PANTHER Gene Information

Gene Symbol(s):

Gprk1

Organism:

Drosophila melanogaster

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Gene Name:

G protein-coupled receptor kinase 1

Gene ID:

FBgn0260798

Protein ID:

P32865

Persistent Id:

PTN000683252

Alternate Ids:

B5RJK1(AltAccession)	FBtr0111121(Ensembl_TRS)
2.7.11.16(EC)	BT022770(EMBL)
3355013(GeneID)	116007484(GI)
Gprk1(Symbol)	FBpp0110413(Ensembl_PRO)
EAA46156(EMBL-CDS)	Gprk-1(Synonym)
GPRK1_DROME(UniProtKB-ID)	FBgn0260798(Ensembl)
FBgn0260798(FlyBase)	NP_001163051(refSeq)
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PANTHER Classification

PANTHER Family:	G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE (PTHR24355)
PANTHER Subfamily:	G PROTEIN-COUPLED RECEPTOR KINASE (PTHR24355:SF18)
PANTHER GO-slim Molecular Function:	protein kinase activity
PANTHER GO-slim Biological Process:	protein phosphorylation
PANTHER GO-slim Cellular Component:
PANTHER protein class:	non-receptor serine/threonine protein kinase

Pathway Categories:

Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway

G-protein receptor kinase

Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction

Rhodopsin kinase

Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway

G protein receptor kinase

Parkinson disease

G-protein related kinase

Angiotensin II-stimulated signaling through G proteins and beta-arrestin

G protein-coupled receptor kinase 3

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	G protein-coupled receptor binding, ATP binding, rhodopsin kinase activity, G protein-coupled receptor kinase activity, phosphatidylinositol binding
GO BP Complete:	phototransduction, visible light, negative regulation of phospholipase C-activating phototransduction signaling pathway, G protein-coupled receptor signaling pathway, signal transduction, positive regulation of smoothened signaling pathway, protein phosphorylation, regulation of signal transduction
GO CC Complete:	cytoplasm, plasma membrane

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

DAG and IP3 signaling, G alpha (s) signalling events, Hedgehog 'on' state, G-protein mediated events, G alpha (i) signalling events, G alpha (q) signalling events, Signaling by Hedgehog, Signal Transduction, Activation of SMO, Intracellular signaling by second messengers, PLC beta mediated events, Signaling by GPCR, CaM pathway, Opioid Signalling, Ca-dependent events, Calmodulin induced events, GPCR downstream signalling

Orthologs

ID	Organism	Type
CHICK\|Ensembl=ENSGALG00010011187.1\|UniProtKB=A0A8V0YGW2	Gallus gallus	O
XENLA\|Gene=LOC121399270\|UniProtKB=A0A1L8HKU5	Xenopus laevis	O
XENLA\|Gene=stk32b.L\|UniProtKB=A0A1L8HTD0	Xenopus laevis	O
XENTR\|Xenbase=XB-GENE-961848\|UniProtKB=A0A6I8S7S8	Xenopus tropicalis	O
CANLF\|Ensembl=ENSCAFG00845024042.1\|UniProtKB=A0A8I3PPM0	Canis lupus familiaris	O
CHICK\|Ensembl=ENSGALG00010001527.1\|UniProtKB=A0A8V0XBZ0	Gallus gallus	O
ANOCA\|Ensembl=ENSACAG00000007586.4\|UniProtKB=G1KGX7	Anolis carolinensis	O
XENLA\|Gene=stk32c.S\|UniProtKB=A0A1L8FEA5	Xenopus laevis	O
XENLA\|Gene=LOC108696109\|UniProtKB=A0A8J0T9F6	Xenopus laevis	O
XENTR\|Xenbase=XB-GENE-949811\|UniProtKB=A0A803KAQ4	Xenopus tropicalis	O
ORNAN\|Ensembl=ENSOANG00000013674.3\|UniProtKB=F7DMC1	Ornithorhynchus anatinus	O
XENLA\|Gene=stk32a.L\|UniProtKB=A0A1L8GXT6	Xenopus laevis	O
XENLA\|Gene=stk32a.S\|UniProtKB=Q6GQ72	Xenopus laevis	O
XENTR\|Xenbase=XB-GENE-490728\|UniProtKB=A0A6I8R893	Xenopus tropicalis	O
DANRE\|Gene=stk32a\|UniProtKB=A0A8M3B519	Danio rerio	O
STRPU\|EnsemblGenome=LOC591895\|UniProtKB=A0A7M7HEJ4	Strongylocentrotus purpuratus	O
HUMAN\|HGNC=289\|UniProtKB=P25098	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000003946.6\|UniProtKB=H2Q482	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000011297.3\|UniProtKB=A0A2I2YB76	Gorilla gorilla gorilla	O
MACMU\|Ensembl=ENSMMUG00000015925.4\|UniProtKB=H9FQI5	Macaca mulatta	O
MOUSE\|MGI=MGI=87940\|UniProtKB=Q99MK8	Mus musculus	O
RAT\|RGD=2062\|UniProtKB=P26817	Rattus norvegicus	O
BOVIN\|Ensembl=ENSBTAG00000005832\|UniProtKB=P21146	Bos taurus	O
PIG\|Ensembl=ENSSSCG00000012918.5\|UniProtKB=A0A5G2QNH5	Sus scrofa	O
HORSE\|Ensembl=ENSECAG00000002944.4\|UniProtKB=F6SK02	Equus caballus	O
FELCA\|Ensembl=ENSFCAG00000003386.6\|UniProtKB=M3W092	Felis catus	O
CANLF\|Ensembl=ENSCAFG00845011204.1\|UniProtKB=A0A8I3NE91	Canis lupus familiaris	O
ORNAN\|Ensembl=ENSOANG00000037510.1\|UniProtKB=A0A6I8PDC2	Ornithorhynchus anatinus	O
CHICK\|Ensembl=ENSGALG00010023175.1\|UniProtKB=A0A8V0ZTS7	Gallus gallus	O
ANOCA\|Ensembl=ENSACAG00000007663.4\|UniProtKB=G1KH29	Anolis carolinensis	O
HUMAN\|HGNC=290\|UniProtKB=P35626	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000014187.6\|UniProtKB=K7B2K4	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000004757.4\|UniProtKB=G3QQ07	Gorilla gorilla gorilla	LDO
MOUSE\|MGI=MGI=87941\|UniProtKB=Q3UYH7	Mus musculus	LDO
RAT\|RGD=2063\|UniProtKB=P26819	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000000005\|UniProtKB=P26818	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000009956.5\|UniProtKB=A0A480X2X7	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000035327.3\|UniProtKB=A0A9L0RS43	Equus caballus	O
HORSE\|Ensembl=ENSECAG00000019326.4\|UniProtKB=A0A3Q2HAD6	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000009926.6\|UniProtKB=M3WCD7	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845028038.1\|UniProtKB=A0A8I3SBB3	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000010516.4\|UniProtKB=A0A5F8GHL2	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000020452.3\|UniProtKB=F7G2S8	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010021212.1\|UniProtKB=A0A8V0ZBF6	Gallus gallus	LDO
XENLA\|Gene=LOC108707086\|UniProtKB=A0A1L8HQ32	Xenopus laevis	O
XENLA\|Gene=LOC108715724\|UniProtKB=A0A1L8HZZ6	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-6043587\|UniProtKB=A0A6I8S283	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000001133.2\|UniProtKB=A0A3B3H7N3	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-030616-382\|UniProtKB=A0A2R8QPB8	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000003030.1\|UniProtKB=W5M5B5	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000001450.3\|UniProtKB=F6VL21	Ciona intestinalis	LDO
BRAFL\|Gene=LOC118425552\|UniProtKB=A0A9J7LXX0	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=LOC100888242\|UniProtKB=A0A7M7LLL5	Strongylocentrotus purpuratus	LDO
CAEEL\|WormBase=WBGene00001709\|UniProtKB=Q09639	Caenorhabditis elegans	LDO
PRIPA\|EnsemblGenome=WBGene00104072\|UniProtKB=A0A2A6CHM7	Pristionchus pacificus	LDO
ANOGA\|EnsemblGenome=AGAP012026\|UniProtKB=A0A1S4H885	Anopheles gambiae	LDO
TRICA\|EnsemblGenome=TC031284\|UniProtKB=A0A139WD85	Tribolium castaneum	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_194156\|UniProtKB=E9G660	Daphnia pulex	LDO
IXOSC\|EnsemblGenome=ISCW009785\|UniProtKB=B7PZR9	Ixodes scapularis	LDO
HELRO\|EnsemblGenome=HelroG75424\|UniProtKB=T1G250	helobdella robusta	LDO
TRIAD\|EnsemblGenome=TriadG59012\|UniProtKB=B3S4A3	Trichoplax adhaerens	LDO
MONBE\|EnsemblGenome=MONBRDRAFT_38629\|UniProtKB=A9V9G9	Monosiga brevicollis	LDO
PHYRM\|Gene=H3GQG0_PHYRM\|UniProtKB=H3GQG0	Phytophthora ramorum	LDO