PANTHER Gene Information

Gene Symbol(s):

Chat

Organism:

Mus musculus

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Gene Name:

Choline O-acetyltransferase

Gene ID:

MGI:88392

Protein ID:

Q03059

Persistent Id:

PTN000502032

Alternate Ids:

MGI:88392(MGI)	BAA20976(EMBL-CDS)
2.3.1.6(EC)	CLAT_MOUSE(UniProtKB-ID)
D12488(EMBL)	4433281(GI)
ChAT(Synonym)	Chat(Symbol)
CHEMBL5900(ChEMBL)
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PANTHER Classification

PANTHER Family:	CARNITINE O-ACYLTRANSFERASE (PTHR22589)
PANTHER Subfamily:	CHOLINE O-ACETYLTRANSFERASE (PTHR22589:SF14)
PANTHER GO-slim Molecular Function:	O-acyltransferase activity acetyltransferase activity
PANTHER GO-slim Biological Process:	nitrogen compound metabolic process neuromuscular synaptic transmission organic substance biosynthetic process
PANTHER GO-slim Cellular Component:	neuron projection cytoplasm
PANTHER protein class:	acyltransferase

Pathway Categories:

Nicotinic acetylcholine receptor signaling pathway

choline acetyltransferase

Muscarinic acetylcholine receptor 2 and 4 signaling pathway

choline acetyltransferase

Muscarinic acetylcholine receptor 1 and 3 signaling pathway

choline acetyltransferase

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	choline binding, choline O-acetyltransferase activity
GO BP Complete:	muscle organ development, establishment of synaptic specificity at neuromuscular junction, adult walking behavior, acetylcholine biosynthetic process, neuromuscular synaptic transmission, neuron differentiation, chemical synaptic transmission, rhythmic excitation, memory, rhythmic behavior, dendrite development
GO CC Complete:	cytoplasm, mitochondrion, neuronal cell body, synapse, neuron projection, axon

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Acetylcholine Neurotransmitter Release Cycle, Transmission across Chemical Synapses, Synthesis of PC, Neuronal System, Phospholipid metabolism, Neurotransmitter release cycle, Metabolism, Glycerophospholipid biosynthesis, Metabolism of lipids

Orthologs

ID	Organism	Type
HUMAN\|HGNC=1912\|UniProtKB=P28329	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000002489.5\|UniProtKB=H2RAF8	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000015179.3\|UniProtKB=G3RGQ8	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000004692.4\|UniProtKB=F6RM01	Macaca mulatta	LDO
RAT\|RGD=1304627\|UniProtKB=P32738	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000016814.6\|UniProtKB=F1MLQ5	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000010392.3\|UniProtKB=A0A2C9F3D4	Sus scrofa	O
PIG\|Ensembl=ENSSSCG00025075663\|UniProtKB=P13222	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000021611.3\|UniProtKB=A0A3Q2GY83	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000002065.6\|UniProtKB=A0A2I2U4U6	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845021769.1\|UniProtKB=A0A8I3PDE8	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000002547.4\|UniProtKB=F7ALU3	Monodelphis domestica	LDO
CHICK\|Gene=CHAT\|UniProtKB=Q90YJ9	Gallus gallus	O
CHICK\|Ensembl=ENSGALG00010010839.1\|UniProtKB=F1P393	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000015249.3\|UniProtKB=H9GM80	Anolis carolinensis	LDO
XENLA\|Gene=chat.S\|UniProtKB=A0A8J1LDM7	Xenopus laevis	O
XENLA\|Gene=chat.L\|UniProtKB=A0A8J0TA63	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-984174\|UniProtKB=A0A8J0QJ80	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000009452.2\|UniProtKB=H2M0C1	Oryzias latipes	O
ORYLA\|Ensembl=ENSORLG00000006943.2\|UniProtKB=A0A3B3I9Z8	Oryzias latipes	LDO
DANRE\|Gene=chata\|UniProtKB=A0A8M9Q9G1	Danio rerio	LDO
DANRE\|ZFIN=ZDB-GENE-140429-2\|UniProtKB=V9Z677	Danio rerio	O
DANRE\|ZFIN=ZDB-GENE-080102-2\|UniProtKB=B2ZGJ1	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000005657.1\|UniProtKB=W5MEN0	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000002571.3\|UniProtKB=F6UEZ5	Ciona intestinalis	LDO
BRAFL\|Gene=LOC118412577\|UniProtKB=A0A9J7MKW3	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=LOC574696\|UniProtKB=A0A7M7NDQ0	Strongylocentrotus purpuratus	LDO
CAEEL\|WormBase=WBGene00000481\|UniProtKB=P32756	Caenorhabditis elegans	LDO
CAEBR\|WormBase=WBGene00030124\|UniProtKB=A8X694	Caenorhabditis briggsae	LDO
PRIPA\|EnsemblGenome=WBGene00101190\|UniProtKB=A0A2A6BY29	Pristionchus pacificus	LDO
DROME\|FlyBase=FBgn0000303\|UniProtKB=P07668	Drosophila melanogaster	LDO
ANOGA\|EnsemblGenome=AGAP002370\|UniProtKB=A0A1S4GEW3	Anopheles gambiae	LDO
TRICA\|EnsemblGenome=TC032116\|UniProtKB=A0A139WMW1	Tribolium castaneum	LDO
DAPPU\|Gene_ORFName=DAPPUDRAFT_45346\|UniProtKB=E9G3N0	Daphnia pulex	LDO
IXOSC\|EnsemblGenome=ISCW022171\|UniProtKB=B7QD11	Ixodes scapularis	LDO
HELRO\|EnsemblGenome=HelroG84274\|UniProtKB=T1G5G8	helobdella robusta	LDO
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g416\|UniProtKB=A7T6K7	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g95805\|UniProtKB=A7RW65	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g163430\|UniProtKB=A7RW66	Nematostella vectensis	O
NEMVE\|Gene_ORFName=NEMVEDRAFT_v1g203043\|UniProtKB=A7RW64	Nematostella vectensis	O
TRIAD\|EnsemblGenome=TriadG28550\|UniProtKB=B3S3X0	Trichoplax adhaerens	O
TRIAD\|EnsemblGenome=TriadG31807\|UniProtKB=B3S9R5	Trichoplax adhaerens	O
TRIAD\|EnsemblGenome=TriadG31498\|UniProtKB=B3S997	Trichoplax adhaerens	O
TRIAD\|EnsemblGenome=TriadG21860\|UniProtKB=B3RPC2	Trichoplax adhaerens	O
TRIAD\|EnsemblGenome=TriadG21707\|UniProtKB=B3RPC1	Trichoplax adhaerens	O
TRIAD\|EnsemblGenome=TriadG21352\|UniProtKB=B3RPE6	Trichoplax adhaerens	O
TRIAD\|EnsemblGenome=TriadG33379\|UniProtKB=B3SCI6	Trichoplax adhaerens	O
TRIAD\|EnsemblGenome=TriadG20587\|UniProtKB=B3RP88	Trichoplax adhaerens	O
CRYNJ\|EnsemblGenome=CNL05760\|UniProtKB=Q5K8G7	Cryptococcus neoformans	O
USTMA\|EnsemblGenome=UMAG_11660\|UniProtKB=A0A0D1E790	Ustilago maydis	O
PUCGT\|EnsemblGenome=PGTG_07182\|UniProtKB=E3K9Q6	Puccinia graminis	O
BATDJ\|Gene_ORFName=BATDEDRAFT_35927\|UniProtKB=F4PAR2	Batrachochytrium dendrobatidis	O
BATDJ\|Gene_ORFName=BATDEDRAFT_10147\|UniProtKB=F4NY05	Batrachochytrium dendrobatidis	O
YEAST\|SGD=S000004506\|UniProtKB=P32796	Saccharomyces cerevisiae	O
EREGS\|EnsemblGenome=AGOS_AAR124C\|UniProtKB=Q75EF7	Eremothecium gossypii	O
CANAL\|CGD=CAL0000184947\|UniProtKB=Q5AMQ5	Candida albicans	O
YARLI\|EnsemblGenome=YALI0_B10340g\|UniProtKB=Q6CF46	Yarrowia lipolytica	O
EMENI\|EnsemblGenome=ANIA_10447\|UniProtKB=C8V468	Emericella nidulans	O
EMENI\|EnsemblGenome=ANIA_06279\|UniProtKB=C8V1G3	Emericella nidulans	O
ASPFU\|EnsemblGenome=AFUA_2G12530\|UniProtKB=Q4X0R8	Neosartorya fumigata	O
NEUCR\|EnsemblGenome=NCU08002\|UniProtKB=Q7SAN8	Neurospora crassa	O
SCLS1\|Gene_ORFName=SS1G_13339\|UniProtKB=A7F6V9	Sclerotinia sclerotiorum	O
PHANO\|EnsemblGenome=SNOG_05975\|UniProtKB=Q0UQI9	Phaeosphaeria nodorum	O
CRYNJ\|EnsemblGenome=CNA05200\|UniProtKB=Q5KNV3	Cryptococcus neoformans	O
USTMA\|EnsemblGenome=UMAG_00789\|UniProtKB=A0A0D1EAZ4	Ustilago maydis	O
PUCGT\|EnsemblGenome=PGTG_04365\|UniProtKB=E3K240	Puccinia graminis	O
PUCGT\|EnsemblGenome=PGTG_04359\|UniProtKB=E3K234	Puccinia graminis	O
PUCGT\|EnsemblGenome=PGTG_04366\|UniProtKB=E3K241	Puccinia graminis	O
BATDJ\|Gene_ORFName=BATDEDRAFT_13099\|UniProtKB=F4P876	Batrachochytrium dendrobatidis	O
THAPS\|EnsemblGenome=THAPSDRAFT_31762\|UniProtKB=B8BTN0	Thalassiosira pseudonana	O
PHYRM\|Gene=H3G9Q7_PHYRM\|UniProtKB=H3G9Q7	Phytophthora ramorum	O