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Gene Symbol(s):
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PIK3R1
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| Organism: |
Canis lupus familiaris |
| View Gene in Tree |
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| Gene Name: |
Phosphatidylinositol 3-kinase regulatory subunit alpha
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| Gene ID: |
ENSCAFG00845011717.1
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| Protein ID: |
A0A8I3N971
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| Persistent Id: |
PTN000016465 |
| Alternate Ids: |
| 487235(GeneID) |
XM_014108822(refSeq) |
| ENSCAFT00845020842(Ensembl_TRS) |
ENSCAFP00845016363(Ensembl_PRO) |
| ENSCAFG00845011717(Ensembl) |
A0A8I3N971(Synonym) |
| A0A8I3N971_CANLF(UniProtKB-ID) |
928128143(GI) |
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Show All
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| GO MF Complete: |
kinase activator activity, insulin binding, protein phosphatase binding, phosphatidylinositol 3-kinase regulator activity, phosphatidylinositol 3-kinase regulatory subunit binding, ErbB-3 class receptor binding, insulin receptor binding, neurotrophin TRKA receptor binding, 1-phosphatidylinositol-3-kinase regulator activity, insulin-like growth factor receptor binding, phosphotyrosine residue binding, protein heterodimerization activity, insulin receptor substrate binding
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| GO BP Complete: |
insulin receptor signaling pathway, positive regulation of RNA splicing, positive regulation of filopodium assembly, transcription by RNA polymerase II, extrinsic apoptotic signaling pathway via death domain receptors, positive regulation of transcription by RNA polymerase II, positive regulation of smooth muscle cell proliferation, phosphatidylinositol 3-kinase/protein kinase B signal transduction, negative regulation of osteoclast differentiation, cellular response to UV, positive regulation of tumor necrosis factor production, positive regulation of focal adhesion disassembly, myeloid leukocyte migration, interleukin-18-mediated signaling pathway, positive regulation of lamellipodium assembly, growth hormone receptor signaling pathway, regulation of protein localization to plasma membrane, positive regulation of protein import into nucleus, B cell differentiation, regulation of toll-like receptor 4 signaling pathway, insulin-like growth factor receptor signaling pathway, intrinsic apoptotic signaling pathway in response to DNA damage, natural killer cell mediated cytotoxicity, positive regulation of endoplasmic reticulum unfolded protein response, osteoclast differentiation, positive regulation of leukocyte migration, negative regulation of stress fiber assembly, intracellular glucose homeostasis, negative regulation of cell-matrix adhesion, protein import into nucleus, negative regulation of apoptotic process, protein stabilization, response to endoplasmic reticulum stress
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| GO CC Complete: |
phosphatidylinositol 3-kinase complex, class IA, nucleus, cis-Golgi network, cell-cell junction, perinuclear endoplasmic reticulum membrane, cytosol
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| Reactome Pathways: |
PI3K Cascade, Interleukin-3, Interleukin-5 and GM-CSF signaling, Insulin receptor signalling cascade, IRS-related events triggered by IGF1R, Signaling by Insulin receptor, IGF1R signaling cascade, CD28 dependent PI3K/Akt signaling, CD28 co-stimulation, RHOA GTPase cycle, RND3 GTPase cycle, Signaling by VEGF, Signaling by NTRK1 (TRKA), Interleukin receptor SHC signaling, PI3K events in ERBB4 signaling, MAPK1/MAPK3 signaling, RHO GTPase cycle, Role of LAT2/NTAL/LAB on calcium mobilization, IRS-mediated signalling, Downstream signaling of activated FGFR3, Signaling by ERBB4, VEGFA-VEGFR2 Pathway, Metabolism of lipids, Innate Immune System, Signaling by MET, Intracellular signaling by second messengers, Antigen activates B Cell Receptor (BCR) leading to generation of second messengers, Regulation of signaling by CBL, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Nervous system development, RAF/MAP kinase cascade, Role of phospholipids in phagocytosis, Signaling by Nuclear Receptors, Signaling by Rho GTPases, Signaling by FGFR, Signaling by Receptor Tyrosine Kinases, Interleukin-2 family signaling, RHOC GTPase cycle, MET activates PI3K/AKT signaling, ESR-mediated signaling, Signaling by PDGF, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, Adaptive Immune System, TCR signaling, RET signaling, Cytokine Signaling in Immune system, Hemostasis, RND1 GTPase cycle, Signaling by ALK, RND2 GTPase cycle, GAB1 signalosome, FLT3 Signaling, Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), MAPK family signaling cascades, Signaling by FGFR3, Signaling by Interleukins, RHOF GTPase cycle, Signaling by FGFR4, Interleukin-7 signaling, RHOG GTPase cycle, Synthesis of PIPs at the plasma membrane, RHOJ GTPase cycle, RAC2 GTPase cycle, Signaling by GPCR, RHOD GTPase cycle, Developmental Biology, DAP12 signaling, Extra-nuclear estrogen signaling, Signaling by SCF-KIT, PI-3K cascade:FGFR2, Downstream signaling of activated FGFR2, Tie2 Signaling, Axon guidance, Fcgamma receptor (FCGR) dependent phagocytosis, Downstream TCR signaling, Signal Transduction, PIP3 activates AKT signaling, Signaling by FGFR2, Metabolism, Signaling by FGFR1, PI Metabolism, Phospholipid metabolism, Downstream signaling of activated FGFR1, PI-3K cascade:FGFR4, RHOU GTPase cycle, PI-3K cascade:FGFR1, Costimulation by the CD28 family, Signaling by the B Cell Receptor (BCR), Signaling by Erythropoietin, G alpha (q) signalling events, Cell surface interactions at the vascular wall, Signaling by ERBB2, Immune System, Downstream signal transduction, DAP12 interactions, PI3K events in ERBB2 signaling, RHOB GTPase cycle, RAC1 GTPase cycle, RHOV GTPase cycle, RAC3 GTPase cycle, CDC42 GTPase cycle, GPCR downstream signalling, Fc epsilon receptor (FCERI) signaling, GPVI-mediated activation cascade, PI3K/AKT activation, PI-3K cascade:FGFR3, Platelet activation, signaling and aggregation, Signaling by NTRKs, Signaling by EGFR, Erythropoietin activates Phosphoinositide-3-kinase (PI3K), Downstream signaling of activated FGFR4, Negative regulation of the PI3K/AKT network
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