PANTHER Gene Information

Gene Symbol(s):

Prl

Organism:

Mus musculus

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Gene Name:

Prolactin

Gene ID:

MGI:97762

Protein ID:

P06879

Persistent Id:

PTN000151924

Alternate Ids:

PRL(Synonym)	53778(GI)
ENSMUST00000224228(Ensembl_TRS)	ENSMUSP00000153245(Ensembl_PRO)
MGI:97762(MGI)	Prl(Symbol)
BAB30787(EMBL-CDS)	X04418(EMBL)
Q544X8(AltAccession)	PRL_MOUSE(UniProtKB-ID)
ENSMUSG00000021342(Ensembl)
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PANTHER Classification

PANTHER Family:	SOMATOTROPIN,PROLACTIN (PTHR11417)
PANTHER Subfamily:	PROLACTIN (PTHR11417:SF5)
PANTHER GO-slim Molecular Function:	hormone activity
PANTHER GO-slim Biological Process:	positive regulation of cell population proliferation positive regulation of receptor signaling pathway via JAK-STAT response to nutrient levels
PANTHER GO-slim Cellular Component:	extracellular space
PANTHER protein class:	peptide hormone

Pathway Categories:

Gonadotropin-releasing hormone receptor pathway

Prolactin

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	hormone activity, prolactin receptor binding
GO BP Complete:	cell population proliferation, signal transduction, positive regulation of cell population proliferation, prolactin signaling pathway, positive regulation of canonical NF-kappaB signal transduction, female pregnancy, regulation of receptor signaling pathway via JAK-STAT, cell surface receptor signaling pathway, lactation, positive regulation of miRNA transcription, positive regulation of lactation, maternal behavior, positive regulation of receptor signaling pathway via JAK-STAT, mammary gland development, epithelial cell proliferation, negative regulation of endothelial cell proliferation, regulation of ossification, response to nutrient levels, positive regulation of epithelial cell proliferation
GO CC Complete:	extracellular space, secretory granule, extracellular region

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Immune System, Growth hormone receptor signaling, Prolactin receptor signaling, Cytokine Signaling in Immune system

Orthologs

ID	Organism	Type
HUMAN\|HGNC=9445\|UniProtKB=P01236	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000017768.4\|UniProtKB=H2QSD1	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000001363.3\|UniProtKB=G3QG92	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000020646.4\|UniProtKB=G7MQU0	Macaca mulatta	LDO
MACMU\|Gene=PRL\|UniProtKB=P55151	Macaca mulatta	LDO
RAT\|RGD=3403\|UniProtKB=P01237	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000031640.4\|UniProtKB=F1N6S6	Bos taurus	O
BOVIN\|Gene=CSH1\|UniProtKB=P09611	Bos taurus	O
BOVIN\|Gene=PRP3\|UniProtKB=P12402	Bos taurus	O
BOVIN\|Gene=PRP2\|UniProtKB=P12401	Bos taurus	O
BOVIN\|Gene=PRP1\|UniProtKB=P05402	Bos taurus	O
BOVIN\|Ensembl=ENSBTAG00000052064.1\|UniProtKB=A0A0M6L0P8	Bos taurus	O
BOVIN\|Ensembl=ENSBTAG00000049869.1\|UniProtKB=E1BC34	Bos taurus	O
BOVIN\|Ensembl=ENSBTAG00000006761.6\|UniProtKB=F1MYF0	Bos taurus	O
BOVIN\|Gene=PRP4\|UniProtKB=P18917	Bos taurus	O
BOVIN\|Ensembl=ENSBTAG00000025314.5\|UniProtKB=Q2WGK0	Bos taurus	O
BOVIN\|Ensembl=ENSBTAG00000036106.4\|UniProtKB=Q2WG99	Bos taurus	O
BOVIN\|Ensembl=ENSBTAG00000025304.5\|UniProtKB=Q2WFM8	Bos taurus	O
BOVIN\|Ensembl=ENSBTAG00000025302.5\|UniProtKB=Q2PEE7	Bos taurus	O
BOVIN\|Ensembl=ENSBTAG00000038718.3\|UniProtKB=A0A0M6L0Q6	Bos taurus	O
BOVIN\|Ensembl=ENSBTAG00000051382.1\|UniProtKB=A0A3Q1M6B7	Bos taurus	O
BOVIN\|Ensembl=ENSBTAG00000049075.1\|UniProtKB=A4PBQ6	Bos taurus	O
BOVIN\|Gene=CSH2\|UniProtKB=P19159	Bos taurus	O
BOVIN\|Ensembl=ENSBTAG00000015274\|UniProtKB=P01239	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000039721.3\|UniProtKB=A0A286ZMS9	Sus scrofa	O
PIG\|Ensembl=ENSSSCG00005013825\|UniProtKB=P01238	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000000114.4\|UniProtKB=A0A9L0SHR2	Equus caballus	LDO
HORSE\|Gene=PRL\|UniProtKB=P12420	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000015035\|UniProtKB=P46403	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845017595.1\|UniProtKB=E2RAF4	Canis lupus familiaris	LDO
MONDO\|Gene=PRL\|UniProtKB=O62819	Monodelphis domestica	O
MONDO\|Ensembl=ENSMODG00000011350.1\|UniProtKB=F6W2N8	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000011127.4\|UniProtKB=F7DGX1	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010008082\|UniProtKB=P14676	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000002939.3\|UniProtKB=G1KBD7	Anolis carolinensis	LDO
XENLA\|Gene=prl.2.S\|UniProtKB=A0A8J0TBC1	Xenopus laevis	O
XENLA\|Gene=LOC108695906\|UniProtKB=A0A8J0T9Y6	Xenopus laevis	O
XENTR\|Gene=LOC100498019\|UniProtKB=A0A8J1JWY0	Xenopus tropicalis	O
XENTR\|Gene=LOC100497196\|UniProtKB=A0A8J1K137	Xenopus tropicalis	O
XENTR\|Ensembl=ENSXETG00000035107\|UniProtKB=A0A6I8RB89	Xenopus tropicalis	O
XENLA\|Gene=prl.1.S\|UniProtKB=Q56A64	Xenopus laevis	O
XENLA\|Gene=prl.1.L\|UniProtKB=Q6DJG3	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-482866\|UniProtKB=A4QNQ2	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000016928.2\|UniProtKB=H2MR01	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-030513-1\|UniProtKB=Q569P7	Danio rerio	LDO