PANTHER Gene Information

Gene Symbol(s):

PCSK4

Organism:

Canis lupus familiaris

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Gene Name:

Proprotein convertase subtilisin_kexin type 4

Gene ID:

ENSCAFG00845012009.1

Protein ID:

A0A8I3NX00

Persistent Id:

PTN009165503

Alternate Ids:

A0A8I3NX00_CANLF(UniProtKB-ID)	ENSCAFT00845021744(Ensembl_TRS)
ENSCAFG00845012009(Ensembl)	ENSCAFP00845017100(Ensembl_PRO)
A0A8I3NX00(Synonym)
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PANTHER Classification

PANTHER Family:	PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED (PTHR42884)
PANTHER Subfamily:	PROPROTEIN CONVERTASE SUBTILISIN_KEXIN TYPE 4 (PTHR42884:SF16)
PANTHER GO-slim Molecular Function:	serine-type endopeptidase activity
PANTHER GO-slim Biological Process:	peptide metabolic process protein processing hormone metabolic process
PANTHER GO-slim Cellular Component:	trans-Golgi network Golgi membrane
PANTHER protein class:	serine protease

Pathway Categories:

Alzheimer disease-amyloid secretase pathway

Furin

Alzheimer disease-presenilin pathway

Furin

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	serine-type endopeptidase activity
GO BP Complete:	binding of sperm to zona pellucida, sperm capacitation, acrosome reaction, protein processing, peptide hormone processing
GO CC Complete:	trans-Golgi network, acrosomal membrane, Golgi membrane

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Orthologs

ID	Organism	Type
HUMAN\|HGNC=8746\|UniProtKB=Q6UW60	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000010204.5\|UniProtKB=H2R6J0	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000007307.3\|UniProtKB=G3QWJ5	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000003056.4\|UniProtKB=A0A5F8A473	Macaca mulatta	LDO
MOUSE\|MGI=MGI=97514\|UniProtKB=P29121	Mus musculus	LDO
RAT\|RGD=620325\|UniProtKB=Q78EH2	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000002305.6\|UniProtKB=G5E527	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000024379.4\|UniProtKB=I3LT46	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000036064.3\|UniProtKB=A0A5F5Q0E6	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000042231.2\|UniProtKB=A0A337SNQ6	Felis catus	LDO
MONDO\|Ensembl=ENSMODG00000005062.5\|UniProtKB=F7ASZ3	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000004488.3\|UniProtKB=A0A6I8PGU8	Ornithorhynchus anatinus	LDO
ANOCA\|Ensembl=ENSACAG00000000486.4\|UniProtKB=H9G3W0	Anolis carolinensis	LDO
XENLA\|Gene=pcsk4.L\|UniProtKB=Q5EE50	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-969614\|UniProtKB=A0A6I8Q8M5	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000011931.2\|UniProtKB=A0A3B3H4Y1	Oryzias latipes	O
DANRE\|ZFIN=ZDB-GENE-040901-2\|UniProtKB=F1QKU2	Danio rerio	O
ORYLA\|Ensembl=ENSORLG00000009133.2\|UniProtKB=H2LZ89	Oryzias latipes	O
DANRE\|ZFIN=ZDB-GENE-040901-1\|UniProtKB=F1QQ43	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000002313.1\|UniProtKB=W5M2W2	lepisosteus oculatus	O
LEPOC\|Ensembl=ENSLOCG00000015082.1\|UniProtKB=W5ND58	lepisosteus oculatus	O
CIOIN\|Ensembl=ENSCING00000006088.3\|UniProtKB=F6YWW9	Ciona intestinalis	O
CIOIN\|Ensembl=ENSCING00000016470.2\|UniProtKB=F6WDF7	Ciona intestinalis	O
BRAFL\|Gene=LOC118413720\|UniProtKB=A0A9J7MN03	Branchiostoma floridae	O
BRAFL\|Gene=LOC118423134\|UniProtKB=A0A9J7MZ93	Branchiostoma floridae	O
BRAFL\|Gene=LOC118410573\|UniProtKB=A0A9J7KQG0	Branchiostoma floridae	O
STRPU\|EnsemblGenome=LOC578721\|UniProtKB=A0A7M7N8B9	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC574878\|UniProtKB=A0A7M7RBS1	Strongylocentrotus purpuratus	O
CAEEL\|WormBase=WBGene00002232\|UniProtKB=O17798	Caenorhabditis elegans	O
CAEBR\|WormBase=WBGene00035938\|UniProtKB=A8XMZ6	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00098806\|UniProtKB=A0A8R1U734	Pristionchus pacificus	O
DROME\|FlyBase=FBgn0004509\|UniProtKB=P26016	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP001330\|UniProtKB=F5HMT2	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC010869\|UniProtKB=A0A139WP98	Tribolium castaneum	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_306271\|UniProtKB=E9GW88	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_126713\|UniProtKB=E9FSP9	Daphnia pulex	O
IXOSC\|EnsemblGenome=ISCW006048\|UniProtKB=B7PPF6	Ixodes scapularis	O
HELRO\|EnsemblGenome=HelroG105284\|UniProtKB=T1EDT0	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG107946\|UniProtKB=T1EEE2	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG170307\|UniProtKB=T1F2W7	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG190143\|UniProtKB=T1FRQ4	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG82350\|UniProtKB=T1G4R0	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG84740\|UniProtKB=T1G5N0	helobdella robusta	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g234208\|UniProtKB=A7RME4	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g134107\|UniProtKB=A7SVH1	Nematostella vectensis	O
TRIAD\|EnsemblGenome=TriadG54612\|UniProtKB=B3RSI8	Trichoplax adhaerens	O
MONBE\|EnsemblGenome=MONBRDRAFT_30798\|UniProtKB=A9UPB2	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_14515\|UniProtKB=A9US94	Monosiga brevicollis	O
YEAST\|SGD=S000005182\|UniProtKB=P13134	Saccharomyces cerevisiae	O
EREGS\|EnsemblGenome=AGOS_ABL203W\|UniProtKB=Q75E73	Eremothecium gossypii	O
CANAL\|CGD=CAL0000186377\|UniProtKB=A0A1D8PEG3	Candida albicans	O
YARLI\|EnsemblGenome=YALI0_F13189g\|UniProtKB=P42781	Yarrowia lipolytica	O
EMENI\|EnsemblGenome=ANIA_03583\|UniProtKB=G5EB75	Emericella nidulans	O
ASPFU\|EnsemblGenome=AFUA_4G12970\|UniProtKB=Q4WQI8	Neosartorya fumigata	O
NEUCR\|EnsemblGenome=NCU03219\|UniProtKB=V5IPW5	Neurospora crassa	O
SCLS1\|EnsemblGenome=SS1G_06027\|UniProtKB=A7EL30	Sclerotinia sclerotiorum	O
PHANO\|EnsemblGenome=SNOG_04420\|UniProtKB=Q0UUZ4	Phaeosphaeria nodorum	O
SCHPO\|PomBase=SPAC22E12.09c\|UniProtKB=Q09175	Schizosaccharomyces pombe	O
SCHJY\|EnsemblGenome=SJAG_04398\|UniProtKB=B6K6Q9	Schizosaccharomyces japonicus	O
CRYNJ\|EnsemblGenome=CNA01380\|UniProtKB=Q5KPV9	Cryptococcus neoformans	O
CRYNJ\|EnsemblGenome=CNH01120\|UniProtKB=Q5KCI3	Cryptococcus neoformans	O
USTMA\|EnsemblGenome=UMAG_02843\|UniProtKB=A0A0D1DXD6	Ustilago maydis	O
PUCGT\|EnsemblGenome=PGTG_08683\|UniProtKB=E3KGS2	Puccinia graminis	O
BATDJ\|Gene_ORFName=BATDEDRAFT_11523\|UniProtKB=F4P3C2	Batrachochytrium dendrobatidis	O
LEIMA\|EnsemblGenome=LMJF_13_1040\|UniProtKB=Q4QG50	Leishmania major	O
GIAIC\|Gene_ORFName=GL50803_0060596\|UniProtKB=A0A644F4P2	Giardia intestinalis	O
GIAIC\|EnsemblGenome=GL50803_2897\|UniProtKB=E2RTR3	Giardia intestinalis	O
GIAIC\|EnsemblGenome=GL50803_9948\|UniProtKB=A8BA31	Giardia intestinalis	O
TRIV3\|Gene_ORFName=TVAG_456780\|UniProtKB=A2DC02	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_187410\|UniProtKB=A2GMZ5	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_444370\|UniProtKB=A2E2H8	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_083790\|UniProtKB=A2DMA3	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_042330\|UniProtKB=A2EUX2	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_270490\|UniProtKB=A2FFZ9	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_184220\|UniProtKB=A2E9V8	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_365540\|UniProtKB=A2DHJ8	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_444380\|UniProtKB=A2E2H9	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_109130\|UniProtKB=A2G1N4	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_103310\|UniProtKB=A2EKP2	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_210920\|UniProtKB=A2F878	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_420190\|UniProtKB=A2ED42	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_444360\|UniProtKB=A2E2H7	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_465250\|UniProtKB=A2DTZ0	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_019800\|UniProtKB=A2DX52	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_276930\|UniProtKB=A2FUF3	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_028690\|UniProtKB=A2E0B6	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_162950\|UniProtKB=A2DFX3	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_444400\|UniProtKB=A2E2I1	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_369830\|UniProtKB=A2FS93	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_142720\|UniProtKB=A2GAP8	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_282560\|UniProtKB=A2DEF9	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_325090\|UniProtKB=A2F144	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_321410\|UniProtKB=A2FK64	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_161600\|UniProtKB=A2EUN3	Trichomonas vaginalis	O
PLAF7\|EnsemblGenome=PF3D7_1136900\|UniProtKB=Q8IHZ5	Plasmodium falciparum	O
PLAF7\|EnsemblGenome=PF3D7_0507500\|UniProtKB=Q8I0V0	Plasmodium falciparum	O
WHEAT\|EnsemblGenome=TraesCS3A02G380300\|UniProtKB=A0A3B6ELI2	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS3A02G380200\|UniProtKB=A0A3B6EMU2	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS3B02G412900\|UniProtKB=A0A077RWL0	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS3D02G373400\|UniProtKB=A0A3B6GYR9	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS3A02G420500\|UniProtKB=A0A3B6EMZ2	Triticum aestivum	O
PYRAE\|EnsemblGenome=PAE0712\|UniProtKB=Q8ZYM3	Pyrobaculum aerophilum	O
CHLAA\|EnsemblGenome=Caur_0716\|UniProtKB=A9WFL7	Chloroflexus aurantiacus	O
STRCO\|Gene_OrderedLocusName=SCO5731\|UniProtKB=O86650	Streptomyces coelicolor	O
STRCO\|Gene_OrderedLocusName=SCO0432\|UniProtKB=Q9RL54	Streptomyces coelicolor	O
STRCO\|Gene_OrderedLocusName=SCO5722\|UniProtKB=O86642	Streptomyces coelicolor	O
MYCTU\|Gene_OrderedLocusName=Rv3449\|UniProtKB=I6YC58	Mycobacterium tuberculosis	O
MYCTU\|Gene_OrderedLocusName=Rv1796\|UniProtKB=O53945	Mycobacterium tuberculosis	O
MYCTU\|Gene_OrderedLocusName=Rv3886c\|UniProtKB=O05458	Mycobacterium tuberculosis	O
GLOVI\|Gene=Q7NC92_GLOVI\|UniProtKB=Q7NC92	Gloeobacter violaceus	O
NEIMB\|EnsemblGenome=NMB1969\|UniProtKB=Q9JXM7	Neisseria meningitidis serogroup b	O
GEOSL\|EnsemblGenome=GSU3219\|UniProtKB=Q747P6	Geobacter sulfurreducens	O
XANCP\|EnsemblGenome=XCC2025\|UniProtKB=Q8P941	Xanthomonas campestris	O