PANTHER Gene Information   
Gene Symbol(s): EGF
Organism: Sus scrofa
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Gene Name: Pro-epidermal growth factor
Gene ID: ENSSSCG00000009134.5
Protein ID: A0A287A231
Persistent Id: PTN002926025
Alternate Ids:
ENSSSCP00000037992(Ensembl_PRO) A0A287A231(Synonym)
ENSSSCG00000009134(Ensembl) A0A287A231_PIG(UniProtKB-ID)
ENSSSCT00000054613(Ensembl_TRS)
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PANTHER Classification
PANTHER Family: VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED (PTHR46513)
PANTHER Subfamily: PRO-EPIDERMAL GROWTH FACTOR (PTHR46513:SF5)  
PANTHER GO-slim Molecular Function: growth factor activity
transmembrane signaling receptor activity
Wnt-protein binding
PANTHER GO-slim Biological Process: canonical Wnt signaling pathway
positive regulation of MAPK cascade
epidermal growth factor receptor signaling pathway
positive regulation of cell population proliferation
PANTHER GO-slim Cellular Component: plasma membrane
PANTHER protein class: transmembrane signal receptor
Pathway Categories: Gonadotropin-releasing hormone receptor pathway
   EGF
EGF receptor signaling pathway
   Epidermal growth factor
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: growth factor activity, calcium ion binding, guanyl-nucleotide exchange factor activity, epidermal growth factor receptor binding, transmembrane receptor protein tyrosine kinase activator activity
GO BP Complete: positive regulation of ubiquitin-dependent protein catabolic process, regulation of calcium ion import, epidermal growth factor receptor signaling pathway, ERBB2-EGFR signaling pathway, positive regulation of cell population proliferation, cerebellar granule cell precursor proliferation, positive regulation of mitotic nuclear division, branching morphogenesis of an epithelial tube, negative regulation of cholesterol efflux, negative regulation of secretion, epithelial cell proliferation, mammary gland alveolus development, angiogenesis, positive regulation of DNA-templated transcription, positive regulation of endothelial cell migration, positive regulation of peptidyl-tyrosine phosphorylation, positive regulation of receptor internalization, positive regulation of epithelial tube formation, positive regulation of cerebellar granule cell precursor proliferation, positive regulation of canonical Wnt signaling pathway, regulation of receptor signaling pathway via JAK-STAT, positive regulation of MAPK cascade, positive regulation of hyaluronan biosynthetic process, positive regulation of protein localization to early endosome, ERK1 and ERK2 cascade, regulation of protein localization to cell surface, positive regulation of gene expression, positive regulation of endothelial cell proliferation, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO CC Complete: extracellular exosome, plasma membrane
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: Cargo recognition for clathrin-mediated endocytosis, ERBB2 Activates PTK6 Signaling, Platelet degranulation , PI3K events in ERBB2 signaling, EGFR downregulation, Signal Transduction, Platelet activation, signaling and aggregation, GAB1 signalosome, Clathrin-mediated endocytosis, ERBB2 Regulates Cell Motility, Signaling by PTK6, Signaling by ERBB2, Signaling by Non-Receptor Tyrosine Kinases, Signaling by ERBB4, Intracellular signaling by second messengers, Response to elevated platelet cytosolic Ca2+, MAPK1/MAPK3 signaling, SHC1 events in EGFR signaling, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, SHC1 events in ERBB2 signaling, Hemostasis, GRB2 events in EGFR signaling, Vesicle-mediated transport, Signaling by EGFR, EGFR interacts with phospholipase C-gamma, Downregulation of ERBB2 signaling, Negative regulation of the PI3K/AKT network, MAPK family signaling cascades, Signaling by Receptor Tyrosine Kinases, Membrane Trafficking, RAF/MAP kinase cascade, PIP3 activates AKT signaling

Orthologs