PANTHER Gene Information

Gene Symbol(s):

Mcm5

Organism:

Rattus norvegicus

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Gene Name:

DNA replication licensing factor MCM5

Gene ID:

1306616

Protein ID:

E9PTS4

Persistent Id:

PTN002267432

Alternate Ids:

ENSRNOG00000014336(Ensembl)	E9PTS4_RAT(UniProtKB-ID)
ENSRNOT00000064731(Ensembl_TRS)	E9PTS4(Synonym)
1306616(RGD)	ENSRNOP00000062524(Ensembl_PRO)
NP_001099640(refSeq)
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PANTHER Classification

PANTHER Family:	DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER (PTHR11630)
PANTHER Subfamily:	DNA REPLICATION LICENSING FACTOR MCM5 (PTHR11630:SF42)
PANTHER GO-slim Molecular Function:	single-stranded DNA binding 3'-5' DNA helicase activity single-stranded DNA helicase activity
PANTHER GO-slim Biological Process:	DNA replication initiation double-strand break repair via break-induced replication
PANTHER GO-slim Cellular Component:	MCM complex nucleus
PANTHER protein class:	DNA metabolism protein

Pathway Categories:

Apoptosis signaling pathway

Heat shock protein 70

Parkinson disease

Heat shock protein 70

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	DNA replication origin binding, ATP binding, double-stranded DNA helicase activity, four-way junction helicase activity, forked DNA-dependent helicase activity, single-stranded 3'-5' DNA helicase activity, 3'-5' DNA helicase activity, single-stranded DNA helicase activity, single-stranded DNA binding, hydrolase activity
GO BP Complete:	DNA replication initiation, double-strand break repair via break-induced replication, DNA unwinding involved in DNA replication
GO CC Complete:	nucleus, CMG complex, MCM complex, nucleoplasm

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Cell Cycle, Mitotic, DNA Replication Pre-Initiation, S Phase, Activation of the pre-replicative complex, Cell Cycle, Cell Cycle Checkpoints, G2/M Checkpoints, Switching of origins to a post-replicative state, Assembly of the pre-replicative complex, Activation of ATR in response to replication stress, Mitotic G1 phase and G1/S transition, DNA Replication, G1/S Transition, Synthesis of DNA, Orc1 removal from chromatin

Orthologs

ID	Organism	Type
HUMAN\|HGNC=6948\|UniProtKB=P33992	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000014299.5\|UniProtKB=H2QLK2	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000009666.3\|UniProtKB=G3R2J0	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000021054.4\|UniProtKB=F6QKN8	Macaca mulatta	LDO
MOUSE\|MGI=MGI=103197\|UniProtKB=P49718	Mus musculus	LDO
BOVIN\|Gene=MCM5\|UniProtKB=Q0V8B7	Bos taurus	O
BOVIN\|Ensembl=ENSBTAG00000015595.6\|UniProtKB=A6H7F8	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000022823.4\|UniProtKB=A0A5G2QHF3	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000014368.4\|UniProtKB=A0A9L0RYX5	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000013844.5\|UniProtKB=A0A2I2UCK4	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845009614.1\|UniProtKB=A0A8I3N7J5	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000001152.6\|UniProtKB=A0A5F8H017	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000010872.3\|UniProtKB=F7AF52	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010015126.1\|UniProtKB=Q5ZKL0	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000016609.3\|UniProtKB=G1KSW1	Anolis carolinensis	LDO
XENLA\|Gene=mcm5-b\|UniProtKB=Q6PCI7	Xenopus laevis	O
XENLA\|Gene=mcm5-a\|UniProtKB=P55862	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-985665\|UniProtKB=Q561P5	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000010517.2\|UniProtKB=H2M425	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-021209-1\|UniProtKB=Q6NV07	Danio rerio	LDO
CIOIN\|Ensembl=ENSCING00000003363.2\|UniProtKB=F7BA18	Ciona intestinalis	LDO
BRAFL\|Gene=LOC118429900\|UniProtKB=A0A9J7NA56	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=LOC578688\|UniProtKB=A0A7M7T4Z3	Strongylocentrotus purpuratus	LDO
CAEEL\|WormBase=WBGene00003157\|UniProtKB=Q21902	Caenorhabditis elegans	LDO
CAEBR\|Gene_ORFName=CBG12303\|UniProtKB=A8XF77	Caenorhabditis briggsae	LDO
PRIPA\|EnsemblGenome=WBGene00109550\|UniProtKB=A0A2A6BB42	Pristionchus pacificus	LDO
DROME\|FlyBase=FBgn0017577\|UniProtKB=Q9VGW6	Drosophila melanogaster	LDO
ANOGA\|EnsemblGenome=AGAP004408\|UniProtKB=Q7QA70	Anopheles gambiae	LDO
TRICA\|EnsemblGenome=TC034773\|UniProtKB=A0A139WF97	Tribolium castaneum	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_227386\|UniProtKB=E9H6I5	Daphnia pulex	LDO
HELRO\|EnsemblGenome=HelroG113800\|UniProtKB=T1EFW8	helobdella robusta	LDO
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g238608\|UniProtKB=A7RIT1	Nematostella vectensis	LDO
TRIAD\|EnsemblGenome=TriadG50365\|UniProtKB=B3S0P8	Trichoplax adhaerens	LDO
MONBE\|EnsemblGenome=MONBRDRAFT_27771\|UniProtKB=A9V696	Monosiga brevicollis	LDO
YEAST\|SGD=S000004264\|UniProtKB=P29496	Saccharomyces cerevisiae	LDO
EREGS\|EnsemblGenome=AGOS_AGR276W\|UniProtKB=Q74ZC3	Eremothecium gossypii	LDO
CANAL\|CGD=CAL0000182764\|UniProtKB=Q59P49	Candida albicans	LDO
YARLI\|EnsemblGenome=YALI0_A01353g\|UniProtKB=Q6CI63	Yarrowia lipolytica	LDO
EMENI\|EnsemblGenome=ANIA_07994\|UniProtKB=Q5AUN6	Emericella nidulans	LDO
ASPFU\|EnsemblGenome=AFUA_5G02520\|UniProtKB=Q4WEC5	Neosartorya fumigata	LDO
NEUCR\|EnsemblGenome=NCU01171\|UniProtKB=Q1K862	Neurospora crassa	LDO
SCLS1\|Gene_ORFName=SS1G_07673\|UniProtKB=A7EQS0	Sclerotinia sclerotiorum	LDO
PHANO\|EnsemblGenome=SNOG_15534\|UniProtKB=Q0TYJ9	Phaeosphaeria nodorum	LDO
SCHPO\|PomBase=SPAC1B2.05\|UniProtKB=P41389	Schizosaccharomyces pombe	LDO
SCHJY\|EnsemblGenome=SJAG_01354\|UniProtKB=B6K0G1	Schizosaccharomyces japonicus	LDO
CRYNJ\|EnsemblGenome=CNB05360\|UniProtKB=Q5KLG5	Cryptococcus neoformans	LDO
USTMA\|EnsemblGenome=UMAG_05064\|UniProtKB=A0A0D1CK07	Ustilago maydis	LDO
PUCGT\|EnsemblGenome=PGTG_07804\|UniProtKB=E3KB23	Puccinia graminis	LDO
BATDJ\|Gene_ORFName=BATDEDRAFT_13316\|UniProtKB=F4P8T2	Batrachochytrium dendrobatidis	LDO
ENTH1\|Gene_ORFName=EHI_069980\|UniProtKB=A0A8U0WNY5	Entamoeba histolytica	LDO
DICDI\|dictyBase=DDB_G0292958\|UniProtKB=Q54CP4	Dictyostelium discoideum	LDO
DICPU\|EnsemblGenome=DICPUDRAFT_31145\|UniProtKB=F0ZGS3	Dictyostelium purpureum	LDO
LEIMA\|EnsemblGenome=LMJF_24_0910\|UniProtKB=Q4QAP2	Leishmania major	LDO
TRYB2\|Gene_ORFName=Tb11.02.3270\|UniProtKB=Q385L1	Trypanosoma brucei	LDO
GIAIC\|EnsemblGenome=GL50803_89112\|UniProtKB=A8BN52	Giardia intestinalis	LDO
TRIV3\|Gene_ORFName=TVAG_484360\|UniProtKB=A2FUI9	Trichomonas vaginalis	LDO
PLAF7\|EnsemblGenome=PF3D7_1211700\|UniProtKB=Q8I5T4	Plasmodium falciparum	LDO
PARTE\|EnsemblGenome=GSPATT00025390001\|UniProtKB=A0EBI9	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00031570001\|UniProtKB=A0BS22	Paramecium tetraurelia	LDO
THAPS\|EnsemblGenome=THAPSDRAFT_31609\|UniProtKB=B8BRW4	Thalassiosira pseudonana	LDO
PHYRM\|Gene=H3G7X1_PHYRM\|UniProtKB=H3G7X1	Phytophthora ramorum	LDO
CHLRE\|EnsemblGenome=CHLRE_01g023150v5\|UniProtKB=A0A2K3E6D5	Chlamydomonas reinhardtii	LDO
AMBTC\|EnsemblGenome=AMTR_s00026p00049360\|UniProtKB=W1PSV0	Amborella trichopoda	LDO
ZOSMR\|Gene_ORFName=ZOSMA_55G00150\|UniProtKB=A0A0K9NW09	Zostera marina	LDO
MUSAM\|EnsemblGenome=Ma10_g30700\|UniProtKB=A0A804L265	Musa acuminata subsp. malaccensis	LDO
SETIT\|EnsemblGenome=SETIT_016456mg\|UniProtKB=K3YQB3	Setaria italica	LDO
SORBI\|EnsemblGenome=SORBI_3004G331600\|UniProtKB=C5XUH8	Sorghum bicolor	LDO
MAIZE\|EnsemblGenome=Zm00001eb257900\|UniProtKB=A0A1D6HNE8	Zea mays	LDO
ORYSJ\|EnsemblGenome=Os02g0797400\|UniProtKB=Q6KAJ4	Oryza sativa	LDO
BRADI\|EnsemblGenome=BRADI_3g54190v3\|UniProtKB=I1IDH7	Brachypodium distachyon	LDO
HORVV\|EnsemblGenome=HORVU.MOREX.r3.6HG0624620\|UniProtKB=A0A8I6Y5P6	Hordeum vulgare subsp. vulgare	LDO
WHEAT\|EnsemblGenome=TraesCS6D02G344100\|UniProtKB=A0A3B6QJY3	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS6A02G360600\|UniProtKB=A0A3B6NVQ1	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS6B02G393500\|UniProtKB=A0A3B6PRQ6	Triticum aestivum	LDO
NELNU\|Gene=LOC104589054\|UniProtKB=A0A1U7YY73	Nelumbo nucifera	LDO
SPIOL\|Gene=LOC110778363\|UniProtKB=A0A9R0HXF3	Spinacia oleracea	LDO
HELAN\|EnsemblGenome=HanXRQr2_Chr05g0204991\|UniProtKB=A0A251UNB8	Helianthus annuus	LDO
LACSA\|Gene_ORFName=LSAT_V11C800414170\|UniProtKB=A0A9R1ULZ7	Lactuca sativa	LDO
ERYGU\|Gene_ORFName=MIMGU_mgv1a001962mg\|UniProtKB=A0A022QW43	Erythranthe guttata	LDO
CAPAN\|EnsemblGenome=T459_18930\|UniProtKB=A0A2G2Z086	Capsicum annuum	LDO
SOLTU\|EnsemblGenome=PGSC0003DMG400011837\|UniProtKB=M1AUY4	Solanum tuberosum	LDO
TOBAC\|Gene=LOC107804766\|UniProtKB=A0A1S4B5R1	Nicotiana tabacum	O
TOBAC\|Gene=LOC107783151\|UniProtKB=A0A1S3Z556	Nicotiana tabacum	LDO
VITVI\|Gene_OrderedLocusName=VIT_11s0149g00130\|UniProtKB=D7T529	Vitis vinifera	LDO
EUCGR\|EnsemblGenome=EUGRSUZ_C00405\|UniProtKB=A0A059CKK2	Eucalyptus grandis	LDO
BRANA\|Gene_ORFName=DARMORV10_C03P55560.1\|UniProtKB=A0A078IIQ0	Brassica napus	LDO
BRACM\|EnsemblGenome=Bra013169\|UniProtKB=M4D9K9	Brassica campestris	LDO
ARATH\|TAIR=locus=2054698\|UniProtKB=O80786	Arabidopsis thaliana	LDO
GOSHI\|Gene=LOC107937982\|UniProtKB=A0A1U8MLU1	Gossypium hirsutum	O
GOSHI\|Gene=LOC107893417\|UniProtKB=A0A1U8I6N3	Gossypium hirsutum	LDO
THECC\|EnsemblGenome=TCM_047088\|UniProtKB=A0A061GJP7	Theobroma cacao	LDO
CITSI\|Gene_ORFName=CISIN_1g004862mg\|UniProtKB=A0A067EW69	Citrus sinensis	LDO
POPTR\|EnsemblGenome=POPTR_018G112800v3\|UniProtKB=A0A2K1WZE5	Populus trichocarpa	O
POPTR\|EnsemblGenome=POPTR_006G188700v3\|UniProtKB=A0A2K2A4G9	Populus trichocarpa	LDO
MANES\|EnsemblGenome=MANES_06G040400\|UniProtKB=A0A2C9VMV9	Manihot esculenta	LDO
RICCO\|Gene_ORFName=RCOM_0701490\|UniProtKB=B9SC12	Ricinus communis	LDO
SOYBN\|EnsemblGenome=GLYMA_13G156400\|UniProtKB=I1LZM7	Glycine max	O
SOYBN\|EnsemblGenome=GLYMA_17G104000\|UniProtKB=I1MTX9	Glycine max	LDO
MEDTR\|EnsemblGenome=MTR_4g116870\|UniProtKB=A0A072UR54	Medicago truncatula	LDO
JUGRE\|EnsemblGenome=Jr06_20030\|UniProtKB=A0A2I4HME4	Juglans regia	LDO
CUCSA\|EnsemblGenome=Csa_2G009300\|UniProtKB=A0A0A0LL55	Cucumis sativus	LDO
PRUPE\|EnsemblGenome=PRUPE_7G252700\|UniProtKB=M5WGC6	Prunus persica	LDO
SELML\|EnsemblGenome=SELMODRAFT_114939\|UniProtKB=D8R9T1	Selaginella moellendorffii	LDO
PHYPA\|EnsemblGenome=Pp3c1_32870\|UniProtKB=A0A2K1LAN4	Physcomitrella patens	LDO
MARPO\|EnsemblGenome=MARPO_0006s0287\|UniProtKB=A0A2R6XQH6	Marchantia polymorpha	LDO
KLENI\|Gene_ORFName=KFL_001840010\|UniProtKB=A0A1Y1I2W6	Klebsormidium nitens	LDO
NITMS\|EnsemblGenome=Nmar_0242\|UniProtKB=A9A310	Nitrosopumilus maritimus	O
KORCO\|EnsemblGenome=Kcr_1352\|UniProtKB=B1L6L9	Korarchaeum cryptofilum	O
SACS2\|EnsemblGenome=SSO0774\|UniProtKB=Q9UXG1	Sulfolobus solfataricus	O
PYRAE\|EnsemblGenome=PAE0901\|UniProtKB=Q8ZY88	Pyrobaculum aerophilum	O
METAC\|EnsemblGenome=MA_3829\|UniProtKB=Q8TJF6	Methanosarcina acetivorans	O
METAC\|EnsemblGenome=MA_0681\|UniProtKB=Q8TSW4	Methanosarcina acetivorans	O
METJA\|EnsemblGenome=MJ_ECL13\|UniProtKB=Q60275	Methanocaldococcus jannaschii	O
METJA\|EnsemblGenome=MJ_1489\|UniProtKB=Q58884	Methanocaldococcus jannaschii	O
METJA\|EnsemblGenome=MJ_0363\|UniProtKB=Q57809	Methanocaldococcus jannaschii	O
METJA\|EnsemblGenome=MJ_0961\|UniProtKB=Q58371	Methanocaldococcus jannaschii	O
HALSA\|EnsemblGenome=VNG_2181G\|UniProtKB=Q9HNA5	Halobacterium salinarum	O
THEKO\|EnsemblGenome=TK1361\|UniProtKB=Q5JGW1	Thermococcus kodakaraensis	O
THEKO\|EnsemblGenome=TK0096\|UniProtKB=Q5JEJ0	Thermococcus kodakaraensis	O
THEKO\|EnsemblGenome=TK1620\|UniProtKB=Q5JIT1	Thermococcus kodakaraensis	O