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comprehensive information about the evolution of protein-coding gene families, particularly
protein phylogeny, function and genetic variation impacting that function. Learn more

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Current Release: PANTHER 19.0 | 15,683 family phylogenetic trees | 144 species | News
Whole genome function views

PANTHER Gene Information

Gene Symbol(s):

GNB4

Organism:

Macaca mulatta

View Gene in Tree

Tree

Gene Name:

G protein subunit beta 4

Gene ID:

ENSMMUG00000004083.4

Protein ID:

F6ZIZ9

Persistent Id:

PTN000457549

Alternate Ids:

ENSMMUG00000004083(Ensembl)	386781163(GI)
NM_001261165(refSeq)	JU476654(EMBL)
F6ZIZ9_MACMU(UniProtKB-ID)	AFE64537(EMBL-CDS)
709489(GeneID)	ENSMMUP00000005459(Ensembl_PRO)
ENSMMUT00000005797(Ensembl_TRS)	F6ZIZ9(Synonym)
Show All

PANTHER Classification

PANTHER Family:	GUANINE NUCLEOTIDE-BINDING PROTEIN BETA G PROTEIN BETA (PTHR19850)
PANTHER Subfamily:	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4 (PTHR19850:SF28)
PANTHER GO-slim Molecular Function:	signaling receptor complex adaptor activity
PANTHER GO-slim Biological Process:	G protein-coupled receptor signaling pathway
PANTHER GO-slim Cellular Component:	plasma membrane protein complex extrinsic component of membrane cytoplasm catalytic complex cytoplasmic side of plasma membrane
PANTHER protein class:	heterotrimeric G-protein

Pathway Categories:

Beta3 adrenergic receptor signaling pathway

G-Protein

Wnt signaling pathway

G protein, beta subunit

Thyrotropin-releasing hormone receptor signaling pathway

G-Protein

GABA-B receptor II signaling

G protein, beta subunit

Histamine H1 receptor mediated signaling pathway

G-Protein

5HT1 type receptor mediated signaling pathway

G-protein

5HT4 type receptor mediated signaling pathway

G-protein

Muscarinic acetylcholine receptor 1 and 3 signaling pathway

Gq-protein

Dopamine receptor mediated signaling pathway

G protein, beta subunit

Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway

G protein-activated inward rectifying potassium channel

Gonadotropin-releasing hormone receptor pathway

Gbeta

Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway

G protein, beta subunit

Endogenous cannabinoid signaling

G protein, beta subunit

Beta1 adrenergic receptor signaling pathway

G-Protein

PI3 kinase pathway

G protein, beta and gamma subunit

5HT2 type receptor mediated signaling pathway

G-protein

Enkephalin release

Gi-protein

Opioid proenkephalin pathway

G-protein

Enkephalin release

Gs-protein

Angiotensin II-stimulated signaling through G proteins and beta-arrestin

G-protein, beta subunit

Opioid prodynorphin pathway

G-protein

Beta2 adrenergic receptor signaling pathway

G-Protein

Histamine H2 receptor mediated signaling pathway

G-Protein

Opioid proopiomelanocortin pathway

G-protein

Muscarinic acetylcholine receptor 2 and 4 signaling pathway

Gi-protein

Metabotropic glutamate receptor group III pathway

Gi-protein

Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction

G protein, beta subunit

Cortocotropin releasing factor receptor signaling pathway

G-Protein

Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway

G protein beta subunit

Metabotropic glutamate receptor group II pathway

G-protein

Oxytocin receptor mediated signaling pathway

G-Protein

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	signaling receptor complex adaptor activity, protein-containing complex binding
GO BP Complete:	G protein-coupled receptor signaling pathway, signal transduction
GO CC Complete:	heterotrimeric G-protein complex, cytoplasm

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

-

Orthologs

ID	Organism	Type
HUMAN\|HGNC=20731\|UniProtKB=Q9HAV0	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000015646.4\|UniProtKB=H2QNS5	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000026248.2\|UniProtKB=G3SB40	Gorilla gorilla gorilla	LDO
MOUSE\|MGI=MGI=104581\|UniProtKB=P29387	Mus musculus	LDO
RAT\|RGD=1359321\|UniProtKB=O35353	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000002767.6\|UniProtKB=A5PKD6	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000037583.3\|UniProtKB=A0A4X1V414	Sus scrofa	LDO
PIG\|Ensembl=ENSSSCG00005001605.1\|UniProtKB=A0A4X1W8E1	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000008196.4\|UniProtKB=A0A9L0R977	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000039564.3\|UniProtKB=A0A2I2U2P0	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845016005.1\|UniProtKB=A0A8I3NPM9	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000021303.3\|UniProtKB=F7G3J2	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000004695.4\|UniProtKB=F7E427	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010018185.1\|UniProtKB=E1BW98	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000004667.2\|UniProtKB=G1KD23	Anolis carolinensis	LDO
XENLA\|Gene=gnb4.S\|UniProtKB=A0A1L8G482	Xenopus laevis	O
XENLA\|Gene=gnb4.L\|UniProtKB=Q6GM38	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-970638\|UniProtKB=Q28G20	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000005797.2\|UniProtKB=A0A3B3HC45	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-041114-167\|UniProtKB=A0A2R8RKX9	Danio rerio	O
DANRE\|Gene=gnb4a\|UniProtKB=A0A8M9NZA4	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000001216.1\|UniProtKB=W5LZ17	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000003768.3\|UniProtKB=F7AW67	Ciona intestinalis	O
BRAFL\|Gene=LOC118430472\|UniProtKB=A0A9J7NAW9	Branchiostoma floridae	O
STRPU\|EnsemblGenome=LOC115917973\|UniProtKB=A0A7M7HEW5	Strongylocentrotus purpuratus	O
CAEEL\|WormBase=WBGene00001679\|UniProtKB=P17343	Caenorhabditis elegans	O
CAEBR\|WormBase=WBGene00026054\|UniProtKB=Q61ZF6	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00114710\|UniProtKB=A0A8R1UF80	Pristionchus pacificus	O
DROME\|FlyBase=FBgn0004623\|UniProtKB=P29829	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP001506\|UniProtKB=Q7PXP3	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC014410\|UniProtKB=D6WLT9	Tribolium castaneum	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_195438\|UniProtKB=E9GD03	Daphnia pulex	O
DROME\|FlyBase=FBgn0001105\|UniProtKB=P26308	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP005911\|UniProtKB=Q7Q6D4	Anopheles gambiae	O
ANOGA\|EnsemblGenome=AGAP005913\|UniProtKB=Q7Q6D2	Anopheles gambiae	O
ANOGA\|EnsemblGenome=AGAP005912\|UniProtKB=Q7Q6D3	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC014882\|UniProtKB=D2A477	Tribolium castaneum	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_206575\|UniProtKB=E9FUX0	Daphnia pulex	O
IXOSC\|EnsemblGenome=ISCW009711\|UniProtKB=B7Q3T6	Ixodes scapularis	O
HELRO\|EnsemblGenome=HelroG92225\|UniProtKB=T1G8D2	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG75178\|UniProtKB=T1G222	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG91325\|UniProtKB=T1G827	helobdella robusta	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g105798\|UniProtKB=A7S5Z1	Nematostella vectensis	O
TRIAD\|EnsemblGenome=TriadG64010\|UniProtKB=B3RZG6	Trichoplax adhaerens	O
MONBE\|EnsemblGenome=MONBRDRAFT_38561\|UniProtKB=A9V8R6	Monosiga brevicollis	O
YEAST\|SGD=S000005738\|UniProtKB=P18851	Saccharomyces cerevisiae	O
EREGS\|EnsemblGenome=AGOS_ACR097W\|UniProtKB=Q75C20	Eremothecium gossypii	O
CANAL\|CGD=CAL0000180995\|UniProtKB=A0A1D8PH43	Candida albicans	O
YARLI\|EnsemblGenome=YALI0_E01364g\|UniProtKB=Q6C7F0	Yarrowia lipolytica	O
EMENI\|EnsemblGenome=ANIA_00081\|UniProtKB=Q5BH99	Emericella nidulans	O
ASPFU\|EnsemblGenome=AFUA_5G12210\|UniProtKB=Q4WVI4	Neosartorya fumigata	O
NEUCR\|EnsemblGenome=NCU00440\|UniProtKB=F5HH30	Neurospora crassa	O
SCLS1\|EnsemblGenome=SS1G_03482\|UniProtKB=A7EDU2	Sclerotinia sclerotiorum	O
PHANO\|EnsemblGenome=SNOG_16044\|UniProtKB=Q0TWX6	Phaeosphaeria nodorum	O
SCHPO\|PomBase=SPBC32H8.07\|UniProtKB=Q10282	Schizosaccharomyces pombe	O
SCHJY\|EnsemblGenome=SJAG_03081\|UniProtKB=B6K398	Schizosaccharomyces japonicus	O
CRYNJ\|EnsemblGenome=CND03830\|UniProtKB=Q5KI86	Cryptococcus neoformans	O
USTMA\|EnsemblGenome=UMAG_00703\|UniProtKB=A0A0D1EDL6	Ustilago maydis	O
PUCGT\|EnsemblGenome=PGTG_03727\|UniProtKB=E3K0E6	Puccinia graminis	O
BATDJ\|Gene_ORFName=BATDEDRAFT_17943\|UniProtKB=F4PD00	Batrachochytrium dendrobatidis	O
ENTH1\|EnsemblGenome=CL6EHI_000240\|UniProtKB=C4LZ87	Entamoeba histolytica	O
DICDI\|dictyBase=DDB_G0277143\|UniProtKB=P36408	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_93216\|UniProtKB=F1A421	Dictyostelium purpureum	O
PARTE\|EnsemblGenome=GSPATT00013334001\|UniProtKB=A0D4A1	Paramecium tetraurelia	O
THAPS\|EnsemblGenome=THAPSDRAFT_37124\|UniProtKB=B8CBT0	Thalassiosira pseudonana	O
PHYRM\|Gene=H3G9J9_PHYRM\|UniProtKB=H3G9J9	Phytophthora ramorum	O
AMBTC\|EnsemblGenome=AMTR_s00059p00065870\|UniProtKB=U5D7V0	Amborella trichopoda	O
ZOSMR\|Gene_ORFName=ZOSMA_123G00150\|UniProtKB=A0A0K9Q2F3	Zostera marina	O
MUSAM\|EnsemblGenome=Ma10_g28650\|UniProtKB=A0A804L1D0	Musa acuminata subsp. malaccensis	O
MUSAM\|EnsemblGenome=Ma09_g09460\|UniProtKB=A0A804KHQ7	Musa acuminata subsp. malaccensis	O
MUSAM\|EnsemblGenome=Ma06_g33350\|UniProtKB=A0A804JN72	Musa acuminata subsp. malaccensis	O
SETIT\|EnsemblGenome=SETIT_036161mg\|UniProtKB=K4ABA4	Setaria italica	O
SORBI\|EnsemblGenome=SORBI_3001G142100\|UniProtKB=C5WQA4	Sorghum bicolor	O
MAIZE\|EnsemblGenome=Zm00001eb052290\|UniProtKB=P49178	Zea mays	O
ORYSJ\|EnsemblGenome=Os03g0669200\|UniProtKB=Q40687	Oryza sativa	O
BRADI\|EnsemblGenome=BRADI_1g12820v3\|UniProtKB=I1GPP8	Brachypodium distachyon	O
HORVV\|EnsemblGenome=HORVU.MOREX.r3.4HG0333760\|UniProtKB=A0A8I6X8T9	Hordeum vulgare subsp. vulgare	O
WHEAT\|EnsemblGenome=TraesCS4B02G019900\|UniProtKB=W5EP05	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS4A02G294000\|UniProtKB=A0A3B6HX51	Triticum aestivum	O
NELNU\|Gene=LOC104601886\|UniProtKB=A0A1U8ALW3	Nelumbo nucifera	O
NELNU\|Gene=LOC104595714\|UniProtKB=A0A1U8A019	Nelumbo nucifera	O
SPIOL\|Gene=LOC110805508\|UniProtKB=A0A9R0KCQ8	Spinacia oleracea	O
HELAN\|EnsemblGenome=HanXRQr2_Chr12g0547531\|UniProtKB=A0A251SUN2	Helianthus annuus	O
HELAN\|EnsemblGenome=HanXRQr2_Chr10g0453161\|UniProtKB=A0A251TNA1	Helianthus annuus	O
LACSA\|Gene_ORFName=LSAT_V11C500271450\|UniProtKB=A0A9R1X988	Lactuca sativa	O
LACSA\|Gene_ORFName=LSAT_V11C700377650\|UniProtKB=A0A9R1X4H2	Lactuca sativa	O
ERYGU\|Gene_ORFName=MIMGU_mgv1a008244mg\|UniProtKB=A0A022RC09	Erythranthe guttata	O
SOLTU\|Gene=GB1\|UniProtKB=P93563	Solanum tuberosum	O
SOLTU\|EnsemblGenome=PGSC0003DMG401000722\|UniProtKB=M0ZJA5	Solanum tuberosum	O
TOBAC\|Gene=LOC107760597\|UniProtKB=A0A1S3X384	Nicotiana tabacum	O
TOBAC\|Gene=LOC107820634\|UniProtKB=A0A1S4CNA1	Nicotiana tabacum	O
TOBAC\|Gene=LOC107776663\|UniProtKB=A0A1S3YJ35	Nicotiana tabacum	O
TOBAC\|Gene=GBB2_TOBAC\|UniProtKB=P93398	Nicotiana tabacum	O
TOBAC\|Gene=GBB3_TOBAC\|UniProtKB=Q40507	Nicotiana tabacum	O
TOBAC\|Gene=GBB1_TOBAC\|UniProtKB=P93397	Nicotiana tabacum	O
TOBAC\|Gene=LOC107793273\|UniProtKB=A0A1S4A324	Nicotiana tabacum	O
VITVI\|EnsemblGenome=Vitvi03g00343\|UniProtKB=D7TQ08	Vitis vinifera	O
EUCGR\|EnsemblGenome=EUGRSUZ_I01264\|UniProtKB=A0A059APK8	Eucalyptus grandis	O
BRANA\|Gene_ORFName=GSBRNA2T00083586001\|UniProtKB=A0A078I813	Brassica napus	O
BRACM\|EnsemblGenome=Bra034628\|UniProtKB=M4F0N3	Brassica campestris	O
BRACM\|EnsemblGenome=Bra017658\|UniProtKB=M4DMC5	Brassica campestris	O
BRACM\|EnsemblGenome=Bra011536\|UniProtKB=M4D4X9	Brassica campestris	O
ARATH\|TAIR=locus=2139489\|UniProtKB=P49177	Arabidopsis thaliana	O
GOSHI\|Gene=LOC107894229\|UniProtKB=A0A1U8IF42	Gossypium hirsutum	O
GOSHI\|Gene=LOC107927977\|UniProtKB=A0A1U8LMB9	Gossypium hirsutum	O
GOSHI\|Gene=LOC107908775\|UniProtKB=A0A1U8JTC9	Gossypium hirsutum	O
THECC\|EnsemblGenome=TCM_006901\|UniProtKB=A0A061E6Y1	Theobroma cacao	O
CITSI\|Gene_ORFName=CISIN_1g016458mg\|UniProtKB=A0A067E1X3	Citrus sinensis	O
POPTR\|EnsemblGenome=POPTR_009G115300v3\|UniProtKB=B9HRN9	Populus trichocarpa	O
POPTR\|EnsemblGenome=POPTR_004G153700v3\|UniProtKB=B9H0Q0	Populus trichocarpa	O
MANES\|EnsemblGenome=MANES_17G100500\|UniProtKB=A0A2C9U6P8	Manihot esculenta	O
MANES\|EnsemblGenome=MANES_15G164000\|UniProtKB=A0A2C9UGN5	Manihot esculenta	O
RICCO\|Gene_ORFName=RCOM_1674940\|UniProtKB=B9RBE4	Ricinus communis	O
SOYBN\|EnsemblGenome=GLYMA_11G118500\|UniProtKB=I1LJE1	Glycine max	O
SOYBN\|EnsemblGenome=GLYMA_12G043900\|UniProtKB=I1LQ45	Glycine max	O
SOYBN\|EnsemblGenome=GLYMA_06G013000\|UniProtKB=I1K777	Glycine max	O
SOYBN\|EnsemblGenome=GLYMA_04G013100\|UniProtKB=C6THC3	Glycine max	O
MEDTR\|EnsemblGenome=MTR_3g116500\|UniProtKB=G7J6K3	Medicago truncatula	O
JUGRE\|EnsemblGenome=Jr16_18100\|UniProtKB=A0A2I4FZ53	Juglans regia	O
JUGRE\|EnsemblGenome=Jr13_07280\|UniProtKB=A0A2I4GVB3	Juglans regia	O
CUCSA\|EnsemblGenome=Csa_7G267960\|UniProtKB=A0A0A0K4B7	Cucumis sativus	O
PRUPE\|EnsemblGenome=PRUPE_8G098100\|UniProtKB=M5VM49	Prunus persica	O
SELML\|EnsemblGenome=SELMODRAFT_142121\|UniProtKB=D8QYQ4	Selaginella moellendorffii	O
SELML\|EnsemblGenome=SELMODRAFT_440157\|UniProtKB=D8R8Y3	Selaginella moellendorffii	O
PHYPA\|EnsemblGenome=Pp3c2_6210\|UniProtKB=A0A2K1L0G1	Physcomitrella patens	O
PHYPA\|EnsemblGenome=Pp3c1_35990\|UniProtKB=A0A2K1LB50	Physcomitrella patens	O
MARPO\|EnsemblGenome=MARPO_0056s0121\|UniProtKB=A0A2R6WUZ6	Marchantia polymorpha	O
KLENI\|Gene_ORFName=KFL_008660040\|UniProtKB=A0A1Y1IMH6	Klebsormidium nitens	O