PANTHER Gene Information   
Gene Symbol(s): ESR1
Organism: Canis lupus familiaris
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Gene Name: Estrogen receptor
Gene ID: ENSCAFG00845000028.1
Protein ID: A0A8I3MAV6
Persistent Id: PTN001532850
Alternate Ids:
ENSCAFT00845000042(Ensembl_TRS) ENSCAFP00845000028(Ensembl_PRO)
A0A8I3MAV6_CANLF(UniProtKB-ID) A0A8I3MAV6(Synonym)
ENSCAFG00845000028(Ensembl)
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PANTHER Classification
PANTHER Family: KNIRPS-RELATED PROTEIN-RELATED (PTHR48092)
PANTHER Subfamily: ESTROGEN RECEPTOR (PTHR48092:SF16)  
PANTHER GO-slim Molecular Function: RNA polymerase II cis-regulatory region sequence-specific DNA binding
DNA-binding transcription factor activity, RNA polymerase II-specific
signaling receptor activity
PANTHER GO-slim Biological Process: regulation of transcription by RNA polymerase II
PANTHER GO-slim Cellular Component: chromatin
nucleus
PANTHER protein class: C4 zinc finger nuclear receptor
Pathway Categories: No pathway information available
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: protein kinase binding, zinc ion binding, identical protein binding, estrogen response element binding, nuclear estrogen receptor activity, DNA-binding transcription activator activity, RNA polymerase II-specific, chromatin binding, steroid binding, beta-catenin binding, transcription coactivator binding, transcription corepressor binding, nuclear receptor activity, TFIIB-class transcription factor binding, TBP-class protein binding, nuclear estrogen receptor binding, ATPase binding, 14-3-3 protein binding
GO BP Complete: vagina development, male gonad development, negative regulation of miRNA transcription, uterus development, regulation of epithelial cell apoptotic process, mammary gland branching involved in pregnancy, epithelial cell development, prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis, negative regulation of canonical NF-kappaB signal transduction, positive regulation of transcription by RNA polymerase II, regulation of branching involved in prostate gland morphogenesis, prostate epithelial cord elongation, negative regulation of transcription by RNA polymerase II, fibroblast proliferation, RNA polymerase II preinitiation complex assembly, cellular response to estradiol stimulus, stem cell differentiation, mammary gland alveolus development, antral ovarian follicle growth, positive regulation of fibroblast proliferation, estrogen receptor signaling pathway, epithelial cell proliferation involved in mammary gland duct elongation, regulation of toll-like receptor signaling pathway, cellular response to estrogen stimulus, regulation of transcription by RNA polymerase II, negative regulation of gene expression, androgen metabolic process, protein localization to chromatin, regulation of inflammatory response
GO CC Complete: nucleus, transcription regulator complex, euchromatin, cytoplasm, chromatin, plasma membrane
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: ESR-mediated signaling, Gene expression (Transcription), Extra-nuclear estrogen signaling, Signaling by ERBB4, Metabolism of proteins, Generic Transcription Pathway, Transcriptional regulation by RUNX1, Nuclear Receptor transcription pathway, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors, Signal Transduction, Signaling by Nuclear Receptors, RUNX1 regulates estrogen receptor mediated transcription, PIP3 activates AKT signaling, Nuclear signaling by ERBB4, Signaling by Receptor Tyrosine Kinases, Intracellular signaling by second messengers, RNA Polymerase II Transcription, Post-translational protein modification, Estrogen-dependent gene expression, TFAP2 (AP-2) family regulates transcription of growth factors and their receptors, Deubiquitination, Negative regulation of the PI3K/AKT network, Ovarian tumor domain proteases

Orthologs