PANTHER Gene Information

Gene Symbol(s):

NEMVEDRAFT_v1g85808

Organism:

Nematostella vectensis

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Gene Name:

Tyrosine-protein kinase receptor (Fragment)

Gene ID:

NEMVEDRAFT_v1g85808

Protein ID:

A7RLS3

Persistent Id:

PTN001230681

Alternate Ids:

156402674(GI)	XM_001639665(refSeq)
A7RLS3(Synonym)	A7RLS3_NEMVE(UniProtKB-ID)
DS469518(EMBL)	EDO47652(EMBL-CDS)
NEMVEDRAFT_v1g85808(Ensembl)
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PANTHER Classification

PANTHER Family:	TYROSINE-PROTEIN KINASE RECEPTOR (PTHR24416)
PANTHER Subfamily:	INSULIN-LIKE RECEPTOR (PTHR24416:SF525)
PANTHER GO-slim Molecular Function:	transmembrane receptor protein tyrosine kinase activity
PANTHER GO-slim Biological Process:	positive regulation of kinase activity transmembrane receptor protein tyrosine kinase signaling pathway multicellular organism development
PANTHER GO-slim Cellular Component:	receptor complex plasma membrane
PANTHER protein class:	transmembrane signal receptor

Pathway Categories:

Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade

Insulin/Insulin like growth factor

PI3 kinase pathway

Insulin Receptor

Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade

Insulin receptor/Insulin like growth factor receptor/insulin related receptor

Insulin/IGF pathway-protein kinase B signaling cascade

Insulin receptor/Insulin like growth factor receptor/insulin related receptor

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	ATP binding, protein tyrosine kinase activity, transmembrane receptor protein tyrosine kinase activity, metal ion binding
GO BP Complete:	multicellular organism development, cell surface receptor protein tyrosine kinase signaling pathway, positive regulation of kinase activity
GO CC Complete:	membrane, receptor complex, plasma membrane

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Orthologs

ID	Organism	Type
HUMAN\|HGNC=6721\|UniProtKB=P29376	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000006948.7\|UniProtKB=H2Q982	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000007006.3\|UniProtKB=G3QVS9	Gorilla gorilla gorilla	O
MACMU\|Ensembl=ENSMMUG00000008170.4\|UniProtKB=F7HBY2	Macaca mulatta	O
MOUSE\|MGI=MGI=96840\|UniProtKB=P08923	Mus musculus	O
RAT\|RGD=1309323\|UniProtKB=A0A8I6GCV6	Rattus norvegicus	O
HORSE\|Ensembl=ENSECAG00000010591.4\|UniProtKB=A0A3Q2IEA9	Equus caballus	O
MONDO\|Ensembl=ENSMODG00000000117.3\|UniProtKB=F6YBY8	Monodelphis domestica	O
HUMAN\|HGNC=427\|UniProtKB=Q9UM73	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000011796.6\|UniProtKB=H2QHP7	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000004378.3\|UniProtKB=G3QP17	Gorilla gorilla gorilla	O
MACMU\|Ensembl=ENSMMUG00000010265.4\|UniProtKB=F6PVR5	Macaca mulatta	O
MOUSE\|MGI=MGI=103305\|UniProtKB=P97793	Mus musculus	O
RAT\|RGD=628622\|UniProtKB=F1LRZ0	Rattus norvegicus	O
BOVIN\|Ensembl=ENSBTAG00000007379.7\|UniProtKB=A0A3Q1MKW9	Bos taurus	O
PIG\|Ensembl=ENSSSCG00000044640.2\|UniProtKB=A0A5G2RBJ3	Sus scrofa	O
HORSE\|Ensembl=ENSECAG00000007080.4\|UniProtKB=F7DDR7	Equus caballus	O
FELCA\|Ensembl=ENSFCAG00000042185.2\|UniProtKB=A0A337SD59	Felis catus	O
CANLF\|Ensembl=ENSCAFG00845011603\|UniProtKB=P0DV84	Canis lupus familiaris	O
MONDO\|Ensembl=ENSMODG00000015531.5\|UniProtKB=F6VHJ5	Monodelphis domestica	O
ORNAN\|Ensembl=ENSOANG00000014473.3\|UniProtKB=F6X759	Ornithorhynchus anatinus	O
CHICK\|Ensembl=ENSGALG00010022572.1\|UniProtKB=A0A8V0ZP30	Gallus gallus	O
ANOCA\|Ensembl=ENSACAG00000013890.3\|UniProtKB=G1KPC7	Anolis carolinensis	O
CHICK\|Ensembl=ENSGALG00010017563.1\|UniProtKB=A0A8V0Z3S3	Gallus gallus	O
ANOCA\|Ensembl=ENSACAG00000008958.4\|UniProtKB=A0A803T8L6	Anolis carolinensis	O
XENLA\|Gene=LOC108699739\|UniProtKB=A0A1L8EZT5	Xenopus laevis	O
XENLA\|Gene=LOC108698980\|UniProtKB=A0A8J0TIV8	Xenopus laevis	O
XENTR\|Ensembl=ENSXETG00000000055\|UniProtKB=F6UBP5	Xenopus tropicalis	O
XENLA\|Gene=LOC108717382\|UniProtKB=A0A8J1KS75	Xenopus laevis	O
XENLA\|Gene=LOC108716096\|UniProtKB=A0A8J1KNP1	Xenopus laevis	O
XENTR\|Gene=alk\|UniProtKB=A0A8J1JM32	Xenopus tropicalis	O
ORYLA\|Ensembl=ENSORLG00000015434.2\|UniProtKB=H2MKV3	Oryzias latipes	O
DANRE\|ZFIN=ZDB-GENE-030616-115\|UniProtKB=F1QVU0	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000014716.1\|UniProtKB=W5NBY0	lepisosteus oculatus	O
ORYLA\|Ensembl=ENSORLG00000022549.1\|UniProtKB=A0A3B3HYV3	Oryzias latipes	O
DANRE\|ZFIN=ZDB-GENE-031027-1\|UniProtKB=F8W3R9	Danio rerio	O
BRAFL\|Gene=LOC118415382\|UniProtKB=A0A9J7MQY2	Branchiostoma floridae	O
STRPU\|EnsemblGenome=LOC587032\|UniProtKB=A0A7M7T3B4	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC105441992\|UniProtKB=A0A7M7PPG6	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC574978\|UniProtKB=A0A7M7N7T2	Strongylocentrotus purpuratus	O
CAEEL\|WormBase=WBGene00004740\|UniProtKB=O76411	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG18982\|UniProtKB=A8XUH7	Caenorhabditis briggsae	O
DROME\|FlyBase=FBgn0040505\|UniProtKB=Q7KJ08	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP012070\|UniProtKB=A0A453YYL0	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC002114\|UniProtKB=D6WGT3	Tribolium castaneum	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_309238\|UniProtKB=E9HB47	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_187767\|UniProtKB=E9G7E5	Daphnia pulex	O
IXOSC\|EnsemblGenome=ISCW000831\|UniProtKB=B7P3J2	Ixodes scapularis	O
HELRO\|EnsemblGenome=HelroG164816\|UniProtKB=T1EVU6	helobdella robusta	O
HUMAN\|HGNC=10261\|UniProtKB=P08922	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000018544.6\|UniProtKB=H2QTM7	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000014048.3\|UniProtKB=G3RSY8	Gorilla gorilla gorilla	O
MACMU\|Ensembl=ENSMMUG00000023738.4\|UniProtKB=F7FRT8	Macaca mulatta	O
MOUSE\|MGI=MGI=97999\|UniProtKB=Q78DX7	Mus musculus	O
RAT\|RGD=3591\|UniProtKB=Q63132	Rattus norvegicus	O
BOVIN\|Ensembl=ENSBTAG00000047600.2\|UniProtKB=A0A3Q1MAM7	Bos taurus	O
PIG\|Ensembl=ENSSSCG00000026978.4\|UniProtKB=A0A287ASK6	Sus scrofa	O
HORSE\|Ensembl=ENSECAG00000023669.4\|UniProtKB=F6XJD0	Equus caballus	O
FELCA\|Ensembl=ENSFCAG00000006448.6\|UniProtKB=A0A5F5Y417	Felis catus	O
CANLF\|Ensembl=ENSCAFG00845006019.1\|UniProtKB=A0A8I3MZY3	Canis lupus familiaris	O
ORNAN\|Ensembl=ENSOANG00000012474.2\|UniProtKB=A0A6I8PJL7	Ornithorhynchus anatinus	O
CHICK\|Gene=ROS1\|UniProtKB=P08941	Gallus gallus	O
CHICK\|Ensembl=ENSGALG00010012360.1\|UniProtKB=F1NQL9	Gallus gallus	O
XENLA\|Gene=LOC108716156\|UniProtKB=A0A1L8G8Y9	Xenopus laevis	O
XENTR\|Gene=ros1\|UniProtKB=A0A8J1JNF8	Xenopus tropicalis	O
DANRE\|Gene=ros1\|UniProtKB=A0A8M3AR79	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000017138.1\|UniProtKB=W5NKM5	lepisosteus oculatus	O
BRAFL\|Gene=LOC118423552\|UniProtKB=A0A9J7LSI9	Branchiostoma floridae	O
DROME\|FlyBase=FBgn0003366\|UniProtKB=P13368	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP000015\|UniProtKB=Q5TUS8	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC001239\|UniProtKB=A0A139WN63	Tribolium castaneum	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_332355\|UniProtKB=E9HPR8	Daphnia pulex	O
HELRO\|EnsemblGenome=HelroG191035\|UniProtKB=T1FSI9	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG63524\|UniProtKB=T1FXG9	helobdella robusta	O
STRPU\|EnsemblGenome=LOC591965\|UniProtKB=A0A7M7N4A8	Strongylocentrotus purpuratus	O
CAEBR\|Gene_ORFName=CBG14688\|UniProtKB=A8XKG5	Caenorhabditis briggsae	O
ANOGA\|EnsemblGenome=AGAP009158\|UniProtKB=A0A1S4H0B2	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC013779\|UniProtKB=D6WJG8	Tribolium castaneum	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_191008\|UniProtKB=E9FVE1	Daphnia pulex	O
IXOSC\|EnsemblGenome=ISCW017105\|UniProtKB=B7P8W2	Ixodes scapularis	O
HELRO\|EnsemblGenome=HelroG142725\|UniProtKB=T1EJ71	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG133578\|UniProtKB=T1EI15	helobdella robusta	O
STRPU\|EnsemblGenome=LOC577336\|UniProtKB=A0A7M7NQ83	Strongylocentrotus purpuratus	O
HELRO\|EnsemblGenome=HelroG82586\|UniProtKB=T1G4U1	helobdella robusta	O
HUMAN\|HGNC=6093\|UniProtKB=P14616	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000001477.5\|UniProtKB=A0A2I3S4A3	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000013800.3\|UniProtKB=G3RD72	Gorilla gorilla gorilla	O
MACMU\|Ensembl=ENSMMUG00000055304.1\|UniProtKB=A0A5F7ZFV3	Macaca mulatta	O
MOUSE\|MGI=MGI=1346037\|UniProtKB=Q9WTL4	Mus musculus	O
RAT\|RGD=67399\|UniProtKB=Q64716	Rattus norvegicus	O
BOVIN\|Ensembl=ENSBTAG00000003054.6\|UniProtKB=F1MC23	Bos taurus	O
PIG\|Ensembl=ENSSSCG00000006465.5\|UniProtKB=F1RHJ5	Sus scrofa	O
HORSE\|Ensembl=ENSECAG00000014650.4\|UniProtKB=F7DS61	Equus caballus	O
FELCA\|Ensembl=ENSFCAG00000030317.4\|UniProtKB=M3WSK8	Felis catus	O
CANLF\|Ensembl=ENSCAFG00845007933.1\|UniProtKB=A0A8I3N217	Canis lupus familiaris	O
MONDO\|Ensembl=ENSMODG00000016712.4\|UniProtKB=A0A5F8G9U3	Monodelphis domestica	O
ORNAN\|Ensembl=ENSOANG00000039052.1\|UniProtKB=A0A6I8NAL3	Ornithorhynchus anatinus	O
CHICK\|Ensembl=ENSGALG00010027350.1\|UniProtKB=H9KZZ2	Gallus gallus	O
ANOCA\|Ensembl=ENSACAG00000015162.4\|UniProtKB=A0A803T030	Anolis carolinensis	O
XENLA\|Gene=insrr.S\|UniProtKB=A0A1L8F4K7	Xenopus laevis	O
XENLA\|Gene=insrr.L\|UniProtKB=A0A8J0TEG3	Xenopus laevis	O
XENTR\|Xenbase=XB-GENE-483108\|UniProtKB=A0A6I8SB61	Xenopus tropicalis	O
HUMAN\|HGNC=5465\|UniProtKB=P08069	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000007489.6\|UniProtKB=H2QA49	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000012828.3\|UniProtKB=G3RAQ4	Gorilla gorilla gorilla	O
MACMU\|Ensembl=ENSMMUG00000012305.4\|UniProtKB=I2CWY3	Macaca mulatta	O
MOUSE\|MGI=MGI=96433\|UniProtKB=Q60751	Mus musculus	O
RAT\|RGD=2869\|UniProtKB=P24062	Rattus norvegicus	O
BOVIN\|Gene=IGF1R\|UniProtKB=Q05688	Bos taurus	O
BOVIN\|Ensembl=ENSBTAG00000021527.6\|UniProtKB=G1K218	Bos taurus	O
PIG\|Ensembl=ENSSSCG00000030560.4\|UniProtKB=F1CK17	Sus scrofa	O
HORSE\|Ensembl=ENSECAG00000021238.3\|UniProtKB=A0A9L0RY64	Equus caballus	O
FELCA\|Ensembl=ENSFCAG00000018164.5\|UniProtKB=M3WPQ6	Felis catus	O
CANLF\|Ensembl=ENSCAFG00845001742.1\|UniProtKB=A0A8I3RQ77	Canis lupus familiaris	O
MONDO\|Ensembl=ENSMODG00000012761.4\|UniProtKB=A0A5F8HGW3	Monodelphis domestica	O
ORNAN\|Ensembl=ENSOANG00000000134.3\|UniProtKB=A0A6I8PAW1	Ornithorhynchus anatinus	O
CHICK\|Ensembl=ENSGALG00010018730.1\|UniProtKB=A0A8V0ZER1	Gallus gallus	O
ANOCA\|Ensembl=ENSACAG00000008089.4\|UniProtKB=R4G9M3	Anolis carolinensis	O
XENLA\|Gene=igf1r\|UniProtKB=O73798	Xenopus laevis	O
XENLA\|Gene=igf1r.L\|UniProtKB=A0A1L8H104	Xenopus laevis	O
XENTR\|Xenbase=XB-GENE-484032\|UniProtKB=A0A6I8RT94	Xenopus tropicalis	O
ORYLA\|Ensembl=ENSORLG00000014732.2\|UniProtKB=A0A3B3HBU9	Oryzias latipes	O
ORYLA\|Ensembl=ENSORLG00000008532.2\|UniProtKB=A0A3B3HEL8	Oryzias latipes	O
DANRE\|Gene=igf1rb\|UniProtKB=A0A8M1PBN6	Danio rerio	O
DANRE\|Gene=igf1ra\|UniProtKB=A0A8N7UZS2	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000014435.1\|UniProtKB=W5NAY2	lepisosteus oculatus	O
HUMAN\|HGNC=6091\|UniProtKB=P06213	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000010386.6\|UniProtKB=K7CJP0	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000013703.3\|UniProtKB=G3RQJ8	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000028907.3\|UniProtKB=A0A1D5QCC6	Macaca mulatta	LDO
MOUSE\|MGI=MGI=96575\|UniProtKB=P15208	Mus musculus	LDO
RAT\|RGD=2917\|UniProtKB=P15127	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000012687.6\|UniProtKB=F1MV64	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000013566.5\|UniProtKB=F1SCL0	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000010127.4\|UniProtKB=F6RLJ3	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000003030.6\|UniProtKB=A0A2I2UE37	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845024484.1\|UniProtKB=A0A8I3PWD4	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000015101.4\|UniProtKB=F7F370	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000002002.4\|UniProtKB=F6SXU2	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010027254.1\|UniProtKB=A0A8V1AFM7	Gallus gallus	LDO
XENLA\|Gene=insr\|UniProtKB=Q9PVZ4	Xenopus laevis	LDO
XENLA\|Gene=insr.L\|UniProtKB=A0A8J1L5W1	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-920733\|UniProtKB=A0A6I8RXV0	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000018568.2\|UniProtKB=H2MWH4	Oryzias latipes	O
ORYLA\|Ensembl=ENSORLG00000017980.2\|UniProtKB=A0A3B3IGG7	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-020503-4\|UniProtKB=Q1LVG4	Danio rerio	O
DANRE\|Gene=insra\|UniProtKB=A0A8M2BIL6	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000004179.1\|UniProtKB=W5M9H7	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000018425.1\|UniProtKB=H2XNP4	Ciona intestinalis	LDO
BRAFL\|Gene=LOC118410612\|UniProtKB=A0A9J7KQJ0	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=LOC579152\|UniProtKB=A0A7M7N7I5	Strongylocentrotus purpuratus	LDO
CAEEL\|WormBase=WBGene00000898\|UniProtKB=Q968Y9	Caenorhabditis elegans	LDO
CAEBR\|Gene_ORFName=CBG15732\|UniProtKB=A8XMN1	Caenorhabditis briggsae	LDO
DROME\|FlyBase=FBgn0283499\|UniProtKB=P09208	Drosophila melanogaster	LDO
ANOGA\|EnsemblGenome=AGAP012424\|UniProtKB=A0A1S4H988	Anopheles gambiae	LDO
TRICA\|EnsemblGenome=TC007370\|UniProtKB=D2A000	Tribolium castaneum	O
TRICA\|EnsemblGenome=TC010784\|UniProtKB=D6W7P5	Tribolium castaneum	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_237791\|UniProtKB=E9G4E1	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_237995\|UniProtKB=E9G4Y0	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_268485\|UniProtKB=E9HXW2	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_270048\|UniProtKB=E9I043	Daphnia pulex	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_118333\|UniProtKB=E9HVG1	Daphnia pulex	O
IXOSC\|EnsemblGenome=ISCW023666\|UniProtKB=B7QM19	Ixodes scapularis	LDO
HELRO\|EnsemblGenome=HelroG91450\|UniProtKB=T1G839	helobdella robusta	LDO
TRIAD\|EnsemblGenome=TriadG4397\|UniProtKB=B3RT13	Trichoplax adhaerens	O
TRIAD\|EnsemblGenome=TriadG12208\|UniProtKB=B3RT14	Trichoplax adhaerens	O
TRIAD\|EnsemblGenome=TriadG22855\|UniProtKB=B3RT16	Trichoplax adhaerens	LDO
MONBE\|EnsemblGenome=MONBRDRAFT_25143\|UniProtKB=A9UYJ2	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_7936\|UniProtKB=A9UYJ1	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_37833\|UniProtKB=A9V451	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_12183\|UniProtKB=A9VBG8	Monosiga brevicollis	LDO