PANTHER Gene Information   
Gene Symbol(s): Pdgfrb
Organism: Rattus norvegicus
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Gene Name: Platelet-derived growth factor receptor beta
Gene ID: 3285
Protein ID: Q05030
Persistent Id: PTN000699197
Alternate Ids:
Pdgfrb(Symbol) 56870(GI)
24629(GeneID) AF359356(EMBL)
PGFRB_RAT(UniProtKB-ID) CD140 antigen-like family member B(Synonym)
XP_006254851(refSeq) Q925F7(AltAccession)
CHEMBL4125(ChEMBL) CAA78489(EMBL-CDS)
3285(RGD) 2.7.10.1(EC)
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PANTHER Classification
PANTHER Family: TYROSINE-PROTEIN KINASE RECEPTOR (PTHR24416)
PANTHER Subfamily: PLATELET-DERIVED GROWTH FACTOR RECEPTOR BETA (PTHR24416:SF53)  
PANTHER GO-slim Molecular Function: growth factor binding
transmembrane receptor protein tyrosine kinase activity
PANTHER GO-slim Biological Process: transmembrane receptor protein tyrosine kinase signaling pathway
positive regulation of kinase activity
angiogenesis
positive regulation of cell migration
cell chemotaxis
PANTHER GO-slim Cellular Component: receptor complex
plasma membrane
PANTHER protein class: transmembrane signal receptor
Pathway Categories: PDGF signaling pathway
   Platelet-Derived Growth Factor B
Angiogenesis
   Platelet-Derived Growth Factor Receptor
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: placental growth factor receptor activity, phosphatidylinositol 3-kinase binding, GTPase activator activity, macrophage colony-stimulating factor receptor activity, insulin-like growth factor receptor activity, boss receptor activity, platelet-derived growth factor receptor activity, hepatocyte growth factor receptor activity, fibroblast growth factor receptor activity, ATP binding, protein tyrosine kinase activity, insulin receptor activity, phospholipase C activator activity, protein kinase binding, platelet-derived growth factor receptor binding, stem cell factor receptor activity, brain-derived neurotrophic factor receptor activity, protein tyrosine kinase collagen receptor activity, vascular endothelial growth factor receptor activity, protein kinase activity, vascular endothelial growth factor binding, GPI-linked ephrin receptor activity, signaling receptor binding, epidermal growth factor receptor activity, platelet-derived growth factor binding, transmembrane-ephrin receptor activity, platelet-derived growth factor beta-receptor activity, platelet-derived growth factor alpha-receptor activity, protein binding, metal ion binding, histone H2AXY142 kinase activity, kinase activity, histone H3Y41 kinase activity, enzyme binding
GO BP Complete: response to hyperoxia, retina vasculature development in camera-type eye, peptidyl-tyrosine phosphorylation, cell migration involved in vasculogenesis, response to estrogen, inner ear development, male gonad development, epidermal growth factor receptor signaling pathway, fibroblast growth factor receptor signaling pathway, protein autophosphorylation, animal organ development, positive regulation of mitotic nuclear division, response to toxic substance, cell chemotaxis, response to retinoic acid, metanephric glomerular mesangial cell proliferation involved in metanephros development, positive regulation of collagen biosynthetic process, response to ceramide, in utero embryonic development, kidney development, metanephric glomerular mesangium development, cardiac myofibril assembly, intracellular signal transduction, Kit signaling pathway, positive regulation of hepatic stellate cell activation, positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway, vascular endothelial growth factor receptor-1 signaling pathway, platelet-derived growth factor receptor-alpha signaling pathway, cellular response to platelet-derived growth factor stimulus, macrophage colony-stimulating factor signaling pathway, platelet-derived growth factor receptor-beta signaling pathway, insulin-like growth factor receptor signaling pathway, lung growth, platelet-derived growth factor receptor signaling pathway, embryonic organ development, response to organic cyclic compound, collagen-activated tyrosine kinase receptor signaling pathway, response to hydrogen peroxide, hepatocyte growth factor receptor signaling pathway, brain-derived neurotrophic factor receptor signaling pathway, aorta morphogenesis, regulation of actin cytoskeleton organization, ruffle assembly, system development, cellular response to growth factor stimulus, ephrin receptor signaling pathway, response to estradiol, metanephric mesenchymal cell migration, positive regulation of chemotaxis, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of cell migration, positive regulation of MAP kinase activity, cell migration involved in coronary angiogenesis, positive regulation of Rho protein signal transduction, multicellular organism development, insulin receptor signaling pathway, positive regulation of cell population proliferation, glycosaminoglycan biosynthetic process, positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway, positive regulation of smooth muscle cell proliferation, positive regulation of calcium-mediated signaling, chemotaxis, regulation of peptidyl-tyrosine phosphorylation, smooth muscle cell chemotaxis, chromatin remodeling, metanephric S-shaped body morphogenesis, blood vessel development, angiogenesis, positive regulation of fibroblast proliferation, response to lipid, positive regulation of smooth muscle cell migration, cellular response to hydrogen peroxide, response to fluid shear stress, positive regulation of DNA biosynthetic process, adrenal gland development, positive regulation of reactive oxygen species metabolic process, signal transduction, cell surface receptor protein tyrosine kinase signaling pathway, smooth muscle tissue development, skeletal system morphogenesis, positive regulation of calcium ion import, tissue homeostasis, metanephric glomerulus morphogenesis, metanephric mesenchyme development, metanephric comma-shaped body morphogenesis, negative regulation of apoptotic process, metanephric glomerular capillary formation, positive regulation of apoptotic process, positive regulation of ERK1 and ERK2 cascade
GO CC Complete: nucleus, cytoplasm, intracellular membrane-bounded organelle, membrane, ruffle, cytoplasmic vesicle, Golgi apparatus, lysosomal lumen, receptor complex, plasma membrane, apical plasma membrane, cell surface
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: Signaling by PDGF, MAPK1/MAPK3 signaling, Downstream signal transduction, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, Negative regulation of the PI3K/AKT network, MAPK family signaling cascades, Signaling by Receptor Tyrosine Kinases, Intracellular signaling by second messengers, Signal Transduction, RAF/MAP kinase cascade, PIP3 activates AKT signaling

Orthologs