PANTHER Gene Information   
Gene Symbol(s): Actg1
Organism: Rattus norvegicus
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Gene Name: Actin, cytoplasmic 2
Gene ID: 1304556
Protein ID: P63259
Persistent Id: PTN000233338
Alternate Ids:
ACTG_RAT(UniProtKB-ID) 287876(GeneID)
NM_001127449(refSeq) P99022(AltAccession)
188536082(GI) 3.6.4.- {ECO:0000250|UniProtKB:P68137}(EC)
X52815(EMBL) ENSRNOG00000036701(Ensembl)
ENSRNOT00000108494(Ensembl_TRS) CAA36999(EMBL-CDS)
Actg(Synonym) Actg1(Symbol)
ENSRNOP00000096150(Ensembl_PRO) 1304556(RGD)
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PANTHER Classification
PANTHER Family: ACTIN (PTHR11937)
PANTHER Subfamily: ACTIN, CYTOPLASMIC 1 (PTHR11937:SF414)  
PANTHER GO-slim Molecular Function: structural constituent of cytoskeleton
nucleosome binding
protein kinase binding
chromatin DNA binding
PANTHER GO-slim Biological Process: cell motility
axonogenesis
chromatin remodeling
PANTHER GO-slim Cellular Component: NuA4 histone acetyltransferase complex
actin filament
axon
synapse
cytoplasm
membrane
PANTHER protein class: actin and actin related protein
Pathway Categories: Cadherin signaling pathway
   Filamentous F-actin
Alzheimer disease-presenilin pathway
   actin
Inflammation mediated by chemokine and cytokine signaling pathway
   F-actin
Wnt signaling pathway
   NFAT Target Genes
Nicotinic acetylcholine receptor signaling pathway
   Actin
Huntington disease
   Actin
Integrin signalling pathway
   Actin
Cytoskeletal regulation by Rho GTPase
   Actin

GO MF Complete: ATP binding, protein kinase binding, identical protein binding, ubiquitin protein ligase binding, structural constituent of postsynaptic actin cytoskeleton, structural constituent of cytoskeleton, profilin binding, hydrolase activity
GO BP Complete: positive regulation of wound healing, protein localization to bicellular tight junction, regulation of synaptic vesicle endocytosis, sarcomere organization, regulation of stress fiber assembly, regulation of transepithelial transport, response to mechanical stimulus, cell motility, regulation of focal adhesion assembly, angiogenesis, axonogenesis, positive regulation of gene expression, response to calcium ion, postsynaptic actin cytoskeleton organization, morphogenesis of a polarized epithelium, tight junction assembly, cellular response to type II interferon, platelet aggregation, positive regulation of cell migration
GO CC Complete: NuA4 histone acetyltransferase complex, phagocytic vesicle, synapse, actin filament, presynaptic actin cytoskeleton, plasma membrane, calyx of Held, Schaffer collateral - CA1 synapse, cytoskeleton, cell-cell junction, extracellular exosome, postsynaptic actin cytoskeleton, focal adhesion, apical part of cell, cytoplasm, dense body, membrane, apical junction complex, actin cytoskeleton, cytosol, filamentous actin, axon, myofibril, basal body patch
Reactome Pathways: Recycling pathway of L1, L1CAM interactions, VEGFA-VEGFR2 Pathway, MAPK family signaling cascades, Hemostasis, RHO GTPases activate IQGAPs, Gap junction trafficking, Cell-cell junction organization, RHO GTPase cycle, Fcgamma receptor (FCGR) dependent phagocytosis, Cell-extracellular matrix interactions, Adherens junctions interactions, EPHB-mediated forward signaling, Regulation of actin dynamics for phagocytic cup formation, MAP2K and MAPK activation, Platelet activation, signaling and aggregation, Signaling by VEGF, Signaling by Receptor Tyrosine Kinases, RHOF GTPase cycle, Innate Immune System, Vesicle-mediated transport, Developmental Biology, RHOBTB GTPase Cycle, MAPK1/MAPK3 signaling, Gap junction degradation, Nervous system development, RHO GTPases Activate WASPs and WAVEs, Platelet degranulation , Signaling by Rho GTPases, Response to elevated platelet cytosolic Ca2+, Signal Transduction, RAF/MAP kinase cascade, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Gap junction trafficking and regulation, Interaction between L1 and Ankyrins, RHOBTB2 GTPase cycle, Axon guidance, EPH-Ephrin signaling, Formation of annular gap junctions, RHO GTPase Effectors, Immune System, RHO GTPases Activate Formins, Cell-Cell communication, Cell junction organization, Membrane Trafficking, Clathrin-mediated endocytosis