PANTHER Gene Information

Gene Symbol(s):

PCSK1

Organism:

Equus caballus

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Gene Name:

Neuroendocrine convertase 1

Gene ID:

ENSECAG00000020422.3

Protein ID:

F6TCF0

Persistent Id:

PTN001325173

Alternate Ids:

149726484(GI)	XP_001504658(refSeq)
ENSECAP00000018229(Ensembl_PRO)	F6TCF0(Synonym)
ENSECAT00000022083(Ensembl_TRS)	F6TCF0_HORSE(UniProtKB-ID)
ENSECAG00000020422(Ensembl)	100064886(GeneID)
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PANTHER Classification

PANTHER Family:	PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED (PTHR42884)
PANTHER Subfamily:	NEUROENDOCRINE CONVERTASE 1 (PTHR42884:SF14)
PANTHER GO-slim Molecular Function:	serine-type endopeptidase activity
PANTHER GO-slim Biological Process:	protein processing
PANTHER GO-slim Cellular Component:	membrane
PANTHER protein class:	serine protease

Pathway Categories:

Alzheimer disease-amyloid secretase pathway

Furin

Alzheimer disease-presenilin pathway

Furin

Endothelin signaling pathway

Furin

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	identical protein binding, endopeptidase activity, serine-type endopeptidase activity, serine-type peptidase activity
GO BP Complete:	insulin processing, proteolysis, peptide biosynthetic process, protein processing, peptide hormone processing
GO CC Complete:	extracellular space, cytoplasm, secretory granule, intracellular membrane-bounded organelle, membrane, endomembrane system, cytoplasmic vesicle, transport vesicle, neuron projection

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Orthologs

ID	Organism	Type
HUMAN\|HGNC=8743\|UniProtKB=P29120	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000017091.5\|UniProtKB=H2QR92	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000006986.3\|UniProtKB=G3QVR2	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000005134.4\|UniProtKB=H9FVB9	Macaca mulatta	LDO
MOUSE\|MGI=MGI=97511\|UniProtKB=P63239	Mus musculus	LDO
RAT\|RGD=3272\|UniProtKB=P28840	Rattus norvegicus	LDO
BOVIN\|Gene=PCSK1\|UniProtKB=Q9GLR1	Bos taurus	O
BOVIN\|Ensembl=ENSBTAG00000020843.6\|UniProtKB=F1MFR6	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00005014097.1\|UniProtKB=A0A4X1VFF1	Sus scrofa	LDO
FELCA\|Ensembl=ENSFCAG00000006327.6\|UniProtKB=M3W5Q0	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845003112.1\|UniProtKB=A0A8I3RR59	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000020079.4\|UniProtKB=F7GI61	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000001210.3\|UniProtKB=F6Z764	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010012232.1\|UniProtKB=A0A8V0YDL8	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000012731.3\|UniProtKB=G1KMV9	Anolis carolinensis	LDO
XENLA\|Gene=pcsk1.S\|UniProtKB=A0A1L8HR72	Xenopus laevis	O
XENLA\|Gene=LOC108717363\|UniProtKB=A0A8J1L617	Xenopus laevis	LDO
XENTR\|Gene=pcsk1\|UniProtKB=A0A8J0QWV0	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000008605.2\|UniProtKB=H2LXE5	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-071009-1\|UniProtKB=B6VCA1	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000001386.1\|UniProtKB=W5LZN5	lepisosteus oculatus	LDO
BRAFL\|Gene=LOC118409753\|UniProtKB=A0A9J7KMU7	Branchiostoma floridae	LDO
TRICA\|EnsemblGenome=TC004402\|UniProtKB=D6X568	Tribolium castaneum	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_59868\|UniProtKB=E9H9G1	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_43136\|UniProtKB=E9FZ50	Daphnia pulex	LDO
IXOSC\|EnsemblGenome=ISCW010275\|UniProtKB=B7PYT9	Ixodes scapularis	LDO
HELRO\|EnsemblGenome=HelroG184031\|UniProtKB=T1FKG6	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG193616\|UniProtKB=T1FV66	helobdella robusta	LDO
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g160244\|UniProtKB=A7RLT1	Nematostella vectensis	LDO
TRIAD\|EnsemblGenome=TriadG22925\|UniProtKB=B3RSJ2	Trichoplax adhaerens	LDO
MONBE\|EnsemblGenome=MONBRDRAFT_30798\|UniProtKB=A9UPB2	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_14515\|UniProtKB=A9US94	Monosiga brevicollis	LDO
YEAST\|SGD=S000005182\|UniProtKB=P13134	Saccharomyces cerevisiae	LDO
EREGS\|EnsemblGenome=AGOS_ABL203W\|UniProtKB=Q75E73	Eremothecium gossypii	LDO
CANAL\|CGD=CAL0000186377\|UniProtKB=A0A1D8PEG3	Candida albicans	LDO
YARLI\|EnsemblGenome=YALI0_F13189g\|UniProtKB=P42781	Yarrowia lipolytica	LDO
EMENI\|EnsemblGenome=ANIA_03583\|UniProtKB=G5EB75	Emericella nidulans	LDO
ASPFU\|EnsemblGenome=AFUA_4G12970\|UniProtKB=Q4WQI8	Neosartorya fumigata	LDO
NEUCR\|EnsemblGenome=NCU03219\|UniProtKB=V5IPW5	Neurospora crassa	LDO
SCLS1\|EnsemblGenome=SS1G_06027\|UniProtKB=A7EL30	Sclerotinia sclerotiorum	LDO
PHANO\|EnsemblGenome=SNOG_04420\|UniProtKB=Q0UUZ4	Phaeosphaeria nodorum	LDO
SCHPO\|PomBase=SPAC22E12.09c\|UniProtKB=Q09175	Schizosaccharomyces pombe	LDO
SCHJY\|EnsemblGenome=SJAG_04398\|UniProtKB=B6K6Q9	Schizosaccharomyces japonicus	LDO
CRYNJ\|EnsemblGenome=CNA01380\|UniProtKB=Q5KPV9	Cryptococcus neoformans	O
CRYNJ\|EnsemblGenome=CNH01120\|UniProtKB=Q5KCI3	Cryptococcus neoformans	LDO
USTMA\|EnsemblGenome=UMAG_02843\|UniProtKB=A0A0D1DXD6	Ustilago maydis	LDO
PUCGT\|EnsemblGenome=PGTG_08683\|UniProtKB=E3KGS2	Puccinia graminis	LDO
BATDJ\|Gene_ORFName=BATDEDRAFT_11523\|UniProtKB=F4P3C2	Batrachochytrium dendrobatidis	LDO
LEIMA\|EnsemblGenome=LMJF_13_1040\|UniProtKB=Q4QG50	Leishmania major	LDO
GIAIC\|Gene_ORFName=GL50803_0060596\|UniProtKB=A0A644F4P2	Giardia intestinalis	LDO
GIAIC\|EnsemblGenome=GL50803_2897\|UniProtKB=E2RTR3	Giardia intestinalis	O
GIAIC\|EnsemblGenome=GL50803_9948\|UniProtKB=A8BA31	Giardia intestinalis	LDO
TRIV3\|Gene_ORFName=TVAG_456780\|UniProtKB=A2DC02	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_187410\|UniProtKB=A2GMZ5	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_444370\|UniProtKB=A2E2H8	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_083790\|UniProtKB=A2DMA3	Trichomonas vaginalis	LDO
TRIV3\|Gene_ORFName=TVAG_042330\|UniProtKB=A2EUX2	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_270490\|UniProtKB=A2FFZ9	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_184220\|UniProtKB=A2E9V8	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_365540\|UniProtKB=A2DHJ8	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_444380\|UniProtKB=A2E2H9	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_109130\|UniProtKB=A2G1N4	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_103310\|UniProtKB=A2EKP2	Trichomonas vaginalis	LDO
TRIV3\|Gene_ORFName=TVAG_210920\|UniProtKB=A2F878	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_420190\|UniProtKB=A2ED42	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_444360\|UniProtKB=A2E2H7	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_465250\|UniProtKB=A2DTZ0	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_019800\|UniProtKB=A2DX52	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_276930\|UniProtKB=A2FUF3	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_028690\|UniProtKB=A2E0B6	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_162950\|UniProtKB=A2DFX3	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_444400\|UniProtKB=A2E2I1	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_369830\|UniProtKB=A2FS93	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_142720\|UniProtKB=A2GAP8	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_282560\|UniProtKB=A2DEF9	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_325090\|UniProtKB=A2F144	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_321410\|UniProtKB=A2FK64	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_161600\|UniProtKB=A2EUN3	Trichomonas vaginalis	O
PLAF7\|EnsemblGenome=PF3D7_1136900\|UniProtKB=Q8IHZ5	Plasmodium falciparum	LDO
PLAF7\|EnsemblGenome=PF3D7_0507500\|UniProtKB=Q8I0V0	Plasmodium falciparum	O
WHEAT\|EnsemblGenome=TraesCS3A02G380300\|UniProtKB=A0A3B6ELI2	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS3A02G380200\|UniProtKB=A0A3B6EMU2	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS3B02G412900\|UniProtKB=A0A077RWL0	Triticum aestivum	LDO
WHEAT\|EnsemblGenome=TraesCS3D02G373400\|UniProtKB=A0A3B6GYR9	Triticum aestivum	LDO
WHEAT\|EnsemblGenome=TraesCS3A02G420500\|UniProtKB=A0A3B6EMZ2	Triticum aestivum	O
PYRAE\|EnsemblGenome=PAE0712\|UniProtKB=Q8ZYM3	Pyrobaculum aerophilum	LDO
CHLAA\|EnsemblGenome=Caur_0716\|UniProtKB=A9WFL7	Chloroflexus aurantiacus	LDO
STRCO\|Gene_OrderedLocusName=SCO5731\|UniProtKB=O86650	Streptomyces coelicolor	O
STRCO\|Gene_OrderedLocusName=SCO0432\|UniProtKB=Q9RL54	Streptomyces coelicolor	O
STRCO\|Gene_OrderedLocusName=SCO5722\|UniProtKB=O86642	Streptomyces coelicolor	LDO
MYCTU\|Gene_OrderedLocusName=Rv3449\|UniProtKB=I6YC58	Mycobacterium tuberculosis	O
MYCTU\|Gene_OrderedLocusName=Rv1796\|UniProtKB=O53945	Mycobacterium tuberculosis	LDO
MYCTU\|Gene_OrderedLocusName=Rv3886c\|UniProtKB=O05458	Mycobacterium tuberculosis	O
GLOVI\|Gene=Q7NC92_GLOVI\|UniProtKB=Q7NC92	Gloeobacter violaceus	LDO
NEIMB\|EnsemblGenome=NMB1969\|UniProtKB=Q9JXM7	Neisseria meningitidis serogroup b	LDO
GEOSL\|EnsemblGenome=GSU3219\|UniProtKB=Q747P6	Geobacter sulfurreducens	LDO
XANCP\|EnsemblGenome=XCC2025\|UniProtKB=Q8P941	Xanthomonas campestris	LDO