PANTHER Gene Information

Gene Symbol(s):

EGF

Organism:

Monodelphis domestica

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Gene Name:

Epidermal growth factor

Gene ID:

ENSMODG00000005870.4

Protein ID:

F6R392

Persistent Id:

PTN001315366

Alternate Ids:

612030148(GI)	F6R392_MONDO(UniProtKB-ID)
ENSMODG00000005870(Ensembl)	XM_007495998(refSeq)
100619143(GeneID)	F6R392(Synonym)
ENSMODT00000038550(Ensembl_TRS)	ENSMODP00000036954(Ensembl_PRO)
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PANTHER Classification

PANTHER Family:	VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED (PTHR46513)
PANTHER Subfamily:	PRO-EPIDERMAL GROWTH FACTOR (PTHR46513:SF5)
PANTHER GO-slim Molecular Function:	growth factor activity transmembrane signaling receptor activity Wnt-protein binding
PANTHER GO-slim Biological Process:	canonical Wnt signaling pathway positive regulation of MAPK cascade epidermal growth factor receptor signaling pathway positive regulation of cell population proliferation
PANTHER GO-slim Cellular Component:	plasma membrane
PANTHER protein class:	transmembrane signal receptor

Pathway Categories:

Gonadotropin-releasing hormone receptor pathway

EGF

EGF receptor signaling pathway

Epidermal growth factor

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	growth factor activity, calcium ion binding, guanyl-nucleotide exchange factor activity, epidermal growth factor receptor binding, transmembrane receptor protein tyrosine kinase activator activity, receptor ligand activity
GO BP Complete:	cell population proliferation, positive regulation of ubiquitin-dependent protein catabolic process, regulation of calcium ion import, epidermal growth factor receptor signaling pathway, ERBB2-EGFR signaling pathway, positive regulation of cell population proliferation, cerebellar granule cell precursor proliferation, positive regulation of mitotic nuclear division, branching morphogenesis of an epithelial tube, negative regulation of cholesterol efflux, negative regulation of secretion, epithelial cell proliferation, mammary gland alveolus development, angiogenesis, positive regulation of DNA-templated transcription, positive regulation of endothelial cell migration, positive regulation of epithelial cell proliferation, positive regulation of peptidyl-tyrosine phosphorylation, positive regulation of phosphorylation, positive regulation of receptor internalization, positive regulation of epithelial tube formation, positive regulation of cerebellar granule cell precursor proliferation, positive regulation of canonical Wnt signaling pathway, regulation of receptor signaling pathway via JAK-STAT, positive regulation of MAPK cascade, positive regulation of hyaluronan biosynthetic process, positive regulation of protein localization to early endosome, ERK1 and ERK2 cascade, regulation of protein localization to cell surface, positive regulation of gene expression, positive regulation of endothelial cell proliferation, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of cell migration
GO CC Complete:	extracellular space, extracellular exosome, membrane, plasma membrane

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Orthologs

ID	Organism	Type
HUMAN\|HGNC=3229\|UniProtKB=P01133	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000016367.5\|UniProtKB=H2QQ13	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000005808.3\|UniProtKB=G3QSQ3	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000010043.4\|UniProtKB=F6TFM0	Macaca mulatta	LDO
MOUSE\|MGI=MGI=95290\|UniProtKB=P01132	Mus musculus	LDO
RAT\|RGD=2542\|UniProtKB=P07522	Rattus norvegicus	LDO
PIG\|Ensembl=ENSSSCG00000009134.5\|UniProtKB=A0A287A231	Sus scrofa	LDO
PIG\|Gene=EGF\|UniProtKB=Q00968	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000010741.4\|UniProtKB=F7B762	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000000506.6\|UniProtKB=A0A5F5Y0J7	Felis catus	O
FELCA\|Gene=EGF\|UniProtKB=Q95ND4	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845030111.1\|UniProtKB=A0A8I3Q5L9	Canis lupus familiaris	O
CANLF\|Gene=EGF\|UniProtKB=Q9BEA0	Canis lupus familiaris	LDO
ORNAN\|Ensembl=ENSOANG00000003668.4\|UniProtKB=A0A6I8MYA0	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010003806.1\|UniProtKB=A0A8V0XLN7	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000010153.4\|UniProtKB=A0A803SU34	Anolis carolinensis	LDO
XENLA\|Gene=egf.L\|UniProtKB=A0A8J1MX61	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-951823\|UniProtKB=A8KBG4	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000020598.2\|UniProtKB=A0A3B3HR79	Oryzias latipes	LDO
DANRE\|Gene=egf\|UniProtKB=A0A8M2B432	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000011771.1\|UniProtKB=W5N1G8	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000017654.2\|UniProtKB=F6WZ22	Ciona intestinalis	O
CIOIN\|Ensembl=ENSCING00000022078.1\|UniProtKB=H2XLM3	Ciona intestinalis	O
BRAFL\|Gene=LOC118427149\|UniProtKB=A0A9J7M3Y3	Branchiostoma floridae	O
BRAFL\|Gene=LOC118427146\|UniProtKB=A0A9J7M151	Branchiostoma floridae	O
BRAFL\|Gene=LOC118409884\|UniProtKB=A0A9J7KNA2	Branchiostoma floridae	O
BRAFL\|Gene=LOC118427150\|UniProtKB=A0A9J7M0V8	Branchiostoma floridae	O
BRAFL\|Gene=LOC118418087\|UniProtKB=A0A9J7LDW4	Branchiostoma floridae	O
BRAFL\|Gene=LOC118418084\|UniProtKB=A0A9J7MUW8	Branchiostoma floridae	O
BRAFL\|Gene=LOC118427152\|UniProtKB=A0A9J7M0S3	Branchiostoma floridae	O
BRAFL\|Gene=LOC118417668\|UniProtKB=A0A9J7MUH3	Branchiostoma floridae	O
BRAFL\|Gene=LOC118405902\|UniProtKB=A0A9J7KGA4	Branchiostoma floridae	O
STRPU\|EnsemblGenome=LOC581905\|UniProtKB=A0A7M7P5D6	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC105438789\|UniProtKB=A0A7M7PMS8	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC115923116\|UniProtKB=A0A7M7NNP7	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC100888447\|UniProtKB=A0A7M7NE90	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC105446596\|UniProtKB=A0A7M7NG87	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC115929295\|UniProtKB=A0A7M7T4T3	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC586685\|UniProtKB=A0A7M7RDE0	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC594262\|UniProtKB=A0A7M7PLJ1	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC115925099\|UniProtKB=A0A7M7NZZ2	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC105446106\|UniProtKB=A0A7M7PI37	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC105443672\|UniProtKB=A0A7M7HKG7	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC115924457\|UniProtKB=A0A7M7NVQ1	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC591940\|UniProtKB=A0A7M7NLH8	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC754161\|UniProtKB=A0A7M7SXU5	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC105446184\|UniProtKB=A0A7M7PJR2	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC757083\|UniProtKB=A0A7M7PKJ0	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC105442855\|UniProtKB=A0A7M7NNI7	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC115924993\|UniProtKB=A0A7M7NZA2	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC115923115\|UniProtKB=A0A7M7NND0	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC105442169\|UniProtKB=A0A7M7NRG6	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC115923430\|UniProtKB=A0A7M7NQ26	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC115926091\|UniProtKB=A0A7M7P7Q5	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC587773\|UniProtKB=A0A7M7NGF7	Strongylocentrotus purpuratus	O
CAEEL\|WormBase=WBGene00004374\|UniProtKB=O44191	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG03794\|UniProtKB=A8WWR1	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00109458\|UniProtKB=A0A2A6BAV3	Pristionchus pacificus	O
CAEEL\|WormBase=WBGene00008779\|UniProtKB=G5EFK8	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG09505\|UniProtKB=A8X8Y5	Caenorhabditis briggsae	O
CAEBR\|WormBase=WBGene00038687\|UniProtKB=A8XVN1	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00100282\|UniProtKB=A0A2A6BMJ2	Pristionchus pacificus	O
DROME\|FlyBase=FBgn0011204\|UniProtKB=Q95RU0	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP007023\|UniProtKB=Q7QIQ6	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC002911\|UniProtKB=D6WHF9	Tribolium castaneum	O
ANOGA\|EnsemblGenome=AGAP008193\|UniProtKB=A0A1S4GXK2	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC031834\|UniProtKB=A0A139WA84	Tribolium castaneum	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_237349\|UniProtKB=E9G3P6	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_314322\|UniProtKB=E9G6S4	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_248813\|UniProtKB=E9GVA3	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_303927\|UniProtKB=E9GIG6	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_313913\|UniProtKB=E9G5N7	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_303856\|UniProtKB=E9GIF7	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_303858\|UniProtKB=E9GIF9	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_318319\|UniProtKB=E9GIG3	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_263601\|UniProtKB=E9HQ28	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_318320\|UniProtKB=E9GIG4	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_303924\|UniProtKB=E9GIG2	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_68539\|UniProtKB=E9I293	Daphnia pulex	O
HELRO\|EnsemblGenome=HelroG180677\|UniProtKB=T1FG57	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG178815\|UniProtKB=T1FDS3	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG188530\|UniProtKB=T1FQ35	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG170722\|UniProtKB=T1F3D0	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG175287\|UniProtKB=T1F941	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG164869\|UniProtKB=T1EVW5	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG185306\|UniProtKB=T1FMN1	helobdella robusta	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g118240\|UniProtKB=A7SH94	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g177505\|UniProtKB=A7RGB1	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g83852\|UniProtKB=A7RJD6	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g212268\|UniProtKB=A7SH97	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g245263\|UniProtKB=A7SH96	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g61732\|UniProtKB=A7RIK9	Nematostella vectensis	O