PANTHER Gene Information

Gene Symbol(s):

THRA

Organism:

Canis lupus familiaris

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Gene Name:

Thyroid hormone receptor alpha

Gene ID:

ENSCAFG00845009925.1

Protein ID:

A0A8I3NDL1

Persistent Id:

PTN009080381

Alternate Ids:

A0A8I3NDL1(Synonym)	ENSCAFT00845017482(Ensembl_TRS)
ENSCAFP00845013607(Ensembl_PRO)	ENSCAFG00845009925(Ensembl)
A0A8I3NDL1_CANLF(UniProtKB-ID)
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PANTHER Classification

PANTHER Family:	NUCLEAR HORMONE RECEPTOR (PTHR24082)
PANTHER Subfamily:	THYROID HORMONE RECEPTOR ALPHA (PTHR24082:SF42)
PANTHER GO-slim Molecular Function:	RNA polymerase II cis-regulatory region sequence-specific DNA binding signaling receptor activity DNA-binding transcription factor activity, RNA polymerase II-specific
PANTHER GO-slim Biological Process:	negative regulation of transcription by RNA polymerase II cell differentiation hormone-mediated signaling pathway intracellular receptor signaling pathway positive regulation of transcription by RNA polymerase II
PANTHER GO-slim Cellular Component:	RNA polymerase II transcription regulator complex
PANTHER protein class:	C4 zinc finger nuclear receptor

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	chromatin DNA binding, zinc ion binding, protein domain specific binding, nuclear receptor activity, RNA polymerase II cis-regulatory region sequence-specific DNA binding, thyroid hormone binding, transcription cis-regulatory region binding, TBP-class protein binding, protein-containing complex binding
GO BP Complete:	female courtship behavior, positive regulation of female receptivity, regulation of myeloid cell apoptotic process, regulation of heart contraction, transcription by RNA polymerase II, thyroid hormone receptor signaling pathway, positive regulation of transcription by RNA polymerase II, regulation of thyroid hormone receptor signaling pathway, learning or memory, hormone-mediated signaling pathway, negative regulation of transcription by RNA polymerase II, response to cold, regulation of lipid catabolic process, retinoic acid receptor signaling pathway, erythrocyte differentiation, thyroid gland development, cartilage condensation, ossification, type I pneumocyte differentiation, negative regulation of RNA polymerase II transcription preinitiation complex assembly, cell differentiation, positive regulation of cold-induced thermogenesis, intracellular receptor signaling pathway
GO CC Complete:	nucleus, RNA polymerase II transcription regulator complex, cytosol

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Gene expression (Transcription), Generic Transcription Pathway, Nuclear Receptor transcription pathway, RNA Polymerase II Transcription

Orthologs

ID	Organism	Type
HUMAN\|HGNC=11796\|UniProtKB=P10827	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000009112.4\|UniProtKB=H2QCV7	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000009661.3\|UniProtKB=A0A2I2ZI23	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000002931.4\|UniProtKB=F7H1N5	Macaca mulatta	LDO
MOUSE\|MGI=MGI=98742\|UniProtKB=P63058	Mus musculus	LDO
RAT\|RGD=3857\|UniProtKB=P63059	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000010745.4\|UniProtKB=A0A3Q1N8R7	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000035969\|UniProtKB=O97716	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000011120.4\|UniProtKB=F6ZL91	Equus caballus	LDO
ORNAN\|Ensembl=ENSOANG00000047374.1\|UniProtKB=A0A6I8PHB7	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010024621\|UniProtKB=P04625	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000002898.4\|UniProtKB=G1KBE2	Anolis carolinensis	LDO
XENLA\|Gene=thra-b\|UniProtKB=P18115	Xenopus laevis	LDO
XENLA\|Gene=thra.S\|UniProtKB=A0A1L8EKN8	Xenopus laevis	O
XENLA\|Gene=thra.L\|UniProtKB=A0A8J0TQR7	Xenopus laevis	LDO
XENLA\|Gene=thra-a\|UniProtKB=P15204	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-5966551\|UniProtKB=B3GR07	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000016941.2\|UniProtKB=A0A3B3H792	Oryzias latipes	O
ORYLA\|Ensembl=ENSORLG00000012005.2\|UniProtKB=Q766D2	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-990415-263\|UniProtKB=Q98867	Danio rerio	O
DANRE\|Gene=thrab\|UniProtKB=A0A8M3B4P5	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000013012.1\|UniProtKB=W5N5X2	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000021968.1\|UniProtKB=H2XNI0	Ciona intestinalis	O
BRAFL\|Gene=LOC118405346\|UniProtKB=A0A9J7KIJ2	Branchiostoma floridae	O
STRPU\|EnsemblGenome=LOC584535\|UniProtKB=A0A7M7N2J7	Strongylocentrotus purpuratus	O
CAEEL\|WormBase=WBGene00003601\|UniProtKB=Q10902	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG04060\|UniProtKB=A8WW43	Caenorhabditis briggsae	O
CAEEL\|WormBase=WBGene00003606\|UniProtKB=Q20765	Caenorhabditis elegans	O
CAEBR\|WormBase=WBGene00028390\|UniProtKB=A8X108	Caenorhabditis briggsae	O
CAEEL\|WormBase=WBGene00004786\|UniProtKB=P41830	Caenorhabditis elegans	O
CAEBR\|WormBase=WBGene00038735\|UniProtKB=A8XVU5	Caenorhabditis briggsae	O
CAEBR\|Gene_ORFName=CBG19536\|UniProtKB=A8XVU6	Caenorhabditis briggsae	O
CAEBR\|Gene_ORFName=CBG17178\|UniProtKB=A8XQM1	Caenorhabditis briggsae	O
CAEEL\|WormBase=WBGene00003675\|UniProtKB=Q9XUK7	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG13679\|UniProtKB=A8XIG9	Caenorhabditis briggsae	O
CAEBR\|WormBase=WBGene00029816\|UniProtKB=A8X5D8	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00272173\|UniProtKB=A0A2A6BTX7	Pristionchus pacificus	O
DROME\|FlyBase=FBgn0000568\|UniProtKB=P13055	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP029560\|UniProtKB=A0A453Z0D2	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC003935\|UniProtKB=D6WHQ0	Tribolium castaneum	O
TRICA\|EnsemblGenome=TC031236\|UniProtKB=A0A139WCF5	Tribolium castaneum	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_205205\|UniProtKB=E9FSB9	Daphnia pulex	O
IXOSC\|EnsemblGenome=ISCW020016\|UniProtKB=B7Q233	Ixodes scapularis	O
HELRO\|EnsemblGenome=HelroG81466\|UniProtKB=T1G4E6	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG67484\|UniProtKB=T1FZ14	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG67463\|UniProtKB=T1FZ12	helobdella robusta	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g108851\|UniProtKB=A7S8G8	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g101676\|UniProtKB=A7S286	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g152310\|UniProtKB=A7TAF5	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g149683\|UniProtKB=A7T846	Nematostella vectensis	O