PANTHER Gene Information   
Gene Symbol(s): PRKACB
Organism: Homo sapiens
View Gene in Tree
Tree Reduced Tree  
Tree Reduced Tree
Gene Name: cAMP-dependent protein kinase catalytic subunit beta
Gene ID: HGNC:9381
Protein ID: P22694
Enhancers: View enhancers for HUMAN|HGNC=9381|UniProtKB=P22694
Genetic Variant Annotation: Annoq
Persistent Id: PTN002519370
Alternate Ids:
B1APG4(AltAccession) 665506016(GI)
ENSG00000142875(Ensembl) NP_001229791(refSeq)
CR936631(EMBL) CAI56774(EMBL-CDS)
KAPCB(Synonym) KAPCB_HUMAN(UniProtKB-ID)
619143(MIM) CHEMBL2918(ChEMBL)
5567(GeneID) HGNC:9381(HGNC)
Show All

PANTHER Classification
PANTHER Family: CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE (PTHR24353)
PANTHER Subfamily: CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA (PTHR24353:SF150)  
PANTHER GO-slim Molecular Function: protein serine/threonine kinase activity
PANTHER GO-slim Biological Process:
PANTHER GO-slim Cellular Component: serine/threonine protein kinase complex
intracellular protein-containing complex
nucleus
cytosol
PANTHER protein class: non-receptor serine/threonine protein kinase
Pathway Categories: Inflammation mediated by chemokine and cytokine signaling pathway
   Protein kinase A
Metabotropic glutamate receptor group II pathway
   Protein kinase A
GABA-B receptor II signaling
   Protein kinase A
Muscarinic acetylcholine receptor 2 and 4 signaling pathway
   Protein kinase A
CCKR signaling map
   PKA-Calpha/beta/gamma
Endothelin signaling pathway
   Protein kinase A
Enkephalin release
   Protein kinase A
Beta1 adrenergic receptor signaling pathway
   Protein kinase A
Histamine H2 receptor mediated signaling pathway
   Protein kinase A
Beta2 adrenergic receptor signaling pathway
   Protein kinase A
Metabotropic glutamate receptor group I pathway
   Protein kinase A
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
   Protein kinase A, catalytic subunit
Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction
   Protein kinase A
5HT1 type receptor mediated signaling pathway
   Protein kinase A
Dopamine receptor mediated signaling pathway
   Protein kinase A
Metabotropic glutamate receptor group III pathway
   Protein kinase A
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: magnesium ion binding, ATP binding, protein binding, ubiquitin protein ligase binding, cAMP-dependent protein kinase activity, protein serine/threonine kinase activity, protein serine kinase activity
GO BP Complete: renal water homeostasis, high-density lipoprotein particle assembly, negative regulation of TORC1 signaling, neural tube closure, signal transduction, vascular endothelial cell response to laminar fluid shear stress, adenylate cyclase-modulating G protein-coupled receptor signaling pathway, protein phosphorylation, negative regulation of smoothened signaling pathway, regulation of protein processing
GO CC Complete: nucleus, centrosome, extracellular exosome, ciliary base, cytosol, plasma membrane, cAMP-dependent protein kinase complex, nucleoplasm
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: MAPK family signaling cascades, Signaling by Hedgehog, Factors involved in megakaryocyte development and platelet production, Opioid Signalling, Plasma lipoprotein assembly, remodeling, and clearance, Infectious disease, Signaling by ROBO receptors, ADORA2B mediated anti-inflammatory cytokines production, Vasopressin regulates renal water homeostasis via Aquaporins, Signaling by Receptor Tyrosine Kinases, PKA activation, Plasma lipoprotein assembly, Post NMDA receptor activation events, HDL assembly, Regulation of glycolysis by fructose 2,6-bisphosphate metabolism, GLI3 is processed to GLI3R by the proteasome, Degradation of GLI2 by the proteasome, Leishmania parasite growth and survival, Hedgehog 'off' state, CaM pathway, Ca-dependent events, C-type lectin receptors (CLRs), Anti-inflammatory response favouring Leishmania parasite infection, DAG and IP3 signaling, Metabolism, PLC beta mediated events, G-protein mediated events, Parasitic Infection Pathways, Metabolism of lipids, Regulation of insulin secretion, DARPP-32 events, Axon guidance, Transport of small molecules, VEGFA-VEGFR2 Pathway, Intracellular signaling by second messengers, FCGR3A-mediated IL10 synthesis, Neuronal System, Neurotransmitter receptors and postsynaptic signal transmission, Transmission across Chemical Synapses, Glucose metabolism, Signaling by VEGF, Signaling by GPCR, Triglyceride metabolism, Signal Transduction, Activation of NMDA receptors and postsynaptic events, Innate Immune System, Glucagon-like Peptide-1 (GLP1) regulates insulin secretion, G alpha (s) signalling events, Hemostasis, Developmental Biology, G alpha (i) signalling events, Rap1 signalling, Glucagon signaling in metabolic regulation, Degradation of GLI1 by the proteasome, PKA-mediated phosphorylation of key metabolic factors, GPCR downstream signalling, Calmodulin induced events, PKA-mediated phosphorylation of CREB, Glycolysis, Disease, Leishmania infection, MAPK6/MAPK4 signaling, Metabolism of carbohydrates, CD209 (DC-SIGN) signaling, Integration of energy metabolism, RET signaling, PKA activation in glucagon signalling, Aquaporin-mediated transport, ROBO receptors bind AKAP5, CREB1 phosphorylation through the activation of Adenylate Cyclase, Immune System, Triglyceride catabolism, Adaptive Immune System, GPER1 signaling, Nervous system development

Orthologs