PANTHER Gene Information

Gene Symbol(s):

DEFA6

Organism:

Pan troglodytes

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Gene Name:

Defensin-6

Gene ID:

ENSPTRG00000051516

Protein ID:

Q5G860

Persistent Id:

PTN001725263

Alternate Ids:

NP_001029079(refSeq)	DEF6(Synonym)
62286496(GI)	DEFA6(Symbol)
AAW78343(EMBL-CDS)	619354(GeneID)
ENSPTRP00000086584(Ensembl_PRO)	AY746440(EMBL)
ENSPTRG00000051516(Ensembl)	DEF6_PANTR(UniProtKB-ID)
ENSPTRT00000089437(Ensembl_TRS)
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PANTHER Classification

PANTHER Family:	ALPHA-DEFENSIN 1 (PTHR11876)
PANTHER Subfamily:	DEFENSIN-6 (PTHR11876:SF3)
PANTHER GO-slim Molecular Function:
PANTHER GO-slim Biological Process:	cellular response to lipopolysaccharide defense response to Gram-negative bacterium antibacterial humoral response innate immune response antimicrobial humoral immune response mediated by antimicrobial peptide defense response to Gram-positive bacterium
PANTHER GO-slim Cellular Component:	extracellular matrix extracellular space
PANTHER protein class:	antimicrobial response protein

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	protein homodimerization activity
GO BP Complete:	disruption of plasma membrane integrity in another organism, innate immune response in mucosa, defense response to Gram-negative bacterium, cellular response to lipopolysaccharide, innate immune response, killing of cells of another organism, antibacterial humoral response, defense response, defense response to fungus, defense response to bacterium, defense response to Gram-positive bacterium, antimicrobial humoral immune response mediated by antimicrobial peptide
GO CC Complete:	extracellular space, cytoplasmic vesicle, transport vesicle, extracellular region, Golgi lumen

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Orthologs

ID	Organism	Type
HUMAN\|HGNC=2765\|UniProtKB=Q01524	Homo sapiens	LDO
GORGO\|Ensembl=ENSGGOG00000010901.3\|UniProtKB=G3R5P2	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000052512.1\|UniProtKB=F7DMC6	Macaca mulatta	LDO
MOUSE\|MGI=MGI=99592\|UniProtKB=P17534	Mus musculus	O
MOUSE\|MGI=MGI=3705236\|UniProtKB=K9J724	Mus musculus	O
MOUSE\|MGI=MGI=3630385\|UniProtKB=Q5G864	Mus musculus	O
MOUSE\|MGI=MGI=3642780\|UniProtKB=F2Z403	Mus musculus	O
MOUSE\|MGI=MGI=94881\|UniProtKB=P17533	Mus musculus	O
MOUSE\|MGI=MGI=94883\|UniProtKB=P28310	Mus musculus	O
MOUSE\|MGI=MGI=94882\|UniProtKB=P28309	Mus musculus	O
MOUSE\|MGI=MGI=102516\|UniProtKB=Q64263	Mus musculus	O
MOUSE\|MGI=MGI=3709048\|UniProtKB=D3Z0J0	Mus musculus	O
MOUSE\|MGI=MGI=94880\|UniProtKB=P11477	Mus musculus	O
MOUSE\|MGI=MGI=99581\|UniProtKB=P50705	Mus musculus	O
MOUSE\|MGI=MGI=99584\|UniProtKB=P28311	Mus musculus	O
MOUSE\|MGI=MGI=3630390\|UniProtKB=Q3L180	Mus musculus	O
MOUSE\|MGI=MGI=3630381\|UniProtKB=Q5G866	Mus musculus	O
MOUSE\|MGI=MGI=99579\|UniProtKB=P50707	Mus musculus	O
MOUSE\|MGI=MGI=102514\|UniProtKB=P50716	Mus musculus	O
MOUSE\|MGI=MGI=99583\|UniProtKB=P28312	Mus musculus	O
MOUSE\|MGI=MGI=99580\|UniProtKB=P50706	Mus musculus	O
MOUSE\|MGI=MGI=3645033\|UniProtKB=D3YX03	Mus musculus	O
MOUSE\|MGI=MGI=3630303\|UniProtKB=Q5ERI8	Mus musculus	O
MOUSE\|MGI=MGI=99582\|UniProtKB=P50704	Mus musculus	O
MOUSE\|MGI=MGI=3711900\|UniProtKB=E9QLQ1	Mus musculus	O
MOUSE\|MGI=MGI=99591\|UniProtKB=P50708	Mus musculus	O
MOUSE\|MGI=MGI=99586\|UniProtKB=P50713	Mus musculus	O
MOUSE\|MGI=MGI=1915259\|UniProtKB=Q45VN2	Mus musculus	O
MOUSE\|MGI=MGI=99588\|UniProtKB=P50711	Mus musculus	O
MOUSE\|MGI=MGI=3611585\|UniProtKB=Q9D848	Mus musculus	O
MOUSE\|MGI=MGI=3646688\|UniProtKB=D3Z1V9	Mus musculus	O
MOUSE\|MGI=MGI=102509\|UniProtKB=P50715	Mus musculus	O
MOUSE\|MGI=MGI=3639039\|UniProtKB=Q8C1N8	Mus musculus	O
MOUSE\|MGI=MGI=3630383\|UniProtKB=Q5G865	Mus musculus	O
MOUSE\|MGI=MGI=1913548\|UniProtKB=Q8C1P2	Mus musculus	O
MOUSE\|MGI=MGI=99590\|UniProtKB=P50709	Mus musculus	O
MOUSE\|MGI=MGI=3708769\|UniProtKB=L7N231	Mus musculus	O
MOUSE\|MGI=MGI=3705230\|UniProtKB=D3YX02	Mus musculus	O
MOUSE\|MGI=MGI=99585\|UniProtKB=P50714	Mus musculus	O
MOUSE\|MGI=MGI=3709605\|UniProtKB=Q5ERJ0	Mus musculus	O
MOUSE\|MGI=MGI=1345152\|UniProtKB=Q64016	Mus musculus	O
MOUSE\|MGI=MGI=99587\|UniProtKB=P50712	Mus musculus	O
MOUSE\|MGI=MGI=3808881\|UniProtKB=E9QPZ2	Mus musculus	O
RAT\|RGD=1304852\|UniProtKB=Q4JEI9	Rattus norvegicus	O
RAT\|RGD=1566065\|UniProtKB=Q4JEI6	Rattus norvegicus	O
RAT\|RGD=1562293\|UniProtKB=Q4JEI8	Rattus norvegicus	O
RAT\|Gene=DEF5_RAT\|UniProtKB=P82106	Rattus norvegicus	O
RAT\|RGD=1564555\|UniProtKB=Q4JEI5	Rattus norvegicus	O
RAT\|RGD=150344900\|UniProtKB=A0A8I6GLV0	Rattus norvegicus	O
RAT\|RGD=1561398\|UniProtKB=Q4JEI2	Rattus norvegicus	O
RAT\|RGD=1587186\|UniProtKB=Q4JEI3	Rattus norvegicus	O
RAT\|Gene=DEF3A_RAT\|UniProtKB=Q62713	Rattus norvegicus	O
RAT\|Ensembl=ENSRNOG00000038135\|UniProtKB=Q9Z1F1	Rattus norvegicus	O
RAT\|RGD=727857\|UniProtKB=Q62714	Rattus norvegicus	O
RAT\|RGD=727951\|UniProtKB=Q62715	Rattus norvegicus	O
RAT\|RGD=1587187\|UniProtKB=F1LSU5	Rattus norvegicus	O
RAT\|Gene=DEF1_RAT\|UniProtKB=Q62716	Rattus norvegicus	O
HORSE\|Ensembl=ENSECAG00000049963.1\|UniProtKB=C8BNH6	Equus caballus	O
HORSE\|Ensembl=ENSECAG00000030501.2\|UniProtKB=C8BNG1	Equus caballus	O
HORSE\|Ensembl=ENSECAG00000033357.1\|UniProtKB=C8BNI9	Equus caballus	O
HORSE\|Ensembl=ENSECAG00000011787\|UniProtKB=A6YB85	Equus caballus	O
HORSE\|Ensembl=ENSECAG00000027869.3\|UniProtKB=A0A3Q2HQJ5	Equus caballus	O
HORSE\|Ensembl=ENSECAG00000039434.1\|UniProtKB=A0A3Q2GSZ3	Equus caballus	O
HORSE\|Ensembl=ENSECAG00000032644.1\|UniProtKB=A0A3Q2IBF0	Equus caballus	O
HORSE\|Ensembl=ENSECAG00000028505.2\|UniProtKB=A0A3Q2L6V2	Equus caballus	O
HORSE\|Ensembl=ENSECAG00000043705.2\|UniProtKB=A0A5F5PG18	Equus caballus	O
HORSE\|Ensembl=ENSECAG00000054883.1\|UniProtKB=C8BNG5	Equus caballus	O
HORSE\|Ensembl=ENSECAG00000037168.3\|UniProtKB=A0A5F5PU65	Equus caballus	O
HORSE\|Ensembl=ENSECAG00000051382.1\|UniProtKB=F6WLD2	Equus caballus	O
ORNAN\|Gene=DEFA2_ORNAN\|UniProtKB=P0C8A2	Ornithorhynchus anatinus	O
ORNAN\|Ensembl=ENSOANG00000037525.1\|UniProtKB=A0A6I8PB05	Ornithorhynchus anatinus	O
ORNAN\|Ensembl=ENSOANG00000050290\|UniProtKB=P0C8A3	Ornithorhynchus anatinus	O
TRIAD\|EnsemblGenome=TriadG55945\|UniProtKB=B3RTJ3	Trichoplax adhaerens	O
TRIAD\|EnsemblGenome=TriadG55948\|UniProtKB=B3RTJ6	Trichoplax adhaerens	O
TRIAD\|EnsemblGenome=TriadG55947\|UniProtKB=B3RTJ5	Trichoplax adhaerens	O
TRIAD\|EnsemblGenome=TriadG63910\|UniProtKB=B3RTJ8	Trichoplax adhaerens	O
TRIAD\|EnsemblGenome=TriadG63869\|UniProtKB=B3RVQ0	Trichoplax adhaerens	O
TRIAD\|EnsemblGenome=TriadG55946\|UniProtKB=B3RTJ4	Trichoplax adhaerens	O
TRIAD\|EnsemblGenome=TriadG55949\|UniProtKB=B3RTJ7	Trichoplax adhaerens	O