PANTHER Gene Information   
Gene Symbol(s): GNB4
Organism: Homo sapiens
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Gene Name: Guanine nucleotide-binding protein subunit beta-4
Gene ID: HGNC:20731
Protein ID: Q9HAV0
Enhancers: View enhancers for HUMAN|HGNC=20731|UniProtKB=Q9HAV0
Genetic Variant Annotation: Annoq
Persistent Id: PTN002500459
Alternate Ids:
B3KMH5(AltAccession) GBB4_HUMAN(UniProtKB-ID)
119598810(GI) XP_006713784(refSeq)
EAW78403(EMBL-CDS) ENSG00000114450(Ensembl)
ENST00000676128(Ensembl_TRS) AK001890(EMBL)
GBB4(Synonym) GNB4(Symbol)
ENSP00000502628(Ensembl_PRO) 615185(MIM)
59345(GeneID) HGNC:20731(HGNC)
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PANTHER Classification
PANTHER Family: GUANINE NUCLEOTIDE-BINDING PROTEIN BETA G PROTEIN BETA (PTHR19850)
PANTHER Subfamily: GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4 (PTHR19850:SF28)  
PANTHER GO-slim Molecular Function: signaling receptor complex adaptor activity
PANTHER GO-slim Biological Process: G protein-coupled receptor signaling pathway
PANTHER GO-slim Cellular Component: plasma membrane protein complex
extrinsic component of membrane
cytoplasm
catalytic complex
cytoplasmic side of plasma membrane
PANTHER protein class: heterotrimeric G-protein
Pathway Categories: Beta3 adrenergic receptor signaling pathway
   G-Protein
Wnt signaling pathway
   G protein, beta subunit
Thyrotropin-releasing hormone receptor signaling pathway
   G-Protein
GABA-B receptor II signaling
   G protein, beta subunit
Histamine H1 receptor mediated signaling pathway
   G-Protein
5HT1 type receptor mediated signaling pathway
   G-protein
5HT4 type receptor mediated signaling pathway
   G-protein
Muscarinic acetylcholine receptor 1 and 3 signaling pathway
   Gq-protein
Dopamine receptor mediated signaling pathway
   G protein, beta subunit
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
   G protein-activated inward rectifying potassium channel
Gonadotropin-releasing hormone receptor pathway
   Gbeta
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
   G protein, beta subunit
Endogenous cannabinoid signaling
   G protein, beta subunit
Beta1 adrenergic receptor signaling pathway
   G-Protein
PI3 kinase pathway
   G protein, beta and gamma subunit
5HT2 type receptor mediated signaling pathway
   G-protein
Enkephalin release
   Gi-protein
Opioid proenkephalin pathway
   G-protein
Enkephalin release
   Gs-protein
Angiotensin II-stimulated signaling through G proteins and beta-arrestin
   G-protein, beta subunit
Opioid prodynorphin pathway
   G-protein
Beta2 adrenergic receptor signaling pathway
   G-Protein
Histamine H2 receptor mediated signaling pathway
   G-Protein
Opioid proopiomelanocortin pathway
   G-protein
Muscarinic acetylcholine receptor 2 and 4 signaling pathway
   Gi-protein
Metabotropic glutamate receptor group III pathway
   Gi-protein
Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction
   G protein, beta subunit
Cortocotropin releasing factor receptor signaling pathway
   G-Protein
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
   G protein beta subunit
Metabotropic glutamate receptor group II pathway
   G-protein
Oxytocin receptor mediated signaling pathway
   G-Protein
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: protein binding, signaling receptor complex adaptor activity, protein-containing complex binding
GO BP Complete: G protein-coupled receptor signaling pathway, substantia nigra development
GO CC Complete: heterotrimeric G-protein complex, extracellular exosome, cytoplasm, cell body, cytosol, lysosomal membrane
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: Ca2+ pathway, Opioid Signalling, Signaling by WNT, Platelet activation, signaling and aggregation, Infectious disease, Protein folding, G protein gated Potassium channels, Activation of kainate receptors upon glutamate binding, ADORA2B mediated anti-inflammatory cytokines production, G-protein beta:gamma signalling, G beta:gamma signalling through PLC beta, Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits, Vasopressin regulates renal water homeostasis via Aquaporins, G alpha (q) signalling events, Inwardly rectifying K+ channels, Signaling by Nuclear Receptors, Thromboxane signalling through TP receptor, Glucagon-type ligand receptors, Leishmania parasite growth and survival, Anti-inflammatory response favouring Leishmania parasite infection, GPCR ligand binding, Metabolism, G beta:gamma signalling through CDC42, Platelet homeostasis, Parasitic Infection Pathways, Regulation of insulin secretion, G alpha (12/13) signalling events, Transport of small molecules, Chaperonin-mediated protein folding, Neuronal System, Neurotransmitter receptors and postsynaptic signal transmission, Transmission across Chemical Synapses, Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding, ESR-mediated signaling, Extra-nuclear estrogen signaling, Signaling by GPCR, G-protein activation, GABA receptor activation, Signal Transduction, Glucagon-like Peptide-1 (GLP1) regulates insulin secretion, GABA B receptor activation, G alpha (s) signalling events, Activation of G protein gated Potassium channels, Hemostasis, G alpha (z) signalling events, Class B/2 (Secretin family receptors), G alpha (i) signalling events, ADP signalling through P2Y purinoceptor 1, Signal amplification, Glucagon signaling in metabolic regulation, Adrenaline,noradrenaline inhibits insulin secretion, GPCR downstream signalling, Prostacyclin signalling through prostacyclin receptor, Metabolism of proteins, Activation of GABAB receptors, ADP signalling through P2Y purinoceptor 12, Disease, Leishmania infection, Thrombin signalling through proteinase activated receptors (PARs), Beta-catenin independent WNT signaling, G beta:gamma signalling through PI3Kgamma, Integration of energy metabolism, Aquaporin-mediated transport, Potassium Channels, Presynaptic function of Kainate receptors, GPER1 signaling, G beta:gamma signalling through BTK

Orthologs