PANTHER Pathway  >   Gamma-aminobutyric acid synthesis >   Succinate semialdehyde dehydrogenase

Pathway Component Details   
Name: Succinate semialdehyde dehydrogenase (Succinic semialdehyde dehydrogenase)
Definition: gamma-Aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system. GABA is converted from glutamic acid by the action of glutamic acid decarboxylase (GAD) of which two isoforms exist GAD65 and GAD67. GABA then is broken down, both within the cell and in the synaptic cleft by GABA transaminase to form succinic semialdehyde. In turn, succinic semialdehyde is converted either to succinic acid by succinic semialdehyde dehydrogenase or into gamma-hydroxybutyric acid (GHB) by succinic semialdehyde reductase. Because GABA modulates the majority of inhibition that is ongoing in the brain, perturbations in GABAergic inhibition have the potential to result in seizures. Therefore, the most common disorder in which GABA is targeted as a treatment is epilepsy. However, other disorders such as psychiatric disease, spasticity, and stiff-person syndrome all have been related to disorders of GABAergic function in the brain.
Category ID: P04481
Synonyms:
Upstream:
Downstream:
Number Families/Subfamilies: 2
Number of Associated Sequences: 15
GO Molecular Function: -
GO Biological Process: -
GO Cellular Component: -
PANTHER protein class: -
References: Medline:15341910  Medline:12891648 

Sequence Association
Panther Subfamily Associated Sequence Definition Confidence Code Evidence
PTHR43353:SF12 Q9UTM8 Putative succinate-semialdehyde dehydrogenase C139.05 [NADP(+)] IC PubMed:12891648  
PTHR43353:SF5 F6T9P8 Succinate-semialdehyde dehydrogenase ISS PubMed:12891648  
  P38067 Succinate-semialdehyde dehydrogenase [NADP(+)] IC PubMed:12891648  
  P51649 Succinate-semialdehyde dehydrogenase, mitochondrial IC PubMed:12891648  
  P51650 Succinate-semialdehyde dehydrogenase, mitochondrial IC PubMed:12891648  
  P94428 Succinate-semialdehyde dehydrogenase [NADP(+)] IC PubMed:12891648  
  Q6A2H0 Succinate-semialdehyde dehydrogenase, mitochondrial IC PubMed:12891648  
  Q7QBI1 AGAP003165-PA IC PubMed:12891648  
  Q8BWF0 Succinate-semialdehyde dehydrogenase, mitochondrial IC PubMed:12891648  
  Q8CJL1 Succinate-semialdehyde dehydrogenase IC PubMed:12891648  
  Q9I6M5 Glutarate-semialdehyde dehydrogenase IC  
  Q9RZE6 Succinate-semialdehyde dehydrogenase IC PubMed:12891648  
  Q9SAK4 Succinate-semialdehyde dehydrogenase, mitochondrial IC PubMed:12891648  
  Q9VBP6 Succinate-semialdehyde dehydrogenase IC PubMed:12891648  
  V5IQD0 Succinate-semialdehyde dehydrogenase IC PubMed:12891648