PANTHER Gene Information

Gene Symbol(s):

GRK2

Organism:

Felis catus

View Gene in Tree

Tree

Gene Name:

G protein-coupled receptor kinase

Gene ID:

ENSFCAG00000003386.6

Protein ID:

M3W092

Persistent Id:

PTN001968407

Alternate Ids:

M3W092_FELCA(UniProtKB-ID)	ENSFCAT00000003386(Ensembl_TRS)
ENSFCAG00000003386(Ensembl)	ENSFCAP00000003124(Ensembl_PRO)
M3W092(Synonym)	AANG04000779(EMBL)
Show All

PANTHER Classification

PANTHER Family:	G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE (PTHR24355)
PANTHER Subfamily:	BETA-ADRENERGIC RECEPTOR KINASE 1 (PTHR24355:SF22)
PANTHER GO-slim Molecular Function:	G protein-coupled receptor binding protein serine/threonine kinase activity
PANTHER GO-slim Biological Process:	regulation of biological quality regulation of heart contraction negative regulation of signal transduction regulation of G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway protein phosphorylation
PANTHER GO-slim Cellular Component:
PANTHER protein class:	non-receptor serine/threonine protein kinase

Pathway Categories:

Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway

G-protein receptor kinase

Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway

G protein receptor kinase

Angiotensin II-stimulated signaling through G proteins and beta-arrestin

G protein-coupled receptor kinase 2

Inflammation mediated by chemokine and cytokine signaling pathway

G-protein receptor kinase

Parkinson disease

G-protein related kinase

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	G protein-coupled receptor binding, ATP binding, G protein-coupled receptor kinase activity, beta-adrenergic receptor kinase activity, protein kinase activity, protein serine/threonine kinase activity, Edg-2 lysophosphatidic acid receptor binding
GO BP Complete:	symbiont entry into host cell, G protein-coupled receptor signaling pathway, signal transduction, negative regulation of striated muscle contraction, cardiac muscle contraction, tachykinin receptor signaling pathway, regulation of the force of heart contraction, heart development, desensitization of G protein-coupled receptor signaling pathway, negative regulation of the force of heart contraction by chemical signal, viral genome replication, receptor internalization, negative regulation of relaxation of smooth muscle
GO CC Complete:	presynapse, postsynapse, cytoplasm, cytoplasmic side of mitochondrial outer membrane, membrane, cytosol, synapse, cell projection, plasma membrane

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Orthologs

ID	Organism	Type
HUMAN\|HGNC=289\|UniProtKB=P25098	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000003946.6\|UniProtKB=H2Q482	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000011297.3\|UniProtKB=A0A2I2YB76	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000015925.4\|UniProtKB=H9FQI5	Macaca mulatta	LDO
MOUSE\|MGI=MGI=87940\|UniProtKB=Q99MK8	Mus musculus	LDO
RAT\|RGD=2062\|UniProtKB=P26817	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000005832\|UniProtKB=P21146	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000012918.5\|UniProtKB=A0A5G2QNH5	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000002944.4\|UniProtKB=F6SK02	Equus caballus	LDO
CANLF\|Ensembl=ENSCAFG00845011204.1\|UniProtKB=A0A8I3NE91	Canis lupus familiaris	LDO
ORNAN\|Ensembl=ENSOANG00000037510.1\|UniProtKB=A0A6I8PDC2	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010023175.1\|UniProtKB=A0A8V0ZTS7	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000007663.4\|UniProtKB=G1KH29	Anolis carolinensis	LDO
XENLA\|Gene=LOC108707086\|UniProtKB=A0A1L8HQ32	Xenopus laevis	O
XENLA\|Gene=LOC108715724\|UniProtKB=A0A1L8HZZ6	Xenopus laevis	O
XENTR\|Xenbase=XB-GENE-6043587\|UniProtKB=A0A6I8S283	Xenopus tropicalis	O
ORYLA\|Ensembl=ENSORLG00000001133.2\|UniProtKB=A0A3B3H7N3	Oryzias latipes	O
DANRE\|ZFIN=ZDB-GENE-030616-382\|UniProtKB=A0A2R8QPB8	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000003030.1\|UniProtKB=W5M5B5	lepisosteus oculatus	O
CIOIN\|Ensembl=ENSCING00000001450.3\|UniProtKB=F6VL21	Ciona intestinalis	O
BRAFL\|Gene=LOC118425552\|UniProtKB=A0A9J7LXX0	Branchiostoma floridae	O
STRPU\|EnsemblGenome=LOC100888242\|UniProtKB=A0A7M7LLL5	Strongylocentrotus purpuratus	O
CAEEL\|WormBase=WBGene00001709\|UniProtKB=Q09639	Caenorhabditis elegans	O
PRIPA\|EnsemblGenome=WBGene00104072\|UniProtKB=A0A2A6CHM7	Pristionchus pacificus	O
DROME\|FlyBase=FBgn0260798\|UniProtKB=P32865	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP012026\|UniProtKB=A0A1S4H885	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC031284\|UniProtKB=A0A139WD85	Tribolium castaneum	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_194156\|UniProtKB=E9G660	Daphnia pulex	O
IXOSC\|EnsemblGenome=ISCW009785\|UniProtKB=B7PZR9	Ixodes scapularis	O
HELRO\|EnsemblGenome=HelroG75424\|UniProtKB=T1G250	helobdella robusta	O
TRIAD\|EnsemblGenome=TriadG59012\|UniProtKB=B3S4A3	Trichoplax adhaerens	O
MONBE\|EnsemblGenome=MONBRDRAFT_38629\|UniProtKB=A9V9G9	Monosiga brevicollis	O
PHYRM\|Gene=H3GQG0_PHYRM\|UniProtKB=H3GQG0	Phytophthora ramorum	O