PANTHER Gene Information   
Gene Symbol(s): ESR1
Organism: Bos taurus
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Gene Name: Estrogen receptor
Gene ID: ENSBTAG00000007159
Protein ID: P49884
Persistent Id: PTN002786969
Alternate Ids:
47824866(GI) Q6QIS5(AltAccession)
407238(GeneID) NP_001001443(refSeq)
CHEMBL2930(ChEMBL) ENSBTAP00000009422(Ensembl_PRO)
ESR1(Symbol) Estradiol receptor(Synonym)
AY538775(EMBL) ENSBTAT00000009422(Ensembl_TRS)
ENSBTAG00000007159(Ensembl) AAB09548(EMBL-CDS)
ESR1_BOVIN(UniProtKB-ID)
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PANTHER Classification
PANTHER Family: KNIRPS-RELATED PROTEIN-RELATED (PTHR48092)
PANTHER Subfamily: ESTROGEN RECEPTOR (PTHR48092:SF16)  
PANTHER GO-slim Molecular Function: RNA polymerase II cis-regulatory region sequence-specific DNA binding
DNA-binding transcription factor activity, RNA polymerase II-specific
signaling receptor activity
PANTHER GO-slim Biological Process: regulation of transcription by RNA polymerase II
PANTHER GO-slim Cellular Component: chromatin
nucleus
PANTHER protein class: C4 zinc finger nuclear receptor
Pathway Categories: No pathway information available
GO MF Complete: protein kinase binding, zinc ion binding, identical protein binding, estrogen response element binding, nuclear estrogen receptor activity, DNA-binding transcription activator activity, RNA polymerase II-specific, sequence-specific DNA binding, chromatin binding, steroid binding, beta-catenin binding, transcription coactivator binding, transcription corepressor binding, nuclear receptor activity, TFIIB-class transcription factor binding, TBP-class protein binding, nuclear estrogen receptor binding, ATPase binding, 14-3-3 protein binding
GO BP Complete: negative regulation of smooth muscle cell apoptotic process, positive regulation of nitric oxide biosynthetic process, vagina development, male gonad development, negative regulation of miRNA transcription, uterus development, regulation of epithelial cell apoptotic process, mammary gland branching involved in pregnancy, epithelial cell development, prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis, negative regulation of canonical NF-kappaB signal transduction, positive regulation of transcription by RNA polymerase II, positive regulation of DNA-binding transcription factor activity, regulation of branching involved in prostate gland morphogenesis, prostate epithelial cord elongation, negative regulation of transcription by RNA polymerase II, fibroblast proliferation, RNA polymerase II preinitiation complex assembly, cellular response to estradiol stimulus, stem cell differentiation, positive regulation of nitric-oxide synthase activity, mammary gland alveolus development, antral ovarian follicle growth, positive regulation of DNA-templated transcription, positive regulation of fibroblast proliferation, estrogen receptor signaling pathway, epithelial cell proliferation involved in mammary gland duct elongation, regulation of toll-like receptor signaling pathway, negative regulation of DNA-binding transcription factor activity, phospholipase C-activating G protein-coupled receptor signaling pathway, cellular response to estrogen stimulus, regulation of transcription by RNA polymerase II, positive regulation of cytosolic calcium ion concentration, negative regulation of gene expression, androgen metabolic process, nuclear receptor-mediated steroid hormone signaling pathway, protein localization to chromatin, regulation of inflammatory response
GO CC Complete: nucleus, transcription regulator complex, euchromatin, cytoplasm, Golgi apparatus, chromatin, plasma membrane
Reactome Pathways: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, Post-translational protein modification, Gene expression (Transcription), Intracellular signaling by second messengers, TFAP2 (AP-2) family regulates transcription of growth factors and their receptors, Signal Transduction, Nuclear signaling by ERBB4, RUNX1 regulates estrogen receptor mediated transcription, Negative regulation of the PI3K/AKT network, SUMOylation of intracellular receptors, PIP3 activates AKT signaling, Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors, Signaling by Nuclear Receptors, Nuclear Receptor transcription pathway, Generic Transcription Pathway, SUMO E3 ligases SUMOylate target proteins, Signaling by Receptor Tyrosine Kinases, Metabolism of proteins, Estrogen-dependent gene expression, RNA Polymerase II Transcription, Deubiquitination, Ovarian tumor domain proteases, SUMOylation, ESR-mediated signaling, Extra-nuclear estrogen signaling, Signaling by ERBB4, Transcriptional regulation by RUNX1