PANTHER Gene Information   
Gene Symbol(s): UBE2D1
Organism: Canis lupus familiaris
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Gene Name: Ubiquitin conjugating enzyme E2 D1
Gene ID: ENSCAFG00845001917.1
Protein ID: A0A8I3MLM6
Persistent Id: PTN000631172
Alternate Ids:
XP_850730(refSeq) A0A8I3MLM6_CANLF(UniProtKB-ID)
ENSCAFT00845003356(Ensembl_TRS) 73952967(GI)
ENSCAFG00845001917(Ensembl) A0A8I3MLM6(Synonym)
608578(GeneID) ENSCAFP00845002662(Ensembl_PRO)
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PANTHER Classification
PANTHER Family: UBIQUITIN-CONJUGATING ENZYME E2 (PTHR24068)
PANTHER Subfamily: UBIQUITIN-CONJUGATING ENZYME E2 D1 (PTHR24068:SF36)  
PANTHER GO-slim Molecular Function: ubiquitin conjugating enzyme activity
ubiquitin protein ligase binding
PANTHER GO-slim Biological Process: protein K48-linked ubiquitination
ubiquitin-dependent protein catabolic process
PANTHER GO-slim Cellular Component: nucleus
ubiquitin ligase complex
PANTHER protein class: ubiquitin-protein ligase
Pathway Categories: Ubiquitin proteasome pathway
   Ubiquitin-conjugating enzyme E2
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: ATP binding, ubiquitin protein ligase activity, ubiquitin conjugating enzyme activity
GO BP Complete: positive regulation of protein polyubiquitination, proteasome-mediated ubiquitin-dependent protein catabolic process, protein K48-linked ubiquitination, negative regulation of TORC1 signaling, ubiquitin-dependent protein catabolic process
GO CC Complete: nucleus, cytoplasm, protein-containing complex
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: Mitotic Metaphase and Anaphase, Autodegradation of Cdh1 by Cdh1:APC/C, Downregulation of SMAD2/3:SMAD4 transcriptional activity, Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer, Protein ubiquitination, Signaling by CSF3 (G-CSF), Inactivation of CSF3 (G-CSF) signaling, Inactivation of APC/C via direct inhibition of the APC/C complex, Synthesis of DNA, Toll Like Receptor 4 (TLR4) Cascade, Class I MHC mediated antigen processing & presentation, Antigen processing: Ubiquitination & Proteasome degradation, Assembly of the pre-replicative complex, APC/C:Cdc20 mediated degradation of Cyclin B, Synthesis of active ubiquitin: roles of E1 and E2 enzymes, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, E3 ubiquitin ligases ubiquitinate target proteins, Cell Cycle, Mitotic, IKK complex recruitment mediated by RIP1, Gene expression (Transcription), Phosphorylation of the APC/C, Cellular response to hypoxia, Regulation of mitotic cell cycle, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, Peroxisomal protein import, APC/C:Cdc20 mediated degradation of Securin, TNF signaling, Downstream TCR signaling, Signal Transduction, Signaling by TGF-beta Receptor Complex, Separation of Sister Chromatids, Innate Immune System, DNA Replication, Cellular responses to stimuli, APC-Cdc20 mediated degradation of Nek2A, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Post-translational protein modification, Signaling by BMP, C-type lectin receptors (CLRs), Cell Cycle Checkpoints, Ovarian tumor domain proteases, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, APC/C-mediated degradation of cell cycle proteins, Mitotic Spindle Checkpoint, FCERI mediated NF-kB activation, Toll-like Receptor Cascades, CDK-mediated phosphorylation and removal of Cdc6, Mitotic Anaphase, Death Receptor Signaling, Immune System, Signaling by TGFB family members, Neddylation, Switching of origins to a post-replicative state, Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase, Regulation of APC/C activators between G1/S and early anaphase, Senescence-Associated Secretory Phenotype (SASP), Cellular Senescence, APC/C:Cdc20 mediated degradation of mitotic proteins, M Phase, Metabolism of proteins, TRIF(TICAM1)-mediated TLR4 signaling , Generic Transcription Pathway, Fc epsilon receptor (FCERI) signaling, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, CLEC7A (Dectin-1) signaling, Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components, Adaptive Immune System, TCR signaling, Protein localization, Cytokine Signaling in Immune system, RNA Polymerase II Transcription, MyD88-independent TLR4 cascade , Regulation of TNFR1 signaling, S Phase, Deubiquitination, DNA Replication Pre-Initiation, Cell Cycle, Cellular responses to stress

Orthologs