PANTHER Gene Information

Gene Symbol(s):

grk-2

Organism:

Caenorhabditis elegans

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Gene Name:

G protein-coupled receptor kinase 2

Gene ID:

WBGene00001709

Protein ID:

Q09639

Persistent Id:

PTN000683250

Alternate Ids:

WBGene00001709(WormBase)	373218878(GI)
W02B3(WormBase_TRS)	CE32946(WormBase_PRO)
WBGene00001709(Ensembl)	W02B3.2(Ensembl_PRO)
NM_064834(refSeq)	GRK2_CAEEL(UniProtKB-ID)
CCD63981(EMBL-CDS)	FO080476(EMBL)
W02B3.2(Ensembl_TRS)	GRK2(Synonym)
2.7.11.16(EC)	grk-2(Symbol)
175223(GeneID)
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PANTHER Classification

PANTHER Family:	G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE (PTHR24355)
PANTHER Subfamily:	G PROTEIN-COUPLED RECEPTOR KINASE (PTHR24355:SF18)
PANTHER GO-slim Molecular Function:	protein kinase activity
PANTHER GO-slim Biological Process:	protein phosphorylation
PANTHER GO-slim Cellular Component:
PANTHER protein class:	non-receptor serine/threonine protein kinase

Pathway Categories:

Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway

G-protein receptor kinase

Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction

Rhodopsin kinase

Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway

G protein receptor kinase

Parkinson disease

G-protein related kinase

Angiotensin II-stimulated signaling through G proteins and beta-arrestin

G protein-coupled receptor kinase 3

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	G protein-coupled receptor binding, ATP binding, G protein-coupled receptor kinase activity, protein kinase activity, protein serine/threonine kinase activity
GO BP Complete:	serotonin catabolic process, response to salt, G protein-coupled receptor signaling pathway, signal transduction, positive regulation of growth rate, positive regulation of egg-laying behavior, protein phosphorylation, olfactory behavior, regulation of signal transduction, hyperosmotic response, positive regulation of locomotion, chemotaxis, positive regulation of cation channel activity, negative regulation of dopamine receptor signaling pathway, positive regulation of chemotaxis, response to stimulus
GO CC Complete:	-

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Signaling by GPCR, Signal Transduction, PLC beta mediated events, G alpha (q) signalling events, Intracellular signaling by second messengers, G-protein mediated events, DAG and IP3 signaling, G alpha (i) signalling events, GPCR downstream signalling, CaM pathway, Calmodulin induced events, Ca-dependent events, Opioid Signalling

Orthologs

ID	Organism	Type
CHICK\|Ensembl=ENSGALG00010011187.1\|UniProtKB=A0A8V0YGW2	Gallus gallus	O
XENLA\|Gene=LOC121399270\|UniProtKB=A0A1L8HKU5	Xenopus laevis	O
XENLA\|Gene=stk32b.L\|UniProtKB=A0A1L8HTD0	Xenopus laevis	O
XENTR\|Xenbase=XB-GENE-961848\|UniProtKB=A0A6I8S7S8	Xenopus tropicalis	O
CANLF\|Ensembl=ENSCAFG00845024042.1\|UniProtKB=A0A8I3PPM0	Canis lupus familiaris	O
CHICK\|Ensembl=ENSGALG00010001527.1\|UniProtKB=A0A8V0XBZ0	Gallus gallus	O
ANOCA\|Ensembl=ENSACAG00000007586.4\|UniProtKB=G1KGX7	Anolis carolinensis	O
XENLA\|Gene=stk32c.S\|UniProtKB=A0A1L8FEA5	Xenopus laevis	O
XENLA\|Gene=LOC108696109\|UniProtKB=A0A8J0T9F6	Xenopus laevis	O
XENTR\|Xenbase=XB-GENE-949811\|UniProtKB=A0A803KAQ4	Xenopus tropicalis	O
ORNAN\|Ensembl=ENSOANG00000013674.3\|UniProtKB=F7DMC1	Ornithorhynchus anatinus	O
XENLA\|Gene=stk32a.L\|UniProtKB=A0A1L8GXT6	Xenopus laevis	O
XENLA\|Gene=stk32a.S\|UniProtKB=Q6GQ72	Xenopus laevis	O
XENTR\|Xenbase=XB-GENE-490728\|UniProtKB=A0A6I8R893	Xenopus tropicalis	O
DANRE\|Gene=stk32a\|UniProtKB=A0A8M3B519	Danio rerio	O
STRPU\|EnsemblGenome=LOC591895\|UniProtKB=A0A7M7HEJ4	Strongylocentrotus purpuratus	O
HUMAN\|HGNC=289\|UniProtKB=P25098	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000003946.6\|UniProtKB=H2Q482	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000011297.3\|UniProtKB=A0A2I2YB76	Gorilla gorilla gorilla	O
MACMU\|Ensembl=ENSMMUG00000015925.4\|UniProtKB=H9FQI5	Macaca mulatta	O
MOUSE\|MGI=MGI=87940\|UniProtKB=Q99MK8	Mus musculus	O
RAT\|RGD=2062\|UniProtKB=P26817	Rattus norvegicus	O
BOVIN\|Ensembl=ENSBTAG00000005832\|UniProtKB=P21146	Bos taurus	O
PIG\|Ensembl=ENSSSCG00000012918.5\|UniProtKB=A0A5G2QNH5	Sus scrofa	O
HORSE\|Ensembl=ENSECAG00000002944.4\|UniProtKB=F6SK02	Equus caballus	O
FELCA\|Ensembl=ENSFCAG00000003386.6\|UniProtKB=M3W092	Felis catus	O
CANLF\|Ensembl=ENSCAFG00845011204.1\|UniProtKB=A0A8I3NE91	Canis lupus familiaris	O
ORNAN\|Ensembl=ENSOANG00000037510.1\|UniProtKB=A0A6I8PDC2	Ornithorhynchus anatinus	O
CHICK\|Ensembl=ENSGALG00010023175.1\|UniProtKB=A0A8V0ZTS7	Gallus gallus	O
ANOCA\|Ensembl=ENSACAG00000007663.4\|UniProtKB=G1KH29	Anolis carolinensis	O
HUMAN\|HGNC=290\|UniProtKB=P35626	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000014187.6\|UniProtKB=K7B2K4	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000004757.4\|UniProtKB=G3QQ07	Gorilla gorilla gorilla	LDO
MOUSE\|MGI=MGI=87941\|UniProtKB=Q3UYH7	Mus musculus	LDO
RAT\|RGD=2063\|UniProtKB=P26819	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000000005\|UniProtKB=P26818	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000009956.5\|UniProtKB=A0A480X2X7	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000035327.3\|UniProtKB=A0A9L0RS43	Equus caballus	O
HORSE\|Ensembl=ENSECAG00000019326.4\|UniProtKB=A0A3Q2HAD6	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000009926.6\|UniProtKB=M3WCD7	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845028038.1\|UniProtKB=A0A8I3SBB3	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000010516.4\|UniProtKB=A0A5F8GHL2	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000020452.3\|UniProtKB=F7G2S8	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010021212.1\|UniProtKB=A0A8V0ZBF6	Gallus gallus	LDO
XENLA\|Gene=LOC108707086\|UniProtKB=A0A1L8HQ32	Xenopus laevis	O
XENLA\|Gene=LOC108715724\|UniProtKB=A0A1L8HZZ6	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-6043587\|UniProtKB=A0A6I8S283	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000001133.2\|UniProtKB=A0A3B3H7N3	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-030616-382\|UniProtKB=A0A2R8QPB8	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000003030.1\|UniProtKB=W5M5B5	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000001450.3\|UniProtKB=F6VL21	Ciona intestinalis	LDO
BRAFL\|Gene=LOC118425552\|UniProtKB=A0A9J7LXX0	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=LOC100888242\|UniProtKB=A0A7M7LLL5	Strongylocentrotus purpuratus	LDO
PRIPA\|EnsemblGenome=WBGene00104072\|UniProtKB=A0A2A6CHM7	Pristionchus pacificus	LDO
DROME\|FlyBase=FBgn0260798\|UniProtKB=P32865	Drosophila melanogaster	LDO
ANOGA\|EnsemblGenome=AGAP012026\|UniProtKB=A0A1S4H885	Anopheles gambiae	LDO
TRICA\|EnsemblGenome=TC031284\|UniProtKB=A0A139WD85	Tribolium castaneum	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_194156\|UniProtKB=E9G660	Daphnia pulex	LDO
IXOSC\|EnsemblGenome=ISCW009785\|UniProtKB=B7PZR9	Ixodes scapularis	LDO
HELRO\|EnsemblGenome=HelroG75424\|UniProtKB=T1G250	helobdella robusta	LDO
TRIAD\|EnsemblGenome=TriadG59012\|UniProtKB=B3S4A3	Trichoplax adhaerens	LDO
MONBE\|EnsemblGenome=MONBRDRAFT_38629\|UniProtKB=A9V9G9	Monosiga brevicollis	LDO
PHYRM\|Gene=H3GQG0_PHYRM\|UniProtKB=H3GQG0	Phytophthora ramorum	LDO