PANTHER Gene Information

Gene Symbol(s):

DLL4

Organism:

Macaca mulatta

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Gene Name:

Delta-like protein

Gene ID:

ENSMMUG00000014541.4

Protein ID:

A0A5F7ZN66

Persistent Id:

PTN000621450

Alternate Ids:

A0A5F7ZN66(Synonym)	ENSMMUG00000014541(Ensembl)
A0A5F7ZN66_MACMU(UniProtKB-ID)	ENSMMUP00000066068(Ensembl_PRO)
ENSMMUT00000091089(Ensembl_TRS)
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PANTHER Classification

PANTHER Family:	NOTCH LIGAND FAMILY MEMBER (PTHR24044)
PANTHER Subfamily:	DELTA-LIKE PROTEIN 4 (PTHR24044:SF320)
PANTHER GO-slim Molecular Function:	signaling receptor binding
PANTHER GO-slim Biological Process:	negative regulation of Notch signaling pathway Notch signaling pathway
PANTHER GO-slim Cellular Component:	plasma membrane
PANTHER protein class:	intercellular signal molecule

Pathway Categories:

Angiogenesis

Delta

Notch signaling pathway

Delta

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	calcium ion binding, Notch binding, receptor ligand activity
GO BP Complete:	regulation of neural retina development, cell communication, negative regulation of cell population proliferation, negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis, negative regulation of Notch signaling pathway, positive regulation of Notch signaling pathway, negative regulation of cell migration involved in sprouting angiogenesis, negative regulation of transcription by RNA polymerase II, angiogenesis, branching involved in blood vessel morphogenesis, cardiac ventricle morphogenesis, cardiac atrium morphogenesis, positive regulation of neural precursor cell proliferation, dorsal aorta morphogenesis, negative regulation of endothelial cell migration, developmental process, negative regulation of blood vessel endothelial cell migration, aortic valve morphogenesis, cellular response to fibroblast growth factor stimulus, ventricular trabecula myocardium morphogenesis, pericardium morphogenesis, ventral spinal cord interneuron fate commitment, T cell differentiation, negative regulation of gene expression, blood vessel remodeling, Notch signaling pathway, blood vessel lumenization, positive regulation of gene expression, cellular response to vascular endothelial growth factor stimulus, regulation of neurogenesis
GO CC Complete:	membrane, plasma membrane

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Orthologs

ID	Organism	Type
HUMAN\|HGNC=2910\|UniProtKB=Q9NR61	Homo sapiens	LDO
GORGO\|Ensembl=ENSGGOG00000028605.2\|UniProtKB=G3SK70	Gorilla gorilla gorilla	LDO
MOUSE\|MGI=MGI=1859388\|UniProtKB=Q9JI71	Mus musculus	LDO
RAT\|RGD=1309740\|UniProtKB=D3ZHH1	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000010361.4\|UniProtKB=Q0V7L8	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00005017001.1\|UniProtKB=A0A4X1URL1	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000013434.3\|UniProtKB=A0A9L0SLB3	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000014721.6\|UniProtKB=M3WL78	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845029137.1\|UniProtKB=A0A8I3Q0Q1	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000000198.4\|UniProtKB=A0A5F8G283	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000012601.3\|UniProtKB=F7G4X4	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010022311.1\|UniProtKB=A0A8V0ZHH9	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000003483.4\|UniProtKB=H9G7L9	Anolis carolinensis	LDO
XENLA\|Gene=LOC108705808\|UniProtKB=A0A8J1LM50	Xenopus laevis	LDO
ORYLA\|Ensembl=ENSORLG00000016743.2\|UniProtKB=H2MQC7	Oryzias latipes	O
ORYLA\|Ensembl=ENSORLG00000018020.2\|UniProtKB=A0A3B3I4U3	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-041014-73\|UniProtKB=Q1ECY3	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000012287.1\|UniProtKB=W5N3B4	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000004194.3\|UniProtKB=F7ALL8	Ciona intestinalis	LDO
BRAFL\|Gene=LOC118417211\|UniProtKB=A0A9J7LBM6	Branchiostoma floridae	LDO
CAEEL\|WormBase=WBGene00015328\|UniProtKB=O44443	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG19989\|UniProtKB=A8XWV9	Caenorhabditis briggsae	O
CAEBR\|Gene_ORFName=CBG19981\|UniProtKB=A8XWV4	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00106762\|UniProtKB=A0A2A6CBX6	Pristionchus pacificus	O
CAEBR\|WormBase=WBGene00031967\|UniProtKB=A8XBI4	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00275663\|UniProtKB=A0A2A6BU86	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00095068\|UniProtKB=A0A2A6BLX6	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00097058\|UniProtKB=A0A2A6BDF7	Pristionchus pacificus	O
CAEEL\|WormBase=WBGene00003001\|UniProtKB=P14585	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG06809\|UniProtKB=A8X345	Caenorhabditis briggsae	O
IXOSC\|EnsemblGenome=ISCW020634\|UniProtKB=B7Q2M9	Ixodes scapularis	O
HELRO\|EnsemblGenome=HelroG80798\|UniProtKB=T1G456	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG133373\|UniProtKB=T1EI04	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG85694\|UniProtKB=T1G618	helobdella robusta	O
DROME\|FlyBase=FBgn0021742\|UniProtKB=Q9VZ44	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP010940\|UniProtKB=A0A1S4H5C2	Anopheles gambiae	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_39669\|UniProtKB=E9FR30	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_323318\|UniProtKB=E9GYJ2	Daphnia pulex	O
DROME\|FlyBase=FBgn0000463\|UniProtKB=P10041	Drosophila melanogaster	LDO
TRICA\|EnsemblGenome=TC004114\|UniProtKB=D6W6S0	Tribolium castaneum	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_63051\|UniProtKB=E9HI96	Daphnia pulex	LDO
IXOSC\|EnsemblGenome=ISCW013622\|UniProtKB=B7QHQ8	Ixodes scapularis	LDO
HELRO\|EnsemblGenome=HelroG77153\|UniProtKB=T1G2T6	helobdella robusta	LDO
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g216602\|UniProtKB=A7SS38	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g128497\|UniProtKB=A7SR75	Nematostella vectensis	LDO
MONBE\|EnsemblGenome=MONBRDRAFT_38707\|UniProtKB=A9V9N1	Monosiga brevicollis	O
GIAIC\|EnsemblGenome=GL50803_24512\|UniProtKB=A8B4D5	Giardia intestinalis	O
CHLRE\|EnsemblGenome=CHLRE_16g690095v5\|UniProtKB=A0A2K3CW78	Chlamydomonas reinhardtii	O