PANTHER Pathway  >   p38 MAPK pathway >   mitogen-activated protein kinase kinase kinase 5

Pathway Component Details   
Name: mitogen-activated protein kinase kinase kinase 5 (ASK1)
Definition: Apoptosis-stimulated kinase is mitogen-activated protein kinase (MAPK) kinase kinase 5; it activates the c-Jun NH2-terminal kinase/stress-activated protein kinase (JNK/SAPK) and p38 signaling pathways. MAPK signaling cascades include MAPK, MAPK kinase (MAPKK), and MAPKK kinase (MAPKKK). MAPKKK phosphorylates and activates its downstream protein kinase, MAPKK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that the MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The protein phosphorylates and activates MAPK kinase 4 (MKK4), also known as SERK1, in vitro, and activates JNK/SAPK during transient expression in COS and HEK293 cells; MAPKKK5 does not activate the MAPK extracellular signal-regulated kinase (ERK).
Category ID: P06043
Synonyms:
Upstream:
Downstream: mitogen-activated protein kinase kinase 6  (MKK6)
mitogen-activated protein kinase kinase 4  (MKK4)
mitogen-activated protein kinase kinase 3  (MKK3)
Number Families/Subfamilies: 1
Number of Associated Sequences: 5
GO Molecular Function: -
GO Biological Process: -
GO Cellular Component: -
PANTHER protein class: -
References: Medline:11493600  Medline:9774977  Medline:8974401  Medline:8940179  OMIM:602448 

Sequence Association
Panther Subfamily Associated Sequence Definition Confidence Code Evidence
PTHR11584:SF332 F1MXH6 mitogen-activated protein kinase kinase kinase ISS PubMed:11730323  
  F1MXH6 mitogen-activated protein kinase kinase kinase ISS PubMed:12566458  
  F1MXH6 mitogen-activated protein kinase kinase kinase ISS PubMed:12697749  
  F1MXH6 mitogen-activated protein kinase kinase kinase ISS PubMed:12968034  
  F1MXH6 mitogen-activated protein kinase kinase kinase ISS PubMed:8974401  
  I0FRT6 mitogen-activated protein kinase kinase kinase ISS PubMed:11730323  
  I0FRT6 mitogen-activated protein kinase kinase kinase ISS PubMed:12566458  
  I0FRT6 mitogen-activated protein kinase kinase kinase ISS PubMed:12697749  
  I0FRT6 mitogen-activated protein kinase kinase kinase ISS PubMed:12968034  
  I0FRT6 mitogen-activated protein kinase kinase kinase ISS PubMed:8974401  
  K7CFQ9 mitogen-activated protein kinase kinase kinase ISS PubMed:11730323  
  K7CFQ9 mitogen-activated protein kinase kinase kinase ISS PubMed:12566458  
  K7CFQ9 mitogen-activated protein kinase kinase kinase ISS PubMed:12697749  
  K7CFQ9 mitogen-activated protein kinase kinase kinase ISS PubMed:12968034  
  K7CFQ9 mitogen-activated protein kinase kinase kinase ISS PubMed:8974401  
  O35099 Mitogen-activated protein kinase kinase kinase 5 TAS PubMed:11730323  
  O35099 Mitogen-activated protein kinase kinase kinase 5 TAS PubMed:12566458  
  O35099 Mitogen-activated protein kinase kinase kinase 5 TAS PubMed:12697749  
  O35099 Mitogen-activated protein kinase kinase kinase 5 TAS PubMed:12968034  
  O35099 Mitogen-activated protein kinase kinase kinase 5 TAS PubMed:8974401  
  Q99683 Mitogen-activated protein kinase kinase kinase 5 TAS PubMed:11730323  
  Q99683 Mitogen-activated protein kinase kinase kinase 5 TAS PubMed:12566458  
  Q99683 Mitogen-activated protein kinase kinase kinase 5 TAS PubMed:12697749  
  Q99683 Mitogen-activated protein kinase kinase kinase 5 TAS PubMed:12968034  
  Q99683 Mitogen-activated protein kinase kinase kinase 5 TAS PubMed:8974401