PANTHER Gene Information

Gene Symbol(s):

NCU01171

Organism:

Neurospora crassa

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Gene Name:

DNA replication licensing factor MCM5

Gene ID:

NCU01171

Protein ID:

Q1K862

Persistent Id:

PTN002267437

Alternate Ids:

EAA32301(EMBL-CDS)	28923084(GI)
XP_961537(refSeq)	Q1K862_NEUCR(UniProtKB-ID)
CM002240(EMBL)	3877733(GeneID)
NCU01171(Ensembl)	Q1K862(Synonym)
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PANTHER Classification

PANTHER Family:	DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER (PTHR11630)
PANTHER Subfamily:	DNA REPLICATION LICENSING FACTOR MCM5 (PTHR11630:SF42)
PANTHER GO-slim Molecular Function:	single-stranded DNA binding 3'-5' DNA helicase activity single-stranded DNA helicase activity
PANTHER GO-slim Biological Process:	DNA replication initiation double-strand break repair via break-induced replication
PANTHER GO-slim Cellular Component:	MCM complex nucleus
PANTHER protein class:	DNA metabolism protein

Pathway Categories:

Apoptosis signaling pathway

Heat shock protein 70

Parkinson disease

Heat shock protein 70

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	ATP hydrolysis activity, double-stranded DNA helicase activity, helicase activity, four-way junction helicase activity, chromatin binding, forked DNA-dependent helicase activity, 3'-5' DNA helicase activity, cohesin loader activity, single-stranded DNA binding, DNA binding, DNA replication origin binding, ATP binding, DNA clamp loader activity, ATP-dependent H2AZ histone chaperone activity, ATP-dependent H3-H4 histone complex chaperone activity, single-stranded 3'-5' DNA helicase activity, single-stranded DNA helicase activity, chromatin extrusion motor activity, hydrolase activity
GO BP Complete:	DNA replication initiation, nuclear DNA replication, double-strand break repair via break-induced replication, DNA replication, regulation of DNA-templated DNA replication initiation, pre-replicative complex assembly involved in nuclear cell cycle DNA replication, DNA unwinding involved in DNA replication, premeiotic DNA replication, transcription elongation by RNA polymerase II, subtelomeric heterochromatin formation, heterochromatin formation, DNA duplex unwinding, chromatin looping
GO CC Complete:	chromosome, telomeric region, nucleus, nuclear pre-replicative complex, CMG complex, cytoplasm, DNA replication preinitiation complex, nuclear replication fork, replication fork protection complex, MCM complex

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Orthologs

ID	Organism	Type
HUMAN\|HGNC=6948\|UniProtKB=P33992	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000014299.5\|UniProtKB=H2QLK2	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000009666.3\|UniProtKB=G3R2J0	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000021054.4\|UniProtKB=F6QKN8	Macaca mulatta	LDO
MOUSE\|MGI=MGI=103197\|UniProtKB=P49718	Mus musculus	LDO
RAT\|RGD=1306616\|UniProtKB=E9PTS4	Rattus norvegicus	LDO
BOVIN\|Gene=MCM5\|UniProtKB=Q0V8B7	Bos taurus	O
BOVIN\|Ensembl=ENSBTAG00000015595.6\|UniProtKB=A6H7F8	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000022823.4\|UniProtKB=A0A5G2QHF3	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000014368.4\|UniProtKB=A0A9L0RYX5	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000013844.5\|UniProtKB=A0A2I2UCK4	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845009614.1\|UniProtKB=A0A8I3N7J5	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000001152.6\|UniProtKB=A0A5F8H017	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000010872.3\|UniProtKB=F7AF52	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010015126.1\|UniProtKB=Q5ZKL0	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000016609.3\|UniProtKB=G1KSW1	Anolis carolinensis	LDO
XENLA\|Gene=mcm5-b\|UniProtKB=Q6PCI7	Xenopus laevis	O
XENLA\|Gene=mcm5-a\|UniProtKB=P55862	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-985665\|UniProtKB=Q561P5	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000010517.2\|UniProtKB=H2M425	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-021209-1\|UniProtKB=Q6NV07	Danio rerio	LDO
CIOIN\|Ensembl=ENSCING00000003363.2\|UniProtKB=F7BA18	Ciona intestinalis	LDO
BRAFL\|Gene=LOC118429900\|UniProtKB=A0A9J7NA56	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=LOC578688\|UniProtKB=A0A7M7T4Z3	Strongylocentrotus purpuratus	LDO
CAEEL\|WormBase=WBGene00003157\|UniProtKB=Q21902	Caenorhabditis elegans	LDO
CAEBR\|Gene_ORFName=CBG12303\|UniProtKB=A8XF77	Caenorhabditis briggsae	LDO
PRIPA\|EnsemblGenome=WBGene00109550\|UniProtKB=A0A2A6BB42	Pristionchus pacificus	LDO
DROME\|FlyBase=FBgn0017577\|UniProtKB=Q9VGW6	Drosophila melanogaster	LDO
ANOGA\|EnsemblGenome=AGAP004408\|UniProtKB=Q7QA70	Anopheles gambiae	LDO
TRICA\|EnsemblGenome=TC034773\|UniProtKB=A0A139WF97	Tribolium castaneum	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_227386\|UniProtKB=E9H6I5	Daphnia pulex	LDO
HELRO\|EnsemblGenome=HelroG113800\|UniProtKB=T1EFW8	helobdella robusta	LDO
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g238608\|UniProtKB=A7RIT1	Nematostella vectensis	LDO
TRIAD\|EnsemblGenome=TriadG50365\|UniProtKB=B3S0P8	Trichoplax adhaerens	LDO
MONBE\|EnsemblGenome=MONBRDRAFT_27771\|UniProtKB=A9V696	Monosiga brevicollis	LDO
YEAST\|SGD=S000004264\|UniProtKB=P29496	Saccharomyces cerevisiae	LDO
EREGS\|EnsemblGenome=AGOS_AGR276W\|UniProtKB=Q74ZC3	Eremothecium gossypii	LDO
CANAL\|CGD=CAL0000182764\|UniProtKB=Q59P49	Candida albicans	LDO
YARLI\|EnsemblGenome=YALI0_A01353g\|UniProtKB=Q6CI63	Yarrowia lipolytica	LDO
EMENI\|EnsemblGenome=ANIA_07994\|UniProtKB=Q5AUN6	Emericella nidulans	LDO
ASPFU\|EnsemblGenome=AFUA_5G02520\|UniProtKB=Q4WEC5	Neosartorya fumigata	LDO
SCLS1\|Gene_ORFName=SS1G_07673\|UniProtKB=A7EQS0	Sclerotinia sclerotiorum	LDO
PHANO\|EnsemblGenome=SNOG_15534\|UniProtKB=Q0TYJ9	Phaeosphaeria nodorum	LDO
SCHPO\|PomBase=SPAC1B2.05\|UniProtKB=P41389	Schizosaccharomyces pombe	LDO
SCHJY\|EnsemblGenome=SJAG_01354\|UniProtKB=B6K0G1	Schizosaccharomyces japonicus	LDO
CRYNJ\|EnsemblGenome=CNB05360\|UniProtKB=Q5KLG5	Cryptococcus neoformans	LDO
USTMA\|EnsemblGenome=UMAG_05064\|UniProtKB=A0A0D1CK07	Ustilago maydis	LDO
PUCGT\|EnsemblGenome=PGTG_07804\|UniProtKB=E3KB23	Puccinia graminis	LDO
BATDJ\|Gene_ORFName=BATDEDRAFT_13316\|UniProtKB=F4P8T2	Batrachochytrium dendrobatidis	LDO
ENTH1\|Gene_ORFName=EHI_069980\|UniProtKB=A0A8U0WNY5	Entamoeba histolytica	LDO
DICDI\|dictyBase=DDB_G0292958\|UniProtKB=Q54CP4	Dictyostelium discoideum	LDO
DICPU\|EnsemblGenome=DICPUDRAFT_31145\|UniProtKB=F0ZGS3	Dictyostelium purpureum	LDO
LEIMA\|EnsemblGenome=LMJF_24_0910\|UniProtKB=Q4QAP2	Leishmania major	LDO
TRYB2\|Gene_ORFName=Tb11.02.3270\|UniProtKB=Q385L1	Trypanosoma brucei	LDO
GIAIC\|EnsemblGenome=GL50803_89112\|UniProtKB=A8BN52	Giardia intestinalis	LDO
TRIV3\|Gene_ORFName=TVAG_484360\|UniProtKB=A2FUI9	Trichomonas vaginalis	LDO
PLAF7\|EnsemblGenome=PF3D7_1211700\|UniProtKB=Q8I5T4	Plasmodium falciparum	LDO
PARTE\|EnsemblGenome=GSPATT00025390001\|UniProtKB=A0EBI9	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00031570001\|UniProtKB=A0BS22	Paramecium tetraurelia	LDO
THAPS\|EnsemblGenome=THAPSDRAFT_31609\|UniProtKB=B8BRW4	Thalassiosira pseudonana	LDO
PHYRM\|Gene=H3G7X1_PHYRM\|UniProtKB=H3G7X1	Phytophthora ramorum	LDO
CHLRE\|EnsemblGenome=CHLRE_01g023150v5\|UniProtKB=A0A2K3E6D5	Chlamydomonas reinhardtii	LDO
AMBTC\|EnsemblGenome=AMTR_s00026p00049360\|UniProtKB=W1PSV0	Amborella trichopoda	LDO
ZOSMR\|Gene_ORFName=ZOSMA_55G00150\|UniProtKB=A0A0K9NW09	Zostera marina	LDO
MUSAM\|EnsemblGenome=Ma10_g30700\|UniProtKB=A0A804L265	Musa acuminata subsp. malaccensis	LDO
SETIT\|EnsemblGenome=SETIT_016456mg\|UniProtKB=K3YQB3	Setaria italica	LDO
SORBI\|EnsemblGenome=SORBI_3004G331600\|UniProtKB=C5XUH8	Sorghum bicolor	LDO
MAIZE\|EnsemblGenome=Zm00001eb257900\|UniProtKB=A0A1D6HNE8	Zea mays	LDO
ORYSJ\|EnsemblGenome=Os02g0797400\|UniProtKB=Q6KAJ4	Oryza sativa	LDO
BRADI\|EnsemblGenome=BRADI_3g54190v3\|UniProtKB=I1IDH7	Brachypodium distachyon	LDO
HORVV\|EnsemblGenome=HORVU.MOREX.r3.6HG0624620\|UniProtKB=A0A8I6Y5P6	Hordeum vulgare subsp. vulgare	LDO
WHEAT\|EnsemblGenome=TraesCS6D02G344100\|UniProtKB=A0A3B6QJY3	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS6A02G360600\|UniProtKB=A0A3B6NVQ1	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS6B02G393500\|UniProtKB=A0A3B6PRQ6	Triticum aestivum	LDO
NELNU\|Gene=LOC104589054\|UniProtKB=A0A1U7YY73	Nelumbo nucifera	LDO
SPIOL\|Gene=LOC110778363\|UniProtKB=A0A9R0HXF3	Spinacia oleracea	LDO
HELAN\|EnsemblGenome=HanXRQr2_Chr05g0204991\|UniProtKB=A0A251UNB8	Helianthus annuus	LDO
LACSA\|Gene_ORFName=LSAT_V11C800414170\|UniProtKB=A0A9R1ULZ7	Lactuca sativa	LDO
ERYGU\|Gene_ORFName=MIMGU_mgv1a001962mg\|UniProtKB=A0A022QW43	Erythranthe guttata	LDO
CAPAN\|EnsemblGenome=T459_18930\|UniProtKB=A0A2G2Z086	Capsicum annuum	LDO
SOLTU\|EnsemblGenome=PGSC0003DMG400011837\|UniProtKB=M1AUY4	Solanum tuberosum	LDO
TOBAC\|Gene=LOC107804766\|UniProtKB=A0A1S4B5R1	Nicotiana tabacum	O
TOBAC\|Gene=LOC107783151\|UniProtKB=A0A1S3Z556	Nicotiana tabacum	LDO
VITVI\|Gene_OrderedLocusName=VIT_11s0149g00130\|UniProtKB=D7T529	Vitis vinifera	LDO
EUCGR\|EnsemblGenome=EUGRSUZ_C00405\|UniProtKB=A0A059CKK2	Eucalyptus grandis	LDO
BRANA\|Gene_ORFName=DARMORV10_C03P55560.1\|UniProtKB=A0A078IIQ0	Brassica napus	LDO
BRACM\|EnsemblGenome=Bra013169\|UniProtKB=M4D9K9	Brassica campestris	LDO
ARATH\|TAIR=locus=2054698\|UniProtKB=O80786	Arabidopsis thaliana	LDO
GOSHI\|Gene=LOC107937982\|UniProtKB=A0A1U8MLU1	Gossypium hirsutum	O
GOSHI\|Gene=LOC107893417\|UniProtKB=A0A1U8I6N3	Gossypium hirsutum	LDO
THECC\|EnsemblGenome=TCM_047088\|UniProtKB=A0A061GJP7	Theobroma cacao	LDO
CITSI\|Gene_ORFName=CISIN_1g004862mg\|UniProtKB=A0A067EW69	Citrus sinensis	LDO
POPTR\|EnsemblGenome=POPTR_018G112800v3\|UniProtKB=A0A2K1WZE5	Populus trichocarpa	O
POPTR\|EnsemblGenome=POPTR_006G188700v3\|UniProtKB=A0A2K2A4G9	Populus trichocarpa	LDO
MANES\|EnsemblGenome=MANES_06G040400\|UniProtKB=A0A2C9VMV9	Manihot esculenta	LDO
RICCO\|Gene_ORFName=RCOM_0701490\|UniProtKB=B9SC12	Ricinus communis	LDO
SOYBN\|EnsemblGenome=GLYMA_13G156400\|UniProtKB=I1LZM7	Glycine max	O
SOYBN\|EnsemblGenome=GLYMA_17G104000\|UniProtKB=I1MTX9	Glycine max	LDO
MEDTR\|EnsemblGenome=MTR_4g116870\|UniProtKB=A0A072UR54	Medicago truncatula	LDO
JUGRE\|EnsemblGenome=Jr06_20030\|UniProtKB=A0A2I4HME4	Juglans regia	LDO
CUCSA\|EnsemblGenome=Csa_2G009300\|UniProtKB=A0A0A0LL55	Cucumis sativus	LDO
PRUPE\|EnsemblGenome=PRUPE_7G252700\|UniProtKB=M5WGC6	Prunus persica	LDO
SELML\|EnsemblGenome=SELMODRAFT_114939\|UniProtKB=D8R9T1	Selaginella moellendorffii	LDO
PHYPA\|EnsemblGenome=Pp3c1_32870\|UniProtKB=A0A2K1LAN4	Physcomitrella patens	LDO
MARPO\|EnsemblGenome=MARPO_0006s0287\|UniProtKB=A0A2R6XQH6	Marchantia polymorpha	LDO
KLENI\|Gene_ORFName=KFL_001840010\|UniProtKB=A0A1Y1I2W6	Klebsormidium nitens	LDO
NITMS\|EnsemblGenome=Nmar_0242\|UniProtKB=A9A310	Nitrosopumilus maritimus	O
KORCO\|EnsemblGenome=Kcr_1352\|UniProtKB=B1L6L9	Korarchaeum cryptofilum	O
SACS2\|EnsemblGenome=SSO0774\|UniProtKB=Q9UXG1	Sulfolobus solfataricus	O
PYRAE\|EnsemblGenome=PAE0901\|UniProtKB=Q8ZY88	Pyrobaculum aerophilum	O
METAC\|EnsemblGenome=MA_3829\|UniProtKB=Q8TJF6	Methanosarcina acetivorans	O
METAC\|EnsemblGenome=MA_0681\|UniProtKB=Q8TSW4	Methanosarcina acetivorans	O
METJA\|EnsemblGenome=MJ_ECL13\|UniProtKB=Q60275	Methanocaldococcus jannaschii	O
METJA\|EnsemblGenome=MJ_1489\|UniProtKB=Q58884	Methanocaldococcus jannaschii	O
METJA\|EnsemblGenome=MJ_0363\|UniProtKB=Q57809	Methanocaldococcus jannaschii	O
METJA\|EnsemblGenome=MJ_0961\|UniProtKB=Q58371	Methanocaldococcus jannaschii	O
HALSA\|EnsemblGenome=VNG_2181G\|UniProtKB=Q9HNA5	Halobacterium salinarum	O
THEKO\|EnsemblGenome=TK1361\|UniProtKB=Q5JGW1	Thermococcus kodakaraensis	O
THEKO\|EnsemblGenome=TK0096\|UniProtKB=Q5JEJ0	Thermococcus kodakaraensis	O
THEKO\|EnsemblGenome=TK1620\|UniProtKB=Q5JIT1	Thermococcus kodakaraensis	O