PANTHER Gene Information

Gene Symbol(s):

thra.L

Organism:

Xenopus laevis

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Gene Name:

Thyroid hormone receptor alpha-A isoform X2

Gene ID:

thra.L

Protein ID:

A0A8J0TQR7

Persistent Id:

PTN009080386

Alternate Ids:

A0A8J0TQR7_XENLA(UniProtKB-ID)	XM_018234145(refSeq)
A0A8J0TQR7(Synonym)	397942(GeneID)
1069388979(GI)
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PANTHER Classification

PANTHER Family:	NUCLEAR HORMONE RECEPTOR (PTHR24082)
PANTHER Subfamily:	THYROID HORMONE RECEPTOR ALPHA (PTHR24082:SF42)
PANTHER GO-slim Molecular Function:	RNA polymerase II cis-regulatory region sequence-specific DNA binding signaling receptor activity DNA-binding transcription factor activity, RNA polymerase II-specific
PANTHER GO-slim Biological Process:	negative regulation of transcription by RNA polymerase II cell differentiation hormone-mediated signaling pathway intracellular receptor signaling pathway positive regulation of transcription by RNA polymerase II
PANTHER GO-slim Cellular Component:	RNA polymerase II transcription regulator complex
PANTHER protein class:	C4 zinc finger nuclear receptor

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	DNA binding, zinc ion binding, protein homodimerization activity, nuclear receptor activity, metal ion binding, protein heterodimerization activity, RNA polymerase II cis-regulatory region sequence-specific DNA binding, thyroid hormone binding, sequence-specific DNA binding, nuclear retinoid X receptor binding, nuclear thyroid hormone receptor binding
GO BP Complete:	negative regulation of transcription by RNA polymerase II, retinoic acid receptor signaling pathway, positive regulation of DNA-templated transcription, cell differentiation, regulation of DNA-templated transcription, thyroid hormone receptor signaling pathway, positive regulation of transcription by RNA polymerase II, programmed cell death
GO CC Complete:	nucleus, RNA polymerase II transcription regulator complex

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Orthologs

ID	Organism	Type
HUMAN\|HGNC=11796\|UniProtKB=P10827	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000009112.4\|UniProtKB=H2QCV7	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000009661.3\|UniProtKB=A0A2I2ZI23	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000002931.4\|UniProtKB=F7H1N5	Macaca mulatta	LDO
MOUSE\|MGI=MGI=98742\|UniProtKB=P63058	Mus musculus	LDO
RAT\|RGD=3857\|UniProtKB=P63059	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000010745.4\|UniProtKB=A0A3Q1N8R7	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000035969\|UniProtKB=O97716	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000011120.4\|UniProtKB=F6ZL91	Equus caballus	LDO
CANLF\|Ensembl=ENSCAFG00845009925.1\|UniProtKB=A0A8I3NDL1	Canis lupus familiaris	LDO
ORNAN\|Ensembl=ENSOANG00000047374.1\|UniProtKB=A0A6I8PHB7	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010024621\|UniProtKB=P04625	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000002898.4\|UniProtKB=G1KBE2	Anolis carolinensis	LDO
XENTR\|Xenbase=XB-GENE-5966551\|UniProtKB=B3GR07	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000016941.2\|UniProtKB=A0A3B3H792	Oryzias latipes	O
ORYLA\|Ensembl=ENSORLG00000012005.2\|UniProtKB=Q766D2	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-990415-263\|UniProtKB=Q98867	Danio rerio	O
DANRE\|Gene=thrab\|UniProtKB=A0A8M3B4P5	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000013012.1\|UniProtKB=W5N5X2	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000021968.1\|UniProtKB=H2XNI0	Ciona intestinalis	O
BRAFL\|Gene=LOC118405346\|UniProtKB=A0A9J7KIJ2	Branchiostoma floridae	O
STRPU\|EnsemblGenome=LOC584535\|UniProtKB=A0A7M7N2J7	Strongylocentrotus purpuratus	O
CAEEL\|WormBase=WBGene00003601\|UniProtKB=Q10902	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG04060\|UniProtKB=A8WW43	Caenorhabditis briggsae	O
CAEEL\|WormBase=WBGene00003606\|UniProtKB=Q20765	Caenorhabditis elegans	O
CAEBR\|WormBase=WBGene00028390\|UniProtKB=A8X108	Caenorhabditis briggsae	O
CAEEL\|WormBase=WBGene00004786\|UniProtKB=P41830	Caenorhabditis elegans	O
CAEBR\|WormBase=WBGene00038735\|UniProtKB=A8XVU5	Caenorhabditis briggsae	O
CAEBR\|Gene_ORFName=CBG19536\|UniProtKB=A8XVU6	Caenorhabditis briggsae	O
CAEBR\|Gene_ORFName=CBG17178\|UniProtKB=A8XQM1	Caenorhabditis briggsae	O
CAEEL\|WormBase=WBGene00003675\|UniProtKB=Q9XUK7	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG13679\|UniProtKB=A8XIG9	Caenorhabditis briggsae	O
CAEBR\|WormBase=WBGene00029816\|UniProtKB=A8X5D8	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00272173\|UniProtKB=A0A2A6BTX7	Pristionchus pacificus	O
DROME\|FlyBase=FBgn0000568\|UniProtKB=P13055	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP029560\|UniProtKB=A0A453Z0D2	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC003935\|UniProtKB=D6WHQ0	Tribolium castaneum	O
TRICA\|EnsemblGenome=TC031236\|UniProtKB=A0A139WCF5	Tribolium castaneum	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_205205\|UniProtKB=E9FSB9	Daphnia pulex	O
IXOSC\|EnsemblGenome=ISCW020016\|UniProtKB=B7Q233	Ixodes scapularis	O
HELRO\|EnsemblGenome=HelroG81466\|UniProtKB=T1G4E6	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG67484\|UniProtKB=T1FZ14	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG67463\|UniProtKB=T1FZ12	helobdella robusta	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g108851\|UniProtKB=A7S8G8	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g101676\|UniProtKB=A7S286	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g152310\|UniProtKB=A7TAF5	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g149683\|UniProtKB=A7T846	Nematostella vectensis	O