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Gene Symbol(s):
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PIK3R1
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| Organism: |
Bos taurus |
| View Gene in Tree |
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| Gene Name: |
Phosphatidylinositol 3-kinase regulatory subunit alpha
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| Gene ID: |
ENSBTAG00000010989
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| Protein ID: |
P23727
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| Persistent Id: |
PTN007422721 |
| Alternate Ids: |
| NM_174575(refSeq) |
Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(Synonym) |
| ENSBTAG00000010989(Ensembl) |
6435559(GI) |
| ENSBTAT00000014594(Ensembl_TRS) |
PIK3R1(Symbol) |
| M61745(EMBL) |
AAA79511(EMBL-CDS) |
| ENSBTAP00000014594(Ensembl_PRO) |
282307(GeneID) |
P85A_BOVIN(UniProtKB-ID) |
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Show All
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| GO MF Complete: |
kinase activator activity, phosphatidylinositol 3-kinase binding, insulin binding, identical protein binding, protein phosphatase binding, phosphatidylinositol 3-kinase regulator activity, phosphatidylinositol 3-kinase regulatory subunit binding, transmembrane receptor protein tyrosine kinase adaptor activity, ErbB-3 class receptor binding, insulin receptor binding, neurotrophin TRKA receptor binding, 1-phosphatidylinositol-3-kinase regulator activity, insulin-like growth factor receptor binding, phosphotyrosine residue binding, protein binding, protein heterodimerization activity, enzyme-substrate adaptor activity, insulin receptor substrate binding, phosphatidylinositol 3-kinase activator activity
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| GO BP Complete: |
insulin receptor signaling pathway, positive regulation of RNA splicing, protein transport, positive regulation of filopodium assembly, transcription by RNA polymerase II, phosphatidylinositol phosphate biosynthetic process, extrinsic apoptotic signaling pathway via death domain receptors, positive regulation of transcription by RNA polymerase II, cellular response to insulin stimulus, positive regulation of smooth muscle cell proliferation, phosphatidylinositol 3-kinase/protein kinase B signal transduction, negative regulation of osteoclast differentiation, substrate adhesion-dependent cell spreading, cellular response to UV, positive regulation of tumor necrosis factor production, positive regulation of focal adhesion disassembly, myeloid leukocyte migration, interleukin-18-mediated signaling pathway, positive regulation of lamellipodium assembly, growth hormone receptor signaling pathway, regulation of protein localization to plasma membrane, positive regulation of protein import into nucleus, B cell differentiation, regulation of toll-like receptor 4 signaling pathway, positive regulation of protein localization to plasma membrane, insulin-like growth factor receptor signaling pathway, positive regulation of D-glucose import, intrinsic apoptotic signaling pathway in response to DNA damage, natural killer cell mediated cytotoxicity, positive regulation of endoplasmic reticulum unfolded protein response, osteoclast differentiation, positive regulation of leukocyte migration, negative regulation of stress fiber assembly, intracellular glucose homeostasis, negative regulation of cell-matrix adhesion, protein import into nucleus, negative regulation of apoptotic process, protein stabilization, response to endoplasmic reticulum stress
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| GO CC Complete: |
phosphatidylinositol 3-kinase complex, class IA, nucleus, phosphatidylinositol 3-kinase complex, cis-Golgi network, cell-cell junction, perinuclear endoplasmic reticulum membrane, cytosol
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| Reactome Pathways: |
Cytokine Signaling in Immune system, Signaling by Interleukins, Adaptive Immune System, Intracellular signaling by second messengers, Downstream signaling of activated FGFR4, PI3K events in ERBB2 signaling, Platelet activation, signaling and aggregation, Signal Transduction, Signaling by ERBB2, GAB1 signalosome, Signaling by PDGF, Hemostasis, Downstream signaling of activated FGFR1, PI-3K cascade:FGFR4, PI-3K cascade:FGFR1, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, RAF/MAP kinase cascade, PIP3 activates AKT signaling, RHO GTPase cycle, Insulin receptor signalling cascade, Signaling by Insulin receptor, Role of LAT2/NTAL/LAB on calcium mobilization, PI-3K cascade:FGFR2, Downstream signaling of activated FGFR2, MAPK1/MAPK3 signaling, Signaling by FGFR, Signaling by Rho GTPases, Regulation of signaling by CBL, Costimulation by the CD28 family, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, RET signaling, RND3 GTPase cycle, Signaling by FGFR1, Signaling by NTRKs, Signaling by FGFR2, Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), Signaling by FGFR3, GPVI-mediated activation cascade, Interleukin-7 signaling, Signaling by FGFR4, Signaling by the B Cell Receptor (BCR), IRS-related events triggered by IGF1R, GP1b-IX-V activation signalling, IGF1R signaling cascade, RND1 GTPase cycle, Axon guidance, Signaling by Nuclear Receptors, RND2 GTPase cycle, Signaling by Receptor Tyrosine Kinases, Tie2 Signaling, Signaling by EGFR, RHOC GTPase cycle, FLT3 Signaling, Metabolism of lipids, Cell surface interactions at the vascular wall, MAPK family signaling cascades, MET activates PI3K/AKT signaling, IRS-mediated signalling, Downstream signal transduction, Signaling by GPCR, ESR-mediated signaling, Signaling by VEGF, G alpha (q) signalling events, Nervous system development, CD28 co-stimulation, Interleukin-3, Interleukin-5 and GM-CSF signaling, Role of phospholipids in phagocytosis, CD28 dependent PI3K/Akt signaling, Antigen activates B Cell Receptor (BCR) leading to generation of second messengers, PI3K Cascade, Signaling by ALK, TCR signaling, Metabolism, Innate Immune System, Negative regulation of the PI3K/AKT network, Fcgamma receptor (FCGR) dependent phagocytosis, Signaling by Erythropoietin, PI3K/AKT activation, RHOG GTPase cycle, RHOJ GTPase cycle, Interleukin receptor SHC signaling, RAC2 GTPase cycle, Immune System, RHOD GTPase cycle, PI Metabolism, Signaling by MET, Phospholipid metabolism, Developmental Biology, GPCR downstream signalling, Signaling by SCF-KIT, Signaling by NTRK1 (TRKA), Extra-nuclear estrogen signaling, Signaling by ERBB4, VEGFA-VEGFR2 Pathway, Synthesis of PIPs at the plasma membrane, PI3K events in ERBB4 signaling, Interleukin-2 family signaling, Downstream TCR signaling, RHOF GTPase cycle, RHOA GTPase cycle, Erythropoietin activates Phosphoinositide-3-kinase (PI3K), RHOV GTPase cycle, RAC1 GTPase cycle, DAP12 interactions, RHOU GTPase cycle, DAP12 signaling, Downstream signaling of activated FGFR3, RAC3 GTPase cycle, CDC42 GTPase cycle, PI-3K cascade:FGFR3, Fc epsilon receptor (FCERI) signaling
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