PANTHER Gene Information

Gene Symbol(s):

Pcsk5

Organism:

Rattus norvegicus

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Gene Name:

Proprotein convertase subtilisin_kexin type 5

Gene ID:

620326

Protein ID:

P41413

Persistent Id:

PTN001325155

Alternate Ids:

116548(GeneID)	457866801(GI)
Subtilisin/kexin-like protease PC5(Synonym)	620326(RGD)
AAA87888(EMBL-CDS)	Pcsk5(Symbol)
ENSRNOG00000012036(Ensembl)	L14933(EMBL)
Q62914(AltAccession)	3.4.21.-(EC)
PCSK5_RAT(UniProtKB-ID)
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PANTHER Classification

PANTHER Family:	PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED (PTHR42884)
PANTHER Subfamily:	PROPROTEIN CONVERTASE SUBTILISIN_KEXIN TYPE 5 (PTHR42884:SF7)
PANTHER GO-slim Molecular Function:	serine-type endopeptidase activity
PANTHER GO-slim Biological Process:	peptide metabolic process protein processing hormone metabolic process
PANTHER GO-slim Cellular Component:	trans-Golgi network Golgi membrane
PANTHER protein class:	serine protease

Pathway Categories:

Alzheimer disease-amyloid secretase pathway

Furin

Alzheimer disease-presenilin pathway

Furin

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	endopeptidase activity, serine-type endopeptidase activity, peptide binding, peptidase activity
GO BP Complete:	anterior/posterior pattern specification, signal peptide processing, positive regulation of vascular associated smooth muscle cell migration, renin secretion into blood stream, cardiac septum development, heart development, embryonic digestive tract development, kidney development, respiratory tube development, positive regulation of integrin-mediated signaling pathway, cellular response to platelet-derived growth factor stimulus, coronary vasculature development, embryonic skeletal system development, determination of left/right symmetry, embryo implantation, positive regulation of smooth muscle cell-matrix adhesion, cytokine precursor processing, vascular associated smooth muscle cell proliferation, peptide biosynthetic process, viral life cycle, response to luteinizing hormone, response to gonadotropin, limb morphogenesis, protein processing, peptide hormone processing, positive regulation of integrin activation
GO CC Complete:	extracellular space, trans-Golgi network, membrane, proximal dendrite, Golgi membrane, Golgi apparatus, perikaryon, Golgi medial cisterna

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

NGF processing, Expression and Processing of Neurotrophins, Signaling by NTRKs, Signaling by Receptor Tyrosine Kinases, Signal Transduction, Transport of small molecules, Plasma lipoprotein remodeling, Plasma lipoprotein assembly, remodeling, and clearance, Assembly of active LPL and LIPC lipase complexes

Orthologs

ID	Organism	Type
HUMAN\|HGNC=8747\|UniProtKB=Q92824	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000021033.5\|UniProtKB=H2QXD2	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000015095.3\|UniProtKB=G3RGI9	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000022023.4\|UniProtKB=A0A1D5R646	Macaca mulatta	LDO
MOUSE\|MGI=MGI=97515\|UniProtKB=Q04592	Mus musculus	LDO
BOVIN\|Ensembl=ENSBTAG00000008101.6\|UniProtKB=A0A3Q1MCD7	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000023520.4\|UniProtKB=A0A8D1ZHZ0	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000006788.4\|UniProtKB=F6VT99	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000027896.4\|UniProtKB=A0A337SGR1	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845010995.1\|UniProtKB=A0A8I3N6N9	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000001932.4\|UniProtKB=A0A5F8GFP3	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000040724.1\|UniProtKB=A0A6I8P5U9	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010015038.1\|UniProtKB=A0A8V0YXI1	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000005525.4\|UniProtKB=R4GDB1	Anolis carolinensis	LDO
XENLA\|Gene=pcsk5.S\|UniProtKB=Q5EE48	Xenopus laevis	O
XENLA\|Gene=pcsk5.L\|UniProtKB=A0A1L8HYP2	Xenopus laevis	LDO
XENTR\|Gene=fur2\|UniProtKB=Q0P4Q8	Xenopus tropicalis	LDO
XENTR\|Xenbase=XB-GENE-959596\|UniProtKB=A0A6I8RXE3	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000004853.2\|UniProtKB=H2LJC9	Oryzias latipes	O
DANRE\|Gene=pcsk5a\|UniProtKB=A0A8M1RIN1	Danio rerio	O
ORYLA\|Ensembl=ENSORLG00000005789.2\|UniProtKB=A0A3B3HF70	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-070822-7\|UniProtKB=Q069L0	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000009798.1\|UniProtKB=W5MUD3	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000005033.3\|UniProtKB=F6SM76	Ciona intestinalis	O
BRAFL\|Gene=LOC118430324\|UniProtKB=A0A9J7M9W2	Branchiostoma floridae	O
BRAFL\|Gene=LOC118432114\|UniProtKB=A0A9J7NDI2	Branchiostoma floridae	O
BRAFL\|Gene=LOC118431777\|UniProtKB=A0A9J7MDV2	Branchiostoma floridae	O
STRPU\|EnsemblGenome=LOC578721\|UniProtKB=A0A7M7N8B9	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC574878\|UniProtKB=A0A7M7RBS1	Strongylocentrotus purpuratus	O
CAEEL\|WormBase=WBGene00002232\|UniProtKB=O17798	Caenorhabditis elegans	O
CAEBR\|WormBase=WBGene00035938\|UniProtKB=A8XMZ6	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00098806\|UniProtKB=A0A8R1U734	Pristionchus pacificus	O
DROME\|FlyBase=FBgn0004509\|UniProtKB=P26016	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP001330\|UniProtKB=F5HMT2	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC010869\|UniProtKB=A0A139WP98	Tribolium castaneum	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_306271\|UniProtKB=E9GW88	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_126713\|UniProtKB=E9FSP9	Daphnia pulex	O
IXOSC\|EnsemblGenome=ISCW006048\|UniProtKB=B7PPF6	Ixodes scapularis	O
HELRO\|EnsemblGenome=HelroG105284\|UniProtKB=T1EDT0	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG107946\|UniProtKB=T1EEE2	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG170307\|UniProtKB=T1F2W7	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG190143\|UniProtKB=T1FRQ4	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG82350\|UniProtKB=T1G4R0	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG84740\|UniProtKB=T1G5N0	helobdella robusta	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g234208\|UniProtKB=A7RME4	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g134107\|UniProtKB=A7SVH1	Nematostella vectensis	O
TRIAD\|EnsemblGenome=TriadG54612\|UniProtKB=B3RSI8	Trichoplax adhaerens	O
MONBE\|EnsemblGenome=MONBRDRAFT_30798\|UniProtKB=A9UPB2	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_14515\|UniProtKB=A9US94	Monosiga brevicollis	O
YEAST\|SGD=S000005182\|UniProtKB=P13134	Saccharomyces cerevisiae	O
EREGS\|EnsemblGenome=AGOS_ABL203W\|UniProtKB=Q75E73	Eremothecium gossypii	O
CANAL\|CGD=CAL0000186377\|UniProtKB=A0A1D8PEG3	Candida albicans	O
YARLI\|EnsemblGenome=YALI0_F13189g\|UniProtKB=P42781	Yarrowia lipolytica	O
EMENI\|EnsemblGenome=ANIA_03583\|UniProtKB=G5EB75	Emericella nidulans	O
ASPFU\|EnsemblGenome=AFUA_4G12970\|UniProtKB=Q4WQI8	Neosartorya fumigata	O
NEUCR\|EnsemblGenome=NCU03219\|UniProtKB=V5IPW5	Neurospora crassa	O
SCLS1\|EnsemblGenome=SS1G_06027\|UniProtKB=A7EL30	Sclerotinia sclerotiorum	O
PHANO\|EnsemblGenome=SNOG_04420\|UniProtKB=Q0UUZ4	Phaeosphaeria nodorum	O
SCHPO\|PomBase=SPAC22E12.09c\|UniProtKB=Q09175	Schizosaccharomyces pombe	O
SCHJY\|EnsemblGenome=SJAG_04398\|UniProtKB=B6K6Q9	Schizosaccharomyces japonicus	O
CRYNJ\|EnsemblGenome=CNA01380\|UniProtKB=Q5KPV9	Cryptococcus neoformans	O
CRYNJ\|EnsemblGenome=CNH01120\|UniProtKB=Q5KCI3	Cryptococcus neoformans	O
USTMA\|EnsemblGenome=UMAG_02843\|UniProtKB=A0A0D1DXD6	Ustilago maydis	O
PUCGT\|EnsemblGenome=PGTG_08683\|UniProtKB=E3KGS2	Puccinia graminis	O
BATDJ\|Gene_ORFName=BATDEDRAFT_11523\|UniProtKB=F4P3C2	Batrachochytrium dendrobatidis	O
LEIMA\|EnsemblGenome=LMJF_13_1040\|UniProtKB=Q4QG50	Leishmania major	O
GIAIC\|Gene_ORFName=GL50803_0060596\|UniProtKB=A0A644F4P2	Giardia intestinalis	O
GIAIC\|EnsemblGenome=GL50803_2897\|UniProtKB=E2RTR3	Giardia intestinalis	O
GIAIC\|EnsemblGenome=GL50803_9948\|UniProtKB=A8BA31	Giardia intestinalis	O
TRIV3\|Gene_ORFName=TVAG_456780\|UniProtKB=A2DC02	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_187410\|UniProtKB=A2GMZ5	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_444370\|UniProtKB=A2E2H8	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_083790\|UniProtKB=A2DMA3	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_042330\|UniProtKB=A2EUX2	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_270490\|UniProtKB=A2FFZ9	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_184220\|UniProtKB=A2E9V8	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_365540\|UniProtKB=A2DHJ8	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_444380\|UniProtKB=A2E2H9	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_109130\|UniProtKB=A2G1N4	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_103310\|UniProtKB=A2EKP2	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_210920\|UniProtKB=A2F878	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_420190\|UniProtKB=A2ED42	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_444360\|UniProtKB=A2E2H7	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_465250\|UniProtKB=A2DTZ0	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_019800\|UniProtKB=A2DX52	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_276930\|UniProtKB=A2FUF3	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_028690\|UniProtKB=A2E0B6	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_162950\|UniProtKB=A2DFX3	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_444400\|UniProtKB=A2E2I1	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_369830\|UniProtKB=A2FS93	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_142720\|UniProtKB=A2GAP8	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_282560\|UniProtKB=A2DEF9	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_325090\|UniProtKB=A2F144	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_321410\|UniProtKB=A2FK64	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_161600\|UniProtKB=A2EUN3	Trichomonas vaginalis	O
PLAF7\|EnsemblGenome=PF3D7_1136900\|UniProtKB=Q8IHZ5	Plasmodium falciparum	O
PLAF7\|EnsemblGenome=PF3D7_0507500\|UniProtKB=Q8I0V0	Plasmodium falciparum	O
WHEAT\|EnsemblGenome=TraesCS3A02G380300\|UniProtKB=A0A3B6ELI2	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS3A02G380200\|UniProtKB=A0A3B6EMU2	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS3B02G412900\|UniProtKB=A0A077RWL0	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS3D02G373400\|UniProtKB=A0A3B6GYR9	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS3A02G420500\|UniProtKB=A0A3B6EMZ2	Triticum aestivum	O
PYRAE\|EnsemblGenome=PAE0712\|UniProtKB=Q8ZYM3	Pyrobaculum aerophilum	O
CHLAA\|EnsemblGenome=Caur_0716\|UniProtKB=A9WFL7	Chloroflexus aurantiacus	O
STRCO\|Gene_OrderedLocusName=SCO5731\|UniProtKB=O86650	Streptomyces coelicolor	O
STRCO\|Gene_OrderedLocusName=SCO0432\|UniProtKB=Q9RL54	Streptomyces coelicolor	O
STRCO\|Gene_OrderedLocusName=SCO5722\|UniProtKB=O86642	Streptomyces coelicolor	O
MYCTU\|Gene_OrderedLocusName=Rv3449\|UniProtKB=I6YC58	Mycobacterium tuberculosis	O
MYCTU\|Gene_OrderedLocusName=Rv1796\|UniProtKB=O53945	Mycobacterium tuberculosis	O
MYCTU\|Gene_OrderedLocusName=Rv3886c\|UniProtKB=O05458	Mycobacterium tuberculosis	O
GLOVI\|Gene=Q7NC92_GLOVI\|UniProtKB=Q7NC92	Gloeobacter violaceus	O
NEIMB\|EnsemblGenome=NMB1969\|UniProtKB=Q9JXM7	Neisseria meningitidis serogroup b	O
GEOSL\|EnsemblGenome=GSU3219\|UniProtKB=Q747P6	Geobacter sulfurreducens	O
XANCP\|EnsemblGenome=XCC2025\|UniProtKB=Q8P941	Xanthomonas campestris	O