PANTHER Gene Information

Gene Symbol(s):

PDGFRB

Organism:

Sus scrofa

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Tree

Gene Name:

Platelet-derived growth factor receptor beta

Gene ID:

ENSSSCG00000022741.4

Protein ID:

F1RL75

Persistent Id:

PTN002400679

Alternate Ids:

F1RL75_PIG(UniProtKB-ID)	F1RL75(Synonym)
ENSSSCT00000015789(Ensembl_TRS)	ENSSSCG00000022741(Ensembl)
ENSSSCP00000015373(Ensembl_PRO)
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PANTHER Classification

PANTHER Family:	TYROSINE-PROTEIN KINASE RECEPTOR (PTHR24416)
PANTHER Subfamily:	PLATELET-DERIVED GROWTH FACTOR RECEPTOR BETA (PTHR24416:SF53)
PANTHER GO-slim Molecular Function:	growth factor binding transmembrane receptor protein tyrosine kinase activity
PANTHER GO-slim Biological Process:	transmembrane receptor protein tyrosine kinase signaling pathway positive regulation of kinase activity angiogenesis positive regulation of cell migration cell chemotaxis
PANTHER GO-slim Cellular Component:	receptor complex plasma membrane
PANTHER protein class:	transmembrane signal receptor

Pathway Categories:

PDGF signaling pathway

Platelet-Derived Growth Factor B

Angiogenesis

Platelet-Derived Growth Factor Receptor

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	placental growth factor receptor activity, GTPase activator activity, macrophage colony-stimulating factor receptor activity, insulin-like growth factor receptor activity, boss receptor activity, hepatocyte growth factor receptor activity, fibroblast growth factor receptor activity, ATP binding, insulin receptor activity, phospholipase C activator activity, protein kinase binding, platelet-derived growth factor receptor binding, stem cell factor receptor activity, brain-derived neurotrophic factor receptor activity, protein tyrosine kinase collagen receptor activity, vascular endothelial growth factor receptor activity, vascular endothelial growth factor binding, GPI-linked ephrin receptor activity, epidermal growth factor receptor activity, platelet-derived growth factor binding, transmembrane-ephrin receptor activity, platelet-derived growth factor beta-receptor activity, platelet-derived growth factor alpha-receptor activity, metal ion binding, histone H2AXY142 kinase activity, histone H3Y41 kinase activity
GO BP Complete:	vascular endothelial growth factor receptor-1 signaling pathway, multicellular organism development, insulin receptor signaling pathway, epidermal growth factor receptor signaling pathway, platelet-derived growth factor receptor-alpha signaling pathway, macrophage colony-stimulating factor signaling pathway, platelet-derived growth factor receptor-beta signaling pathway, insulin-like growth factor receptor signaling pathway, cell surface receptor protein tyrosine kinase signaling pathway, fibroblast growth factor receptor signaling pathway, collagen-activated tyrosine kinase receptor signaling pathway, positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway, cell chemotaxis, hepatocyte growth factor receptor signaling pathway, positive regulation of smooth muscle cell proliferation, positive regulation of calcium-mediated signaling, chromatin remodeling, brain-derived neurotrophic factor receptor signaling pathway, angiogenesis, ephrin receptor signaling pathway, positive regulation of ERK1 and ERK2 cascade, positive regulation of smooth muscle cell migration, Kit signaling pathway, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO CC Complete:	cytoplasmic vesicle, Golgi apparatus, lysosomal lumen, receptor complex, plasma membrane

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

MAPK family signaling cascades, Negative regulation of the PI3K/AKT network, Intracellular signaling by second messengers, Signaling by PDGF, Signaling by Receptor Tyrosine Kinases, Downstream signal transduction, MAPK1/MAPK3 signaling, Signal Transduction, RAF/MAP kinase cascade, PIP3 activates AKT signaling, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

Orthologs

ID	Organism	Type
HUMAN\|HGNC=8804\|UniProtKB=P09619	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000044533.1\|UniProtKB=A0A2I3S8A5	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000007244.3\|UniProtKB=G3QWE1	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000011557.4\|UniProtKB=A0A1D5Q2Y8	Macaca mulatta	LDO
MOUSE\|MGI=MGI=97531\|UniProtKB=P05622	Mus musculus	LDO
RAT\|RGD=3285\|UniProtKB=Q05030	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000002804.7\|UniProtKB=F1N759	Bos taurus	LDO
HORSE\|Ensembl=ENSECAG00000024793.3\|UniProtKB=F6Q748	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000003634.6\|UniProtKB=M3W0P6	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845008241.1\|UniProtKB=A0A8I3N488	Canis lupus familiaris	LDO
CANLF\|Gene=PDGFRB\|UniProtKB=Q6QNF3	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000009737.4\|UniProtKB=F6XAD2	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000002294.4\|UniProtKB=F7AKL5	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010016785.1\|UniProtKB=A0A8V0YZE5	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000015352.4\|UniProtKB=G1KR75	Anolis carolinensis	LDO
XENLA\|Gene=pdgfrb.S\|UniProtKB=A0A1L8GR79	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-6096145\|UniProtKB=A0A6I8SLH0	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000012831.2\|UniProtKB=A0A3B3I4L8	Oryzias latipes	O
ORYLA\|Ensembl=ENSORLG00000004786.2\|UniProtKB=H2LJ41	Oryzias latipes	LDO
DANRE\|Gene=pdgfrb\|UniProtKB=A0A8M9QKL5	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000011097.1\|UniProtKB=W5MZ28	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000003493.3\|UniProtKB=F6TLX0	Ciona intestinalis	O
BRAFL\|Gene=LOC118418363\|UniProtKB=A0A9J7MV71	Branchiostoma floridae	O
BRAFL\|Gene=LOC118403946\|UniProtKB=A0A9J7HIK2	Branchiostoma floridae	O
BRAFL\|Gene=LOC118419709\|UniProtKB=A0A9J7LFS0	Branchiostoma floridae	O
STRPU\|EnsemblGenome=LOC105444281\|UniProtKB=A0A7M7NBJ5	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC105438002\|UniProtKB=A0A7M7NGH8	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC579430\|UniProtKB=A0A7M7NBH9	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC105437797\|UniProtKB=A0A7M7P5W9	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC115918442\|UniProtKB=A0A7M7NFV5	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC575248\|UniProtKB=A0A7M7NGI9	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC105443986\|UniProtKB=A0A7M7NDD9	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC593142\|UniProtKB=A0A7M7PJZ3	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC105445932\|UniProtKB=A0A7M7NC15	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC105444011\|UniProtKB=A0A7M7NDZ4	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC105443826\|UniProtKB=A0A7M7NBR9	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC105439256\|UniProtKB=A0A7M7NFB8	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC100892684\|UniProtKB=A0A7M7NF85	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC115921149\|UniProtKB=A0A7M7NC60	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC105444275\|UniProtKB=A0A7M7ND25	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC590825\|UniProtKB=A0A7M7NBI9	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC100888196\|UniProtKB=A0A7M7LL81	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC100888329\|UniProtKB=A0A7M7P467	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC579837\|UniProtKB=A0A7M7RCU0	Strongylocentrotus purpuratus	O
CAEEL\|WormBase=WBGene00017310\|UniProtKB=A0A2C9C3B4	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG19102\|UniProtKB=A8XUS9	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00103469\|UniProtKB=A0A2A6CRG6	Pristionchus pacificus	O
CAEEL\|WormBase=WBGene00008599\|UniProtKB=Q19238	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG05239\|UniProtKB=A8WZG4	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00107078\|UniProtKB=A0A2A6CZ19	Pristionchus pacificus	O
CAEEL\|WormBase=WBGene00002195\|UniProtKB=F3NWW5	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG22767\|UniProtKB=A8Y2V0	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00276578\|UniProtKB=A0A2A6B4J7	Pristionchus pacificus	O
CAEEL\|WormBase=WBGene00015087\|UniProtKB=Q10915	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG11187\|UniProtKB=A8XCN3	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00304683\|UniProtKB=A0A8R1Z946	Pristionchus pacificus	O
CAEEL\|WormBase=WBGene00011169\|UniProtKB=Q21868	Caenorhabditis elegans	O
CAEEL\|WormBase=WBGene00002199\|UniProtKB=P34891	Caenorhabditis elegans	O
CAEEL\|WormBase=WBGene00011339\|UniProtKB=O18008	Caenorhabditis elegans	O
CAEEL\|WormBase=WBGene00002200\|UniProtKB=P34892	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG04906\|UniProtKB=A8WYS1	Caenorhabditis briggsae	O
CAEBR\|Gene_ORFName=CBG13386\|UniProtKB=A8XHW0	Caenorhabditis briggsae	O
CAEBR\|Gene_ORFName=CBG13385\|UniProtKB=A8XHW1	Caenorhabditis briggsae	O
CAEEL\|WormBase=WBGene00020678\|UniProtKB=A0A1I6CMA1	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG01733\|UniProtKB=A8WQZ3	Caenorhabditis briggsae	O
CAEEL\|WormBase=WBGene00021745\|UniProtKB=Q9N4T2	Caenorhabditis elegans	O
CAEEL\|WormBase=WBGene00003862\|UniProtKB=Q17833	Caenorhabditis elegans	O
CAEEL\|WormBase=WBGene00002211\|UniProtKB=O17955	Caenorhabditis elegans	O
CAEEL\|WormBase=WBGene00003863\|UniProtKB=Q23677	Caenorhabditis elegans	O
CAEEL\|WormBase=WBGene00011168\|UniProtKB=Q21867	Caenorhabditis elegans	O
CAEEL\|WormBase=WBGene00012270\|UniProtKB=Q95ZK1	Caenorhabditis elegans	O
CAEBR\|WormBase=WBGene00027499\|UniProtKB=A8WYS2	Caenorhabditis briggsae	O
CAEBR\|Gene_ORFName=CBG04913\|UniProtKB=A8WYS8	Caenorhabditis briggsae	O
CAEBR\|WormBase=WBGene00027448\|UniProtKB=A8WYM1	Caenorhabditis briggsae	O
CAEBR\|WormBase=WBGene00027500\|UniProtKB=A8WYS3	Caenorhabditis briggsae	O
CAEEL\|WormBase=WBGene00006897\|UniProtKB=Q21041	Caenorhabditis elegans	O
CAEEL\|WormBase=WBGene00006894\|UniProtKB=G5ED65	Caenorhabditis elegans	O
CAEEL\|WormBase=WBGene00006896\|UniProtKB=Q21038	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG17535\|UniProtKB=A8XR68	Caenorhabditis briggsae	O
CAEBR\|Gene_ORFName=CBG17536\|UniProtKB=A8XR69	Caenorhabditis briggsae	O
CAEBR\|Gene_ORFName=CBG17534\|UniProtKB=A8XR67	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00278186\|UniProtKB=A0A2A6B1V3	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00278185\|UniProtKB=A0A2A6B2E3	Pristionchus pacificus	O
DROME\|FlyBase=FBgn0032006\|UniProtKB=E1JHB7	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP008813\|UniProtKB=A0A1S4GZA9	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC007584\|UniProtKB=A0A139WIY2	Tribolium castaneum	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_58385\|UniProtKB=E9H5T6	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_305264\|UniProtKB=E9GQ40	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_48616\|UniProtKB=E9GD08	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_4284\|UniProtKB=E9GD15	Daphnia pulex	O
DAPPU\|Gene_ORFName=DAPPUDRAFT_44144\|UniProtKB=E9FZB6	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_43719\|UniProtKB=E9FZF2	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_308023\|UniProtKB=E9H5G0	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_114299\|UniProtKB=E9HHQ5	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_130278\|UniProtKB=E9HM17	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_110024\|UniProtKB=E9H4Z3	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_325477\|UniProtKB=E9H4U6	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_331276\|UniProtKB=E9HLZ6	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_110251\|UniProtKB=E9H5G3	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_61463\|UniProtKB=E9HD20	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_119760\|UniProtKB=E9HZE7	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_302458\|UniProtKB=E9HNF0	Daphnia pulex	O
DAPPU\|Gene_ORFName=DAPPUDRAFT_48631\|UniProtKB=E9GCS3	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_108386\|UniProtKB=E9H018	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_53509\|UniProtKB=E9GQD0	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_308030\|UniProtKB=E9H5J0	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_253800\|UniProtKB=E9H5G1	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_58353\|UniProtKB=E9H5T9	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_64428\|UniProtKB=E9HNF3	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_302459\|UniProtKB=E9HNF4	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_130102\|UniProtKB=E9HGU7	Daphnia pulex	O
IXOSC\|EnsemblGenome=ISCW005359\|UniProtKB=B7PKS1	Ixodes scapularis	O
HELRO\|EnsemblGenome=HelroG133386\|UniProtKB=T1EI07	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG170959\|UniProtKB=T1F3M5	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG75629\|UniProtKB=T1G278	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG141355\|UniProtKB=T1EJ33	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG89500\|UniProtKB=T1G7D9	helobdella robusta	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g94990\|UniProtKB=A7RVU0	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g115371\|UniProtKB=A7SEI8	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g94997\|UniProtKB=A7RVT8	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g87486\|UniProtKB=A7RN88	Nematostella vectensis	O
NEMVE\|Gene_ORFName=NEMVEDRAFT_v1g87445\|UniProtKB=A7RN91	Nematostella vectensis	O
TRIAD\|EnsemblGenome=TriadG50752\|UniProtKB=B3S5N3	Trichoplax adhaerens	O
TRIAD\|EnsemblGenome=TriadG25090\|UniProtKB=B3RWV1	Trichoplax adhaerens	O
MONBE\|EnsemblGenome=MONBRDRAFT_30176\|UniProtKB=A9VD80	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_2692\|UniProtKB=A9UPY9	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_27311\|UniProtKB=A9V4X6	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_34526\|UniProtKB=A9VCA3	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_33842\|UniProtKB=A9V7V7	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_33860\|UniProtKB=A9V7Z4	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_44299\|UniProtKB=A9V2D0	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_44298\|UniProtKB=A9UWK2	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_27155\|UniProtKB=A9V4G9	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_16001\|UniProtKB=A9UW70	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_27552\|UniProtKB=A9V5L8	Monosiga brevicollis	O