PANTHER Gene Information

Gene Symbol(s):

TYMS

Organism:

Homo sapiens

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Gene Name:

Thymidylate synthase

Gene ID:

HGNC:12441

Protein ID:

P04818

Enhancers:

View enhancers for HUMAN|HGNC=12441|UniProtKB=P04818

Genetic Variant Annotation:

Annoq

Persistent Id:

PTN002480093

Alternate Ids:

TYSY(Synonym)	848130331(GI)
BC002567(EMBL)	TYMS{ECO:0000312\|HGNC:HGNC:12441}(Symbol)
TYSY_HUMAN(UniProtKB-ID)	620040(MIM)
CHEMBL1952(ChEMBL)	Q8WYK4(AltAccession)
2.1.1.45 {ECO:0000269\|PubMed:11278511}(EC)	MetaCyc:HS11096-MON(BioCyc)
ENSG00000176890(Ensembl)	AAH83512(EMBL-CDS)
HGNC:12441(HGNC)	7298(GeneID)
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PANTHER Classification

PANTHER Family:	THYMIDYLATE SYNTHASE 1 (PTHR11548)
PANTHER Subfamily:	THYMIDYLATE SYNTHASE (PTHR11548:SF2)
PANTHER GO-slim Molecular Function:	methyltransferase activity
PANTHER GO-slim Biological Process:	pyrimidine nucleotide metabolic process nucleoside monophosphate metabolic process carbohydrate derivative biosynthetic process organonitrogen compound biosynthetic process nucleotide biosynthetic process
PANTHER GO-slim Cellular Component:	cytosol mitochondrion
PANTHER protein class:	methyltransferase

Pathway Categories:

Tetrahydrofolate biosynthesis

Dihydrofolate synthase

Formyltetrahydrofolate biosynthesis

Dihydrofolate reductase

De novo pyrimidine deoxyribonucleotide biosynthesis

Thymidylate synthase

Tetrahydrofolate biosynthesis

Dihydrofolate reductase

Formyltetrahydrofolate biosynthesis

Thymidylate synthase

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	thymidylate synthase activity, protein homodimerization activity, mRNA regulatory element binding translation repressor activity, sequence-specific mRNA binding, folic acid binding
GO BP Complete:	response to cytokine, intestinal epithelial cell maturation, response to progesterone, dTMP biosynthetic process, response to xenobiotic stimulus, developmental growth, circadian rhythm, response to toxic substance, dTTP biosynthetic process, response to ethanol, liver regeneration, response to organophosphorus, response to glucocorticoid, response to folic acid, DNA biosynthetic process, uracil metabolic process, tetrahydrofolate interconversion, response to vitamin A, negative regulation of translation, methylation, cartilage development
GO CC Complete:	nucleus, cytoplasm, mitochondrial matrix, mitochondrion, cytosol, mitochondrial inner membrane

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Metabolism of nucleotides, Metabolism, Mitotic G1 phase and G1/S transition, Cell Cycle, Mitotic, Cell Cycle, Interconversion of nucleotide di- and triphosphates, G1/S Transition, G1/S-Specific Transcription

Orthologs

ID	Organism	Type
PANTR\|Ensembl=ENSPTRG00000009822.5\|UniProtKB=H2QE68	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000014000.3\|UniProtKB=G3SAP3	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000004046.4\|UniProtKB=F6ZR77	Macaca mulatta	LDO
MOUSE\|MGI=MGI=98878\|UniProtKB=P07607	Mus musculus	LDO
RAT\|RGD=3921\|UniProtKB=P45352	Rattus norvegicus	LDO
BOVIN\|Gene=TYMS\|UniProtKB=Q2TA32	Bos taurus	O
BOVIN\|Ensembl=ENSBTAG00000053268.1\|UniProtKB=A0A3Q1NID0	Bos taurus	O
BOVIN\|Ensembl=ENSBTAG00000007003.5\|UniProtKB=F1MY63	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000040678.3\|UniProtKB=A0A287AFN2	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000023203.4\|UniProtKB=A0A9L0T6Q2	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000009230.5\|UniProtKB=M3WB14	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845001914.1\|UniProtKB=A0A8I3MMV4	Canis lupus familiaris	LDO
ORNAN\|Ensembl=ENSOANG00000044424.1\|UniProtKB=A0A6I8NBI6	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010003884.1\|UniProtKB=A0A8V0XB09	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000008456.4\|UniProtKB=G1KHU7	Anolis carolinensis	LDO
XENLA\|Gene=tyms.L\|UniProtKB=A1L2V6	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-1001385\|UniProtKB=Q0IHX3	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000011063.2\|UniProtKB=H2M5Y9	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-040426-59\|UniProtKB=Q6P045	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000010997.1\|UniProtKB=W5MYN1	lepisosteus oculatus	LDO
BRAFL\|Gene=LOC118409720\|UniProtKB=A0A9J7KMW3	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=LOC593137\|UniProtKB=A0A7M7P3M0	Strongylocentrotus purpuratus	LDO
CAEEL\|WormBase=WBGene00022455\|UniProtKB=Q9N588	Caenorhabditis elegans	LDO
CAEBR\|WormBase=WBGene00039295\|UniProtKB=A8XXD3	Caenorhabditis briggsae	LDO
PRIPA\|EnsemblGenome=WBGene00097987\|UniProtKB=A0A2A6B4T4	Pristionchus pacificus	LDO
DROME\|FlyBase=FBgn0024920\|UniProtKB=O76511	Drosophila melanogaster	LDO
ANOGA\|EnsemblGenome=AGAP010457\|UniProtKB=Q7QDW7	Anopheles gambiae	LDO
TRICA\|EnsemblGenome=TC004238\|UniProtKB=D7EIA1	Tribolium castaneum	O
TRICA\|EnsemblGenome=TC007732\|UniProtKB=D2A1S6	Tribolium castaneum	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_319193\|UniProtKB=E9GKZ1	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_304293\|UniProtKB=E9GKZ0	Daphnia pulex	LDO
IXOSC\|EnsemblGenome=ISCW024938\|UniProtKB=B7QMU1	Ixodes scapularis	O
IXOSC\|EnsemblGenome=ISCW014062\|UniProtKB=B7QLC8	Ixodes scapularis	O
IXOSC\|EnsemblGenome=ISCW000960\|UniProtKB=B7P7E2	Ixodes scapularis	LDO
HELRO\|EnsemblGenome=HelroG87612\|UniProtKB=T1G6T0	helobdella robusta	LDO
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g227987\|UniProtKB=A7RH38	Nematostella vectensis	LDO
TRIAD\|EnsemblGenome=TriadG18453\|UniProtKB=B3RLB4	Trichoplax adhaerens	LDO
MONBE\|EnsemblGenome=MONBRDRAFT_32402\|UniProtKB=A9UZA9	Monosiga brevicollis	LDO
YEAST\|SGD=S000005600\|UniProtKB=P06785	Saccharomyces cerevisiae	LDO
EREGS\|EnsemblGenome=AGOS_ADR219C\|UniProtKB=Q759Q4	Eremothecium gossypii	LDO
CANAL\|CGD=CAL0000189182\|UniProtKB=P12461	Candida albicans	LDO
YARLI\|EnsemblGenome=YALI0_C10901g\|UniProtKB=Q6CCB3	Yarrowia lipolytica	LDO
EMENI\|EnsemblGenome=ANIA_07028\|UniProtKB=C8VB77	Emericella nidulans	LDO
ASPFU\|EnsemblGenome=AFUA_4G04270\|UniProtKB=Q4W9N9	Neosartorya fumigata	LDO
NEUCR\|EnsemblGenome=NCU10053\|UniProtKB=Q7S072	Neurospora crassa	LDO
SCLS1\|EnsemblGenome=SS1G_08456\|UniProtKB=A7ET01	Sclerotinia sclerotiorum	LDO
PHANO\|EnsemblGenome=SNOG_12584\|UniProtKB=Q0U6N0	Phaeosphaeria nodorum	LDO
SCHPO\|PomBase=SPAC15E1.04\|UniProtKB=Q9UTI7	Schizosaccharomyces pombe	LDO
SCHJY\|EnsemblGenome=SJAG_04627\|UniProtKB=B6K7B9	Schizosaccharomyces japonicus	LDO
CRYNJ\|EnsemblGenome=CNJ01230\|UniProtKB=P0CS12	Cryptococcus neoformans	LDO
USTMA\|EnsemblGenome=UMAG_02407\|UniProtKB=A0A0D1E1R6	Ustilago maydis	LDO
PUCGT\|EnsemblGenome=PGTG_15305\|UniProtKB=E3KYR7	Puccinia graminis	LDO
BATDJ\|Gene_ORFName=BATDEDRAFT_10605\|UniProtKB=F4P0R5	Batrachochytrium dendrobatidis	LDO
LEIMA\|EnsemblGenome=LMJF_06_0860\|UniProtKB=P07382	Leishmania major	LDO
TRYB2\|Gene_ORFName=Tb927.7.5480\|UniProtKB=Q582G3	Trypanosoma brucei	LDO
PLAF7\|EnsemblGenome=PF3D7_0417200\|UniProtKB=Q8I1R6	Plasmodium falciparum	LDO
PARTE\|EnsemblGenome=GSPATT00019973001\|UniProtKB=Q27828	Paramecium tetraurelia	LDO
THAPS\|EnsemblGenome=THAPS_13647\|UniProtKB=B5YMV7	Thalassiosira pseudonana	LDO
PHYRM\|Gene=H3GWN7_PHYRM\|UniProtKB=H3GWN7	Phytophthora ramorum	LDO
CHLRE\|EnsemblGenome=CHLRE_17g715900v5\|UniProtKB=A0A2K3CPY4	Chlamydomonas reinhardtii	LDO
AMBTC\|EnsemblGenome=AMTR_s00014p00122790\|UniProtKB=W1PPK0	Amborella trichopoda	LDO
ZOSMR\|Gene_ORFName=ZOSMA_5G02610\|UniProtKB=A0A0K9NUT2	Zostera marina	LDO
MUSAM\|EnsemblGenome=Ma02_g16110\|UniProtKB=A0A804I3E0	Musa acuminata subsp. malaccensis	LDO
SETIT\|EnsemblGenome=SETIT_026222mg\|UniProtKB=K3ZI20	Setaria italica	O
SETIT\|EnsemblGenome=SETIT_029497mg\|UniProtKB=K3ZSB7	Setaria italica	LDO
SORBI\|EnsemblGenome=SORBI_3005G115500\|UniProtKB=A0A1B6PRT5	Sorghum bicolor	LDO
MAIZE\|Gene=DRTS\|UniProtKB=O81395	Zea mays	O
MAIZE\|EnsemblGenome=Zm00001eb169580\|UniProtKB=A0A1D6PSY9	Zea mays	O
MAIZE\|EnsemblGenome=Zm00001eb112740\|UniProtKB=A0A1D6F5H8	Zea mays	LDO
ORYSJ\|Gene_OrderedLocusName=LOC_Os12g26060\|UniProtKB=Q2QRX6	Oryza sativa	O
BRADI\|EnsemblGenome=BRADI_4g07810v3\|UniProtKB=A0A0Q3HES9	Brachypodium distachyon	O
HORVV\|EnsemblGenome=HORVU.MOREX.r3.2HG0205550\|UniProtKB=F2DUZ4	Hordeum vulgare subsp. vulgare	O
WHEAT\|EnsemblGenome=TraesCS2D02G520000\|UniProtKB=A0A3B6DPV5	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS2A02G518600\|UniProtKB=A0A3B6B884	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS2B02G547000\|UniProtKB=A0A3B6CEZ9	Triticum aestivum	O
ORYSJ\|EnsemblGenome=Os11g0484400\|UniProtKB=Q2R481	Oryza sativa	LDO
NELNU\|Gene=LOC104595633\|UniProtKB=A0A1U8A108	Nelumbo nucifera	LDO
SPIOL\|Gene=LOC110803064\|UniProtKB=A0A9R0KB06	Spinacia oleracea	LDO
HELAN\|EnsemblGenome=HanXRQr2_Chr13g0619231\|UniProtKB=A0A251SYK8	Helianthus annuus	O
HELAN\|EnsemblGenome=HanXRQr2_Chr03g0109521\|UniProtKB=A0A251V7L6	Helianthus annuus	LDO
LACSA\|Gene_ORFName=LSAT_V11C900499360\|UniProtKB=A0A9R1WW08	Lactuca sativa	O
LACSA\|Gene_ORFName=LSAT_V11C400194360\|UniProtKB=A0A9R1XF14	Lactuca sativa	LDO
ERYGU\|Gene_ORFName=MIMGU_mgv1a004601mg\|UniProtKB=A0A022R1Q8	Erythranthe guttata	LDO
CAPAN\|EnsemblGenome=T459_00605\|UniProtKB=A0A1U8DXM1	Capsicum annuum	LDO
SOLTU\|EnsemblGenome=PGSC0003DMG400000736\|UniProtKB=M0ZJD1	Solanum tuberosum	LDO
SOLLC\|EnsemblGenome=Solyc01g109830.3\|UniProtKB=A0A3Q7EUX7	Solanum lycopersicum	LDO
TOBAC\|Gene=LOC107794251\|UniProtKB=A0A1S4A6M3	Nicotiana tabacum	O
TOBAC\|Gene=LOC107792811\|UniProtKB=A0A1S4A1Q9	Nicotiana tabacum	LDO
VITVI\|Gene_OrderedLocusName=VIT_18s0001g12940\|UniProtKB=F6H1I8	Vitis vinifera	O
EUCGR\|EnsemblGenome=EUGRSUZ_F01594\|UniProtKB=A0A059BPA9	Eucalyptus grandis	O
JUGRE\|EnsemblGenome=Jr11_20980\|UniProtKB=A0A2I4ENY3	Juglans regia	O
JUGRE\|Gene=LOC108991352\|UniProtKB=A0A6P9ERY0	Juglans regia	O
VITVI\|EnsemblGenome=Vitvi03g04109\|UniProtKB=F6I0M2	Vitis vinifera	LDO
EUCGR\|EnsemblGenome=EUGRSUZ_A01332\|UniProtKB=A0A059DFL3	Eucalyptus grandis	O
EUCGR\|EnsemblGenome=EUGRSUZ_G01624\|UniProtKB=A0A059BCN4	Eucalyptus grandis	LDO
BRANA\|Gene_ORFName=GSBRNA2T00015870001\|UniProtKB=A0A078G7S1	Brassica napus	O
BRACM\|EnsemblGenome=Bra000581\|UniProtKB=M4C8Q3	Brassica campestris	O
ARATH\|TAIR=locus=2049389\|UniProtKB=Q9SIK4	Arabidopsis thaliana	O
BRACM\|EnsemblGenome=Bra013079\|UniProtKB=M4D9B9	Brassica campestris	LDO
BRACM\|EnsemblGenome=Bra011543\|UniProtKB=M4D4Y6	Brassica campestris	LDO
ARATH\|TAIR=locus=2042649\|UniProtKB=Q05762	Arabidopsis thaliana	LDO
BRANA\|Gene_ORFName=GSBRNA2T00081771001\|UniProtKB=A0A078I5G1	Brassica napus	O
BRACM\|EnsemblGenome=Bra017662\|UniProtKB=M4DMC9	Brassica campestris	O
ARATH\|TAIR=locus=2139544\|UniProtKB=Q05763	Arabidopsis thaliana	O
GOSHI\|Gene=LOC107908795\|UniProtKB=A0A1U8JTF5	Gossypium hirsutum	O
GOSHI\|Gene=LOC107928896\|UniProtKB=A0A1U8LR30	Gossypium hirsutum	O
GOSHI\|Gene=LOC107927990\|UniProtKB=A0A1U8LJ43	Gossypium hirsutum	O
GOSHI\|Gene=LOC107937003\|UniProtKB=A0A1U8MEM0	Gossypium hirsutum	LDO
THECC\|EnsemblGenome=TCM_006844\|UniProtKB=A0A061E0T8	Theobroma cacao	LDO
CITSI\|Gene_ORFName=CISIN_1g009747mg\|UniProtKB=A0A067E213	Citrus sinensis	LDO
POPTR\|EnsemblGenome=POPTR_009G119200v3\|UniProtKB=B9HRK6	Populus trichocarpa	O
POPTR\|EnsemblGenome=POPTR_004G157400v3\|UniProtKB=A0A2K2AVA6	Populus trichocarpa	LDO
MANES\|EnsemblGenome=MANES_04G073700\|UniProtKB=A0A2C9W2M5	Manihot esculenta	O
MANES\|EnsemblGenome=MANES_11G084400\|UniProtKB=A0A2C9UZN7	Manihot esculenta	LDO
RICCO\|Gene_ORFName=RCOM_1595270\|UniProtKB=B9R7Y4	Ricinus communis	O
RICCO\|Gene_ORFName=RCOM_1447960\|UniProtKB=B9RH79	Ricinus communis	LDO
SOYBN\|EnsemblGenome=GLYMA_12G041000\|UniProtKB=I1LQ11	Glycine max	LDO
SOYBN\|EnsemblGenome=GLYMA_06G010600\|UniProtKB=I1K754	Glycine max	O
SOYBN\|Gene=DRTS_SOYBN\|UniProtKB=P51820	Glycine max	O
SOYBN\|EnsemblGenome=GLYMA_04G010800\|UniProtKB=K7KHI6	Glycine max	O
SOYBN\|EnsemblGenome=GLYMA_11G115200\|UniProtKB=A0A0R0HFN7	Glycine max	O
MEDTR\|EnsemblGenome=MTR_6g015630\|UniProtKB=A0A072UH24	Medicago truncatula	O
MEDTR\|EnsemblGenome=MTR_3g117080\|UniProtKB=G7J765	Medicago truncatula	O
MEDTR\|EnsemblGenome=MTR_4g070670\|UniProtKB=G7JHF2	Medicago truncatula	LDO
JUGRE\|EnsemblGenome=Jr13_07690\|UniProtKB=A0A2I4E7I6	Juglans regia	O
JUGRE\|EnsemblGenome=Jr16_17840\|UniProtKB=A0A2I4DTY5	Juglans regia	LDO
CUCSA\|EnsemblGenome=Csa_2G248730\|UniProtKB=A0A0A0LPA5	Cucumis sativus	LDO
PRUPE\|EnsemblGenome=PRUPE_8G092500\|UniProtKB=A0A251MVI5	Prunus persica	LDO
SELML\|EnsemblGenome=SELMODRAFT_404548\|UniProtKB=D8QVP4	Selaginella moellendorffii	O
SELML\|EnsemblGenome=SELMODRAFT_233517\|UniProtKB=D8SA97	Selaginella moellendorffii	LDO
PHYPA\|EnsemblGenome=Pp3c14_22050\|UniProtKB=A0A2K1JJE8	Physcomitrella patens	LDO
MARPO\|EnsemblGenome=MARPO_0082s0036\|UniProtKB=A0A2R6WJZ5	Marchantia polymorpha	LDO
KLENI\|Gene_ORFName=KFL_000430150\|UniProtKB=A0A1Y1HPI3	Klebsormidium nitens	LDO
METAC\|EnsemblGenome=MA_4543\|UniProtKB=Q8THH4	Methanosarcina acetivorans	O
METJA\|EnsemblGenome=MJ_0511\|UniProtKB=Q57931	Methanocaldococcus jannaschii	O
STRR6\|EnsemblGenome=spr0585\|UniProtKB=P67050	Streptococcus pneumoniae	O
BACSU\|EnsemblGenome=BSU_17680\|UniProtKB=P0CI79	Bacillus subtilis	O
FUSNN\|EnsemblGenome=FN0240\|UniProtKB=Q8RGP6	Fusobacterium nucleatum	O
MYCTU\|Gene_OrderedLocusName=Rv2764c\|UniProtKB=P9WFR9	Mycobacterium tuberculosis	O
MYCGE\|EnsemblGenome=MG_227\|UniProtKB=P47469	mycoplasma genitalium	O
CLOBH\|Gene_OrderedLocusName=CBO0768\|UniProtKB=A5HZW1	Clostridium botulinum	O
STAA8\|EnsemblGenome=SAOUHSC_01435\|UniProtKB=Q2FYK5	Staphylococcus aureus	O
LISMO\|EnsemblGenome=CAC99952\|UniProtKB=Q8Y626	Listeria monocytogenes	O
BACSU\|EnsemblGenome=BSU_21820\|UniProtKB=P11044	Bacillus subtilis	O
BACCR\|EnsemblGenome=BC_2191\|UniProtKB=Q81E05	Bacillus cereus	O
DEIRA\|EnsemblGenome=DR_2630\|UniProtKB=Q9RR67	Deinococcus radiodurans	O
BACTN\|EnsemblGenome=BT_2047\|UniProtKB=Q8A639	Bacteroides thetaiotaomicron	O
RHOBA\|EnsemblGenome=RB12614\|UniProtKB=Q7UID0	Rhodopirellula baltica	O
NEIMB\|EnsemblGenome=NMB1709\|UniProtKB=Q9JY72	Neisseria meningitidis serogroup b	O
BRADU\|EnsemblGenome=BAC51777\|UniProtKB=Q89G35	Bradyrhizobium diazoefficiens	O
COXBU\|EnsemblGenome=CBU_1547\|UniProtKB=Q83BG2	Coxiella burnetii	O
HAEIN\|EnsemblGenome=HI_0905\|UniProtKB=P44420	Haemophilus influenzae	O
SHEON\|Gene_OrderedLocusName=SO_1335\|UniProtKB=Q8EH94	Shewanella oneidensis	O
VIBCH\|EnsemblGenome=VC_0675\|UniProtKB=O66108	Vibrio cholerae	O
XANCP\|EnsemblGenome=XCC0787\|UniProtKB=Q8PCE7	Xanthomonas campestris	O
PSEAE\|EnsemblGenome=PA0342\|UniProtKB=Q9I6F1	Pseudomonas aeruginosa	O
SALTY\|EnsemblGenome=STM3001\|UniProtKB=Q8ZMA9	Salmonella typhimurium	O
YERPE\|EnsemblGenome=YP_2875\|UniProtKB=Q8ZHV1	Yersinia pestis	O
ECOLI\|EnsemblGenome=BAE76896\|UniProtKB=P0A884	Escherichia coli	O