PANTHER Gene Information   
Gene Symbol(s): Mbd2
Organism: Rattus norvegicus
View Gene in Tree
Tree Reduced Tree  
Tree Reduced Tree
Gene Name: Methyl-CpG binding domain protein 2
Gene ID: 1595452
Protein ID: D4A986
Persistent Id: PTN001391278
Alternate Ids:
ENSRNOT00000016112(Ensembl_TRS) ENSRNOP00000016112(Ensembl_PRO)
ENSRNOG00000011853(Ensembl) D4A986(Synonym)
D4A986_RAT(UniProtKB-ID) 1595452(RGD)
Show All

PANTHER Classification
PANTHER Family: METHYL-CPG BINDING PROTEIN, MBD (PTHR12396)
PANTHER Subfamily: METHYL-CPG-BINDING DOMAIN PROTEIN 2 (PTHR12396:SF5)  
PANTHER GO-slim Molecular Function: nucleotide binding
sequence-specific DNA binding
PANTHER GO-slim Biological Process: negative regulation of transcription by RNA polymerase II
DNA methylation-dependent heterochromatin formation
PANTHER GO-slim Cellular Component: nucleus
PANTHER protein class: chromatin/chromatin-binding, or -regulatory protein
Pathway Categories: No pathway information available
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: DNA binding, protein domain specific binding, identical protein binding, siRNA binding, C2H2 zinc finger domain binding, mRNA binding, chromatin binding, methyl-CpG binding, molecular adaptor activity
GO BP Complete: protein-containing complex assembly, embryonic organ development, response to organic cyclic compound, epigenetic regulation of gene expression, regulation of cell population proliferation, DNA methylation-dependent constitutive heterochromatin formation, response to mechanical stimulus, maternal behavior, negative regulation of transcription by RNA polymerase II, chromatin remodeling, ventricular cardiac muscle tissue development, response to estradiol, Wnt signaling pathway, positive regulation of Wnt signaling pathway, response to nutrient levels, cellular response to organic cyclic compound
GO CC Complete: heterochromatin, nucleus, cytoplasm, NuRD complex, histone deacetylase complex, cytosol, chromatin, nucleoplasm
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: RNA Polymerase I Promoter Clearance, RNA Polymerase I Transcription, NoRC negatively regulates rRNA expression, Epigenetic regulation of gene expression, RNA Polymerase I Promoter Opening, Negative epigenetic regulation of rRNA expression, Gene expression (Transcription)

Orthologs