Pathway Component Details
| Name: | G-Protein |
| Definition: | Numerous hormones, neurotransmitters, chemokines, local mediators, and sensory stimuli exert their effects on cells by binding to heptahelical membrane receptors coupled to heterotrimeric G proteins. These highly specialized transducers can modulate the activity of multiple signaling pathways leading to diverse biological responses. In vivo, specific combinations of G alpha- and G beta gamma-subunits are likely required for connecting individual receptors to signaling pathways. The structural determinants of receptor-G protein-effector specificity are not completely understood and, in addition to involving interaction domains of these primary acting proteins, also require the participation of scaffolding and regulatory proteins. Beta 3 adrenergic receptors couple to Gs (alpha subunit), but it is still unknown which of the beta and gamma subunits are involved in signal processing. |
| Category ID: | P04448 |
| Synonyms: | |
| Upstream: | |
| Downstream: | |
| Number Families/Subfamilies: | 27 |
| Number of Associated Sequences: | 141 |
| GO Molecular Function: |
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| GO Biological Process: |
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| GO Cellular Component: |
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| PANTHER protein class: |
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| References: | Medline:14671004 |
Sequence Association
| Panther Subfamily | Associated Sequence | Definition | Confidence Code | Evidence |
| PTHR10218:SF212 | P20354 | G protein alpha s subunit | ISS | PubMed:14765990 |
| P20354 | G protein alpha s subunit | ISS | PubMed:2106672 | |
| Q7KPV0 | Guanine nucleotide-binding protein G(S) subunit alpha | ISS | ||
| PTHR10218:SF233 | E1BS74 | G protein subunit alpha L | ISS | |
| F7CB49 | G protein subunit alpha L | ISS | ||
| P38405 | Guanine nucleotide-binding protein G(olf) subunit alpha | ISS | ||
| Q5U3H6 | Guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type | ISS | ||
| Q8CGK7 | Guanine nucleotide-binding protein G(olf) subunit alpha | ISS | ||
| PTHR10218:SF348 | Q6R0H7 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas | ISS | PubMed:14765990 |
| Q6R0H7 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas | ISS | PubMed:2106672 | |
| PTHR10218:SF357 | A0A5F8HKY5 | GNAS complex locus | ISS | PubMed:14765990 |
| A0A5F8HKY5 | GNAS complex locus | ISS | PubMed:2106672 | |
| F6PUU7 | GNAS complex locus | ISS | PubMed:14500986 | |
| F6PUU7 | GNAS complex locus | ISS | PubMed:14765990 | |
| F6PUU7 | GNAS complex locus | ISS | PubMed:2106672 | |
| F6PUU7 | GNAS complex locus | ISS | PubMed:6309844 | |
| PTHR10218:SF366 | A0A6I8N6J2 | GNAS complex locus | ISS | PubMed:2106672 |
| PTHR10218:SF367 | Q05337 | Guanine nucleotide-binding protein G(f) subunit alpha | ISS | |
| Q7Q5C3 | AGAP006521-PA | ISS | ||
| PTHR13809:SF11 | A0A8I3MYE3 | Guanine nucleotide-binding protein subunit gamma | ISS | |
| A4IGZ2 | Guanine nucleotide-binding protein subunit gamma | ISS | ||
| F7GI54 | Guanine nucleotide-binding protein subunit gamma | ISS | ||
| G3V8K2 | Guanine nucleotide-binding protein subunit gamma | ISS | ||
| H2Q3W7 | Guanine nucleotide-binding protein subunit gamma | ISS | ||
| P63214 | Guanine nucleotide-binding protein G(I)_G(S)_G(O) subunit gamma-3 | ISS | ||
| P63215 | Guanine nucleotide-binding protein G(I)_G(S)_G(O) subunit gamma-3 | IC | ||
| P63216 | Guanine nucleotide-binding protein G(I)_G(S)_G(O) subunit gamma-3 | IC | ||
| Q90Z40 | Guanine nucleotide-binding protein subunit gamma | IC | ||
| PTHR13809:SF19 | A0A8I3MNZ2 | Guanine nucleotide-binding protein subunit gamma | ISS | |
| F1MYW8 | Guanine nucleotide-binding protein subunit gamma | ISS | ||
| F6YZA3 | Guanine nucleotide-binding protein subunit gamma | ISS | ||
| P63077 | Guanine nucleotide-binding protein G(I)_G(S)_G(O) subunit gamma-8 | IC | ||
| P63078 | Guanine nucleotide-binding protein G(I)_G(S)_G(O) subunit gamma-8 | IC | ||
| Q9UK08 | Guanine nucleotide-binding protein G(I)_G(S)_G(O) subunit gamma-8 | IC | ||
| PTHR13809:SF21 | A0A5F8AMR0 | Guanine nucleotide-binding protein subunit gamma | ISS | |
| A4IFL6 | Guanine nucleotide-binding protein subunit gamma | ISS | ||
| F7G7I9 | Guanine nucleotide-binding protein subunit gamma | ISS | ||
| H2Q1D9 | Guanine nucleotide-binding protein subunit gamma | ISS | ||
| K7E376 | Guanine nucleotide-binding protein subunit gamma | ISS | ||
| P50150 | Guanine nucleotide-binding protein G(I)_G(S)_G(O) subunit gamma-4 | IC | ||
| P50153 | Guanine nucleotide-binding protein G(I)_G(S)_G(O) subunit gamma-4 | IC | ||
| PTHR13809:SF25 | F6VPY1 | Guanine nucleotide-binding protein subunit gamma | ISS | |
| P59768 | Guanine nucleotide-binding protein G(I)_G(S)_G(O) subunit gamma-2 | IC | ||
| P63212 | Guanine nucleotide-binding protein G(I)_G(S)_G(O) subunit gamma-2 | ISS | ||
| P63213 | Guanine nucleotide-binding protein G(I)_G(S)_G(O) subunit gamma-2 | IC | ||
| Q5ZJ03 | Guanine nucleotide-binding protein subunit gamma | IC | ||
| PTHR13809:SF28 | O14610 | Guanine nucleotide-binding protein G(I)_G(S)_G(O) subunit gamma-T2 | IC | |
| P50154 | Guanine nucleotide-binding protein G(I)_G(S)_G(O) subunit gamma-T2 | IC | ||
| Q61017 | Guanine nucleotide-binding protein G(I)_G(S)_G(O) subunit gamma-T2 | IC | ||
| Q6PBR4 | Guanine nucleotide-binding protein subunit gamma | ISS | ||
| PTHR13809:SF5 | A0A8I3PWP4 | Guanine nucleotide-binding protein subunit gamma | ISS | |
| F2Z3T8 | Guanine nucleotide-binding protein subunit gamma | ISS | ||
| F6XHP0 | Guanine nucleotide-binding protein subunit gamma | ISS | ||
| F7ERP8 | Guanine nucleotide-binding protein subunit gamma | ISS | ||
| P63217 | Guanine nucleotide-binding protein G(I)_G(S)_G(O) subunit gamma-5 | ISS | ||
| P63218 | Guanine nucleotide-binding protein G(I)_G(S)_G(O) subunit gamma-5 | IC | ||
| P63219 | Guanine nucleotide-binding protein G(I)_G(S)_G(O) subunit gamma-5 | ISS | ||
| Q6TH03 | Guanine nucleotide-binding protein subunit gamma | ISS | ||
| Q80SZ7 | Guanine nucleotide-binding protein G(I)_G(S)_G(O) subunit gamma-5 | IC | ||
| R4GKD1 | Guanine nucleotide-binding protein subunit gamma | ISS | ||
| PTHR13809:SF51 | H2PZA6 | G protein subunit gamma 5 | ISS | |
| PTHR13809:SF52 | F6W548 | G protein subunit gamma 12 | ISS | |
| F7ASR8 | Uncharacterized protein | ISS | ||
| PTHR13809:SF6 | A0A8I3N081 | Guanine nucleotide-binding protein subunit gamma | ISS | |
| F7CFG8 | Guanine nucleotide-binding protein subunit gamma | ISS | ||
| K7AE17 | Guanine nucleotide-binding protein subunit gamma | ISS | ||
| P50151 | Guanine nucleotide-binding protein G(I)_G(S)_G(O) subunit gamma-10 | IC | ||
| Q3SZ98 | Guanine nucleotide-binding protein subunit gamma | ISS | ||
| Q9CXP8 | Guanine nucleotide-binding protein G(I)_G(S)_G(O) subunit gamma-10 | IC | ||
| PTHR13809:SF8 | A0A5F8GE23 | Guanine nucleotide-binding protein subunit gamma | ISS | |
| F6V461 | Guanine nucleotide-binding protein subunit gamma | ISS | ||
| F7BB02 | Guanine nucleotide-binding protein subunit gamma | ISS | ||
| O60262 | Guanine nucleotide-binding protein G(I)_G(S)_G(O) subunit gamma-7 | IC | ||
| P30671 | Guanine nucleotide-binding protein G(I)_G(S)_G(O) subunit gamma-7 | IC | ||
| P43425 | Guanine nucleotide-binding protein G(I)_G(S)_G(O) subunit gamma-7 | IC | ||
| Q28H40 | Guanine nucleotide-binding protein subunit gamma | ISS | ||
| Q61016 | Guanine nucleotide-binding protein G(I)_G(S)_G(O) subunit gamma-7 | IC | ||
| Q6DGZ5 | Guanine nucleotide-binding protein subunit gamma | ISS | ||
| PTHR13809:SF9 | F6SSS3 | Guanine nucleotide-binding protein subunit gamma | ISS | |
| G3V6P8 | Guanine nucleotide-binding protein subunit gamma | ISS | ||
| H2QZN8 | Guanine nucleotide-binding protein subunit gamma | ISS | ||
| Q28024 | Guanine nucleotide-binding protein G(I)_G(S)_G(O) subunit gamma-12 | IC | ||
| Q9DAS9 | Guanine nucleotide-binding protein G(I)_G(S)_G(O) subunit gamma-12 | IC | ||
| Q9UBI6 | Guanine nucleotide-binding protein G(I)_G(S)_G(O) subunit gamma-12 | IC | ||
| PTHR19850:SF25 | A0A9J7NAW9 | LOW QUALITY PROTEIN: guanine nucleotide-binding protein subunit beta-1-like | ISS | |
| A7EDU2 | Guanine nucleotide-binding protein beta subunit | ISS | ||
| B7Q3T6 | THO complex subunit, putative | ISS | ||
| E9FUX0 | Guanine nucleotide binding protein, beta subunit | ISS | ||
| F1A421 | Guanine nucleotide-binding protein subunit beta | ISS | ||
| F5HH30 | Guanine nucleotide-binding protein beta subunit | IC | ||
| P17343 | Guanine nucleotide-binding protein subunit beta-1 | IC | ||
| P18851 | Guanine nucleotide-binding protein subunit beta | IC | ||
| P26308 | Guanine nucleotide-binding protein subunit beta-1 | IC | ||
| P36408 | Guanine nucleotide-binding protein subunit beta | IC | ||
| P49177 | Guanine nucleotide-binding protein subunit beta | IC | ||
| Q10282 | Guanine nucleotide-binding protein subunit beta | IC | ||
| Q5BH99 | G-protein beta subunit | IC | ||
| Q5KI86 | Uncharacterized protein | IC | ||
| Q7Q6D2 | AGAP005913-PA | IC | ||
| Q7Q6D3 | AGAP005912-PA | IC | ||
| Q7Q6D4 | AGAP005911-PA | IC | ||
| PTHR19850:SF27 | P11017 | Guanine nucleotide-binding protein G(I)_G(S)_G(T) subunit beta-2 | IC | |
| P54313 | Guanine nucleotide-binding protein G(I)_G(S)_G(T) subunit beta-2 | IC | ||
| P62879 | Guanine nucleotide-binding protein G(I)_G(S)_G(T) subunit beta-2 | IC | ||
| P62880 | Guanine nucleotide-binding protein G(I)_G(S)_G(T) subunit beta-2 | IC | ||
| PTHR19850:SF28 | A0A8I3NPM9 | G protein subunit beta 4 | ISS | |
| A0A8M9NZA4 | Guanine nucleotide-binding protein subunit beta-4 | ISS | ||
| A5PKD6 | G protein subunit beta 4 | ISS | ||
| E1BW98 | G protein subunit beta 4 | IC | ||
| F6ZIZ9 | G protein subunit beta 4 | ISS | ||
| F7E427 | G protein subunit beta 4 | ISS | ||
| F7G3J2 | G protein subunit beta 4 | ISS | ||
| H2QNS5 | G protein subunit beta 4 | ISS | ||
| P29387 | Guanine nucleotide-binding protein subunit beta-4 | IC | ||
| Q9HAV0 | Guanine nucleotide-binding protein subunit beta-4 | IC | ||
| PTHR19850:SF29 | A0A8V0ZD90 | G protein subunit beta 1 | IC | |
| F6PGC8 | G protein subunit beta 1 | ISS | ||
| F6PVT7 | G protein subunit beta 1 | ISS | ||
| F7FXA9 | G protein subunit beta 1 | ISS | ||
| P54311 | Guanine nucleotide-binding protein G(I)_G(S)_G(T) subunit beta-1 | IC | ||
| P62871 | Guanine nucleotide-binding protein G(I)_G(S)_G(T) subunit beta-1 | IC | ||
| P62872 | Guanine nucleotide-binding protein G(I)_G(S)_G(T) subunit beta-1 | ISS | ||
| P62873 | Guanine nucleotide-binding protein G(I)_G(S)_G(T) subunit beta-1 | IC | ||
| P62874 | Guanine nucleotide-binding protein G(I)_G(S)_G(T) subunit beta-1 | IC | ||
| Q6PH57 | Guanine nucleotide-binding protein G(I)_G(S)_G(T) subunit beta-1 | ISS | ||
| Q803H5 | Gnb1l protein | ISS | ||
| PTHR19850:SF31 | E1BB14 | G protein subunit beta 3 | ISS | |
| F7CTP1 | G protein subunit beta 3 | ISS | ||
| F7CXD0 | G protein subunit beta 3 | ISS | ||
| H2R3A6 | G protein subunit beta 3 | ISS | ||
| P16520 | Guanine nucleotide-binding protein G(I)_G(S)_G(T) subunit beta-3 | IC | ||
| P52287 | Guanine nucleotide-binding protein G(I)_G(S)_G(T) subunit beta-3 | IC | ||
| Q61011 | Guanine nucleotide-binding protein G(I)_G(S)_G(T) subunit beta-3 | IC | ||
| Q6DH55 | Guanine nucleotide binding protein (G protein), beta polypeptide 3, like | ISS | ||
| PTHR19850:SF35 | Q6P025 | Gnb3 protein | ISS | |
| PTHR19850:SF36 | F7H6T7 | G protein subunit beta 5 | ISS | |
| H2Q9G5 | G protein subunit beta 5 | ISS | ||
| O14775 | Guanine nucleotide-binding protein subunit beta-5 | IC | ||
| P62881 | Guanine nucleotide-binding protein subunit beta-5 | IC | ||
| Q20636 | Guanine nucleotide-binding protein subunit beta-2 | IC | ||
| Q9W3J1 | Gbeta5 | IC | ||
| PTHR19850:SF37 | Q6PBY0 | Guanine nucleotide-binding protein subunit beta-5b | ISS | |
| PTHR19850:SF40 | A1L271 | Guanine nucleotide-binding protein subunit beta-5a | ISS | |
| PTHR19850:SF43 | P29829 | Guanine nucleotide-binding protein subunit beta-2 | IC | |
| Q7PXP3 | AGAP001506-PA | IC |
