PANTHER Gene Information   
Gene Symbol(s): GNB5
Organism: Homo sapiens
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Gene Name: Guanine nucleotide-binding protein subunit beta-5
Gene ID: HGNC:4401
Protein ID: O14775
Enhancers: View enhancers for HUMAN|HGNC=4401|UniProtKB=O14775
Genetic Variant Annotation: Annoq
Persistent Id: PTN002500449
Alternate Ids:
B2RBR5(AltAccession) AAC63826(EMBL-CDS)
617173(MIM) BC013997(EMBL)
HGNC:4401(HGNC) Transducin beta chain 5(Synonym)
ENSG00000069966(Ensembl) 10681(GeneID)
GNB5(Symbol) GNB5_HUMAN(UniProtKB-ID)
5911941(GI)
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PANTHER Classification
PANTHER Family: GUANINE NUCLEOTIDE-BINDING PROTEIN BETA G PROTEIN BETA (PTHR19850)
PANTHER Subfamily: GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5 (PTHR19850:SF36)  
PANTHER GO-slim Molecular Function: signaling receptor complex adaptor activity
PANTHER GO-slim Biological Process: G protein-coupled receptor signaling pathway
dopamine receptor signaling pathway
PANTHER GO-slim Cellular Component: plasma membrane protein complex
extrinsic component of membrane
cytoplasm
catalytic complex
cytoplasmic side of plasma membrane
PANTHER protein class: heterotrimeric G-protein
Pathway Categories: Beta3 adrenergic receptor signaling pathway
   G-Protein
Thyrotropin-releasing hormone receptor signaling pathway
   G-Protein
Histamine H1 receptor mediated signaling pathway
   G-Protein
5HT1 type receptor mediated signaling pathway
   G-protein
5HT4 type receptor mediated signaling pathway
   G-protein
Muscarinic acetylcholine receptor 1 and 3 signaling pathway
   Gq-protein
Gonadotropin-releasing hormone receptor pathway
   Gbeta
Beta1 adrenergic receptor signaling pathway
   G-Protein
PI3 kinase pathway
   G protein, beta and gamma subunit
5HT2 type receptor mediated signaling pathway
   G-protein
Enkephalin release
   Gi-protein
Opioid proenkephalin pathway
   G-protein
Enkephalin release
   Gs-protein
Angiotensin II-stimulated signaling through G proteins and beta-arrestin
   G-protein, beta subunit
Opioid prodynorphin pathway
   G-protein
Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction
   G protein, beta subunit 5L
Beta2 adrenergic receptor signaling pathway
   G-Protein
Histamine H2 receptor mediated signaling pathway
   G-Protein
Opioid proopiomelanocortin pathway
   G-protein
Muscarinic acetylcholine receptor 2 and 4 signaling pathway
   Gi-protein
Metabotropic glutamate receptor group III pathway
   Gi-protein
Cortocotropin releasing factor receptor signaling pathway
   G-Protein
Metabotropic glutamate receptor group II pathway
   G-protein
Oxytocin receptor mediated signaling pathway
   G-Protein
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: protein binding, GTPase activity, GTPase activator activity, protein-folding chaperone binding, G-protein gamma-subunit binding, signaling receptor complex adaptor activity
GO BP Complete: light adaption, G protein-coupled receptor signaling pathway, signal transduction, negative regulation of voltage-gated calcium channel activity, G protein-coupled dopamine receptor signaling pathway, dark adaptation, positive regulation of GTPase activity
GO CC Complete: nucleus, presynapse, heterotrimeric G-protein complex, cytoplasm, GTPase activator complex, cytosol
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: Ca2+ pathway, Opioid Signalling, Signaling by WNT, Platelet activation, signaling and aggregation, Infectious disease, Protein folding, G protein gated Potassium channels, Activation of kainate receptors upon glutamate binding, ADORA2B mediated anti-inflammatory cytokines production, G-protein beta:gamma signalling, G beta:gamma signalling through PLC beta, Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits, Vasopressin regulates renal water homeostasis via Aquaporins, G alpha (q) signalling events, Inwardly rectifying K+ channels, Signaling by Nuclear Receptors, Thromboxane signalling through TP receptor, Glucagon-type ligand receptors, Leishmania parasite growth and survival, Anti-inflammatory response favouring Leishmania parasite infection, GPCR ligand binding, Metabolism, G beta:gamma signalling through CDC42, Platelet homeostasis, Parasitic Infection Pathways, Regulation of insulin secretion, G alpha (12/13) signalling events, Transport of small molecules, Chaperonin-mediated protein folding, Neuronal System, Neurotransmitter receptors and postsynaptic signal transmission, Transmission across Chemical Synapses, Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding, ESR-mediated signaling, Extra-nuclear estrogen signaling, Signaling by GPCR, G-protein activation, GABA receptor activation, Signal Transduction, Glucagon-like Peptide-1 (GLP1) regulates insulin secretion, GABA B receptor activation, G alpha (s) signalling events, Activation of G protein gated Potassium channels, Hemostasis, G alpha (z) signalling events, Class B/2 (Secretin family receptors), G alpha (i) signalling events, ADP signalling through P2Y purinoceptor 1, Signal amplification, Adrenaline,noradrenaline inhibits insulin secretion, GPCR downstream signalling, Prostacyclin signalling through prostacyclin receptor, Metabolism of proteins, Activation of GABAB receptors, ADP signalling through P2Y purinoceptor 12, Disease, Leishmania infection, Thrombin signalling through proteinase activated receptors (PARs), Beta-catenin independent WNT signaling, G beta:gamma signalling through PI3Kgamma, Integration of energy metabolism, Aquaporin-mediated transport, Potassium Channels, Presynaptic function of Kainate receptors, GPER1 signaling, G beta:gamma signalling through BTK

Orthologs