PANTHER Gene Information   
Gene Symbol(s): FURIN
Organism: Canis lupus familiaris
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Gene Name: Furin, paired basic amino acid cleaving enzyme
Gene ID: ENSCAFG00845002348.1
Protein ID: A0A8I3N1T9
Persistent Id: PTN000082949
Alternate Ids:
ENSCAFP00845003316(Ensembl_PRO) A0A8I3N1T9_CANLF(UniProtKB-ID)
A0A8I3N1T9(Synonym) ENSCAFG00845002348(Ensembl)
ENSCAFT00845004147(Ensembl_TRS)
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PANTHER Classification
PANTHER Family: PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED (PTHR42884)
PANTHER Subfamily: FURIN (PTHR42884:SF1)  
PANTHER GO-slim Molecular Function: serine-type endopeptidase activity
PANTHER GO-slim Biological Process: peptide metabolic process
protein processing
hormone metabolic process
PANTHER GO-slim Cellular Component: trans-Golgi network
Golgi membrane
PANTHER protein class: serine protease
Pathway Categories: Alzheimer disease-amyloid secretase pathway
   Furin
Alzheimer disease-presenilin pathway
   Furin
Endothelin signaling pathway
   Furin
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: serine-type endopeptidase inhibitor activity, heparan sulfate binding, serine-type endopeptidase activity, protease binding, heparin binding, peptide binding, nerve growth factor binding
GO BP Complete: regulation of cholesterol transport, dibasic protein processing, signal peptide processing, positive regulation of viral entry into host cell, regulation of signal transduction, nerve growth factor production, zymogen activation, negative regulation of low-density lipoprotein particle receptor catabolic process, negative regulation of transforming growth factor beta1 production, cytokine precursor processing, peptide biosynthetic process, blastocyst formation, viral life cycle, peptide hormone processing, secretion by cell
GO CC Complete: trans-Golgi network, trans-Golgi network transport vesicle, membrane raft, Golgi membrane, endoplasmic reticulum, endosome membrane, extracellular region, plasma membrane, cell surface
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription, Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer, Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation, Signaling by Receptor Tyrosine Kinases, Signaling by TGFB family members, Removal of aminoterminal propeptides from gamma-carboxylated proteins, Collagen degradation, Plasma lipoprotein remodeling, NGF processing, Developmental Biology, Plasma lipoprotein assembly, remodeling, and clearance, Expression and Processing of Neurotrophins, Activation of Matrix Metalloproteinases, Gene expression (Transcription), Metabolism of proteins, Elastic fibre formation, Generic Transcription Pathway, Signaling by PDGF, Extracellular matrix organization, Degradation of the extracellular matrix, Formation of the cornified envelope, Transport of small molecules, Signaling by TGF-beta Receptor Complex, Signal Transduction, Keratinization, Signaling by NTRKs, RNA Polymerase II Transcription, Assembly of active LPL and LIPC lipase complexes, TGF-beta receptor signaling activates SMADs, Post-translational protein modification, Gamma-carboxylation, transport, and amino-terminal cleavage of proteins

Orthologs