PANTHER Gene Information

Gene Symbol(s):

ppara

Organism:

Danio rerio

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Gene Name:

Peroxisome proliferator-activated receptor alpha

Gene ID:

ZDB-GENE-990415-211

Protein ID:

A6XMH7

Persistent Id:

PTN000638023

Alternate Ids:

A6XMH7_DANRE(UniProtKB-ID)	NM_001102567(refSeq)
DQ839548(EMBL)	156523279(GI)
A6XMH7(Synonym)	ABI30003(EMBL-CDS)
557714(GeneID)	ZDB-GENE-990415-211(ZFIN)
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PANTHER Classification

PANTHER Family:	NUCLEAR HORMONE RECEPTOR (PTHR24082)
PANTHER Subfamily:	PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PTHR24082:SF197)
PANTHER GO-slim Molecular Function:	DNA-binding transcription repressor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding signaling receptor activity
PANTHER GO-slim Biological Process:	negative regulation of transcription by RNA polymerase II negative regulation of inflammatory response regulation of lipid metabolic process cell differentiation regulation of localization fatty acid metabolic process hormone-mediated signaling pathway positive regulation of transcription by RNA polymerase II
PANTHER GO-slim Cellular Component:
PANTHER protein class:	C4 zinc finger nuclear receptor

Pathway Categories:

Gonadotropin-releasing hormone receptor pathway

PPARalpha/gamma

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	DNA binding, DNA-binding transcription factor activity, zinc ion binding, nuclear receptor activity, metal ion binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, sequence-specific DNA binding, DNA-binding transcription repressor activity, RNA polymerase II-specific
GO BP Complete:	negative regulation of transcription by RNA polymerase II, negative regulation of inflammatory response, cell differentiation, regulation of DNA-templated transcription, negative regulation of cholesterol storage, response to activity, positive regulation of transcription by RNA polymerase II, positive regulation of fatty acid metabolic process, cellular response to cold, fatty acid metabolic process, hormone-mediated signaling pathway
GO CC Complete:	nucleus

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

SUMO E3 ligases SUMOylate target proteins, Post-translational protein modification, Cellular responses to stimuli, Metabolism of lipids, Cellular response to chemical stress, Cytoprotection by HMOX1, Metabolism of proteins, SUMOylation of intracellular receptors, Regulation of lipid metabolism by PPARalpha, Metabolism, Cellular responses to stress, SUMOylation

Orthologs

ID	Organism	Type
HUMAN\|HGNC=9232\|UniProtKB=Q07869	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000014505.6\|UniProtKB=H2QLW3	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000042788.1\|UniProtKB=A0A2I2Z0P2	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000016258.4\|UniProtKB=G7N476	Macaca mulatta	LDO
MOUSE\|MGI=MGI=104740\|UniProtKB=P23204	Mus musculus	LDO
RAT\|RGD=3369\|UniProtKB=P37230	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000008063.5\|UniProtKB=Q5EA13	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000000006.5\|UniProtKB=F1SM76	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000000484.4\|UniProtKB=A0A9L0T8I5	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000005547.5\|UniProtKB=M3W486	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845010405.1\|UniProtKB=A0A8I3NDH4	Canis lupus familiaris	LDO
CANLF\|Ensembl=ENSCAFG00805026790\|UniProtKB=Q95N78	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000007365.3\|UniProtKB=F7ADB3	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000006277.2\|UniProtKB=F6VPM6	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010023058.1\|UniProtKB=A0A1D5PJQ2	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000004788.3\|UniProtKB=G1KD82	Anolis carolinensis	LDO
XENLA\|Gene=ppara\|UniProtKB=P37232	Xenopus laevis	O
XENLA\|Gene=ppara.S\|UniProtKB=Q6PAY0	Xenopus laevis	O
XENLA\|Gene=ppara.L\|UniProtKB=Q5PPL6	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-480229\|UniProtKB=F7C0K4	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000011091.2\|UniProtKB=H2M628	Oryzias latipes	O
ORYLA\|Ensembl=ENSORLG00000002413.2\|UniProtKB=H2LAT3	Oryzias latipes	LDO
LEPOC\|Ensembl=ENSLOCG00000017030.1\|UniProtKB=W5NK92	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000013188.2\|UniProtKB=Q4H2X6	Ciona intestinalis	O
BRAFL\|Gene=LOC118405726\|UniProtKB=A0A9J7HKH0	Branchiostoma floridae	O
STRPU\|EnsemblGenome=LOC579208\|UniProtKB=A0A7M7RDK4	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC576339\|UniProtKB=A0A7M7NVX1	Strongylocentrotus purpuratus	O
CAEEL\|WormBase=WBGene00003601\|UniProtKB=Q10902	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG04060\|UniProtKB=A8WW43	Caenorhabditis briggsae	O
CAEEL\|WormBase=WBGene00003606\|UniProtKB=Q20765	Caenorhabditis elegans	O
CAEBR\|WormBase=WBGene00028390\|UniProtKB=A8X108	Caenorhabditis briggsae	O
CAEEL\|WormBase=WBGene00004786\|UniProtKB=P41830	Caenorhabditis elegans	O
CAEBR\|WormBase=WBGene00038735\|UniProtKB=A8XVU5	Caenorhabditis briggsae	O
CAEBR\|Gene_ORFName=CBG19536\|UniProtKB=A8XVU6	Caenorhabditis briggsae	O
CAEBR\|Gene_ORFName=CBG17178\|UniProtKB=A8XQM1	Caenorhabditis briggsae	O
CAEEL\|WormBase=WBGene00003675\|UniProtKB=Q9XUK7	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG13679\|UniProtKB=A8XIG9	Caenorhabditis briggsae	O
CAEBR\|WormBase=WBGene00029816\|UniProtKB=A8X5D8	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00272173\|UniProtKB=A0A2A6BTX7	Pristionchus pacificus	O
DROME\|FlyBase=FBgn0000568\|UniProtKB=P13055	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP029560\|UniProtKB=A0A453Z0D2	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC003935\|UniProtKB=D6WHQ0	Tribolium castaneum	O
TRICA\|EnsemblGenome=TC031236\|UniProtKB=A0A139WCF5	Tribolium castaneum	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_205205\|UniProtKB=E9FSB9	Daphnia pulex	O
IXOSC\|EnsemblGenome=ISCW020016\|UniProtKB=B7Q233	Ixodes scapularis	O
HELRO\|EnsemblGenome=HelroG81466\|UniProtKB=T1G4E6	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG67484\|UniProtKB=T1FZ14	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG67463\|UniProtKB=T1FZ12	helobdella robusta	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g108851\|UniProtKB=A7S8G8	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g101676\|UniProtKB=A7S286	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g152310\|UniProtKB=A7TAF5	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g149683\|UniProtKB=A7T846	Nematostella vectensis	O