Pathway Component Details
| Name: | G-Protein |
| Definition: | Numerous hormones, neurotransmitters, chemokines, local mediators, and sensory stimuli exert their effects on cells by binding to heptahelical membrane receptors coupled to heterotrimeric G proteins. These highly specialized transducers can modulate the activity of multiple signaling pathways leading to diverse biological responses. In vivo, specific combinations of G alpha- and G beta gamma-subunits are likely required for connecting individual receptors to signaling pathways. The structural determinants of receptor-G protein-effector specificity are not completely understood and, in addition to involving interaction domains of these primary acting proteins, also require the participation of scaffolding and regulatory proteins. H2 receptors couple to Gs (alpha subunit), but it is still unknown which of the beta and gamma subunits are involved in signal processing. |
| Category ID: | P04490 |
| Synonyms: | |
| Upstream: | |
| Downstream: | |
| Number Families/Subfamilies: | 27 |
| Number of Associated Sequences: | 141 |
| GO Molecular Function: |
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| GO Biological Process: |
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| GO Cellular Component: |
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| PANTHER protein class: |
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| References: | Medline:14671004 |
Sequence Association
| Panther Subfamily | Associated Sequence | Definition | Confidence Code | Evidence |
| PTHR10218:SF212 | P20354 | G protein alpha s subunit | ISS | PubMed:14765990 |
| P20354 | G protein alpha s subunit | ISS | PubMed:2106672 | |
| Q7KPV0 | Guanine nucleotide-binding protein G(S) subunit alpha | ISS | ||
| PTHR10218:SF233 | E1BS74 | G protein subunit alpha L | ISS | |
| F7CB49 | G protein subunit alpha L | ISS | ||
| P38405 | Guanine nucleotide-binding protein G(olf) subunit alpha | ISS | ||
| Q5U3H6 | Guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type | ISS | ||
| Q8CGK7 | Guanine nucleotide-binding protein G(olf) subunit alpha | ISS | ||
| PTHR10218:SF348 | Q6R0H7 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas | ISS | PubMed:14765990 |
| Q6R0H7 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas | ISS | PubMed:2106672 | |
| PTHR10218:SF357 | A0A5F8HKY5 | GNAS complex locus | ISS | PubMed:14765990 |
| A0A5F8HKY5 | GNAS complex locus | ISS | PubMed:2106672 | |
| F6PUU7 | GNAS complex locus | ISS | PubMed:14500986 | |
| F6PUU7 | GNAS complex locus | ISS | PubMed:14765990 | |
| F6PUU7 | GNAS complex locus | ISS | PubMed:2106672 | |
| F6PUU7 | GNAS complex locus | ISS | PubMed:6309844 | |
| PTHR10218:SF366 | A0A6I8N6J2 | GNAS complex locus | ISS | PubMed:2106672 |
| PTHR10218:SF367 | Q05337 | Guanine nucleotide-binding protein G(f) subunit alpha | ISS | |
| Q7Q5C3 | AGAP006521-PA | ISS | ||
| PTHR13809:SF11 | A0A8I3MYE3 | Guanine nucleotide-binding protein subunit gamma | ISS | |
| A4IGZ2 | Guanine nucleotide-binding protein subunit gamma | ISS | ||
| F7GI54 | Guanine nucleotide-binding protein subunit gamma | ISS | ||
| G3V8K2 | Guanine nucleotide-binding protein subunit gamma | ISS | ||
| H2Q3W7 | Guanine nucleotide-binding protein subunit gamma | ISS | ||
| P63214 | Guanine nucleotide-binding protein G(I)_G(S)_G(O) subunit gamma-3 | ISS | ||
| P63215 | Guanine nucleotide-binding protein G(I)_G(S)_G(O) subunit gamma-3 | IC | ||
| P63216 | Guanine nucleotide-binding protein G(I)_G(S)_G(O) subunit gamma-3 | IC | ||
| Q90Z40 | Guanine nucleotide-binding protein subunit gamma | IC | ||
| PTHR13809:SF19 | A0A8I3MNZ2 | Guanine nucleotide-binding protein subunit gamma | ISS | |
| F1MYW8 | Guanine nucleotide-binding protein subunit gamma | ISS | ||
| F6YZA3 | Guanine nucleotide-binding protein subunit gamma | ISS | ||
| P63077 | Guanine nucleotide-binding protein G(I)_G(S)_G(O) subunit gamma-8 | IC | ||
| P63078 | Guanine nucleotide-binding protein G(I)_G(S)_G(O) subunit gamma-8 | IC | ||
| Q9UK08 | Guanine nucleotide-binding protein G(I)_G(S)_G(O) subunit gamma-8 | IC | ||
| PTHR13809:SF21 | A0A5F8AMR0 | Guanine nucleotide-binding protein subunit gamma | ISS | |
| A4IFL6 | Guanine nucleotide-binding protein subunit gamma | ISS | ||
| F7G7I9 | Guanine nucleotide-binding protein subunit gamma | ISS | ||
| H2Q1D9 | Guanine nucleotide-binding protein subunit gamma | ISS | ||
| K7E376 | Guanine nucleotide-binding protein subunit gamma | ISS | ||
| P50150 | Guanine nucleotide-binding protein G(I)_G(S)_G(O) subunit gamma-4 | IC | ||
| P50153 | Guanine nucleotide-binding protein G(I)_G(S)_G(O) subunit gamma-4 | IC | ||
| PTHR13809:SF25 | F6VPY1 | Guanine nucleotide-binding protein subunit gamma | ISS | |
| P59768 | Guanine nucleotide-binding protein G(I)_G(S)_G(O) subunit gamma-2 | IC | ||
| P63212 | Guanine nucleotide-binding protein G(I)_G(S)_G(O) subunit gamma-2 | ISS | ||
| P63213 | Guanine nucleotide-binding protein G(I)_G(S)_G(O) subunit gamma-2 | IC | ||
| Q5ZJ03 | Guanine nucleotide-binding protein subunit gamma | IC | ||
| PTHR13809:SF28 | O14610 | Guanine nucleotide-binding protein G(I)_G(S)_G(O) subunit gamma-T2 | IC | |
| P50154 | Guanine nucleotide-binding protein G(I)_G(S)_G(O) subunit gamma-T2 | IC | ||
| Q61017 | Guanine nucleotide-binding protein G(I)_G(S)_G(O) subunit gamma-T2 | IC | ||
| Q6PBR4 | Guanine nucleotide-binding protein subunit gamma | ISS | ||
| PTHR13809:SF5 | A0A8I3PWP4 | Guanine nucleotide-binding protein subunit gamma | ISS | |
| F2Z3T8 | Guanine nucleotide-binding protein subunit gamma | ISS | ||
| F6XHP0 | Guanine nucleotide-binding protein subunit gamma | ISS | ||
| F7ERP8 | Guanine nucleotide-binding protein subunit gamma | ISS | ||
| P63217 | Guanine nucleotide-binding protein G(I)_G(S)_G(O) subunit gamma-5 | ISS | ||
| P63218 | Guanine nucleotide-binding protein G(I)_G(S)_G(O) subunit gamma-5 | IC | ||
| P63219 | Guanine nucleotide-binding protein G(I)_G(S)_G(O) subunit gamma-5 | ISS | ||
| Q6TH03 | Guanine nucleotide-binding protein subunit gamma | ISS | ||
| Q80SZ7 | Guanine nucleotide-binding protein G(I)_G(S)_G(O) subunit gamma-5 | IC | ||
| R4GKD1 | Guanine nucleotide-binding protein subunit gamma | ISS | ||
| PTHR13809:SF51 | H2PZA6 | G protein subunit gamma 5 | ISS | |
| PTHR13809:SF52 | F6W548 | G protein subunit gamma 12 | ISS | |
| F7ASR8 | Uncharacterized protein | ISS | ||
| PTHR13809:SF6 | A0A8I3N081 | Guanine nucleotide-binding protein subunit gamma | ISS | |
| F7CFG8 | Guanine nucleotide-binding protein subunit gamma | ISS | ||
| K7AE17 | Guanine nucleotide-binding protein subunit gamma | ISS | ||
| P50151 | Guanine nucleotide-binding protein G(I)_G(S)_G(O) subunit gamma-10 | IC | ||
| Q3SZ98 | Guanine nucleotide-binding protein subunit gamma | ISS | ||
| Q9CXP8 | Guanine nucleotide-binding protein G(I)_G(S)_G(O) subunit gamma-10 | IC | ||
| PTHR13809:SF8 | A0A5F8GE23 | Guanine nucleotide-binding protein subunit gamma | ISS | |
| F6V461 | Guanine nucleotide-binding protein subunit gamma | ISS | ||
| F7BB02 | Guanine nucleotide-binding protein subunit gamma | ISS | ||
| O60262 | Guanine nucleotide-binding protein G(I)_G(S)_G(O) subunit gamma-7 | IC | ||
| P30671 | Guanine nucleotide-binding protein G(I)_G(S)_G(O) subunit gamma-7 | IC | ||
| P43425 | Guanine nucleotide-binding protein G(I)_G(S)_G(O) subunit gamma-7 | IC | ||
| Q28H40 | Guanine nucleotide-binding protein subunit gamma | ISS | ||
| Q61016 | Guanine nucleotide-binding protein G(I)_G(S)_G(O) subunit gamma-7 | IC | ||
| Q6DGZ5 | Guanine nucleotide-binding protein subunit gamma | ISS | ||
| PTHR13809:SF9 | F6SSS3 | Guanine nucleotide-binding protein subunit gamma | ISS | |
| G3V6P8 | Guanine nucleotide-binding protein subunit gamma | ISS | ||
| H2QZN8 | Guanine nucleotide-binding protein subunit gamma | ISS | ||
| Q28024 | Guanine nucleotide-binding protein G(I)_G(S)_G(O) subunit gamma-12 | IC | ||
| Q9DAS9 | Guanine nucleotide-binding protein G(I)_G(S)_G(O) subunit gamma-12 | IC | ||
| Q9UBI6 | Guanine nucleotide-binding protein G(I)_G(S)_G(O) subunit gamma-12 | IC | ||
| PTHR19850:SF25 | A0A9J7NAW9 | LOW QUALITY PROTEIN: guanine nucleotide-binding protein subunit beta-1-like | ISS | |
| A7EDU2 | Guanine nucleotide-binding protein beta subunit | ISS | ||
| B7Q3T6 | THO complex subunit, putative | ISS | ||
| E9FUX0 | Guanine nucleotide binding protein, beta subunit | ISS | ||
| F1A421 | Guanine nucleotide-binding protein subunit beta | ISS | ||
| F5HH30 | Guanine nucleotide-binding protein beta subunit | IC | ||
| P17343 | Guanine nucleotide-binding protein subunit beta-1 | IC | ||
| P18851 | Guanine nucleotide-binding protein subunit beta | IC | ||
| P26308 | Guanine nucleotide-binding protein subunit beta-1 | IC | ||
| P36408 | Guanine nucleotide-binding protein subunit beta | IC | ||
| P49177 | Guanine nucleotide-binding protein subunit beta | IC | ||
| Q10282 | Guanine nucleotide-binding protein subunit beta | IC | ||
| Q5BH99 | G-protein beta subunit | IC | ||
| Q5KI86 | Uncharacterized protein | IC | ||
| Q7Q6D2 | AGAP005913-PA | IC | ||
| Q7Q6D3 | AGAP005912-PA | IC | ||
| Q7Q6D4 | AGAP005911-PA | IC | ||
| PTHR19850:SF27 | P11017 | Guanine nucleotide-binding protein G(I)_G(S)_G(T) subunit beta-2 | IC | |
| P54313 | Guanine nucleotide-binding protein G(I)_G(S)_G(T) subunit beta-2 | IC | ||
| P62879 | Guanine nucleotide-binding protein G(I)_G(S)_G(T) subunit beta-2 | IC | ||
| P62880 | Guanine nucleotide-binding protein G(I)_G(S)_G(T) subunit beta-2 | IC | ||
| PTHR19850:SF28 | A0A8I3NPM9 | G protein subunit beta 4 | ISS | |
| A0A8M9NZA4 | Guanine nucleotide-binding protein subunit beta-4 | ISS | ||
| A5PKD6 | G protein subunit beta 4 | ISS | ||
| E1BW98 | G protein subunit beta 4 | IC | ||
| F6ZIZ9 | G protein subunit beta 4 | ISS | ||
| F7E427 | G protein subunit beta 4 | ISS | ||
| F7G3J2 | G protein subunit beta 4 | ISS | ||
| H2QNS5 | G protein subunit beta 4 | ISS | ||
| P29387 | Guanine nucleotide-binding protein subunit beta-4 | IC | ||
| Q9HAV0 | Guanine nucleotide-binding protein subunit beta-4 | IC | ||
| PTHR19850:SF29 | A0A8V0ZD90 | G protein subunit beta 1 | IC | |
| F6PGC8 | G protein subunit beta 1 | ISS | ||
| F6PVT7 | G protein subunit beta 1 | ISS | ||
| F7FXA9 | G protein subunit beta 1 | ISS | ||
| P54311 | Guanine nucleotide-binding protein G(I)_G(S)_G(T) subunit beta-1 | IC | ||
| P62871 | Guanine nucleotide-binding protein G(I)_G(S)_G(T) subunit beta-1 | IC | ||
| P62872 | Guanine nucleotide-binding protein G(I)_G(S)_G(T) subunit beta-1 | ISS | ||
| P62873 | Guanine nucleotide-binding protein G(I)_G(S)_G(T) subunit beta-1 | IC | ||
| P62874 | Guanine nucleotide-binding protein G(I)_G(S)_G(T) subunit beta-1 | IC | ||
| Q6PH57 | Guanine nucleotide-binding protein G(I)_G(S)_G(T) subunit beta-1 | ISS | ||
| Q803H5 | Gnb1l protein | ISS | ||
| PTHR19850:SF31 | E1BB14 | G protein subunit beta 3 | ISS | |
| F7CTP1 | G protein subunit beta 3 | ISS | ||
| F7CXD0 | G protein subunit beta 3 | ISS | ||
| H2R3A6 | G protein subunit beta 3 | ISS | ||
| P16520 | Guanine nucleotide-binding protein G(I)_G(S)_G(T) subunit beta-3 | IC | ||
| P52287 | Guanine nucleotide-binding protein G(I)_G(S)_G(T) subunit beta-3 | IC | ||
| Q61011 | Guanine nucleotide-binding protein G(I)_G(S)_G(T) subunit beta-3 | IC | ||
| Q6DH55 | Guanine nucleotide binding protein (G protein), beta polypeptide 3, like | ISS | ||
| PTHR19850:SF35 | Q6P025 | Gnb3 protein | ISS | |
| PTHR19850:SF36 | F7H6T7 | G protein subunit beta 5 | ISS | |
| H2Q9G5 | G protein subunit beta 5 | ISS | ||
| O14775 | Guanine nucleotide-binding protein subunit beta-5 | IC | ||
| P62881 | Guanine nucleotide-binding protein subunit beta-5 | IC | ||
| Q20636 | Guanine nucleotide-binding protein subunit beta-2 | IC | ||
| Q9W3J1 | Gbeta5 | IC | ||
| PTHR19850:SF37 | Q6PBY0 | Guanine nucleotide-binding protein subunit beta-5b | ISS | |
| PTHR19850:SF40 | A1L271 | Guanine nucleotide-binding protein subunit beta-5a | ISS | |
| PTHR19850:SF43 | P29829 | Guanine nucleotide-binding protein subunit beta-2 | IC | |
| Q7PXP3 | AGAP001506-PA | IC |
