PANTHER Gene Information

Gene Symbol(s):

GRK2

Organism:

Gallus gallus

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Gene Name:

G protein-coupled receptor kinase

Gene ID:

ENSGALG00010023175.1

Protein ID:

A0A8V0ZTS7

Persistent Id:

PTN002806968

Alternate Ids:

A0A8V0ZTS7_CHICK(UniProtKB-ID)	A0A8V0ZTS7(Synonym)
ENSGALT00010056490(Ensembl_TRS)	ENSGALG00010023175(Ensembl)
ENSGALP00010034233(Ensembl_PRO)
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PANTHER Classification

PANTHER Family:	G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE (PTHR24355)
PANTHER Subfamily:	BETA-ADRENERGIC RECEPTOR KINASE 1 (PTHR24355:SF22)
PANTHER GO-slim Molecular Function:	G protein-coupled receptor binding protein serine/threonine kinase activity
PANTHER GO-slim Biological Process:	regulation of biological quality regulation of heart contraction negative regulation of signal transduction regulation of G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway protein phosphorylation
PANTHER GO-slim Cellular Component:
PANTHER protein class:	non-receptor serine/threonine protein kinase

Pathway Categories:

Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway

G-protein receptor kinase

Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway

G protein receptor kinase

Angiotensin II-stimulated signaling through G proteins and beta-arrestin

G protein-coupled receptor kinase 2

Inflammation mediated by chemokine and cytokine signaling pathway

G-protein receptor kinase

Parkinson disease

G-protein related kinase

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	G protein-coupled receptor binding, ATP binding, G protein-coupled receptor kinase activity, Edg-2 lysophosphatidic acid receptor binding
GO BP Complete:	regulation of the force of heart contraction, symbiont entry into host cell, heart development, desensitization of G protein-coupled receptor signaling pathway, negative regulation of the force of heart contraction by chemical signal, G protein-coupled receptor signaling pathway, viral genome replication, negative regulation of striated muscle contraction, cardiac muscle contraction, tachykinin receptor signaling pathway, receptor internalization, negative regulation of relaxation of smooth muscle
GO CC Complete:	presynapse, postsynapse, cytoplasmic side of mitochondrial outer membrane, cytosol, cell projection, plasma membrane

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Orthologs

ID	Organism	Type
HUMAN\|HGNC=289\|UniProtKB=P25098	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000003946.6\|UniProtKB=H2Q482	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000011297.3\|UniProtKB=A0A2I2YB76	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000015925.4\|UniProtKB=H9FQI5	Macaca mulatta	LDO
MOUSE\|MGI=MGI=87940\|UniProtKB=Q99MK8	Mus musculus	LDO
RAT\|RGD=2062\|UniProtKB=P26817	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000005832\|UniProtKB=P21146	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000012918.5\|UniProtKB=A0A5G2QNH5	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000002944.4\|UniProtKB=F6SK02	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000003386.6\|UniProtKB=M3W092	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845011204.1\|UniProtKB=A0A8I3NE91	Canis lupus familiaris	LDO
ORNAN\|Ensembl=ENSOANG00000037510.1\|UniProtKB=A0A6I8PDC2	Ornithorhynchus anatinus	LDO
ANOCA\|Ensembl=ENSACAG00000007663.4\|UniProtKB=G1KH29	Anolis carolinensis	LDO
XENLA\|Gene=LOC108707086\|UniProtKB=A0A1L8HQ32	Xenopus laevis	O
XENLA\|Gene=LOC108715724\|UniProtKB=A0A1L8HZZ6	Xenopus laevis	O
XENTR\|Xenbase=XB-GENE-6043587\|UniProtKB=A0A6I8S283	Xenopus tropicalis	O
ORYLA\|Ensembl=ENSORLG00000001133.2\|UniProtKB=A0A3B3H7N3	Oryzias latipes	O
DANRE\|ZFIN=ZDB-GENE-030616-382\|UniProtKB=A0A2R8QPB8	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000003030.1\|UniProtKB=W5M5B5	lepisosteus oculatus	O
CIOIN\|Ensembl=ENSCING00000001450.3\|UniProtKB=F6VL21	Ciona intestinalis	O
BRAFL\|Gene=LOC118425552\|UniProtKB=A0A9J7LXX0	Branchiostoma floridae	O
STRPU\|EnsemblGenome=LOC100888242\|UniProtKB=A0A7M7LLL5	Strongylocentrotus purpuratus	O
CAEEL\|WormBase=WBGene00001709\|UniProtKB=Q09639	Caenorhabditis elegans	O
PRIPA\|EnsemblGenome=WBGene00104072\|UniProtKB=A0A2A6CHM7	Pristionchus pacificus	O
DROME\|FlyBase=FBgn0260798\|UniProtKB=P32865	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP012026\|UniProtKB=A0A1S4H885	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC031284\|UniProtKB=A0A139WD85	Tribolium castaneum	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_194156\|UniProtKB=E9G660	Daphnia pulex	O
IXOSC\|EnsemblGenome=ISCW009785\|UniProtKB=B7PZR9	Ixodes scapularis	O
HELRO\|EnsemblGenome=HelroG75424\|UniProtKB=T1G250	helobdella robusta	O
TRIAD\|EnsemblGenome=TriadG59012\|UniProtKB=B3S4A3	Trichoplax adhaerens	O
MONBE\|EnsemblGenome=MONBRDRAFT_38629\|UniProtKB=A9V9G9	Monosiga brevicollis	O
PHYRM\|Gene=H3GQG0_PHYRM\|UniProtKB=H3GQG0	Phytophthora ramorum	O