PANTHER Gene Information   
Gene Symbol(s): GNG12
Organism: Homo sapiens
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Gene Name: Guanine nucleotide-binding protein G(I)_G(S)_G(O) subunit gamma-12
Gene ID: HGNC:19663
Protein ID: Q9UBI6
Enhancers: View enhancers for HUMAN|HGNC=19663|UniProtKB=Q9UBI6
Genetic Variant Annotation: Annoq
Persistent Id: PTN002492821
Alternate Ids:
HGNC:19663(HGNC) ENSP00000360021(Ensembl_PRO)
AAM12593(EMBL-CDS) 55970(GeneID)
119626890(GI) ENSG00000172380(Ensembl)
Q69YP5(AltAccession) XP_016857300(refSeq)
BC005940(EMBL) GBG12_HUMAN(UniProtKB-ID)
ENST00000370982(Ensembl_TRS) GBG12(Synonym)
615405(MIM) GNG12(Symbol)
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PANTHER Classification
PANTHER Family: GUANINE NUCLEOTIDE-BINDING PROTEIN GAMMA SUBUNIT (PTHR13809)
PANTHER Subfamily: GUANINE NUCLEOTIDE-BINDING PROTEIN G(I)_G(S)_G(O) SUBUNIT GAMMA-12 (PTHR13809:SF9)  
PANTHER GO-slim Molecular Function: protein binding
PANTHER GO-slim Biological Process: G protein-coupled receptor signaling pathway
PANTHER GO-slim Cellular Component: plasma membrane protein complex
extrinsic component of membrane
catalytic complex
cytoplasmic side of plasma membrane
PANTHER protein class: heterotrimeric G-protein
Pathway Categories: Beta3 adrenergic receptor signaling pathway
   G-Protein
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
   G protein gamma subunit
Thyrotropin-releasing hormone receptor signaling pathway
   G-Protein
Histamine H1 receptor mediated signaling pathway
   G-Protein
Inflammation mediated by chemokine and cytokine signaling pathway
   G protein, beta and gamma subunit
5HT1 type receptor mediated signaling pathway
   G-protein
5HT4 type receptor mediated signaling pathway
   G-protein
Muscarinic acetylcholine receptor 1 and 3 signaling pathway
   Gq-protein
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
   G protein-activated inward rectifying potassium channel
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
   G-protein, gamma subunit
Beta1 adrenergic receptor signaling pathway
   G-Protein
Wnt signaling pathway
   G-protein, gamma subunit
5HT2 type receptor mediated signaling pathway
   G-protein
Enkephalin release
   Gi-protein
Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction
   G protein gamma subunit
Opioid proenkephalin pathway
   G-protein
Enkephalin release
   Gs-protein
Opioid prodynorphin pathway
   G-protein
Beta2 adrenergic receptor signaling pathway
   G-Protein
Histamine H2 receptor mediated signaling pathway
   G-Protein
Opioid proopiomelanocortin pathway
   G-protein
Muscarinic acetylcholine receptor 2 and 4 signaling pathway
   Gi-protein
Cortocotropin releasing factor receptor signaling pathway
   G-Protein
Oxytocin receptor mediated signaling pathway
   G-Protein
Metabotropic glutamate receptor group II pathway
   G-protein

GO MF Complete: protein binding, G-protein beta-subunit binding, PDZ domain binding
GO BP Complete: G protein-coupled receptor signaling pathway, signal transduction
GO CC Complete: heterotrimeric G-protein complex, extracellular exosome, plasma membrane
Reactome Pathways: Ca2+ pathway, Opioid Signalling, Signaling by WNT, Platelet activation, signaling and aggregation, Infectious disease, Protein folding, G protein gated Potassium channels, Activation of kainate receptors upon glutamate binding, ADORA2B mediated anti-inflammatory cytokines production, G-protein beta:gamma signalling, G beta:gamma signalling through PLC beta, Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits, Vasopressin regulates renal water homeostasis via Aquaporins, G alpha (q) signalling events, Inwardly rectifying K+ channels, Signaling by Nuclear Receptors, Thromboxane signalling through TP receptor, Glucagon-type ligand receptors, Leishmania parasite growth and survival, Anti-inflammatory response favouring Leishmania parasite infection, GPCR ligand binding, Metabolism, G beta:gamma signalling through CDC42, Platelet homeostasis, Parasitic Infection Pathways, Regulation of insulin secretion, G alpha (12/13) signalling events, Transport of small molecules, Chaperonin-mediated protein folding, Neuronal System, Neurotransmitter receptors and postsynaptic signal transmission, Transmission across Chemical Synapses, Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding, ESR-mediated signaling, Extra-nuclear estrogen signaling, Signaling by GPCR, G-protein activation, GABA receptor activation, Signal Transduction, Glucagon-like Peptide-1 (GLP1) regulates insulin secretion, GABA B receptor activation, G alpha (s) signalling events, Activation of G protein gated Potassium channels, Hemostasis, G alpha (z) signalling events, Class B/2 (Secretin family receptors), G alpha (i) signalling events, ADP signalling through P2Y purinoceptor 1, Signal amplification, Glucagon signaling in metabolic regulation, Adrenaline,noradrenaline inhibits insulin secretion, GPCR downstream signalling, Prostacyclin signalling through prostacyclin receptor, Metabolism of proteins, Activation of GABAB receptors, ADP signalling through P2Y purinoceptor 12, Disease, Leishmania infection, Thrombin signalling through proteinase activated receptors (PARs), Beta-catenin independent WNT signaling, G beta:gamma signalling through PI3Kgamma, Integration of energy metabolism, Aquaporin-mediated transport, Potassium Channels, Presynaptic function of Kainate receptors, GPER1 signaling, G beta:gamma signalling through BTK