Pathway Component Details
| Name: | Protein kinase A, catalytic subunit (PKA-c) |
| Definition: | The Protein Kinase A (PKA) Catalytic Subunit (a homodimer) is capable of kinase activity when the Regulatory Subunit binds cAMP and releases the Catalytic Subunit. The Catalytic Subunit then targets various downstream molecules for phosphorylation. Two targets include Glycogen Synthase Kinase and Phosphorylase b Kinase, the activation of which result in the conversion of glycogen to glucose-1-phosphate. A third target for the Protein Kinase A Catalytic Subunit is the CREB protein. Phosphorylation of CREB requires nuclear import of the PKA Catalytic Subunit. Phosphorylated CREB recruits transcriptional machinery to genes downstream of CREB-Binding Elements and up-regulates their transcription. |
| Category ID: | P00707 |
| Synonyms: | |
| Upstream: | |
| Downstream: |
Phosphorylase b kinase
Glycogen synthase kinase (GSK) cAMP response element binding protein (CREB) |
| Number Families/Subfamilies: | 5 |
| Number of Associated Sequences: | 18 |
| GO Molecular Function: |
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| GO Biological Process: |
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| GO Cellular Component: |
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| PANTHER protein class: |
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| References: |
Sequence Association
| Panther Subfamily | Associated Sequence | Definition | Confidence Code | Evidence |
| PTHR24353:SF116 | A0A5K1UDP0 | cAMP-dependent protein kinase | ISS | PubMed:10218114 |
| A0A5K1UDP0 | cAMP-dependent protein kinase | ISS | PubMed:10553940 | |
| A0A5K1UDP0 | cAMP-dependent protein kinase | ISS | PubMed:11035810 | |
| A0A5K1UDP0 | cAMP-dependent protein kinase | ISS | PubMed:1319556 | |
| A0A5K1UDP0 | cAMP-dependent protein kinase | ISS | PubMed:14744463 | |
| A0A5K1UDP0 | cAMP-dependent protein kinase | ISS | PubMed:15313841 | |
| A0A5K1UDP0 | cAMP-dependent protein kinase | ISS | PubMed:89107990 | |
| A0A8M2BIA6 | cAMP-dependent protein kinase | ISS | PubMed:10218114 | |
| A0A8M2BIA6 | cAMP-dependent protein kinase | ISS | PubMed:10553940 | |
| A0A8M2BIA6 | cAMP-dependent protein kinase | ISS | PubMed:11035810 | |
| A0A8M2BIA6 | cAMP-dependent protein kinase | ISS | PubMed:1319556 | |
| A0A8M2BIA6 | cAMP-dependent protein kinase | ISS | PubMed:14744463 | |
| A0A8M2BIA6 | cAMP-dependent protein kinase | ISS | PubMed:15313841 | |
| A0A8M2BIA6 | cAMP-dependent protein kinase | ISS | PubMed:89107990 | |
| H2R1G3 | cAMP-dependent protein kinase | ISS | PubMed:10218114 | |
| H2R1G3 | cAMP-dependent protein kinase | ISS | PubMed:10553940 | |
| H2R1G3 | cAMP-dependent protein kinase | ISS | PubMed:11035810 | |
| H2R1G3 | cAMP-dependent protein kinase | ISS | PubMed:1319556 | |
| H2R1G3 | cAMP-dependent protein kinase | ISS | PubMed:14744463 | |
| H2R1G3 | cAMP-dependent protein kinase | ISS | PubMed:15313841 | |
| H2R1G3 | cAMP-dependent protein kinase | ISS | PubMed:89107990 | |
| PTHR24353:SF135 | Q6DBV8 | cAMP-dependent protein kinase | ISS | PubMed:10218114 |
| Q6DBV8 | cAMP-dependent protein kinase | ISS | PubMed:10553940 | |
| Q6DBV8 | cAMP-dependent protein kinase | ISS | PubMed:11035810 | |
| Q6DBV8 | cAMP-dependent protein kinase | ISS | PubMed:1319556 | |
| Q6DBV8 | cAMP-dependent protein kinase | ISS | PubMed:14744463 | |
| Q6DBV8 | cAMP-dependent protein kinase | ISS | PubMed:15313841 | |
| Q6DBV8 | cAMP-dependent protein kinase | ISS | PubMed:2394752 | |
| Q6DBV8 | cAMP-dependent protein kinase | ISS | PubMed:89107990 | |
| PTHR24353:SF137 | H2QXB9 | cAMP-dependent protein kinase | ISS | PubMed:10218114 |
| H2QXB9 | cAMP-dependent protein kinase | ISS | PubMed:10553940 | |
| H2QXB9 | cAMP-dependent protein kinase | ISS | PubMed:11035810 | |
| H2QXB9 | cAMP-dependent protein kinase | ISS | PubMed:1319556 | |
| H2QXB9 | cAMP-dependent protein kinase | ISS | PubMed:14744463 | |
| H2QXB9 | cAMP-dependent protein kinase | ISS | PubMed:15313841 | |
| H2QXB9 | cAMP-dependent protein kinase | ISS | PubMed:89107990 | |
| O62846 | cAMP-dependent protein kinase catalytic subunit gamma (Fragment) | ISS | PubMed:10218114 | |
| O62846 | cAMP-dependent protein kinase catalytic subunit gamma (Fragment) | ISS | PubMed:10553940 | |
| O62846 | cAMP-dependent protein kinase catalytic subunit gamma (Fragment) | ISS | PubMed:11035810 | |
| O62846 | cAMP-dependent protein kinase catalytic subunit gamma (Fragment) | ISS | PubMed:1319556 | |
| O62846 | cAMP-dependent protein kinase catalytic subunit gamma (Fragment) | ISS | PubMed:14744463 | |
| O62846 | cAMP-dependent protein kinase catalytic subunit gamma (Fragment) | ISS | PubMed:15313841 | |
| O62846 | cAMP-dependent protein kinase catalytic subunit gamma (Fragment) | ISS | PubMed:89107990 | |
| P22612 | cAMP-dependent protein kinase catalytic subunit gamma | IDA | PubMed:10553940 | |
| P22612 | cAMP-dependent protein kinase catalytic subunit gamma | IDA | PubMed:11035810 | |
| P22612 | cAMP-dependent protein kinase catalytic subunit gamma | IDA | PubMed:1319556 | |
| P22612 | cAMP-dependent protein kinase catalytic subunit gamma | IDA | PubMed:14744463 | |
| P22612 | cAMP-dependent protein kinase catalytic subunit gamma | IDA | PubMed:15313841 | |
| PTHR24353:SF150 | P05131 | cAMP-dependent protein kinase catalytic subunit beta | ISS | PubMed:10553940 |
| P05131 | cAMP-dependent protein kinase catalytic subunit beta | ISS | PubMed:11035810 | |
| P05131 | cAMP-dependent protein kinase catalytic subunit beta | ISS | PubMed:1319556 | |
| P05131 | cAMP-dependent protein kinase catalytic subunit beta | ISS | PubMed:14744463 | |
| P05131 | cAMP-dependent protein kinase catalytic subunit beta | ISS | PubMed:15313841 | |
| P22694 | cAMP-dependent protein kinase catalytic subunit beta | IDA | PubMed:10553940 | |
| P22694 | cAMP-dependent protein kinase catalytic subunit beta | IDA | PubMed:11035810 | |
| P22694 | cAMP-dependent protein kinase catalytic subunit beta | IDA | PubMed:1319556 | |
| P22694 | cAMP-dependent protein kinase catalytic subunit beta | IDA | PubMed:14744463 | |
| P22694 | cAMP-dependent protein kinase catalytic subunit beta | IDA | PubMed:15313841 | |
| P68181 | cAMP-dependent protein kinase catalytic subunit beta | ISS | PubMed:10553940 | |
| P68181 | cAMP-dependent protein kinase catalytic subunit beta | ISS | PubMed:11035810 | |
| P68181 | cAMP-dependent protein kinase catalytic subunit beta | ISS | PubMed:1319556 | |
| P68181 | cAMP-dependent protein kinase catalytic subunit beta | ISS | PubMed:14744463 | |
| P68181 | cAMP-dependent protein kinase catalytic subunit beta | ISS | PubMed:15313841 | |
| P68182 | cAMP-dependent protein kinase catalytic subunit beta | ISS | PubMed:10218114 | |
| P68182 | cAMP-dependent protein kinase catalytic subunit beta | ISS | PubMed:10553940 | |
| P68182 | cAMP-dependent protein kinase catalytic subunit beta | ISS | PubMed:11035810 | |
| P68182 | cAMP-dependent protein kinase catalytic subunit beta | ISS | PubMed:1319556 | |
| P68182 | cAMP-dependent protein kinase catalytic subunit beta | ISS | PubMed:14744463 | |
| P68182 | cAMP-dependent protein kinase catalytic subunit beta | ISS | PubMed:15313841 | |
| P68182 | cAMP-dependent protein kinase catalytic subunit beta | ISS | PubMed:89107990 | |
| PTHR24353:SF82 | A0A5F8GM38 | cAMP-dependent protein kinase | ISS | PubMed:10218114 |
| A0A5F8GM38 | cAMP-dependent protein kinase | ISS | PubMed:10433257 | |
| A0A5F8GM38 | cAMP-dependent protein kinase | ISS | PubMed:10553940 | |
| A0A5F8GM38 | cAMP-dependent protein kinase | ISS | PubMed:11035810 | |
| A0A5F8GM38 | cAMP-dependent protein kinase | ISS | PubMed:1319556 | |
| A0A5F8GM38 | cAMP-dependent protein kinase | ISS | PubMed:14744463 | |
| A0A5F8GM38 | cAMP-dependent protein kinase | ISS | PubMed:15313841 | |
| A0A5F8GM38 | cAMP-dependent protein kinase | ISS | PubMed:2394752 | |
| A0A5F8GM38 | cAMP-dependent protein kinase | ISS | PubMed:6087160 | |
| A0A5F8GM38 | cAMP-dependent protein kinase | ISS | PubMed:89107990 | |
| H2QFK0 | Protein kinase cAMP-activated catalytic subunit alpha | ISS | PubMed:10218114 | |
| H2QFK0 | Protein kinase cAMP-activated catalytic subunit alpha | ISS | PubMed:10553940 | |
| H2QFK0 | Protein kinase cAMP-activated catalytic subunit alpha | ISS | PubMed:11035810 | |
| H2QFK0 | Protein kinase cAMP-activated catalytic subunit alpha | ISS | PubMed:1319556 | |
| H2QFK0 | Protein kinase cAMP-activated catalytic subunit alpha | ISS | PubMed:14744463 | |
| H2QFK0 | Protein kinase cAMP-activated catalytic subunit alpha | ISS | PubMed:15313841 | |
| H2QFK0 | Protein kinase cAMP-activated catalytic subunit alpha | ISS | PubMed:2394752 | |
| H2QFK0 | Protein kinase cAMP-activated catalytic subunit alpha | ISS | PubMed:6087160 | |
| H2QFK0 | Protein kinase cAMP-activated catalytic subunit alpha | ISS | PubMed:89107990 | |
| P00517 | cAMP-dependent protein kinase catalytic subunit alpha | ISS | PubMed:10553940 | |
| P00517 | cAMP-dependent protein kinase catalytic subunit alpha | ISS | PubMed:11035810 | |
| P00517 | cAMP-dependent protein kinase catalytic subunit alpha | ISS | PubMed:1319556 | |
| P00517 | cAMP-dependent protein kinase catalytic subunit alpha | ISS | PubMed:14744463 | |
| P00517 | cAMP-dependent protein kinase catalytic subunit alpha | ISS | PubMed:15313841 | |
| P00517 | cAMP-dependent protein kinase catalytic subunit alpha | ISS | PubMed:6087160 | |
| P05132 | cAMP-dependent protein kinase catalytic subunit alpha | IDA | PubMed:10433257 | |
| P05132 | cAMP-dependent protein kinase catalytic subunit alpha | IDA | PubMed:10553940 | |
| P05132 | cAMP-dependent protein kinase catalytic subunit alpha | IDA | PubMed:11035810 | |
| P05132 | cAMP-dependent protein kinase catalytic subunit alpha | IDA | PubMed:1319556 | |
| P05132 | cAMP-dependent protein kinase catalytic subunit alpha | IDA | PubMed:14744463 | |
| P05132 | cAMP-dependent protein kinase catalytic subunit alpha | IDA | PubMed:15313841 | |
| P17612 | cAMP-dependent protein kinase catalytic subunit alpha | IDA | PubMed:10553940 | |
| P17612 | cAMP-dependent protein kinase catalytic subunit alpha | IDA | PubMed:11035810 | |
| P17612 | cAMP-dependent protein kinase catalytic subunit alpha | IDA | PubMed:1319556 | |
| P17612 | cAMP-dependent protein kinase catalytic subunit alpha | IDA | PubMed:14744463 | |
| P17612 | cAMP-dependent protein kinase catalytic subunit alpha | IDA | PubMed:15313841 | |
| P17612 | cAMP-dependent protein kinase catalytic subunit alpha | IDA | PubMed:6087160 | |
| P27791 | cAMP-dependent protein kinase catalytic subunit alpha | ISS | PubMed:10433257 | |
| P27791 | cAMP-dependent protein kinase catalytic subunit alpha | ISS | PubMed:10553940 | |
| P27791 | cAMP-dependent protein kinase catalytic subunit alpha | ISS | PubMed:11035810 | |
| P27791 | cAMP-dependent protein kinase catalytic subunit alpha | ISS | PubMed:1319556 | |
| P27791 | cAMP-dependent protein kinase catalytic subunit alpha | ISS | PubMed:14744463 | |
| P27791 | cAMP-dependent protein kinase catalytic subunit alpha | ISS | PubMed:15313841 | |
| Q8MJ44 | cAMP-dependent protein kinase catalytic subunit alpha | ISS | PubMed:10553940 | |
| Q8MJ44 | cAMP-dependent protein kinase catalytic subunit alpha | ISS | PubMed:11035810 | |
| Q8MJ44 | cAMP-dependent protein kinase catalytic subunit alpha | ISS | PubMed:1319556 | |
| Q8MJ44 | cAMP-dependent protein kinase catalytic subunit alpha | ISS | PubMed:14744463 | |
| Q8MJ44 | cAMP-dependent protein kinase catalytic subunit alpha | ISS | PubMed:15313841 | |
| Q8MJ44 | cAMP-dependent protein kinase catalytic subunit alpha | ISS | PubMed:2394752 | |
| Q8MJ44 | cAMP-dependent protein kinase catalytic subunit alpha | ISS | PubMed:6087160 |
