PANTHER Gene Information

Gene Symbol(s):

Alk

Organism:

Drosophila melanogaster

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Gene Name:

receptor protein-tyrosine kinase

Gene ID:

FBgn0040505

Protein ID:

Q7KJ08

Persistent Id:

PTN000699471

Alternate Ids:

440214452(GI)	FBgn0040505(Ensembl)
Q7KJ08_DROME(UniProtKB-ID)	NP_652600(refSeq)
FBgn0040505(FlyBase)	53425(GeneID)
FBtr0331926(Ensembl_TRS)	FBpp0304259(Ensembl_PRO)
Q7KJ08(Synonym)	AAF36990(EMBL-CDS)
AE013599(EMBL)
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PANTHER Classification

PANTHER Family:	TYROSINE-PROTEIN KINASE RECEPTOR (PTHR24416)
PANTHER Subfamily:	RECEPTOR PROTEIN-TYROSINE KINASE (PTHR24416:SF604)
PANTHER GO-slim Molecular Function:	transmembrane receptor protein tyrosine kinase activity
PANTHER GO-slim Biological Process:	positive regulation of kinase activity transmembrane receptor protein tyrosine kinase signaling pathway regulation of neuron differentiation multicellular organism development
PANTHER GO-slim Cellular Component:	receptor complex plasma membrane
PANTHER protein class:	transmembrane signal receptor

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	ATP binding, protein binding, transmembrane receptor protein tyrosine kinase activity
GO BP Complete:	negative regulation of neuromuscular synaptic transmission, multicellular organism development, mesoderm development, cell surface receptor protein tyrosine kinase signaling pathway, axon guidance, positive regulation of MAPK cascade, regulation of neuron differentiation, regulation of growth, trans-synaptic signaling by neuropeptide, visceral muscle development, compound eye photoreceptor development, digestive tract development, negative regulation of cell size, positive regulation of ERK1 and ERK2 cascade, positive regulation of kinase activity, regulation of olfactory learning
GO CC Complete:	type Is terminal bouton, postsynapse, subsynaptic reticulum, membrane, type Ib terminal bouton, neuromuscular junction, receptor complex, plasma membrane

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Orthologs

ID	Organism	Type
HUMAN\|HGNC=6721\|UniProtKB=P29376	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000006948.7\|UniProtKB=H2Q982	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000007006.3\|UniProtKB=G3QVS9	Gorilla gorilla gorilla	O
MACMU\|Ensembl=ENSMMUG00000008170.4\|UniProtKB=F7HBY2	Macaca mulatta	O
MOUSE\|MGI=MGI=96840\|UniProtKB=P08923	Mus musculus	O
RAT\|RGD=1309323\|UniProtKB=A0A8I6GCV6	Rattus norvegicus	O
HORSE\|Ensembl=ENSECAG00000010591.4\|UniProtKB=A0A3Q2IEA9	Equus caballus	O
MONDO\|Ensembl=ENSMODG00000000117.3\|UniProtKB=F6YBY8	Monodelphis domestica	O
HUMAN\|HGNC=427\|UniProtKB=Q9UM73	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000011796.6\|UniProtKB=H2QHP7	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000004378.3\|UniProtKB=G3QP17	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000010265.4\|UniProtKB=F6PVR5	Macaca mulatta	LDO
MOUSE\|MGI=MGI=103305\|UniProtKB=P97793	Mus musculus	LDO
RAT\|RGD=628622\|UniProtKB=F1LRZ0	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000007379.7\|UniProtKB=A0A3Q1MKW9	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000044640.2\|UniProtKB=A0A5G2RBJ3	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000007080.4\|UniProtKB=F7DDR7	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000042185.2\|UniProtKB=A0A337SD59	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845011603\|UniProtKB=P0DV84	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000015531.5\|UniProtKB=F6VHJ5	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000014473.3\|UniProtKB=F6X759	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010022572.1\|UniProtKB=A0A8V0ZP30	Gallus gallus	O
ANOCA\|Ensembl=ENSACAG00000013890.3\|UniProtKB=G1KPC7	Anolis carolinensis	O
CHICK\|Ensembl=ENSGALG00010017563.1\|UniProtKB=A0A8V0Z3S3	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000008958.4\|UniProtKB=A0A803T8L6	Anolis carolinensis	LDO
XENLA\|Gene=LOC108699739\|UniProtKB=A0A1L8EZT5	Xenopus laevis	O
XENLA\|Gene=LOC108698980\|UniProtKB=A0A8J0TIV8	Xenopus laevis	O
XENTR\|Ensembl=ENSXETG00000000055\|UniProtKB=F6UBP5	Xenopus tropicalis	O
XENLA\|Gene=LOC108717382\|UniProtKB=A0A8J1KS75	Xenopus laevis	O
XENLA\|Gene=LOC108716096\|UniProtKB=A0A8J1KNP1	Xenopus laevis	LDO
XENTR\|Gene=alk\|UniProtKB=A0A8J1JM32	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000015434.2\|UniProtKB=H2MKV3	Oryzias latipes	O
DANRE\|ZFIN=ZDB-GENE-030616-115\|UniProtKB=F1QVU0	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000014716.1\|UniProtKB=W5NBY0	lepisosteus oculatus	O
ORYLA\|Ensembl=ENSORLG00000022549.1\|UniProtKB=A0A3B3HYV3	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-031027-1\|UniProtKB=F8W3R9	Danio rerio	LDO
BRAFL\|Gene=LOC118415382\|UniProtKB=A0A9J7MQY2	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=LOC587032\|UniProtKB=A0A7M7T3B4	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC105441992\|UniProtKB=A0A7M7PPG6	Strongylocentrotus purpuratus	LDO
STRPU\|EnsemblGenome=LOC574978\|UniProtKB=A0A7M7N7T2	Strongylocentrotus purpuratus	LDO
CAEEL\|WormBase=WBGene00004740\|UniProtKB=O76411	Caenorhabditis elegans	LDO
CAEBR\|Gene_ORFName=CBG18982\|UniProtKB=A8XUH7	Caenorhabditis briggsae	LDO
ANOGA\|EnsemblGenome=AGAP012070\|UniProtKB=A0A453YYL0	Anopheles gambiae	LDO
TRICA\|EnsemblGenome=TC002114\|UniProtKB=D6WGT3	Tribolium castaneum	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_309238\|UniProtKB=E9HB47	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_187767\|UniProtKB=E9G7E5	Daphnia pulex	LDO
IXOSC\|EnsemblGenome=ISCW000831\|UniProtKB=B7P3J2	Ixodes scapularis	LDO
HELRO\|EnsemblGenome=HelroG164816\|UniProtKB=T1EVU6	helobdella robusta	LDO
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g85808\|UniProtKB=A7RLS3	Nematostella vectensis	O
TRIAD\|EnsemblGenome=TriadG4397\|UniProtKB=B3RT13	Trichoplax adhaerens	O
TRIAD\|EnsemblGenome=TriadG12208\|UniProtKB=B3RT14	Trichoplax adhaerens	O
TRIAD\|EnsemblGenome=TriadG22855\|UniProtKB=B3RT16	Trichoplax adhaerens	O
MONBE\|EnsemblGenome=MONBRDRAFT_25143\|UniProtKB=A9UYJ2	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_7936\|UniProtKB=A9UYJ1	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_37833\|UniProtKB=A9V451	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_12183\|UniProtKB=A9VBG8	Monosiga brevicollis	O