PANTHER Gene Information

Gene Symbol(s):

Defa8

Organism:

Rattus norvegicus

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Gene Name:

Defensin alpha 8

Gene ID:

1566065

Protein ID:

Q4JEI6

Persistent Id:

PTN000222408

Alternate Ids:

Q4JEI6_RAT(UniProtKB-ID)	NP_001028249(refSeq)
49823536(GI)	AY623760(EMBL)
ENSRNOT00000045057(Ensembl_TRS)	Q4JEI6(Synonym)
ENSRNOP00000044476(Ensembl_PRO)	1566065(RGD)
ENSRNOG00000062395(Ensembl)	613224(GeneID)
AAT68759(EMBL-CDS)
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PANTHER Classification

PANTHER Family:	ALPHA-DEFENSIN 1 (PTHR11876)
PANTHER Subfamily:	ALPHA-DEFENSIN 1-RELATED (PTHR11876:SF2)
PANTHER GO-slim Molecular Function:
PANTHER GO-slim Biological Process:	cellular response to lipopolysaccharide defense response to Gram-negative bacterium antibacterial humoral response innate immune response antimicrobial humoral immune response mediated by antimicrobial peptide defense response to Gram-positive bacterium
PANTHER GO-slim Cellular Component:	extracellular matrix extracellular space
PANTHER protein class:	antimicrobial response protein

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	-
GO BP Complete:	disruption of plasma membrane integrity in another organism, innate immune response in mucosa, defense response to Gram-negative bacterium, cellular response to lipopolysaccharide, antibacterial humoral response, defense response to Gram-positive bacterium, antimicrobial humoral immune response mediated by antimicrobial peptide
GO CC Complete:	extracellular space

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Neutrophil degranulation, Immune System, Defensins, Innate Immune System, Antimicrobial peptides, Alpha-defensins

Orthologs

ID	Organism	Type
GORGO\|Ensembl=ENSGGOG00000039811.1\|UniProtKB=A0A2I2YQC3	Gorilla gorilla gorilla	O
MACMU\|Gene=RTD3_MACMU\|UniProtKB=Q9GLR2	Macaca mulatta	O
MACMU\|Gene=RTD1B\|UniProtKB=P82271	Macaca mulatta	O
MACMU\|Gene=RTD1A\|UniProtKB=P82270	Macaca mulatta	O
MACMU\|Ensembl=ENSMMUG00000049881.1\|UniProtKB=A0A5F8AES1	Macaca mulatta	O
MACMU\|Ensembl=ENSMMUG00000054742.1\|UniProtKB=A0A5F7Z7A6	Macaca mulatta	O
HUMAN\|HGNC=2763\|UniProtKB=P12838	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000034369\|UniProtKB=Q5G862	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000010900.3\|UniProtKB=G3R5N8	Gorilla gorilla gorilla	O
HUMAN\|HGNC=2765\|UniProtKB=Q01524	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000051516\|UniProtKB=Q5G860	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000010901.3\|UniProtKB=G3R5P2	Gorilla gorilla gorilla	O
MACMU\|Ensembl=ENSMMUG00000052512.1\|UniProtKB=F7DMC6	Macaca mulatta	O
PANTR\|Gene=DEFA7\|UniProtKB=Q5G859	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000040805.1\|UniProtKB=A0A2I2Y9B9	Gorilla gorilla gorilla	O
HUMAN\|HGNC=2762\|UniProtKB=P59666	Homo sapiens	O
HUMAN\|HGNC=2761\|UniProtKB=P59665	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000050573\|UniProtKB=Q5G863	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000004514.3\|UniProtKB=G3QPD5	Gorilla gorilla gorilla	O
MACMU\|Gene=DEF8_MACMU\|UniProtKB=P60032	Macaca mulatta	O
MACMU\|Gene=DEF3_MACMU\|UniProtKB=P60031	Macaca mulatta	O
MACMU\|Ensembl=ENSMMUG00000018517\|UniProtKB=P60030	Macaca mulatta	O
HUMAN\|HGNC=2764\|UniProtKB=Q01523	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000049316\|UniProtKB=Q5G861	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000016102.3\|UniProtKB=G3RJ35	Gorilla gorilla gorilla	O
MACMU\|Ensembl=ENSMMUG00000040721.2\|UniProtKB=A0A1D5QQV7	Macaca mulatta	O
MACMU\|Ensembl=ENSMMUG00000045717.2\|UniProtKB=F7DY92	Macaca mulatta	O
MACMU\|Ensembl=ENSMMUG00000054369.1\|UniProtKB=A0A5F7ZH18	Macaca mulatta	O
MACMU\|Ensembl=ENSMMUG00000054195.1\|UniProtKB=A0A5F8AQZ0	Macaca mulatta	O
MACMU\|Gene=DEF4_MACMU\|UniProtKB=P82319	Macaca mulatta	O
MACMU\|Gene=DEF6_MACMU\|UniProtKB=P82320	Macaca mulatta	O
MOUSE\|MGI=MGI=99592\|UniProtKB=P17534	Mus musculus	O
MOUSE\|MGI=MGI=3705236\|UniProtKB=K9J724	Mus musculus	O
MOUSE\|MGI=MGI=3630385\|UniProtKB=Q5G864	Mus musculus	O
MOUSE\|MGI=MGI=3642780\|UniProtKB=F2Z403	Mus musculus	O
MOUSE\|MGI=MGI=94881\|UniProtKB=P17533	Mus musculus	O
MOUSE\|MGI=MGI=94883\|UniProtKB=P28310	Mus musculus	O
MOUSE\|MGI=MGI=94882\|UniProtKB=P28309	Mus musculus	O
MOUSE\|MGI=MGI=102516\|UniProtKB=Q64263	Mus musculus	O
MOUSE\|MGI=MGI=3709048\|UniProtKB=D3Z0J0	Mus musculus	O
MOUSE\|MGI=MGI=94880\|UniProtKB=P11477	Mus musculus	O
MOUSE\|MGI=MGI=99581\|UniProtKB=P50705	Mus musculus	O
MOUSE\|MGI=MGI=99584\|UniProtKB=P28311	Mus musculus	O
MOUSE\|MGI=MGI=3630390\|UniProtKB=Q3L180	Mus musculus	O
MOUSE\|MGI=MGI=3630381\|UniProtKB=Q5G866	Mus musculus	LDO
MOUSE\|MGI=MGI=99579\|UniProtKB=P50707	Mus musculus	O
MOUSE\|MGI=MGI=102514\|UniProtKB=P50716	Mus musculus	O
MOUSE\|MGI=MGI=99583\|UniProtKB=P28312	Mus musculus	O
MOUSE\|MGI=MGI=99580\|UniProtKB=P50706	Mus musculus	O
MOUSE\|MGI=MGI=3645033\|UniProtKB=D3YX03	Mus musculus	O
MOUSE\|MGI=MGI=3630303\|UniProtKB=Q5ERI8	Mus musculus	O
MOUSE\|MGI=MGI=99582\|UniProtKB=P50704	Mus musculus	O
MOUSE\|MGI=MGI=3711900\|UniProtKB=E9QLQ1	Mus musculus	O
MOUSE\|MGI=MGI=99591\|UniProtKB=P50708	Mus musculus	O
MOUSE\|MGI=MGI=99586\|UniProtKB=P50713	Mus musculus	O
MOUSE\|MGI=MGI=1915259\|UniProtKB=Q45VN2	Mus musculus	O
MOUSE\|MGI=MGI=99588\|UniProtKB=P50711	Mus musculus	O
MOUSE\|MGI=MGI=3611585\|UniProtKB=Q9D848	Mus musculus	O
MOUSE\|MGI=MGI=3646688\|UniProtKB=D3Z1V9	Mus musculus	O
MOUSE\|MGI=MGI=102509\|UniProtKB=P50715	Mus musculus	O
MOUSE\|MGI=MGI=3639039\|UniProtKB=Q8C1N8	Mus musculus	O
MOUSE\|MGI=MGI=3630383\|UniProtKB=Q5G865	Mus musculus	O
MOUSE\|MGI=MGI=1913548\|UniProtKB=Q8C1P2	Mus musculus	O
MOUSE\|MGI=MGI=99590\|UniProtKB=P50709	Mus musculus	O
MOUSE\|MGI=MGI=3708769\|UniProtKB=L7N231	Mus musculus	O
MOUSE\|MGI=MGI=3705230\|UniProtKB=D3YX02	Mus musculus	O
MOUSE\|MGI=MGI=99585\|UniProtKB=P50714	Mus musculus	O
MOUSE\|MGI=MGI=3709605\|UniProtKB=Q5ERJ0	Mus musculus	O
MOUSE\|MGI=MGI=1345152\|UniProtKB=Q64016	Mus musculus	O
MOUSE\|MGI=MGI=99587\|UniProtKB=P50712	Mus musculus	O
MOUSE\|MGI=MGI=3808881\|UniProtKB=E9QPZ2	Mus musculus	O
HORSE\|Ensembl=ENSECAG00000049963.1\|UniProtKB=C8BNH6	Equus caballus	O
HORSE\|Ensembl=ENSECAG00000030501.2\|UniProtKB=C8BNG1	Equus caballus	O
HORSE\|Ensembl=ENSECAG00000033357.1\|UniProtKB=C8BNI9	Equus caballus	O
HORSE\|Ensembl=ENSECAG00000011787\|UniProtKB=A6YB85	Equus caballus	O
HORSE\|Ensembl=ENSECAG00000027869.3\|UniProtKB=A0A3Q2HQJ5	Equus caballus	O
HORSE\|Ensembl=ENSECAG00000039434.1\|UniProtKB=A0A3Q2GSZ3	Equus caballus	O
HORSE\|Ensembl=ENSECAG00000032644.1\|UniProtKB=A0A3Q2IBF0	Equus caballus	O
HORSE\|Ensembl=ENSECAG00000028505.2\|UniProtKB=A0A3Q2L6V2	Equus caballus	O
HORSE\|Ensembl=ENSECAG00000043705.2\|UniProtKB=A0A5F5PG18	Equus caballus	O
HORSE\|Ensembl=ENSECAG00000054883.1\|UniProtKB=C8BNG5	Equus caballus	O
HORSE\|Ensembl=ENSECAG00000037168.3\|UniProtKB=A0A5F5PU65	Equus caballus	O
HORSE\|Ensembl=ENSECAG00000051382.1\|UniProtKB=F6WLD2	Equus caballus	O
ORNAN\|Gene=DEFA2_ORNAN\|UniProtKB=P0C8A2	Ornithorhynchus anatinus	O
ORNAN\|Ensembl=ENSOANG00000037525.1\|UniProtKB=A0A6I8PB05	Ornithorhynchus anatinus	O
ORNAN\|Ensembl=ENSOANG00000050290\|UniProtKB=P0C8A3	Ornithorhynchus anatinus	O
TRIAD\|EnsemblGenome=TriadG55945\|UniProtKB=B3RTJ3	Trichoplax adhaerens	O
TRIAD\|EnsemblGenome=TriadG55948\|UniProtKB=B3RTJ6	Trichoplax adhaerens	O
TRIAD\|EnsemblGenome=TriadG55947\|UniProtKB=B3RTJ5	Trichoplax adhaerens	O
TRIAD\|EnsemblGenome=TriadG63910\|UniProtKB=B3RTJ8	Trichoplax adhaerens	O
TRIAD\|EnsemblGenome=TriadG63869\|UniProtKB=B3RVQ0	Trichoplax adhaerens	O
TRIAD\|EnsemblGenome=TriadG55946\|UniProtKB=B3RTJ4	Trichoplax adhaerens	O
TRIAD\|EnsemblGenome=TriadG55949\|UniProtKB=B3RTJ7	Trichoplax adhaerens	O