PANTHER Gene Information

Gene Symbol(s):

DPYD

Organism:

Homo sapiens

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Gene Name:

Dihydropyrimidine dehydrogenase [NADP(+)]

Gene ID:

HGNC:3012

Protein ID:

Q12882

Enhancers:

View enhancers for HUMAN|HGNC=3012|UniProtKB=Q12882

Genetic Variant Annotation:

Annoq

Persistent Id:

PTN002534438

Alternate Ids:

BC131777(EMBL)	160332325(GI)
DPYD_HUMAN(UniProtKB-ID)	AAI08743(EMBL-CDS)
1806(GeneID)	Q16761(AltAccession)
274270(MIM)	HGNC:3012(HGNC)
DPYD(Synonym)	CHEMBL3172(ChEMBL)
MetaCyc:HS06975-MON(BioCyc)	ENSG00000188641(Ensembl)
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PANTHER Classification

PANTHER Family:	DIHYDROPYRIMIDINE DEHYDROGENASE [NADP(+)] (PTHR43073)
PANTHER Subfamily:	DIHYDROPYRIMIDINE DEHYDROGENASE [NADP(+)] (PTHR43073:SF2)
PANTHER GO-slim Molecular Function:
PANTHER GO-slim Biological Process:
PANTHER GO-slim Cellular Component:
PANTHER protein class:	dehydrogenase

Pathway Categories:

Pyrimidine Metabolism

Dihydrouracil Dehydrogenase

GENE ONTOLOGY DATABASE ANNOTATIONS

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REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Metabolism of nucleotides, Metabolism, Nucleotide catabolism, Pyrimidine catabolism

Orthologs

ID	Organism	Type
PANTR\|Ensembl=ENSPTRG00000000990.7\|UniProtKB=H2PZG2	Pan troglodytes	LDO
MACMU\|Ensembl=ENSMMUG00000020726.4\|UniProtKB=A0A5F7ZRM8	Macaca mulatta	LDO
MOUSE\|MGI=MGI=2139667\|UniProtKB=Q8CHR6	Mus musculus	LDO
RAT\|RGD=621218\|UniProtKB=O89000	Rattus norvegicus	LDO
BOVIN\|Gene=DPYD\|UniProtKB=Q28007	Bos taurus	O
BOVIN\|Ensembl=ENSBTAG00000031358.4\|UniProtKB=F1N549	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000006878.5\|UniProtKB=F1S550	Sus scrofa	O
PIG\|Gene=DPYD\|UniProtKB=Q28943	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000010881.4\|UniProtKB=F7AQA4	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000039421.3\|UniProtKB=A0A2I2UPM5	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845014137.1\|UniProtKB=A0A8I3NMY5	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000004065.4\|UniProtKB=F6VWD0	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000003850.3\|UniProtKB=F7FH18	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010024191.1\|UniProtKB=A0A8V0ZWJ2	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000005513.4\|UniProtKB=G1KED2	Anolis carolinensis	LDO
XENLA\|Gene=dpyd.L\|UniProtKB=A0A1L8GMQ4	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-1000802\|UniProtKB=A0A6I8QRG6	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000013626.2\|UniProtKB=H2MET3	Oryzias latipes	LDO
DANRE\|Gene=dpyda.1\|UniProtKB=A0A8M6YVM7	Danio rerio	O
DANRE\|ZFIN=ZDB-GENE-040426-2459\|UniProtKB=Q6NYG8	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000008253.1\|UniProtKB=W5MNR9	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000003770.3\|UniProtKB=F6TIR0	Ciona intestinalis	LDO
BRAFL\|Gene_ORFName=BRAFLDRAFT_129513\|UniProtKB=C3YCJ1	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=LOC575768\|UniProtKB=A0A7M7T4A2	Strongylocentrotus purpuratus	LDO
CAEEL\|WormBase=WBGene00016103\|UniProtKB=Q18164	Caenorhabditis elegans	LDO
CAEBR\|Gene_ORFName=CBG14689\|UniProtKB=A8XKG6	Caenorhabditis briggsae	LDO
PRIPA\|EnsemblGenome=WBGene00115941\|UniProtKB=A0A2A6BF87	Pristionchus pacificus	LDO
DROME\|FlyBase=FBgn0086450\|UniProtKB=Q9W374	Drosophila melanogaster	LDO
ANOGA\|EnsemblGenome=AGAP001021\|UniProtKB=Q7QHY0	Anopheles gambiae	LDO
TRICA\|EnsemblGenome=TC010364\|UniProtKB=D6WGA9	Tribolium castaneum	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_202177\|UniProtKB=E9HC99	Daphnia pulex	LDO
IXOSC\|EnsemblGenome=ISCW022746\|UniProtKB=B7QG52	Ixodes scapularis	LDO
HELRO\|EnsemblGenome=HelroG69873\|UniProtKB=T1FZZ2	helobdella robusta	LDO
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g190441\|UniProtKB=A7SJG5	Nematostella vectensis	LDO
ENTH1\|EnsemblGenome=CL6EHI_012980\|UniProtKB=C4LX69	Entamoeba histolytica	LDO
DICDI\|dictyBase=DDB_G0267966\|UniProtKB=Q55FT1	Dictyostelium discoideum	LDO
DICPU\|EnsemblGenome=DICPUDRAFT_94040\|UniProtKB=F0ZEL9	Dictyostelium purpureum	LDO
TRIV3\|Gene_ORFName=TVAG_151830\|UniProtKB=A2ELU8	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_468240\|UniProtKB=A2E0R3	Trichomonas vaginalis	LDO
PARTE\|EnsemblGenome=GSPATT00007208001\|UniProtKB=A0CDX9	Paramecium tetraurelia	LDO
CHLRE\|EnsemblGenome=CHLRE_13g578750v5\|UniProtKB=A0A2K3D064	Chlamydomonas reinhardtii	LDO
AMBTC\|EnsemblGenome=AMTR_s00176p00027530\|UniProtKB=W1PTJ4	Amborella trichopoda	LDO
ZOSMR\|Gene_ORFName=ZOSMA_66G00650\|UniProtKB=A0A0K9NUN1	Zostera marina	LDO
MUSAM\|EnsemblGenome=Ma08_g23660\|UniProtKB=A0A804K9Z8	Musa acuminata subsp. malaccensis	LDO
SETIT\|EnsemblGenome=SETIT_017307mg\|UniProtKB=K3YSR2	Setaria italica	LDO
SORBI\|EnsemblGenome=SORBI_3004G246200\|UniProtKB=C5XZ92	Sorghum bicolor	LDO
MAIZE\|EnsemblGenome=Zm00001eb253890\|UniProtKB=B4FZU9	Zea mays	LDO
ORYSJ\|EnsemblGenome=Os02g0736400\|UniProtKB=Q6Z744	Oryza sativa	LDO
BRADI\|EnsemblGenome=BRADI_3g59890v3\|UniProtKB=I1IFH8	Brachypodium distachyon	LDO
HORVV\|EnsemblGenome=HORVU.MOREX.r3.6HG0613490\|UniProtKB=F2DDM9	Hordeum vulgare subsp. vulgare	LDO
WHEAT\|EnsemblGenome=TraesCS6D02G278900\|UniProtKB=A0A3B6QHL7	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS6B02G328700\|UniProtKB=A0A3B6PQ55	Triticum aestivum	LDO
WHEAT\|EnsemblGenome=TraesCS6A02G299200\|UniProtKB=A0A3B6NU95	Triticum aestivum	O
NELNU\|Gene=LOC104607306\|UniProtKB=A0A1U8B517	Nelumbo nucifera	LDO
SPIOL\|Gene=LOC110779297\|UniProtKB=A0A9R0HYS8	Spinacia oleracea	LDO
HELAN\|EnsemblGenome=HanXRQr2_Chr16g0747241\|UniProtKB=A0A251RYR3	Helianthus annuus	LDO
HELAN\|EnsemblGenome=HanXRQr2_Chr15g0715731\|UniProtKB=A0A251SBM6	Helianthus annuus	LDO
LACSA\|Gene_ORFName=LSAT_V11C900475240\|UniProtKB=A0A9R1UDW5	Lactuca sativa	LDO
ERYGU\|Gene_ORFName=MIMGU_mgv1a006949mg\|UniProtKB=A0A022QDC8	Erythranthe guttata	LDO
CAPAN\|EnsemblGenome=T459_09904\|UniProtKB=A0A2G3A0R6	Capsicum annuum	LDO
SOLTU\|EnsemblGenome=PGSC0003DMG400033683\|UniProtKB=M1D7F6	Solanum tuberosum	LDO
SOLLC\|EnsemblGenome=Solyc03g097910.3\|UniProtKB=Q8H6B5	Solanum lycopersicum	LDO
TOBAC\|Gene=LOC107809801\|UniProtKB=A0A1S4BMA9	Nicotiana tabacum	O
TOBAC\|Gene=LOC107809767\|UniProtKB=A0A1S4BM72	Nicotiana tabacum	LDO
VITVI\|EnsemblGenome=Vitvi17g00163\|UniProtKB=F6GSP9	Vitis vinifera	LDO
EUCGR\|EnsemblGenome=EUGRSUZ_K02286\|UniProtKB=A0A059A4F5	Eucalyptus grandis	LDO
BRANA\|Gene_ORFName=DARMORV10_A01P36570.1\|UniProtKB=A0A078I7H7	Brassica napus	O
BRACM\|EnsemblGenome=Bra021275\|UniProtKB=M4DXM9	Brassica campestris	O
BRANA\|Gene_ORFName=DARMORV10_C01P46400.1\|UniProtKB=A0A078IIT4	Brassica napus	LDO
BRACM\|EnsemblGenome=Bra022246\|UniProtKB=M4E0E9	Brassica campestris	LDO
ARATH\|TAIR=locus=2088570\|UniProtKB=Q9LVI9	Arabidopsis thaliana	LDO
GOSHI\|Gene=LOC107890863\|UniProtKB=A0A1U8HY49	Gossypium hirsutum	LDO
THECC\|EnsemblGenome=TCM_012994\|UniProtKB=A0A061FW13	Theobroma cacao	LDO
CITSI\|Gene_ORFName=CISIN_1g014581mg\|UniProtKB=A0A067DY11	Citrus sinensis	LDO
POPTR\|EnsemblGenome=POPTR_015G030600v3\|UniProtKB=B9N381	Populus trichocarpa	LDO
MANES\|EnsemblGenome=MANES_06G002900\|UniProtKB=A0A2C9VLK4	Manihot esculenta	LDO
RICCO\|Gene_ORFName=RCOM_0084140\|UniProtKB=B9T6I2	Ricinus communis	LDO
SOYBN\|EnsemblGenome=GLYMA_07G105400\|UniProtKB=I1KJ84	Glycine max	O
SOYBN\|EnsemblGenome=GLYMA_09G172700\|UniProtKB=C6TKV3	Glycine max	LDO
MEDTR\|EnsemblGenome=MTR_6g071210\|UniProtKB=G7KQB6	Medicago truncatula	LDO
JUGRE\|EnsemblGenome=Jr06_16180\|UniProtKB=A0A6P9EI48	Juglans regia	O
JUGRE\|EnsemblGenome=Jr15_11180\|UniProtKB=A0A2I4EW38	Juglans regia	LDO
CUCSA\|EnsemblGenome=Csa_1G042970\|UniProtKB=A0A0A0LTU0	Cucumis sativus	LDO
PRUPE\|EnsemblGenome=PRUPE_5G236800\|UniProtKB=M5WUB1	Prunus persica	LDO
SELML\|EnsemblGenome=SELMODRAFT_80950\|UniProtKB=D8QYS2	Selaginella moellendorffii	LDO
PHYPA\|EnsemblGenome=Pp3c23_13670\|UniProtKB=A0A2K1IJ87	Physcomitrella patens	O
PHYPA\|EnsemblGenome=Pp3c20_21870\|UniProtKB=A0A2K1IW28	Physcomitrella patens	LDO
MARPO\|EnsemblGenome=MARPO_0033s0018\|UniProtKB=A0A2R6X677	Marchantia polymorpha	LDO
KLENI\|Gene_ORFName=KFL_000490300\|UniProtKB=A0A0U9HQY1	Klebsormidium nitens	LDO