSMMUG00000003056.4\|UniProtKB=A0A5F8A473	Macaca mulatta	O
MOUSE\|MGI=MGI=97514\|UniProtKB=P29121	Mus musculus	O
RAT\|RGD=620325\|UniProtKB=Q78EH2	Rattus norvegicus	O
BOVIN\|Ensembl=ENSBTAG00000002305.6\|UniProtKB=G5E527	Bos taurus	O
PIG\|Ensembl=ENSSSCG00000024379.4\|UniProtKB=I3LT46	Sus scrofa	O
HORSE\|Ensembl=ENSECAG00000036064.3\|UniProtKB=A0A5F5Q0E6	Equus caballus	O
FELCA\|Ensembl=ENSFCAG00000042231.2\|UniProtKB=A0A337SNQ6	Felis catus	O
CANLF\|Ensembl=ENSCAFG00845012009.1\|UniProtKB=A0A8I3NX00	Canis lupus familiaris	O
MONDO\|Ensembl=ENSMODG00000005062.5\|UniProtKB=F7ASZ3	Monodelphis domestica	O
ORNAN\|Ensembl=ENSOANG00000004488.3\|UniProtKB=A0A6I8PGU8	Ornithorhynchus anatinus	O
ANOCA\|Ensembl=ENSACAG00000000486.4\|UniProtKB=H9G3W0	Anolis carolinensis	O
XENLA\|Gene=pcsk4.L\|UniProtKB=Q5EE50	Xenopus laevis	O
XENTR\|Xenbase=XB-GENE-969614\|UniProtKB=A0A6I8Q8M5	Xenopus tropicalis	O
HUMAN\|HGNC=8568\|UniProtKB=P09958	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000007461.3\|UniProtKB=H2QA34	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000008162.3\|UniProtKB=G3QYP4	Gorilla gorilla gorilla	O
MACMU\|Ensembl=ENSMMUG00000004657.4\|UniProtKB=G7MVY8	Macaca mulatta	O
MOUSE\|MGI=MGI=97513\|UniProtKB=P23188	Mus musculus	O
RAT\|RGD=3274\|UniProtKB=P23377	Rattus norvegicus	O
BOVIN\|Gene=FURIN\|UniProtKB=Q28193	Bos taurus	O
BOVIN\|Ensembl=ENSBTAG00000002939.4\|UniProtKB=B0JYR0	Bos taurus	O
PIG\|Ensembl=ENSSSCG00000001817.4\|UniProtKB=F1RMJ1	Sus scrofa	O
HORSE\|Ensembl=ENSECAG00000019913.3\|UniProtKB=F7DHR9	Equus caballus	O
FELCA\|Ensembl=ENSFCAG00000006091.6\|UniProtKB=M3W594	Felis catus	O
CANLF\|Ensembl=ENSCAFG00845002348.1\|UniProtKB=A0A8I3N1T9	Canis lupus familiaris	O
MONDO\|Ensembl=ENSMODG00000019452.3\|UniProtKB=F6RXE5	Monodelphis domestica	O
ORNAN\|Ensembl=ENSOANG00000047447.1\|UniProtKB=A0A6I8P5R3	Ornithorhynchus anatinus	O
CHICK\|Ensembl=ENSGALG00010000058.1\|UniProtKB=A0A8V0X4D8	Gallus gallus	O
ANOCA\|Ensembl=ENSACAG00000004561.4\|UniProtKB=H9G9G0	Anolis carolinensis	O
XENLA\|Gene=furin.L\|UniProtKB=Q5XHG7	Xenopus laevis	O
XENLA\|Gene=furin\|UniProtKB=P29119	Xenopus laevis	O
XENLA\|Gene=furin.S\|UniProtKB=Q6DE77	Xenopus laevis	O
XENTR\|Xenbase=XB-GENE-999035\|UniProtKB=F7CEB1	Xenopus tropicalis	O
ORYLA\|Ensembl=ENSORLG00000011931.2\|UniProtKB=A0A3B3H4Y1	Oryzias latipes	O
DANRE\|ZFIN=ZDB-GENE-040901-2\|UniProtKB=F1QKU2	Danio rerio	O
ORYLA\|Ensembl=ENSORLG00000009133.2\|UniProtKB=H2LZ89	Oryzias latipes	O
DANRE\|ZFIN=ZDB-GENE-040901-1\|UniProtKB=F1QQ43	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000002313.1\|UniProtKB=W5M2W2	lepisosteus oculatus	O
LEPOC\|Ensembl=ENSLOCG00000015082.1\|UniProtKB=W5ND58	lepisosteus oculatus	O
CIOIN\|Ensembl=ENSCING00000006088.3\|UniProtKB=F6YWW9	Ciona intestinalis	O
CIOIN\|Ensembl=ENSCING00000016470.2\|UniProtKB=F6WDF7	Ciona intestinalis	O
BRAFL\|Gene=LOC118413720\|UniProtKB=A0A9J7MN03	Branchiostoma floridae	O
BRAFL\|Gene=LOC118423134\|UniProtKB=A0A9J7MZ93	Branchiostoma floridae	O
BRAFL\|Gene=LOC118410573\|UniProtKB=A0A9J7KQG0	Branchiostoma floridae	O
STRPU\|EnsemblGenome=LOC578721\|UniProtKB=A0A7M7N8B9	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC574878\|UniProtKB=A0A7M7RBS1	Strongylocentrotus purpuratus	O
CAEEL\|WormBase=WBGene00002232\|UniProtKB=O17798	Caenorhabditis elegans	O
CAEBR\|WormBase=WBGene00035938\|UniProtKB=A8XMZ6	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00098806\|UniProtKB=A0A8R1U734	Pristionchus pacificus	O
DROME\|FlyBase=FBgn0004509\|UniProtKB=P26016	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP001330\|UniProtKB=F5HMT2	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC010869\|UniProtKB=A0A139WP98	Tribolium castaneum	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_306271\|UniProtKB=E9GW88	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_126713\|UniProtKB=E9FSP9	Daphnia pulex	O
IXOSC\|EnsemblGenome=ISCW006048\|UniProtKB=B7PPF6	Ixodes scapularis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g234208\|UniProtKB=A7RME4	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g134107\|UniProtKB=A7SVH1	Nematostella vectensis	O
TRIAD\|EnsemblGenome=TriadG54612\|UniProtKB=B3RSI8	Trichoplax adhaerens	O
MONBE\|EnsemblGenome=MONBRDRAFT_30798\|UniProtKB=A9UPB2	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_14515\|UniProtKB=A9US94	Monosiga brevicollis	O
YEAST\|SGD=S000005182\|UniProtKB=P13134	Saccharomyces cerevisiae	O
EREGS\|EnsemblGenome=AGOS_ABL203W\|UniProtKB=Q75E73	Eremothecium gossypii	O
CANAL\|CGD=CAL0000186377\|UniProtKB=A0A1D8PEG3	Candida albicans	O
YARLI\|EnsemblGenome=YALI0_F13189g\|UniProtKB=P42781	Yarrowia lipolytica	O
EMENI\|EnsemblGenome=ANIA_03583\|UniProtKB=G5EB75	Emericella nidulans	O
ASPFU\|EnsemblGenome=AFUA_4G12970\|UniProtKB=Q4WQI8	Neosartorya fumigata	O
NEUCR\|EnsemblGenome=NCU03219\|UniProtKB=V5IPW5	Neurospora crassa	O
SCLS1\|EnsemblGenome=SS1G_06027\|UniProtKB=A7EL30	Sclerotinia sclerotiorum	O
PHANO\|EnsemblGenome=SNOG_04420\|UniProtKB=Q0UUZ4	Phaeosphaeria nodorum	O
SCHPO\|PomBase=SPAC22E12.09c\|UniProtKB=Q09175	Schizosaccharomyces pombe	O
SCHJY\|EnsemblGenome=SJAG_04398\|UniProtKB=B6K6Q9	Schizosaccharomyces japonicus	O
CRYNJ\|EnsemblGenome=CNA01380\|UniProtKB=Q5KPV9	Cryptococcus neoformans	O
CRYNJ\|EnsemblGenome=CNH01120\|UniProtKB=Q5KCI3	Cryptococcus neoformans	O
USTMA\|EnsemblGenome=UMAG_02843\|UniProtKB=A0A0D1DXD6	Ustilago maydis	O
PUCGT\|EnsemblGenome=PGTG_08683\|UniProtKB=E3KGS2	Puccinia graminis	O
BATDJ\|Gene_ORFName=BATDEDRAFT_11523\|UniProtKB=F4P3C2	Batrachochytrium dendrobatidis	O
LEIMA\|EnsemblGenome=LMJF_13_1040\|UniProtKB=Q4QG50	Leishmania major	O
GIAIC\|Gene_ORFName=GL50803_0060596\|UniProtKB=A0A644F4P2	Giardia intestinalis	O
GIAIC\|EnsemblGenome=GL50803_2897\|UniProtKB=E2RTR3	Giardia intestinalis	O
GIAIC\|EnsemblGenome=GL50803_9948\|UniProtKB=A8BA31	Giardia intestinalis	O
TRIV3\|Gene_ORFName=TVAG_456780\|UniProtKB=A2DC02	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_187410\|UniProtKB=A2GMZ5	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_444370\|UniProtKB=A2E2H8	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_083790\|UniProtKB=A2DMA3	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_042330\|UniProtKB=A2EUX2	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_270490\|UniProtKB=A2FFZ9	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_184220\|UniProtKB=A2E9V8	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_365540\|UniProtKB=A2DHJ8	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_444380\|UniProtKB=A2E2H9	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_109130\|UniProtKB=A2G1N4	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_103310\|UniProtKB=A2EKP2	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_210920\|UniProtKB=A2F878	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_420190\|UniProtKB=A2ED42	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_444360\|UniProtKB=A2E2H7	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_465250\|UniProtKB=A2DTZ0	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_019800\|UniProtKB=A2DX52	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_276930\|UniProtKB=A2FUF3	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_028690\|UniProtKB=A2E0B6	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_162950\|UniProtKB=A2DFX3	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_444400\|UniProtKB=A2E2I1	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_369830\|UniProtKB=A2FS93	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_142720\|UniProtKB=A2GAP8	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_282560\|UniProtKB=A2DEF9	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_325090\|UniProtKB=A2F144	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_321410\|UniProtKB=A2FK64	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_161600\|UniProtKB=A2EUN3	Trichomonas vaginalis	O
PLAF7\|EnsemblGenome=PF3D7_1136900\|UniProtKB=Q8IHZ5	Plasmodium falciparum	O
PLAF7\|EnsemblGenome=PF3D7_0507500\|UniProtKB=Q8I0V0	Plasmodium falciparum	O
WHEAT\|EnsemblGenome=TraesCS3A02G380300\|UniProtKB=A0A3B6ELI2	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS3A02G380200\|UniProtKB=A0A3B6EMU2	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS3B02G412900\|UniProtKB=A0A077RWL0	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS3D02G373400\|UniProtKB=A0A3B6GYR9	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS3A02G420500\|UniProtKB=A0A3B6EMZ2	Triticum aestivum	O
PYRAE\|EnsemblGenome=PAE0712\|UniProtKB=Q8ZYM3	Pyrobaculum aerophilum	O
CHLAA\|EnsemblGenome=Caur_0716\|UniProtKB=A9WFL7	Chloroflexus aurantiacus	O
STRCO\|Gene_OrderedLocusName=SCO5731\|UniProtKB=O86650	Streptomyces coelicolor	O
STRCO\|Gene_OrderedLocusName=SCO0432\|UniProtKB=Q9RL54	Streptomyces coelicolor	O
STRCO\|Gene_OrderedLocusName=SCO5722\|UniProtKB=O86642	Streptomyces coelicolor	O
MYCTU\|Gene_OrderedLocusName=Rv3449\|UniProtKB=I6YC58	Mycobacterium tuberculosis	O
MYCTU\|Gene_OrderedLocusName=Rv1796\|UniProtKB=O53945	Mycobacterium tuberculosis	O
MYCTU\|Gene_OrderedLocusName=Rv3886c\|UniProtKB=O05458	Mycobacterium tuberculosis	O
GLOVI\|Gene=Q7NC92_GLOVI\|UniProtKB=Q7NC92	Gloeobacter violaceus	O
NEIMB\|EnsemblGenome=NMB1969\|UniProtKB=Q9JXM7	Neisseria meningitidis serogroup b	O
GEOSL\|EnsemblGenome=GSU3219\|UniProtKB=Q747P6	Geobacter sulfurreducens	O
XANCP\|EnsemblGenome=XCC2025\|UniProtKB=Q8P941	Xanthomonas campestris	O