PANTHER Gene Information   
Gene Symbol(s): eff
Organism: Drosophila melanogaster
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Gene Name: Ubiquitin-conjugating enzyme E2-17 kDa
Gene ID: FBgn0011217
Protein ID: P25867
Persistent Id: PTN000631278
Alternate Ids:
UBCD1_DROME(UniProtKB-ID) eff(Symbol)
NM_001275650(refSeq) Q9VFG6(AltAccession)
442619106(GI) 2.3.2.23(EC)
CAA44453(EMBL-CDS) FBgn0011217(Ensembl)
FBtr0310554(Ensembl_TRS) AE014297(EMBL)
FBpp0307824(Ensembl_PRO) Ubiquitin-protein ligase(Synonym)
41785(GeneID) FBgn0011217(FlyBase)
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PANTHER Classification
PANTHER Family: UBIQUITIN-CONJUGATING ENZYME E2 (PTHR24068)
PANTHER Subfamily: UBIQUITIN-CONJUGATING ENZYME E2-17 KDA (PTHR24068:SF74)  
PANTHER GO-slim Molecular Function: ubiquitin conjugating enzyme activity
PANTHER GO-slim Biological Process: protein polyubiquitination
PANTHER GO-slim Cellular Component: nucleus
PANTHER protein class: ubiquitin-protein ligase
Pathway Categories: Ubiquitin proteasome pathway
   Ubiquitin-conjugating enzyme E2
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: protein binding, ubiquitin protein ligase binding, ubiquitin conjugating enzyme activity
GO BP Complete: peptidoglycan recognition protein signaling pathway, protein polyubiquitination, male meiotic nuclear division, regulation of R7 cell differentiation, negative regulation of smoothened signaling pathway, mitotic cell cycle, ubiquitin-dependent protein catabolic process, compound eye photoreceptor cell differentiation, female germ-line stem cell asymmetric division, regulation of protein stability, compound eye morphogenesis, chromosome organization, germ-line stem cell population maintenance, protein linear polyubiquitination, anaphase-promoting complex-dependent catabolic process, neuron remodeling, protein ubiquitination
GO CC Complete: nucleus, cytosol
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: Cellular Senescence, Senescence-Associated Secretory Phenotype (SASP), Deubiquitination, Signal Transduction, APC/C:Cdc20 mediated degradation of Cyclin B, Signaling by TGFB family members, Peroxisomal protein import, Post-translational protein modification, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, Autodegradation of Cdh1 by Cdh1:APC/C, Ubiquitination and proteolysis of phosphorylated CI, Regulation of TNFR1 signaling, DNA Replication, Cellular responses to stimuli, Cell Cycle Checkpoints, RNA Polymerase II Transcription, Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components, Inactivation of APC/C via direct inhibition of the APC/C complex, Generic Transcription Pathway, Immune System, E3 ubiquitin ligases ubiquitinate target proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, Synthesis of active ubiquitin: roles of E1 and E2 enzymes, Metabolism of proteins, Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer, Ubiquitination and degradation of phosphorylated ARM, Downregulation of SMAD2/3:SMAD4 transcriptional activity, Hedgehog pathway, Mitotic Spindle Checkpoint, M Phase, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, Neddylation, Mitotic Anaphase, Cellular response to hypoxia, Drosophila signaling pathways, CDK-mediated phosphorylation and removal of Cdc6, APC/C:Cdc20 mediated degradation of mitotic proteins, Signaling by BMP, Regulation of APC/C activators between G1/S and early anaphase, TNF signaling, Switching of origins to a post-replicative state, Cellular responses to stress, Ovarian tumor domain proteases, Wingless pathway, Gene expression (Transcription), Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Protein ubiquitination, APC/C-mediated degradation of cell cycle proteins, Mitotic Metaphase and Anaphase, S Phase, Protein localization, Separation of Sister Chromatids, Class I MHC mediated antigen processing & presentation, Cell Cycle, Death Receptor Signaling, Antigen processing: Ubiquitination & Proteasome degradation, Phosphorylation of the APC/C, Adaptive Immune System, N-HH ligand not bound to PTC receptor complex, APC-Cdc20 mediated degradation of Nek2A, Signaling by TGF-beta Receptor Complex, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, WG ligand not bound to FZ receptors, Regulation of mitotic cell cycle, Synthesis of DNA, APC/C:Cdc20 mediated degradation of Securin, Cell Cycle, Mitotic

Orthologs