PANTHER Gene Information

Gene Symbol(s):

Arpc1a

Organism:

Rattus norvegicus

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Gene Name:

Actin-related protein 2_3 complex subunit 1A

Gene ID:

620834

Protein ID:

Q99PD4

Persistent Id:

PTN001322651

Alternate Ids:

NP_112408(refSeq)	AAK01364(EMBL-CDS)
620834(RGD)	81824(GeneID)
ARC1A(Synonym)	Arpc1a(Symbol)
59797636(GI)	AF315378(EMBL)
ARC1A_RAT(UniProtKB-ID)
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PANTHER Classification

PANTHER Family:	ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1 (PTHR10709)
PANTHER Subfamily:	ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT 1A (PTHR10709:SF11)
PANTHER GO-slim Molecular Function:	actin filament binding
PANTHER GO-slim Biological Process:	Arp2/3 complex-mediated actin nucleation
PANTHER GO-slim Cellular Component:	Arp2/3 protein complex
PANTHER protein class:	actin or actin-binding cytoskeletal protein

Pathway Categories:

Inflammation mediated by chemokine and cytokine signaling pathway

Actin related protein 2/3 complex

Integrin signalling pathway

Actin related protein 2/3 complex

Cytoskeletal regulation by Rho GTPase

Actin related protein 2/3 complex

Huntington disease

Actin related protein 2/3 complex

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	actin filament binding, actin binding
GO BP Complete:	biological_process, Arp2/3 complex-mediated actin nucleation
GO CC Complete:	nucleus, site of double-strand break, muscle cell projection membrane, cytoplasm, synapse, glutamatergic synapse, Arp2/3 protein complex

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Nervous system development, RHO GTPases Activate WASPs and WAVEs, Signaling by Rho GTPases, Signal Transduction, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Fcgamma receptor (FCGR) dependent phagocytosis, Axon guidance, EPH-Ephrin signaling, EPHB-mediated forward signaling, RHO GTPase Effectors, Immune System, Regulation of actin dynamics for phagocytic cup formation, Innate Immune System, Vesicle-mediated transport, Developmental Biology, Membrane Trafficking, Clathrin-mediated endocytosis

Orthologs

ID	Organism	Type
PANTR\|Ensembl=ENSPTRG00000051667.1\|UniProtKB=A0A2I3TQ84	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000039925.1\|UniProtKB=A0A2I2YC68	Gorilla gorilla gorilla	O
PANTR\|Ensembl=ENSPTRG00000050251.1\|UniProtKB=A0A2I3T7D9	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000037353.1\|UniProtKB=A0A2I2YDG6	Gorilla gorilla gorilla	O
HUMAN\|HGNC=703\|UniProtKB=Q92747	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000033819.3\|UniProtKB=H2QV00	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000039217.1\|UniProtKB=G3R1E2	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000001458.4\|UniProtKB=H9FNS7	Macaca mulatta	LDO
MOUSE\|MGI=MGI=1928896\|UniProtKB=Q9R0Q6	Mus musculus	LDO
BOVIN\|Ensembl=ENSBTAG00000049440.1\|UniProtKB=A0A3Q1NMB5	Bos taurus	O
BOVIN\|Ensembl=ENSBTAG00000004242\|UniProtKB=Q1JP79	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000007609.5\|UniProtKB=F1REX9	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000050899.1\|UniProtKB=A0A9L0S565	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000015065.6\|UniProtKB=M3WLV8	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845003616.1\|UniProtKB=A0A8I3MPK0	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000048722.1\|UniProtKB=A0A5F8G810	Monodelphis domestica	O
MONDO\|Ensembl=ENSMODG00000016729.3\|UniProtKB=A0A5F8HHQ2	Monodelphis domestica	O
MONDO\|Ensembl=ENSMODG00000001303.4\|UniProtKB=F7BZM9	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000007724.4\|UniProtKB=F6QTB5	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010021325.1\|UniProtKB=A0A8V0ZJ54	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000012777.4\|UniProtKB=H9GJ97	Anolis carolinensis	LDO
XENLA\|Gene_ORFName=XELAEV_18047443mg\|UniProtKB=Q8AVT9	Xenopus laevis	LDO
XENLA\|Gene_ORFName=XELAEV_18045070mg\|UniProtKB=A0A1L8EXB5	Xenopus laevis	O
XENLA\|Gene=arpc1a.S\|UniProtKB=A0A8J0U071	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-6034682\|UniProtKB=Q28I17	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000009096.2\|UniProtKB=H2LZ39	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-040116-1\|UniProtKB=Q7ZUQ0	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000004549.1\|UniProtKB=W5MAM8	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000004481.3\|UniProtKB=F6TEZ1	Ciona intestinalis	O
BRAFL\|Gene=LOC118429270\|UniProtKB=A0A9J7M8V7	Branchiostoma floridae	O
STRPU\|EnsemblGenome=LOC581455\|UniProtKB=A0A7M7HPN8	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC585909\|UniProtKB=A0A7M7NSH7	Strongylocentrotus purpuratus	O
CAEEL\|WormBase=WBGene00000201\|UniProtKB=A0A3P6PCS5	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG18174\|UniProtKB=A8XT67	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00274703\|UniProtKB=A0A2A6CY92	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00274999\|UniProtKB=A0A2A6BP68	Pristionchus pacificus	O
DROME\|FlyBase=FBgn0001961\|UniProtKB=O97182	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP008908\|UniProtKB=Q7PWN2	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC000050\|UniProtKB=D6WDC6	Tribolium castaneum	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_300535\|UniProtKB=E9HDB8	Daphnia pulex	O
IXOSC\|EnsemblGenome=ISCW011129\|UniProtKB=B7Q740	Ixodes scapularis	O
HELRO\|EnsemblGenome=HelroG185993\|UniProtKB=T1FNJ1	helobdella robusta	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g236117\|UniProtKB=A7SZA7	Nematostella vectensis	O
TRIAD\|EnsemblGenome=TriadG60814\|UniProtKB=B3S988	Trichoplax adhaerens	O
MONBE\|EnsemblGenome=MONBRDRAFT_35994\|UniProtKB=A9UR80	Monosiga brevicollis	O
YEAST\|SGD=S000000438\|UniProtKB=P38328	Saccharomyces cerevisiae	O
EREGS\|EnsemblGenome=AGOS_AFL022W\|UniProtKB=Q754U3	Eremothecium gossypii	O
CANAL\|CGD=CAL0000175984\|UniProtKB=A0A1D8PT60	Candida albicans	O
YARLI\|EnsemblGenome=YALI0_B17380g\|UniProtKB=Q6CE98	Yarrowia lipolytica	O
EMENI\|EnsemblGenome=ANIA_05778\|UniProtKB=Q5B102	Emericella nidulans	O
ASPFU\|EnsemblGenome=AFUA_6G06500\|UniProtKB=Q4WNG0	Neosartorya fumigata	O
NEUCR\|EnsemblGenome=NCU02781\|UniProtKB=Q7SE13	Neurospora crassa	O
SCLS1\|EnsemblGenome=SS1G_04510\|UniProtKB=A7EGR8	Sclerotinia sclerotiorum	O
PHANO\|EnsemblGenome=SNOG_03354\|UniProtKB=Q0UY10	Phaeosphaeria nodorum	O
SCHPO\|PomBase=SPBC14C8.06\|UniProtKB=P78774	Schizosaccharomyces pombe	O
SCHJY\|EnsemblGenome=SJAG_02075\|UniProtKB=B6JZN3	Schizosaccharomyces japonicus	O
CRYNJ\|EnsemblGenome=CNF00940\|UniProtKB=Q5KFQ5	Cryptococcus neoformans	O
USTMA\|EnsemblGenome=UMAG_05906\|UniProtKB=A0A0D1DQB3	Ustilago maydis	O
PUCGT\|EnsemblGenome=PGTG_02224\|UniProtKB=E3JXI8	Puccinia graminis	O
BATDJ\|Gene_ORFName=BATDEDRAFT_18271\|UniProtKB=F4NT44	Batrachochytrium dendrobatidis	O
ENTH1\|EnsemblGenome=CL6EHI_045000\|UniProtKB=C4LTB5	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_094120\|UniProtKB=C4LYJ9	Entamoeba histolytica	O
DICDI\|dictyBase=DDB_G0277825\|UniProtKB=O96622	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_95056\|UniProtKB=F0ZRS0	Dictyostelium purpureum	O
LEIMA\|EnsemblGenome=LMJF_18_0920\|UniProtKB=Q4QDV0	Leishmania major	O
TRYB2\|Gene_ORFName=Tb10.389.0270\|UniProtKB=Q388S8	Trypanosoma brucei	O
TRIV3\|Gene_ORFName=TVAG_035180\|UniProtKB=A2DAJ2	Trichomonas vaginalis	O
PLAF7\|EnsemblGenome=PF3D7_1118800\|UniProtKB=Q8IIH9	Plasmodium falciparum	O
PARTE\|EnsemblGenome=GSPATT00010112001\|UniProtKB=A0CSS3	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00006678001\|UniProtKB=A0C9A5	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00002218001\|UniProtKB=A0DGC2	Paramecium tetraurelia	O
PHYRM\|Gene=H3GNT1_PHYRM\|UniProtKB=H3GNT1	Phytophthora ramorum	O
CHLRE\|EnsemblGenome=CHLRE_16g648100v5\|UniProtKB=A0A2K3CSQ7	Chlamydomonas reinhardtii	O
AMBTC\|EnsemblGenome=AMTR_s00039p00197260\|UniProtKB=U5CRM6	Amborella trichopoda	O
ZOSMR\|Gene_ORFName=ZOSMA_15G01330\|UniProtKB=A0A0K9PV25	Zostera marina	O
MUSAM\|EnsemblGenome=Ma11_g07370\|UniProtKB=A0A804L5A3	Musa acuminata subsp. malaccensis	O
SETIT\|EnsemblGenome=SETIT_017523mg\|UniProtKB=K3YTC8	Setaria italica	O
SORBI\|EnsemblGenome=SORBI_3004G345400\|UniProtKB=A0A194YU89	Sorghum bicolor	O
MAIZE\|EnsemblGenome=Zm00001eb258930\|UniProtKB=C4IZE9	Zea mays	O
MAIZE\|EnsemblGenome=Zm00001eb191400\|UniProtKB=B6TA39	Zea mays	O
ORYSJ\|EnsemblGenome=Os02g0817200\|UniProtKB=Q6K699	Oryza sativa	O
BRADI\|EnsemblGenome=BRADI_3g55390v3\|UniProtKB=I1IDX5	Brachypodium distachyon	O
HORVV\|EnsemblGenome=HORVU.MOREX.r3.6HG0629710\|UniProtKB=A0A8I6YX20	Hordeum vulgare subsp. vulgare	O
WHEAT\|EnsemblGenome=TraesCS6B02G432000\|UniProtKB=A0A3B6PTP7	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCSU02G081300\|UniProtKB=A0A341ZB41	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS6D02G377800\|UniProtKB=A0A3B6QKZ3	Triticum aestivum	O
NELNU\|Gene=LOC104608427\|UniProtKB=A0A1U8QAN3	Nelumbo nucifera	O
NELNU\|Gene=LOC104609009\|UniProtKB=A0A1U8AYS2	Nelumbo nucifera	O
SPIOL\|Gene=LOC110783720\|UniProtKB=A0A9R0I6W9	Spinacia oleracea	O
HELAN\|EnsemblGenome=HanXRQr2_Chr16g0756401\|UniProtKB=A0A251S1U5	Helianthus annuus	O
LACSA\|Gene_ORFName=LSAT_V11C400178040\|UniProtKB=A0A9R1VSC6	Lactuca sativa	O
ERYGU\|Gene_ORFName=MIMGU_mgv1a008285mg\|UniProtKB=A0A022S272	Erythranthe guttata	O
SOLLC\|EnsemblGenome=Solyc05g006470.3\|UniProtKB=A0A3Q7GDR2	Solanum lycopersicum	O
TOBAC\|Gene=LOC107784652\|UniProtKB=A0A1S3ZA87	Nicotiana tabacum	O
TOBAC\|Gene=LOC107832594\|UniProtKB=A0A1S4DR85	Nicotiana tabacum	O
VITVI\|EnsemblGenome=Vitvi12g02215\|UniProtKB=E0CTY0	Vitis vinifera	O
EUCGR\|EnsemblGenome=EUGRSUZ_K01189\|UniProtKB=A0A058ZZP8	Eucalyptus grandis	O
BRANA\|Gene_ORFName=DARMORV10_A05P14760.1\|UniProtKB=A0A078FF85	Brassica napus	O
BRANA\|Gene_ORFName=DARMORV10_C03P20380.1\|UniProtKB=A0A078GBX8	Brassica napus	O
BRANA\|Gene_ORFName=GSBRNA2T00043385001\|UniProtKB=A0A078GYH3	Brassica napus	O
BRANA\|Gene_ORFName=DARMORV10_C04P19760.1\|UniProtKB=A0A078ICQ8	Brassica napus	O
BRACM\|EnsemblGenome=Bra021676\|UniProtKB=M4DYT0	Brassica campestris	O
BRACM\|EnsemblGenome=Bra022818\|UniProtKB=M4E218	Brassica campestris	O
ARATH\|TAIR=locus=2042491\|UniProtKB=Q9SJW6	Arabidopsis thaliana	O
ARATH\|TAIR=locus=2052871\|UniProtKB=O80856	Arabidopsis thaliana	O
GOSHI\|Gene=LOC107896882\|UniProtKB=A0A1U8IMN2	Gossypium hirsutum	O
GOSHI\|Gene=LOC107914491\|UniProtKB=A0A1U8K8T5	Gossypium hirsutum	O
THECC\|EnsemblGenome=TCM_001800\|UniProtKB=A0A061DJX7	Theobroma cacao	O
CITSI\|Gene_ORFName=CISIN_1g016982mg\|UniProtKB=A0A067EU28	Citrus sinensis	O
POPTR\|EnsemblGenome=POPTR_014G141700v3\|UniProtKB=B9IA44	Populus trichocarpa	O
MANES\|EnsemblGenome=MANES_02G087100\|UniProtKB=A0A2C9WC45	Manihot esculenta	O
MANES\|EnsemblGenome=MANES_01G129200\|UniProtKB=A0A251LR00	Manihot esculenta	O
RICCO\|Gene_ORFName=RCOM_0540370\|UniProtKB=B9SIS1	Ricinus communis	O
SOYBN\|EnsemblGenome=GLYMA_10G216300\|UniProtKB=I1LD74	Glycine max	O
SOYBN\|EnsemblGenome=GLYMA_18G103800\|UniProtKB=I1N0U4	Glycine max	O
SOYBN\|EnsemblGenome=GLYMA_08G311700\|UniProtKB=K7LA18	Glycine max	O
MEDTR\|EnsemblGenome=MTR_3g049070\|UniProtKB=G7IZZ4	Medicago truncatula	O
JUGRE\|EnsemblGenome=Jr10_16440\|UniProtKB=A0A2I4F971	Juglans regia	O
CUCSA\|EnsemblGenome=Csa_6G422800\|UniProtKB=A0A0A0KHX9	Cucumis sativus	O
PRUPE\|EnsemblGenome=PRUPE_3G170000\|UniProtKB=M5X5D3	Prunus persica	O
SELML\|EnsemblGenome=SELMODRAFT_140479\|UniProtKB=D8QRC4	Selaginella moellendorffii	O
SELML\|EnsemblGenome=SELMODRAFT_171977\|UniProtKB=D8RJH8	Selaginella moellendorffii	O
PHYPA\|EnsemblGenome=Pp3c18_4810\|UniProtKB=A0A2K1IZY5	Physcomitrella patens	O
PHYPA\|EnsemblGenome=Pp3c19_12930\|UniProtKB=A0A2K1IY81	Physcomitrella patens	O
MARPO\|EnsemblGenome=MARPO_0116s0052\|UniProtKB=A0A2R6WB43	Marchantia polymorpha	O
MARPO\|EnsemblGenome=MARPO_0090s0056\|UniProtKB=A0A2R6WHJ8	Marchantia polymorpha	O
KLENI\|Gene_ORFName=KFL_000020310\|UniProtKB=A0A1Y1HKK6	Klebsormidium nitens	O