PANTHER Pathway  >   p38 MAPK pathway >   mitogen-activated protein kinase kinase 4

Pathway Component Details   
Name: mitogen-activated protein kinase kinase 4 (MKK4)
Definition: Stress-activated protein kinase (SAPK)/extracellular signal-regulated kinase (ERK) kinase is a dual-specificity protein kinase that activates c-Jun NH2-terminal kinases (JNKs) and Mpk2.
Category ID: P06034
Synonyms:
Upstream: mitogen-activated protein kinase kinase kinase 4  (MEKK4)
mitogen-activated protein kinase kinase kinase 5  (ASK1)
mixed lineage kinase 2  (MLK2)
Downstream: p38-beta mitogen-activated protein kinase  (p38beta)
p38-alpha mitogen-activated protein kinase  (p38alpha)
Number Families/Subfamilies: 2
Number of Associated Sequences: 5
GO Molecular Function: -
GO Biological Process: -
GO Cellular Component: -
PANTHER protein class: -
References: Medline:7716521  OMIM:601335 

Sequence Association
Panther Subfamily Associated Sequence Definition Confidence Code Evidence
PTHR48013:SF15 A0A1D5QAU9 Mitogen-activated protein kinase kinase 4 ISS PubMed:10207617  
  A0A1D5QAU9 Mitogen-activated protein kinase kinase 4 ISS PubMed:11730323  
  A0A1D5QAU9 Mitogen-activated protein kinase kinase 4 ISS PubMed:12040174  
  A0A1D5QAU9 Mitogen-activated protein kinase kinase 4 ISS PubMed:7716521  
  A0A3Q1N7I1 Mitogen-activated protein kinase kinase 4 ISS PubMed:10207617  
  A0A3Q1N7I1 Mitogen-activated protein kinase kinase 4 ISS PubMed:11730323  
  A0A3Q1N7I1 Mitogen-activated protein kinase kinase 4 ISS PubMed:12040174  
  A0A3Q1N7I1 Mitogen-activated protein kinase kinase 4 ISS PubMed:7716521  
  P47809 Dual specificity mitogen-activated protein kinase kinase 4 RCA PubMed:10207617  
  P47809 Dual specificity mitogen-activated protein kinase kinase 4 RCA PubMed:11730323  
  P47809 Dual specificity mitogen-activated protein kinase kinase 4 RCA PubMed:12040174  
PTHR48013:SF29 H2QCA7 Mitogen-activated protein kinase kinase 4 ISS PubMed:10207617  
  H2QCA7 Mitogen-activated protein kinase kinase 4 ISS PubMed:11730323  
  H2QCA7 Mitogen-activated protein kinase kinase 4 ISS PubMed:12040174  
  H2QCA7 Mitogen-activated protein kinase kinase 4 ISS PubMed:7716521  
  P45985 Dual specificity mitogen-activated protein kinase kinase 4 IDA PubMed:10207617  
  P45985 Dual specificity mitogen-activated protein kinase kinase 4 IDA PubMed:11730323  
  P45985 Dual specificity mitogen-activated protein kinase kinase 4 IDA PubMed:12040174  
  P45985 Dual specificity mitogen-activated protein kinase kinase 4 IDA PubMed:7716521